Thank you for standing by. Welcome to Schrodinger's Conference Call to review First Quarter 2020 Financial Results. My name is Joanna, and I will be your operator for today's call. Please be advised that this call is being recorded at the company's request. Now, I would like to introduce your host for today's conference, Ms.

Jaren Madden, Senior Vice President of Investor Relations and Corporate Affairs. Please go ahead..

Thank you, and good afternoon, everyone. Welcome to today's call during which we will provide an update on the company and review our first quarter 2023 financial results. Earlier today, we issued a press release summarizing our financial results and progress across the company, which is available on our website at shordinger.com.

Here with me on our call today are Ramy Farid, Chief Executive Officer; Geoff Porges, Chief Financial Officer; and Karen Akinsanya, President of R&D Therapeutics. Following our prepared remarks, we'll open the call for Q&A.

I'd like to remind you that during today's call, management will make statements related to our business that are forward-looking and are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, including, without limitation, statements related to our outlook for the full year 2023, our quarter ending June 30, 2023, our strategic plans to accelerate the growth of our software business and advance our collaborative and proprietary drug discovery programs, the timing of potential IND submissions and the initiation of clinical trials for our proprietary drug discovery programs, the clinical potential and favorable properties of our compounds, our expectations related to the use of our cash resources as well as our future operating expenses.

These forward-looking statements reflect our current views about our plans, intentions, expectations, strategies and prospects which are based on the information currently available to us and on assumptions we have made.

Actual results may differ materially from what we project today due to a number of important factors, including the considerations described in the Risk Factors section and elsewhere in the filings we make with the SEC, including our Form 10-Q for the quarter ended March 31, 2023.

These forward-looking statements represent our views only as of today, and we caution you that we may not update them in the future, whether as a result of new information, future events or otherwise. Also included in today's call are certain non-GAAP financial measures.

These non-GAAP financial measures are not prepared in accordance with generally accepted accounting principles and should be considered only in addition to and not a substitute for or superior to GAAP measures.

Please refer to the tables at the end of our press release, which is available on our website for reconciliations of these non-GAAP measures to the most directly comparable GAAP measures. With that, I'd like to turn the call over to Ramy..

Thanks, Jaren, and thank you, everyone, for joining us today. We are very pleased with our strong start to the year. We reported quarterly revenue of $64.8 million, a 33% increase over the first quarter of last year. We strengthened our balance sheet significantly, and we continue to advance our pipeline.

Schrodinger has been pursuing the vision of conducting molecular discovery through integrating the accuracy of physics with the speed and scale of machine learning.

This presented many challenges when we started 33 years ago, but we remain steadfast and eventually overcame them and even founded companies along our journey to help validate our approach. Today, we have many success stories that have validated our approach and we believe the benefits of using our platform are becoming irrefutable.

We are thrilled with the recent progress of the drug discovery programs at companies we co-founded, including Nimbus Structure and Morphic. These programs, which are now in the clinic, serve as very strong validation of our unique approach and give us tremendous confidence in the potential of our own proprietary pipeline.

As you will hear from Karen, we have made very important progress with our pipeline this quarter. We now have 2 Phase I studies of our MALT1 inhibitor SGR-1505 underway. And our IND submission for our CDC7 inhibitor, SGR2921 is on track for the first half of this year.

We are also making excellent progress across our collaborative programs, including advancing our SOS1KRAS program to development candidate status. This program is partnered with BMS and contributed significantly to our reported drug discovery revenue in the first quarter.

Our computational platform is the engine that enables the discovery of better therapeutics and novel materials faster and at lower cost compared to traditional methods. We continue to invest in our platform to push the frontiers of molecular discovery. Our initiatives include focusing on expanding the number of addressable targets.

We, for example, recently published research showing how our computational methods can be used to refine AI-generated protein structures to sufficiently high accuracy to be useful in physics enabled drug discovery. Our Q1 results illustrate the broad opportunities we have to create value from our unique computational platform.

We reported strong contributions from our software business, significant milestones and new capital from our collaborations and successfully transitioned our proprietary portfolio into the clinic. With this strong start, we are well positioned to deliver on our objectives for the year.

Before turning the call over to Jeff, I want to highlight that last week, we published our inaugural corporate sustainability report. While we have always been committed to doing the right thing, this report represents a major milestone in formalizing our strategy around key ESG matters.

