Prelude Therapeutics Incorporated

Prelude Therapeutics Incorporated

PRLDยทNASDAQ

$3.50

+14%
HealthcareBiotechnology

Prelude Therapeutics Incorporated, a clinical-stage precision oncology company, focuses on the discovery and development of novel precision cancer medicines to underserved patients. It is developing PRT543 that is in Phase 1 clinical trials in select solid tumors and myeloid malignancies; and PRT811, which is in Phase 1 clinical trials in solid tumors, including glioblastoma multiforme. The company is also developing PRT1419, a potent and selective inhibitor of the anti-apoptotic protein; PRT2527, a potent inhibitor of CDK9 that exhibits high kinome selectivity; PRT-SCA2, which is in preclinical stage for multiple genomically selected cancers; PRT3645, a brain penetrant molecule that potently and selectively targets CDK4/6; and PRT-K4 that is in preclinical stage for solid tumors. The company was incorporated in 2016 and is headquartered in Wilmington, Delaware.

At a Glance

Live Snapshot
Market Cap$199.26M
EPS-1.2900
P/E Ratio-2.24
Earnings Date08/13/2026
3Y-
5Y-
10Y-
3Y-14.0%
5Y+75.0%
10Y+578.0%
3Y-33.0%
5Y+22.0%
10Y+335.0%
Prelude Therapeutics Incorporated

Prelude Therapeutics Incorporated Profit Bridge

PRLD ยท NASDAQ
Revenue12.14M
Cost of Goods Sold (1.71M)
Gross Profit10.43M
Operating Expenses (115.00M)
Operating Income-104.57M
Interest Expense (0.00)
Other Income/Expense5.07M
Pretax Income-99.50M
Income Tax (0.00)
Net Income-99.50M
Net Income
-99.50M

Profitability Analysis

Gross Margin

85.9%

Exceptional pricing power and cost management. The company retains over half of revenue after direct costs.

Operating Margin

-861.3%

Operating losses indicate the core business is unprofitable. Requires restructuring or revenue growth.

Net Profit Margin

-819.6%

Net losses indicate the company is burning cash. Sustainability depends on path to profitability.

Profitability Insight

Margin squeeze alert: Healthy gross margins but weak operating margins suggest excessive operating expenses. Cost optimization could unlock significant value.

Prelude Therapeutics Incorporated Income Statement

PRLD โ€ข NASDAQ

Prelude Therapeutics Incorporated Income StatementDec 2025Dec 2024Dec 2023Dec 2022Dec 2021Dec 2020Dec 2019Dec 2018
REVENUE
12.1M
7M
0.0
0.0
0.0
0.0
0.0
0.0
GROSS PROFIT
(1.7M)
(0.0)
(0.0)
(0.0)
(0.0)
(0.0)
(382K)
(149K)
10.4M
7M
0.0
0.0
0.0
0.0
-382K
-149K
OPERATING INCOME
(115M)
(146.7M)
(132.3M)
(123.5M)
(113.7M)
(58.8M)
(28.1M)
(15M)
(22.4M)
(28.7M)
(28.9M)
(30.7M)
(27M)
(10.6M)
(3.8M)
(2.4M)
(94.3M)
(118M)
(103.4M)
(92.9M)
(86.8M)
(48.2M)
(24.3M)
(12.6M)
-104.6M
-139.7M
-132.3M
-123.5M
-113.7M
-58.8M
-28.1M
-15M
PRE-TAX INCOME
-1.7M
(0.0)
-1.0
(0.0)
(0.0)
(0.0)
(539K)
(0.0)
5.1M
12.5M
10.4M
8.1M
2M
1.8M
539K
295K
-99.5M
-127.2M
-121.8M
-115.4M
-111.7M
-56.9M
-27.6M
-14.7M
NET INCOME
(0.0)
(0.0)
(0.0)
(0.0)
(0.0)
(0.0)
(210.1K)
(0.0)
-99.5M
-127.2M
-121.8M
-115.4M
-111.7M
-56.9M
-27.6M
-14.7M

SEC Filings

PRLD - Filing history and reports

Filing TypeFiling DatePeriod EndingFiscal YearActions
10-Q

10-Q 2026 Q1

Q1

May 12, 2026
March 31, 2026
2026
8-K

8-K 2026

N/A

May 12, 2026
May 12, 2026
2026
DEF 14A

DEF 14A 2026

N/A

April 29, 2026
June 09, 2026
2026
8-K

8-K 2026

N/A

April 21, 2026
April 20, 2026
2026
8-K

8-K 2026

N/A

April 20, 2026
April 20, 2026
2026
8-K

8-K 2026

N/A

April 15, 2026
April 15, 2026
2026
8-K

8-K 2026

N/A

March 12, 2026
March 12, 2026
2026
10-K

10-K 2025 FY

FY

March 10, 2026
December 31, 2025
2025
8-K

8-K 2026

N/A

March 10, 2026
March 10, 2026
2026
8-K

8-K 2026

N/A

February 03, 2026
January 29, 2026
2026
Showing 1 to 10 of 106 filings