Axsome Therapeutics, Inc.

Axsome Therapeutics, Inc.

AXSMยทNASDAQ

$233.49

+5.1%
HealthcareBiotechnology

Axsome Therapeutics, Inc., a biopharmaceutical company, engages in the development of novel therapies for central nervous system (CNS) disorders in the United States. The company's product pipeline includes AXS-05, a therapeutic for the treatment of major depressive disorder and resistant depression disorders; and that is in the Phase III clinical trial to treat Alzheimer's disease agitation, as well as that has completed phase II clinical trial for the treatment of smoking cessation. It is also developing AXS-07, a novel, oral, rapidly absorbed, multi-mechanistic, and investigational medicine that has completed two Phase III trials for the acute treatment of migraine; AXS-12, a selective and potent norepinephrine reuptake inhibitor, which is in Phase III trial to treat narcolepsy; and AXS-14, a novel, oral, and investigational medicine that is in Phase III trial for the treatment of fibromyalgia. Axsome Therapeutics, Inc. has a research collaboration agreement with Duke University for evaluating AXS-05 in smoking cessation. The company was incorporated in 2012 and is based in New York, New York.

At a Glance

Live Snapshot
Market Cap$12.02B
EPS-3.6800
P/E Ratio-49.60
Earnings Date08/03/2026
3Y+1176.0%
5Y-
10Y-
3Y-2.0%
5Y+78.0%
10Y+573.0%
3Y-20.0%
5Y+19.0%
10Y+339.0%
Axsome Therapeutics, Inc.

Axsome Therapeutics, Inc. Profit Bridge

AXSM ยท NASDAQ
Revenue638.50M
Cost of Goods Sold (47.48M)
Gross Profit591.02M
Operating Expenses (760.25M)
Operating Income-169.24M
Interest Expense (6.56M)
Other Income/Expense-14.47M
Pretax Income-183.70M
Income Tax (-530.00K)
Net Income-183.17M
Net Income
-183.17M

Profitability Analysis

Gross Margin

92.6%

Exceptional pricing power and cost management. The company retains over half of revenue after direct costs.

Operating Margin

-26.5%

Operating losses indicate the core business is unprofitable. Requires restructuring or revenue growth.

Net Profit Margin

-28.7%

Net losses indicate the company is burning cash. Sustainability depends on path to profitability.

Profitability Insight

Margin squeeze alert: Healthy gross margins but weak operating margins suggest excessive operating expenses. Cost optimization could unlock significant value.

Axsome Therapeutics, Inc. Income Statement

AXSM โ€ข NASDAQ

Axsome Therapeutics, Inc. Income StatementDec 2025Dec 2024Dec 2023Dec 2022Dec 2021Dec 2020Dec 2019Dec 2018Dec 2017Dec 2016Dec 2015Dec 2014Dec 2013
REVENUE
638.5M
385.7M
270.6M
50M
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
GROSS PROFIT
(47.5M)
(33.3M)
(26.1M)
(5.2M)
(0.0)
(0.0)
(37.3K)
(48.9K)
(42.6K)
(20.5K)
(3.5K)
(0.0)
(0.0)
591M
352.4M
244.5M
44.8M
0.0
0.0
-37.3K
-48.9K
-42.6K
-20.5K
-3.5K
0.0
0.0
OPERATING INCOME
(760.3M)
(633M)
(476.4M)
(224.6M)
(124.7M)
(99.1M)
(67.1M)
(32.8M)
(27.2M)
(27.5M)
(9.2M)
(5.7M)
(1.8M)
(570.6M)
(411.4M)
(323.1M)
(159.3M)
(66.6M)
(28.9M)
(13.6M)
(9.4M)
(7.2M)
(6.3M)
(2.4M)
(1.4M)
(304.2K)
(183.3M)
(187.1M)
(97.9M)
(57.9M)
(58.1M)
(70.2M)
(53.6M)
(23.5M)
(20M)
(21.2M)
(6.8M)
(4.3M)
(1.5M)
-169.2M
-280.6M
-231.8M
-179.8M
-124.7M
-99.1M
-67.2M
-32.8M
-27.2M
-27.5M
-9.2M
-5.7M
-1.8M
PRE-TAX INCOME
(6.6M)
(6.6M)
(6.5M)
(7.3M)
(5.7M)
(2.6M)
(1.2M)
(1.1M)
(1.3M)
(132.4K)
(915K)
(2.2M)
(327.2K)
2.8M
-6.6M
-6.5M
-7.3M
-5.7M
0.0
0.0
-1.1M
-1.3M
-132.4K
0.0
0.0
-327.2K
(6.4M)
(34.5M)
(55.3M)
(7.4M)
(0.0)
-53.6K
-139.4K
(0.0)
(0.0)
(0.0)
(0.0)
(0.0)
(0.0)
-14.5M
-6.6M
-6.5M
-7.3M
-5.7M
-3.8M
-1.1M
1.7M
-1.8M
341.9K
-1.4M
-328.5K
-327.2K
-183.7M
-287.1M
-238.3M
-187.1M
-130.4M
-102.9M
-68.3M
-31M
-28.9M
-27.2M
-10.6M
-6M
-2.2M
NET INCOME
-530K
(85K)
(960K)
(0.0)
(0.0)
(0.0)
(0.0)
(0.0)
(0.0)
(0.0)
(1.4M)
(0.0)
(0.0)
-183.2M
-287.2M
-239.2M
-187.1M
-130.4M
-102.9M
-68.3M
-31M
-28.9M
-27.2M
-12.2M
-6M
-2.2M

SEC Filings

AXSM - Filing history and reports

Filing TypeFiling DatePeriod EndingFiscal YearActions
8-K

8-K 2026

N/A

June 03, 2026
June 03, 2026
2026
10-Q

10-Q 2026 Q1

Q1

May 04, 2026
March 31, 2026
2026
8-K

8-K 2026

N/A

May 04, 2026
May 04, 2026
2026
8-K

8-K 2026

N/A

April 30, 2026
April 30, 2026
2026
DEF 14A

DEF 14A 2026

N/A

April 24, 2026
April 24, 2026
2026
8-K

8-K 2026

N/A

April 01, 2026
April 01, 2026
2026
8-K

8-K 2026

N/A

February 23, 2026
February 23, 2026
2026
10-K

10-K 2025 FY

FY

February 23, 2026
December 31, 2025
2025
8-K

8-K 2026

N/A

February 17, 2026
February 17, 2026
2026
8-K

8-K 2026

N/A

January 12, 2026
January 12, 2026
2026
Showing 1 to 10 of 288 filings