I would also like to take the opportunity to express my deep gratitude for the dedication and hard work of all our exceptionally talented employees who are critical to achieving our mission.

Geoff?.

Thank you, Ramy, and good afternoon, everyone. Shorting had an excellent quarter in Q1. We made significant progress with our pipeline. We reported a record quarterly revenue results. We showed continued positive trends in our expense and margin performance, and we strengthened our balance sheet materially.

Our results were consistent with our overall expectations and financial guidance for the quarter, and we remain very positive about our business outlook for the year. Let me turn to the financial results for the quarter. Software revenue for the quarter was $32 million, which was just under the $33 million we reported in Q1 2022.

Q1 2022 benefited from several large multiyear deals that were not up for renewal in Q1 2023. As expected, our software revenue declined compared to Q4 as we implemented the multiyear annual software contracts that were signed in the last few weeks of 2022.

Drug Discovery revenue for the quarter was $32.6 million and more than doubled compared to Q1 2022. We if the revenue was associated with the recognition of a milestone in our BMS collaboration that reached development candidate status during the quarter. The rest of our Discovery revenue came from a variety of collaborations and programs.

Total revenue was $64.8 million and increased by 33% compared to Q1 last year and by 14% compared to Q4 2022. Our results this quarter reflect the benefits of our balanced business model with software and discovery collaborations, contributing similar revenue and driving total revenue to our highest ever quarterly total.

Cost of revenue for the quarter was $19 million and decreased by 8% compared to Q1 2022, but increased by 5% compared to Q4.

The decrease year-over-year reflects the progression of our drug discovery business, reallocation of internal discovery teams from collaboration programs to proprietary programs and reduced royalty obligations in our software business. The overall gross margin increased to 71% this quarter compared to 58% in the same quarter of 2022.

As we indicated previously, we expect our software gross margin to generally trend in line to slightly higher than last year and also anticipate that the profitability of our drug discovery business will trend positively, although it will bounce around widely from quarter-to-quarter depending on milestone payments and revenue recognition.

Total operating expenses were $76 million compared to $57 million in the same quarter a year ago. R&D was $41 million and increased by 46% from $28 million in Q1 2022.

The increase was driven by increased headcount as we added staff to support new programs and advance our existing programs into late preclinical and clinical development and as we reallocate our teams from collaborations to proprietary programs.

This quarter, we are also absorbing the forecast of our Structural Biology solutions organization, formerly known exile, who have now been deployed exclusively to the characterization of protein structures for our internal drug discovery and collaboration activities.

CRO expenses also increased year-over-year, driven by the progress of our existing programs and the addition of early undisclosed programs to our portfolio. Technology spending also increased as our portfolio broadened and advanced.

We expect our R&D expenses to increase through the year as we progress the most advanced programs in our portfolio into clinical development and increase our investment into our earlier molecules and programs.

We intend to outline the progress and potential of the most advanced programs and also discuss several of the earlier programs at our first roading Pipeline Day, which we are planning for September this year. During the quarter, our sales and marketing expense was $9 million, an increase by 37% compared to the prior year Q1.

The increase was mainly due to increased staffing to support our geographic expansion to commercialize into new industry verticals and to support our growing number of global accounts. Our sales and marketing expense is likely to follow the distribution of our software revenue for the rest of the year.

Our G&A expense was $26 million in Q1, which is an increase of 19% compared to Q1 2022. This increase was due to higher headcount, royalty obligations associated with the Nimbus distribution and accelerated amortization of intangible assets related to our Extel acquisition in Q1 2022.

Travel and lease expenses have also increased, and we expect quarterly G&A to be relatively stable through the balance of 2023. We Overall, our loss from operations was $30.5 million in Q1 compared to $28.6 million in Q1 2022 and $28.5 million in Q4 2022. Other income items were highly significant this quarter.

We recognized a gain of $147 million from Nimbus in Q1 as a result of the sale of the TYK2 program to Takeda Pharmaceuticals. We also reported a gain of $35.7 million from a change in fair value of equity investments, which compares to a loss of $6.2 million in Q1 2022.

This change reflects the mark-to-market valuation for our equity ownership in structured Therapeutics and the market adjustment and valuation of our ownership stake in Morphic. Other income was $2.9 million and reflects the higher interest we are receiving on our investment portfolio.

