Prelude Therapeutics Incorporated

Prelude Therapeutics Incorporated

PRLD·NASDAQ

$3.50

+14%
HealthcareBiotechnology

Prelude Therapeutics Incorporated, a clinical-stage precision oncology company, focuses on the discovery and development of novel precision cancer medicines to underserved patients. It is developing PRT543 that is in Phase 1 clinical trials in select solid tumors and myeloid malignancies; and PRT811, which is in Phase 1 clinical trials in solid tumors, including glioblastoma multiforme. The company is also developing PRT1419, a potent and selective inhibitor of the anti-apoptotic protein; PRT2527, a potent inhibitor of CDK9 that exhibits high kinome selectivity; PRT-SCA2, which is in preclinical stage for multiple genomically selected cancers; PRT3645, a brain penetrant molecule that potently and selectively targets CDK4/6; and PRT-K4 that is in preclinical stage for solid tumors. The company was incorporated in 2016 and is headquartered in Wilmington, Delaware.

At a Glance

Live Snapshot
Market Cap$199.26M
EPS-1.2900
P/E Ratio-2.24
Earnings Date08/13/2026
-114.83%
Return on Invested Capital
25%
3Y+86.0%
5Y+315.0%
10Y+7.0%
-144.96%
Return on Equity
50%
3Y+145.0%
5Y+440.0%
10Y-324.0%
-70.41%
Return on Assets
-3%
3Y+34.0%
5Y+177.0%
10Y-21.0%
Prelude Therapeutics Incorporated

Prelude Therapeutics Incorporated Management Team

PRLD · NASDAQ
MB

Mr. Bryant David Lim J.D.

Chief Financial Officer, Chief Legal Officer & Corporate Secretary

Compensation

$621,017

Born 1971(Age 55)
male
MM

Ms. Michele Porreca M.B.A.

Chief People Officer

female
DP

Dr. Peggy A. Scherle Ph.D.

Chief Scientific Officer

Compensation

$868,617

Born 1962(Age 64)
DA

Dr. Andrew P. Combs Ph.D.

Executive Vice President & Chief Chemistry Officer

Compensation

$562,461

Born 1967(Age 59)
DK

Dr. Krishna Vaddi D.V.M., Ph.D.

Founder, Chief Executive Officer & Director

Compensation

$881,092

Born 1966(Age 60)
DE

Dr. Edna Huang M.D.

President & Chief Medical Officer

Compensation

$843,233

Born 1973(Age 53)
MA

Ms. Aimee Crombie Ph.D.

Senior Vice President and Head of Strategic Planning & Operations

female
DW

Dr. William B. Novotny M.D.

Senior Vice President of Clinical Development

DM

Dr. Madhu Pudipeddi Ph.D.

Senior Vice President of Technical Operations

MN

Mr. Naveen Babbar Ph.D.

Senior Vice President of Translation Medicine

male
prld

Prelude Therapeutics Incorporated Insider Positioning

PRLD · NASDAQ

During the last 12 months, insiders have purchased $7.95M worth of PRLD shares, with no selling activity reported.

3 Months

Bought

3.8M

7.50M

Sold

0

0.00

Net Activity

+7.5M

+$7.50M

3-6 Months

Bought

0

0.00

Sold

0

0.00

Net Activity

+0

+$0

6-9 Months

Bought

121.3K

168.59K

Sold

0

0.00

Net Activity

+169K

+$169K

9-12 Months

Bought

266.0K

276.64K

Sold

0

0.00

Net Activity

+277K

+$277K

Top Buyers

1
BDP

Bonita David P

Director, 10 Percent Owner:

1.7M shares2 transactions

$7.54M

2
SV

Sandor Victor

Director

159.3K shares2 transactions

$208K

3
BBAL

Baker Bros. Advisors Lp

Director, 10 Percent Owner:

2.2M shares2 transactions

$79K

4
BM

Babler Martin

Director

38.0K shares1 transactions

$40K

5
DM

Dier Mardi

Director

38.0K shares1 transactions

$40K

Top Sellers

No selling activity

Insider Activity Analysis

Net Insider Sentiment

Bullish

Strong bullish signal with $7.95M net buying. Insiders are aggressively accumulating shares, suggesting significant confidence in future prospects.

Buy/Sell Ratio

∞:1

Perfect buy/sell ratio. Only buying activity with zero selling—the most bullish possible insider signal.

Recent Trend (3 Months)

$7.50M

Very strong recent buying momentum. Recent insider purchases significantly outpace sales, suggesting near-term optimism.

Insider Participation

High Buying

5 insider buyers vs. 0 sellers. Broad-based buying across management team suggests widespread confidence.

Insider Activity Insight

Strong confluence of bullish signals: High buy/sell ratio, multiple insiders participating, and recent buying momentum all point to significant insider confidence. This level of coordinated buying often precedes positive developments.

SEC Filings

PRLD - Filing history and reports

Filing TypeFiling DatePeriod EndingFiscal YearActions
DEF 14A

DEF 14A 2026

N/A

April 29, 2026
June 09, 2026
2026
DEF 14A

DEF 14A 2025

N/A

April 29, 2025
June 12, 2025
2025
DEF 14A

DEF 14A 2024

N/A

April 26, 2024
June 14, 2024
2024
DEF 14A

DEF 14A 2023

N/A

April 28, 2023
June 16, 2023
2023
DEF 14A

DEF 14A 2022

N/A

April 29, 2022
June 17, 2022
2022
DEF 14A

DEF 14A 2021

N/A

April 29, 2021
June 18, 2021
2021
Showing 1 to 6 of 6 filings