Prelude Therapeutics Incorporated

Prelude Therapeutics Incorporated

PRLD·NASDAQ

$3.50

+14%
HealthcareBiotechnology

Prelude Therapeutics Incorporated, a clinical-stage precision oncology company, focuses on the discovery and development of novel precision cancer medicines to underserved patients. It is developing PRT543 that is in Phase 1 clinical trials in select solid tumors and myeloid malignancies; and PRT811, which is in Phase 1 clinical trials in solid tumors, including glioblastoma multiforme. The company is also developing PRT1419, a potent and selective inhibitor of the anti-apoptotic protein; PRT2527, a potent inhibitor of CDK9 that exhibits high kinome selectivity; PRT-SCA2, which is in preclinical stage for multiple genomically selected cancers; PRT3645, a brain penetrant molecule that potently and selectively targets CDK4/6; and PRT-K4 that is in preclinical stage for solid tumors. The company was incorporated in 2016 and is headquartered in Wilmington, Delaware.

At a Glance

Live Snapshot
Market Cap$199.26M
EPS-1.2900
P/E Ratio-2.24
Earnings Date08/13/2026
prld

Prelude Therapeutics Incorporated Street Expectations Map

PRLD · NASDAQ

Wall Street analysts project that PRLD stock may rise significantly over the coming 12 months. The consensus 1-year price target stands at 8.00, with estimates ranging from a low of 8.00 to a high of 8.00.

Lowest Target
8.00
128.57%
Consensus Target
8.00
128.57%
Highest Target
8.00
128.57%

The consensus 1-year price target stands at 8.00, with estimates ranging from a low of 8.00 to a high of 8.00.

Analyst Consensus Analysis

Upside Potential

+128.6%

Substantial upside potential. Analysts see significant value gap, suggesting the stock may be materially undervalued at current levels.

Analyst Agreement

0.0% spread

High analyst agreement. Narrow target range indicates strong consensus on valuation, suggesting clear investment thesis and predictable outlook.

Analyst Conviction

Very High

Strong buy conviction: High upside with tight consensus suggests compelling investment opportunity backed by analyst confidence.

Market Sentiment Insight

Rare opportunity: Exceptional upside potential with strong analyst consensus creates a compelling setup. The combination of significant price target premium and tight agreement suggests high-conviction undervaluation that may attract institutional capital.

prld

Prelude Therapeutics Incorporated Forward Estimates of Revenue

PRLD · NASDAQ
Latest Revenue
12.14M
FY 2025
Avg Estimate
28.45M
FY 2026
Estimate Range
3.44M - 78.46M
Analyst Spread

Forward Growth Analysis

Projected Growth+134.3%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage3 Analysts

Limited coverage may indicate reduced institutional interest or information availability.

Estimate Spread264%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookNeutral

Mixed signals—some positive indicators offset by concerns about growth or uncertainty.

Key Insight

Limited coverage with volatile estimates: Few analysts covering despite significant projected changes may indicate information gaps or emerging risks.

prld

Prelude Therapeutics Incorporated Forward Estimates of Net Income

PRLD · NASDAQ
Latest Net Income
-99.50M
FY 2025
Avg Estimate
-22.87M
FY 2026
Estimate Range
-163.10M - 7.10M
Analyst Spread

Forward Growth Analysis

Projected Growth+77.0%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage3 Analysts

Limited coverage may indicate reduced institutional interest or information availability.

Estimate Spread744%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookNeutral

Mixed signals—some positive indicators offset by concerns about growth or uncertainty.

Key Insight

Limited coverage with volatile estimates: Few analysts covering despite significant projected changes may indicate information gaps or emerging risks.

prld

Prelude Therapeutics Incorporated Forward Estimates of EPS

PRLD · NASDAQ
Latest EPS
-1.29
FY 2025
Avg Estimate
$-0.65
FY 2026
Estimate Range
$-2.12 - $0.09
Analyst Spread

Forward Growth Analysis

Projected Growth+50.0%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage2 Analysts

Limited coverage may indicate reduced institutional interest or information availability.

Estimate Spread343%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookNeutral

Mixed signals—some positive indicators offset by concerns about growth or uncertainty.