Overall, total other income was $186 million, and we reported a noncash tax expense of $26.4 million. As a result of these items, we reported net income of $129 million and earnings per share of $1.75 on a fully diluted basis.

We expect the tax liability that we reported in Q1 to be progressively reversed through the remaining quarters of the year as we incur expected operating losses in future quarters. Our non-GAAP net loss for the quarter was $27.5 million, and cash used in operating activities during the quarter was $31 million.

Based on the results and events in the quarter, our cash balance improved significantly. As of March 31, 2023, we reported cash resources and marketable securities of $532 million compared to $456 million at the end of December 2022.

Subsequent to the end of the quarter, we received the cash from our partner BMS for the development milestone and the second part of the distribution from Nimbus. While these payments were included in our Q1 2023 results, the cash added $61 million to our cash and marketable securities balance subsequent to the end of the quarter.

I'll now discuss our financial guidance. Our revenue guidance for the year is unchanged at 13% to 17% growth for software revenue and $79 million for drug discovery revenue.

We anticipate that Q2 software revenue will be in the range of $27 million to $31 million and expect the balance of our drug discovery revenue guidance to be distributed more towards Q3 and Q4 than Q2. Compared to Q4, Q2 offers relatively few of the large customer renewal and new business opportunities that drive our incremental revenue.

And for that reason, we do not forecast being growth in the quarter. Our expectations for profitability and expense growth are unchanged, and we continue to expect our cash position at year-end to be above our cash position at the start of the year. I'll now provide a brief update on corporate and business development activity.

The last few months have seen remarkable progress for shorting as partner companies. Our partners number Therapeutics and Morphic Therapeutic and structured therapeutics of all advanced companies and as drug developers. In all 3 of these companies, Schrodinger as a founder, investor and drug discovery partner.

They have all been long-standing beneficiaries of our technology and our scientists had key roles in the discovery of their drug cabinets that are in clinical development. We congratulate all 3 companies on their success and are proud of the contributions our staff and technology have made to their innovations.

As equity holders in these companies, there remain significant sources of value for Schrodinger, and we see opportunities for further success and value creation for each of them in the future.

More importantly, the success of these companies provides even more validation for our technology platform, and it's the same technology platform and team that are building our proprietary portfolio.

We have other equity investments in emerging companies in our portfolio now and are actively considering more opportunities to invest our time, technology and capital into other entrepreneurial ventures.

Beyond our new company activity, we continue to be engaged in discussions about new collaborations and specific program partnerships with companies across the industry. With the value of our inventions becoming even more apparent, we plan to be selective and thoughtful about our commitments to new partners.

We have the resources and increasingly the capabilities to advance programs on our own account and will only partner them when we believe the terms match our assessment of the risk-adjusted value of the program, including the value of the unique product attributes and features that our technology confers.

We see many opportunities for our venture corporate and business development activities to continue to add value to Schrodinger in 2023 and well into the future. I'll now turn the call over to Karen to discuss our collaborations and our pipeline..

Thank you, Jeff, and good afternoon, everyone. We are really pleased with the advancements we've made so far this year across our pipeline of proprietary and collaborative programs. We continue to see success from our drug candidates discovered with our collaborators such as Morphic alpha 4 beta 7 inhibitor.

We currently have 9 collaborative programs in the clinic, highlighting our strong research team who work with our partners to design differentiated molecules, leveraging the full power of our computational platform.

This quarter, we also reported that the SOS1 KRAS Precision Oncology program, which we licensed to BMS as part of a multi-target collaboration has advanced a development candidate status.

Now that our therapeutics team has transitioned the program to BMS for preclinical and clinical development, we have the opportunity to add additional development, regulatory and commercial milestone payments as well as royalties on sales as the program progresses.

We are continuing to work with BMS on oncology, immunology and neurology programs within the collaboration, and we are pleased with how these programs are progressing.

The achievement of this significant milestone payment represents an important turning point for our therapeutics business and shows the value creation opportunity from our more recent drug discovery business development activities and partnered programs. Turning to our wholly owned programs. I'll start with an update on SGR-1505, our MART-1 inhibitor.

