Axsome Therapeutics, Inc.

Axsome Therapeutics, Inc.

AXSM·NASDAQ

$233.49

+5.1%
HealthcareBiotechnology

Axsome Therapeutics, Inc., a biopharmaceutical company, engages in the development of novel therapies for central nervous system (CNS) disorders in the United States. The company's product pipeline includes AXS-05, a therapeutic for the treatment of major depressive disorder and resistant depression disorders; and that is in the Phase III clinical trial to treat Alzheimer's disease agitation, as well as that has completed phase II clinical trial for the treatment of smoking cessation. It is also developing AXS-07, a novel, oral, rapidly absorbed, multi-mechanistic, and investigational medicine that has completed two Phase III trials for the acute treatment of migraine; AXS-12, a selective and potent norepinephrine reuptake inhibitor, which is in Phase III trial to treat narcolepsy; and AXS-14, a novel, oral, and investigational medicine that is in Phase III trial for the treatment of fibromyalgia. Axsome Therapeutics, Inc. has a research collaboration agreement with Duke University for evaluating AXS-05 in smoking cessation. The company was incorporated in 2012 and is based in New York, New York.

At a Glance

Live Snapshot
Market Cap$12.02B
EPS-3.6800
P/E Ratio-63.45
Earnings Date08/03/2026
-43.95%
Return on Invested Capital
-46%
3Y-42.0%
5Y-27.0%
10Y-50.0%
-207.46%
Return on Equity
-59%
3Y+21.0%
5Y+129.0%
10Y+65.0%
-26.55%
Return on Assets
-47%
3Y-53.0%
5Y-52.0%
10Y-63.0%
Axsome Therapeutics, Inc.

Axsome Therapeutics, Inc. Management Team

AXSM · NASDAQ
MA

Mr. Ari Maizel

Chief Commercial Officer

Compensation

$898,662

Born 1979(Age 47)
male
MN

Mr. Nick Pizzie CPA, M.B.A.

Chief Financial Officer

Compensation

$956,487

Born 1975(Age 51)
male
MM

Mr. Mark L. Jacobson M.A.

Chief Operating Officer

Compensation

$1,045,959

Born 1983(Age 43)
male
DO

Darren Opland

Director of Corporate Communications

DH

Dr. Herriot Tabuteau M.D.

Founder, Chairman, Chief Executive Officer & President

Compensation

$1,864,930

Born 1968(Age 58)
MH

Mr. Hunter Murdock Esq.

General Counsel & Secretary

Compensation

$945,697

Born 1980(Age 46)
male
axsm

Axsome Therapeutics, Inc. Insider Positioning

AXSM · NASDAQ

During the last 12 months, insiders have purchased $102K and sold $126.04M worth of AXSM shares, resulting in $125.94M of net selling activity.

3 Months

Bought

0

0.00

Sold

29.8K

6.47M

Net Activity

-6.5M

-$6.47M

3-6 Months

Bought

0

0.00

Sold

283.0K

48.47M

Net Activity

-48.5M

-$48.47M

6-9 Months

Bought

800

101.76K

Sold

386.9K

50.18M

Net Activity

-50.1M

-$50.08M

9-12 Months

Bought

0

0.00

Sold

180.3K

20.92M

Net Activity

-20.9M

-$20.92M

Top Buyers

1
CM

Coleman Mark

Director

800 shares1 transactions

$102K

Top Sellers

1
TH

Tabuteau Herriot

Director, 10 Percent Owner, Officer: Chief Executive Officer

508.7K shares15 transactions

$74.35M

2
JML

Jacobson Mark L.

Officer: Chief Operating Officer

115.1K shares6 transactions

$15.30M

3
JR

Jeffs Roger

Director

110.2K shares6 transactions

$13.37M

4
CM

Coleman Mark

Director

42.5K shares4 transactions

$8.05M

5
SME

Saad Mark E

Director

40.5K shares2 transactions

$6.32M

Insider Activity Analysis

Net Insider Sentiment

Bearish

Strong bearish signal with $125.94M net selling. Heavy insider selling may indicate concerns about valuation or near-term prospects.

Buy/Sell Ratio

0.00:1

Very poor ratio. Heavy selling with minimal buying suggests insiders may be concerned about valuation or outlook.

Recent Trend (3 Months)

$6.47M

Heavy recent selling activity. Recent insider sales notably exceed purchases—may warrant investigation into company developments.

Insider Participation

High Selling

5 insider sellers vs. 1 buyers. Widespread selling across multiple insiders may signal concerns.

Insider Activity Insight

Multiple red flags: Heavy selling, numerous sellers, and continued recent selling create a concerning pattern. Investigate fundamental drivers and consider whether company guidance or industry conditions have deteriorated.

SEC Filings

AXSM - Filing history and reports

Filing TypeFiling DatePeriod EndingFiscal YearActions
DEF 14A

DEF 14A 2026

N/A

April 24, 2026
April 24, 2026
2026
DEF 14A

DEF 14A 2025

N/A

April 25, 2025
April 25, 2025
2025
DEF 14A

DEF 14A 2024

N/A

April 26, 2024
April 26, 2024
2024
DEF 14A

DEF 14A

N/A

April 21, 2023
April 21, 2023
 
DEF 14A

DEF 14A 2022

N/A

April 22, 2022
April 22, 2022
2022
DEF 14A

DEF 14A 2021

N/A

April 23, 2021
June 04, 2021
2021
DEF 14A

DEF 14A 2020

N/A

April 21, 2020
June 05, 2020
2020
DEF 14A

DEF 14A 2019

N/A

April 26, 2019
June 07, 2019
2019
DEF 14A

DEF 14A 2018

N/A

April 30, 2018
June 01, 2018
2018
DEF 14A

DEF 14A 2017

N/A

April 28, 2017
June 02, 2017
2017
Showing 1 to 10 of 11 filings