Key Insight

Limited coverage with volatile estimates: Few analysts covering despite significant projected changes may indicate information gaps or emerging risks.

prld

Prelude Therapeutics Incorporated Forward Estimates of EBIT

PRLD · NASDAQ
Latest EBIT
-104.57M
FY 2025
Avg Estimate
5.69M
FY 2026
Estimate Range
687.12K - 15.69M
Analyst Spread

Forward Growth Analysis

Projected Growth+105.4%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage3 Analysts

Limited coverage may indicate reduced institutional interest or information availability.

Estimate Spread264%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookNeutral

Mixed signals—some positive indicators offset by concerns about growth or uncertainty.

Key Insight

Limited coverage with volatile estimates: Few analysts covering despite significant projected changes may indicate information gaps or emerging risks.

prld

Prelude Therapeutics Incorporated Forward Estimates of EBITDA

PRLD · NASDAQ
Latest EBITDA
-102.86M
FY 2025
Avg Estimate
5.69M
FY 2026
Estimate Range
687.12K - 15.69M
Analyst Spread

Forward Growth Analysis

Projected Growth+105.5%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage3 Analysts

Limited coverage may indicate reduced institutional interest or information availability.

Estimate Spread264%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookNeutral

Mixed signals—some positive indicators offset by concerns about growth or uncertainty.

Key Insight

Limited coverage with volatile estimates: Few analysts covering despite significant projected changes may indicate information gaps or emerging risks.

prld

Prelude Therapeutics Incorporated Forward Estimates of SG&A Expense

PRLD · NASDAQ
Latest SG&A Expense
22.41M
FY 2025
Avg Estimate
50.91M
FY 2026
Estimate Range
6.15M - 140.42M
Analyst Spread

Forward Growth Analysis

Projected Growth+127.2%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage3 Analysts

Limited coverage may indicate reduced institutional interest or information availability.

Estimate Spread264%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookNeutral

Mixed signals—some positive indicators offset by concerns about growth or uncertainty.

Key Insight

Limited coverage with volatile estimates: Few analysts covering despite significant projected changes may indicate information gaps or emerging risks.

prld

Prelude Therapeutics Incorporated Insider Positioning

PRLD · NASDAQ

During the last 12 months, insiders have purchased $7.95M worth of PRLD shares, with no selling activity reported.

3 Months

Bought

3.8M

7.50M

Sold

0

0.00

Net Activity

+7.5M

+$7.50M

3-6 Months

Bought

0

0.00

Sold

0

0.00

Net Activity

+0

+$0

6-9 Months

Bought

121.3K

168.59K

Sold

0

0.00

Net Activity

+169K

+$169K

9-12 Months

Bought

266.0K

276.64K

Sold

0

0.00

Net Activity

+277K

+$277K

Top Buyers

1
BDP

Bonita David P

Director, 10 Percent Owner:

1.7M shares2 transactions

$7.54M

2
SV

Sandor Victor

Director

159.3K shares2 transactions

$208K

3
BBAL

Baker Bros. Advisors Lp

Director, 10 Percent Owner:

2.2M shares2 transactions

$79K

4
BM

Babler Martin

Director

38.0K shares1 transactions

$40K

5
DM

Dier Mardi

Director

38.0K shares1 transactions

$40K

Top Sellers

No selling activity

Insider Activity Analysis

Net Insider Sentiment

Bullish

Strong bullish signal with $7.95M net buying. Insiders are aggressively accumulating shares, suggesting significant confidence in future prospects.

Buy/Sell Ratio

∞:1

Perfect buy/sell ratio. Only buying activity with zero selling—the most bullish possible insider signal.

Recent Trend (3 Months)

$7.50M

Very strong recent buying momentum. Recent insider purchases significantly outpace sales, suggesting near-term optimism.

Insider Participation

High Buying

5 insider buyers vs. 0 sellers. Broad-based buying across management team suggests widespread confidence.

Insider Activity Insight

Strong confluence of bullish signals: High buy/sell ratio, multiple insiders participating, and recent buying momentum all point to significant insider confidence. This level of coordinated buying often precedes positive developments.