Our clinical development team is pursuing a global development strategy to gather safety pharmacokinetic pharmacodynamics and preliminary antitumor activity. We are pleased that dosing is underway in patients with advanced B-cell malignancies. We've also begun dosing in a second study of SGR 1505 in healthy subjects.

This study is designed to generate additional data on the profile of SGR 1505 to support our clinical development plans.

The healthy subject study includes drug-drug interaction and food effect cohorts, and we plan to leverage the data from these pharmacology assessments to inform our ongoing and planned trials in B-cell malignancies and potentially other indications.

Moving to SGR2921, our CDC7 inhibitor, we are nearing the completion of our IND-enabling studies and are on track for an IND submission to the FDA in the first half of this year.

SGR2921 exhibits strong antitumor activity in multiple preclinical patient-derived AML models independent of genetic drivers, both as monotherapy and in combination with standard of care agents. Based on these data, we are planning to initiate a Phase I study in patients with relapsed/refractory AML.

Earlier this year, we selected our Wen development candidate, SGR3515, which has shown durable antitumor activity in preclinical models used to study more advanced 1 inhibitors.

Clinical data from other companies we won programs has provided encouraging evidence of clinical activity in several forms of cancer with high unmet need, including proof of concept in uterine and ovarian cancers.

We are excited about the profile of SGR-3515 and believe it may offer advantages over prior inhibitors, including minimal drug-drug interaction potential and optimized kinase selectivity.

In addition, our translational work has progressed substantially with the identification of potential synthetic lethality relationships and sensitive tumor types to inform our Phase I trial design. We are continuing to characterize SGR3515 as we move through IND-enabling studies to enable an IND submission to the FDA next year.

To date, we have primarily pursued programs and design challenges for targets with previously known protein structures.

Following the integration of our structural biology capabilities in 2022, we are making important strides in obtaining novel protein structures to further support first-in-class product opportunities for targets with strong evidence of activity in humans.

We are continuing to initiate new programs that we may elect to partner or advance independently to key inflection points. We have several undisclosed programs at various discovery stages in multiple areas, including oncology and immunology.

In summary, we are very pleased with the progress we have made this quarter and expect continued advancements in 2023 across our pipeline of collaborative and proprietary programs.

We are excited about the work we are doing to advance better medicines to patients, and we look forward to sharing more details about our work at Pipeline Day in late September. I will now turn it back over to Ramy..

Thank you, Karen. As you can hear, we are off to a strong start this year and are very well positioned to deliver on our goals for the year. We look forward to keeping you updated on our progress over the coming months. At this time, we'd be happy to take your questions..

Thank you. [Operator Instructions] First question comes from Vikram Purohit of Morgan Stanley..

So we had 2 on drug discovery revenues.

First, do you still hold $100 million as a potential target for this line item? And then secondly, for the $70 million to $90 million guidance, could you just remind us what the bookends of this guidance contemplate?.

Sure, Vikram. So yes, we still have the goal of achieving $100 million this year. Our guidance is $70 million to $90 million.

We had a really good quarter, as you can see in Q1 with the achievement of the Solan [ph] milestone from BMS -- and we see a number of paths to getting to certainly into the guidance range for the year, but also to getting to that strategic goal.

As we indicated when we provided the guidance, we are contemplating significant business development activity to achieve the goal, but it's not necessary to -- that we get a significant contribution to get to the low end of the guidance range by any means. So we're still maintaining that guidance.

And as I indicated in my commentary, though, the revenue outlook is going to be skewed towards the back half of the year just because of the timing of all the elements that contribute to that range..

Understood. And if I could ask a follow-up on that question then.

So if there is a point in the year at which you could revisit the guidance and think of potentially moving it upwards, would it then be in the second half of the year when you'd have that clarity?.

Look, as I just suggested, part of this is contingent upon progressing business development discussions. We don't want to signal how the cadence of those discussions or the timing. If there's something to announce, then we'll announce it.

But then, of course, we'd aim to update our guidance on the quarterly call just as we would normally do throughout the year..

The next question comes from Michael Yee at Jefferies..

This is Vision [ph] for Michael have a question on software guidance for next quarter. So looking at previous years, the cadence and decrease in Q2 is not unusual. But just curious on the year-to-year guidance midpoint, which is just below your last year revenue, which I believe was $30 million for software.

