UPB - NASDAQ

UB

Upstream Bio, Inc.

UPB·NASDAQ

$20.97

-5.9%
HealthcareBiotechnology

Upstream Bio, Inc., a clinical-stage biotechnology company, develops treatments for inflammatory diseases that focuses on severe respiratory disorders. It develops verekitug, a monoclonal antibody that targets and inhibits the thymic stromal lymphopoietin receptor. The company also develops therapies to treat severe asthma, chronic rhinosinusitis with nasal polyps, and chronic obstructive pulmonary disease. Upstream Bio, Inc. was incorporated in 2021 and is based in Waltham, Massachusetts.

StatementsValue Model

At a Glance

Live Snapshot
Market Cap$1.13B
EPS-0.7400
P/E Ratio-3.69
Earnings Date11/06/2025
2.37M
Revenue
3Y+96.0%
5Y+96.0%
10Y+96.0%
-62.81M
Net Income
206%
3Y+163.0%
5Y+163.0%
10Y+163.0%
-59.17M
Operating Cash Flow
56%
3Y+211.0%
5Y+211.0%
10Y+211.0%
UB

Upstream Bio, Inc. Profit Bridge

UPB · NASDAQ
Revenue2.37M
Cost of Goods Sold (89.00K)
Gross Profit2.37M
Operating Expenses (80.13M)
Operating Income-77.76M
Interest Expense (0.00)
Other Income/Expense14.96M
Pretax Income-62.81M
Income Tax (0.00)
Net Income-62.81M
Net Income
-62.81M

Profitability Analysis

Gross Margin

100.0%

Exceptional pricing power and cost management. The company retains over half of revenue after direct costs.

Operating Margin

-3281.2%

Operating losses indicate the core business is unprofitable. Requires restructuring or revenue growth.

Net Profit Margin

-2650.0%

Net losses indicate the company is burning cash. Sustainability depends on path to profitability.

Profitability Insight

Margin squeeze alert: Healthy gross margins but weak operating margins suggest excessive operating expenses. Cost optimization could unlock significant value.

Upstream Bio, Inc. Income Statement

UPB • NASDAQ

Upstream Bio, Inc. Income StatementDec 2024Dec 2023Dec 2022
REVENUE
Revenue
2.4M
2.4M
1.2M
GROSS PROFIT
Cost of Revenue
(89K)
(60K)
(7K)
Gross Profit
2.4M
2.4M
1.2M
OPERATING INCOME
Operating Expenses
(80.1M)
(42.5M)
(25.1M)
Selling, General & Administrative
(17.2M)
(10.7M)
(6.5M)
Research & Development
(63M)
(31.8M)
(18.7M)
Operating Income
-77.8M
-40.1M
-23.9M
PRE-TAX INCOME
Net Interest Income
12.1M
4.2M
205K
Total Other Income Expenses Net
15M
19.6M
41K
Income Before Tax
-62.8M
-20.5M
-23.9M
NET INCOME
Net Income
-62.8M
-20.5M
-23.9M

SEC Filings

UPB - Filing history and reports

No SEC filings available for UPB

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