Like what are some factors here that might have driven this increase? And do you have any comments on whether this might be the trend for the rest of the year, keeping in mind a full year guidance unchanged 13% to 17%..

So yes, thanks for the question. Our Q2 guidance reflects our current expectations for our renewals and continuing software contracts during the quarter. The outlook is affected by the size and number of contracts that are up for renewal in the period and the opportunities that those contracts present for significant increases in scale and value.

Put simply, the customers in Q2 are relatively small in terms of their annual contract value. Because of this mix of customers, the absence of biotech IPO and follow-on financing activity is most acutely felt in this period.

The opportunities for growth in our business and also the alignment with our commercial activities are increasingly focused on the large global customers and the renewals for those customers are increasingly concentrated at the end of the year.

Now to look towards the end of the year, we are already actively discussing new million dollar plus software contracts and increases in existing contracts with more than a dozen global biopharma customers. A number of these are likely to be multimillion dollar multiyear contracts.

We also expect the large multiyear contracts that we signed in Q4 of 2021 to be renewed in Q4 this year. It's these discussions and their potential but out to pin our confidence in our guidance for the full year.

Ramy, is there anything you'd like to add?.

Yes. Thanks, Jeff. That was perfectly stated. I agree with all of that.

I just want to emphasize that we're feeling really confident about the outlook for the year, given the stage of these discussions, the number of them and the enthusiasm that we're seeing from our customers to really deploy our platform on their discovery programs at scale, and that's the key.

I think you know I've been doing this for a long time, and I can see a real clear shift and the nature of these discussions. I think it can actually be summarized by saying that companies are feeling more of a sense of urgency to fully deploy our technology on their programs.

And this is really giving us increased confidence that these deals will close when they come up for renewal later in the year..

Thank you. The next question comes from David Lebowitz from Citi..

Specifically on cadence as we go through the year on the software side. I know that the second quarter and third quarter historically have been down quarters, relatively speaking, you've given guidance for 2Q guidance for the full year is maintained. Does the balance of that, I guess, guided that shift from 1Q to 2Q.

Is that something we think of as moving towards all towards the year-end? Or does some of that growth find its way into 3Q?.

Thanks for the question, David. Look, we're not giving guidance for Q3 at this stage. But I think from my answer to the earlier question, you can tell that we have line of sight to really substantial renewals in Q4. We do think there are opportunities in Q3 that can contribute to the quarter and to get some of that growth.

But at this stage, we're not updating -- providing guidance for Q3. It's relatively early days, but we're very confident about the back half of the year and about our full year numbers..

Would it be fair to say, I mean, every year, pretty much since 2019, the fourth quarter as a percentage of annual has ticked up.

Would it be fair to say that trend is probably going to continue in '23 as well?.

That's definitely our sense. I don't want to give you a sort of firm sense of that percentage only because the conversations that I mentioned and that Ramy alluded to, we're not sort of locking in a timing for those conversations coming to fruition. But I think as a general observation, I think you're correct..

Agreed. Thank you for taking my questions..

Thanks..

Thank you. Our next question comes from Vince German at Markets [ph]..

Rating all the progress on the quarter. So with some meaningful payoffs from some of your partnerships, success with Morphis success with some of your partners, I guess, how are you thinking about capital allocation now that you've had some more revenues coming in.

Are you more focused on acquiring assets that you can maybe utilize your platform for, clearly, investing in R&D and your own capabilities? Just how do you think about that going forward?.

Thanks for the question, Evan. I think we've signaled in my prepared remarks and in other comments that we're continuing to invest substantial capital into our platform. And -- my sense from being here for about 9 months now is that we're in a very dynamic environment with lots of opportunities to continue to prosecute this platform.

But we're also very excited about the proprietary portfolio, in particular, that Karen outlined and the opportunities that we have there. So our first priority way above all others is to continue to invest in our platform and our own portfolio. And as you point out, very well capitalized to do that. Now we are looking at additional opportunities.

You can hear from Karen's comments about enabling more targets for our platform. We think that's a very sensible adjacency. And we're looking actively at putting capital there. And you've seen us already do that. I'm not telegraphing anything specific, but that's a logical extension of the value creation from our platform.

Beyond that, we're a well-capitalized company and an industry that's going through a fair amount of disruption right now. So we're always engaged in conversations, but it sort of -- I don't think that we're most excited about what we're doing ourselves on our own account. We think that we have a highly differentiated platform..

Yes, exactly. And I'll just add, we see ourselves, and I think the industry sees us as the gold standard and really the leader in this space. And we very much intend to keep it that way by continuing to invest in the underlying science and continue to make the kinds of breakthroughs that are having such a huge impact on discovery projects..

Excellent. Thank you for that. I appreciate it..

Yes. Thanks..

Thank you. The next question comes from Chris Shibutani of Goldman Sachs..

Two questions. Jeff, since you've joined now for 9 months and had the chance to sort of look under the hood at the books and thinking about how contracts were structured and whatnot.

I think historically, what investors have struggled with is trying to get an understanding of visibility about how that -- how you have visibility and the guidance gets shaped and from the Q&A discussion from this earnings report, that seems to also be the case.

Is there something that you're observing? I see that you're doing a 4 quarters of rolling cumulative revenues for the company. But anything about the approach, the way your contract restructure that we see as a potential way for you to strengthen your visibility and in turn, improve ours.

And then a second question, much congratulations on all the clinical development success of the collaborators, Morphic and IMV, certainly a tremendous outcome there.

Is there some way that you can translate that in any quantifiable form clearly has a halo effect, but is there anything that somehow can quantifiably generate greater conviction in your potential customers because C1 do one, but then is there an assurance that, that can be replicated on the forward, I suppose, would have to be in their mind.

Just curious how you're thinking about presenting that beyond the obvious successes and the revenues to the collaboration..

Chris, I'll start off and talk a little bit about the visibility on software and the contracts. And then maybe Ron can talk about the sort of secondary effects that we're seeing from things like Martin and how that's spilling over to our participation in the market overall the industry.

So starting up on the visibility of software; look -- as you can imagine, Chris, what I prefer that we had like a very steady sort of through the year, revenue ramp up, of course, that would make our lives and your lives easier and make everything more predictable.

But the reality is that our current contracts and our revenue is heavily driven by those large customers, and they tend to make their step-up at the end of the year.

We go through the full year R&D cycle, and they say, do we like this? Do we not like this? And then, how much -- how many more people do you want to use it? How many more programs, how many more licenses, and that's what drives that step up.

As you know, there are a number of different models for software sales and licensing and revenue recognition, our contracts currently drive the revenue recognition that you're seeing and that sort of heavy skewing upfront.

-- we are certainly contemplating whether there are things that we can modify in our contracts, particularly as we're shifting more and more over to sort of cloud-hosted relationships. That could alter that and to be kind of transparent, smoothing out a little bit.

That is not something that we are ready to implement now and that would entail some changes to our contracts and how we go to market. But I think that it would certainly behoove us to take a hard look at that. So you can imagine that we're doing that.

But again, to reiterate, there's a huge amount of excitement about our technology in those largest customers. And we're not going to hold up realizing the potential of that excitement to change over to a certain format of contracting or revenue. I mean our primary focus is growing the business and capitalizing on these opportunities.

Rob, do you want to talk about that?.

Yes. I will add that everything that Jeff said was right, but also I think it's important to point out that we have gotten pretty good at predicting the quarters, and we've been really, really good about meeting our guidance, and we have a long track record of that.

So I hope that we've gotten to a point where you can trust us when we talk about our guidance and what we see in future quarters and for the full year. Now I'm going to try and answer the question you asked the second question, Chris, but I won't go for too long in case I'm not answering your question, and please tell me if I'm not.

So the -- it's really become -- I mean we're really excited about this. The validation that we're getting from our partners that go back quite a way. As we talked about Nimbus and Morphic and structure, but also our more recent collaborations and then, of course, our internal programs.

And we're -- that's pretty excite, really overwhelming set of validation that I think is unique for a platform company, and we're really putting a big effort into getting that story out, talking about them. And we're so fortunate to have fantastic partners that are not shy about participating there.

We have a lot of our partners are joining us in those discussions and talking about our role and the technology and expertise. That's been incredibly helpful as you can imagine. We have lots of internal -- lots of meetings and various venues in which we can present that data.

And I can tell you that -- and this is what I was saying before, there's no question that heads of research and pharma companies are noticing, and it's really changing the nature of the discussions. I think this enthusiasm we're talking about is the direct result of us getting those really compelling stories out there.

Did I answer your question?.

Yes, that was really helpful. I appreciate the perspective. Thanks..

Thank you. [Operator Instructions] Our next question comes from Michael Ryskin at Bank of America..

Great. A couple for me real quick. One is in the past, you've sort of given us a lot of color on your customer mix and your customer closures. So I certainly recognize that a lot of it is biased towards larger pharma and larger biotech on the software side of things.

I'm just wondering, with the tail end of that, the smaller biotechs, are you seeing any change in terms of conversations in terms of tone just in the last couple of months? Obviously, there's been a lot of debate there. It's a small part of your mix, but so I'm just curious if you deterioration in that part of your.

Jeff, do you want to take the first one Yes, and then if there's any....

Sure. So just to comment on the customer mix. As we've said in the past, normally, if I take the full year, the smaller biopharma companies is a relatively small component of our revenue, but -- to give you a little bit of context, the Q2 average customer size is less than half of the full year average customer size.

So that's just the mix of when customers are renewing and those contracts are up. So that's why I highlighted in my earlier answer that the effect of emerging companies not being financed is most felt in that sort of quarter.

Now what we're seeing is sort of -- it's the absence of new, meaning we're not seeing a new company show up and say, okay, we want to sign a significant software contract and start our drug discovery activities.

We're definitely in a position to have conversations with venture capital and with investors in some kind of companies that are almost virtual companies that would like to use our software to go after a particular target, and we're engaged in those discussions.

But the volume of them and the opportunities really aren't what they have been in prior years. But the counter to that is that the existing customers are generally sticky. The -- increasingly, they've been using our technology for their drug discovery efforts for 2, 3, 4, 5 years, and they're not going away.

It's just the absence of the new that is giving out contributing to that revenue guidance that I provided. So hopefully, that helps answer your question..

I think it was the second....

I think that was it, right? Was there a second part?.

That was the first part. So the second part is unrelated to that. But second question is sort of if you look at your drug discovery revenue this year and you look at sort of the cash inflows you've recognized year-to-date in some of the comments you made about 2Q, really positive contributors to the balance sheet.

And as we think about drug discovery going forward, it should continue to be a meaningful and potentially growing part of the business. So you roll that together and you're rolling -- you add in the gross profit dollars you generated from software.

You're approaching the area where your free cash flow breakeven, sometimes positive ones a little bit negative, but starting this year and potentially going out, does that change your perspective in any way in terms of your rate of spend on internal programs, if you think about it from a -- we are now essentially self-cash sufficient?.

Yes. That's a really, really good question. And certainly a question that we all think about quite a lot. At conclusion, I think, from those discussions is that we have a unique technology, a unique time point and probably a unique opportunity to invest in our technology and invest in the programs that are emerging from the technology.

And so -- you're right. If you kind of look ahead at some trajectories, you can kind of see the picture that you described. But I think that we -- if we fail to capitalize on all of those uniques that I described, then we will fail to achieve the value that we think that we can achieve and that we can deliver for investors.

So I think that we want to really take advantage of all of these opportunities..

Thank you. The next question comes from Gaurav Goparaju from Berenberg [ph]..

This is Annabel [ph] on for Gaurav. I have 2 questions. One, regarding Nimbus and Takeda, given the $147 million tax received, which was 4% of the $4 billion upfront payment by Takeda, should we assume a similar percentage to Shortage on the potential $2 billion in sales-based milestones, which would imply around $74 million in cash if achieved.

And then also the starting year, are you seeing more software revenue contribution from existing customers increasing the consumption or from new customers licensing software for the first time..

Okay. Let me add I'll tackle the first question. Yes is the answer. We are assuming that we get the additional distribution for those last 2 revenue milestones. As you know, there are significant revenue tranches that would trigger those milestones. But yes, if those miles turns occur, we would assume that the distribution is as you calculated. Go ahead..

Yes. No, no, no..

Sorry, you go ahead..

Go ahead..

So they're really, really simple, and it's what we've been saying in the answer to the question about where the growth is coming from absolutely coming more and more from existing customers increasing their usage of the software and more and more from larger customers, which again is why we're seeing this shift in Q4..

Thank you. Ramy, I am showing no further questions at this time. That concludes today's call. You may now disconnect..