Cue Biopharma, Inc.

Cue Biopharma, Inc.

CUE·NASDAQ

$28.25

+4.7%
HealthcareBiotechnology

Cue Biopharma, Inc., a clinical-stage biopharmaceutical company, develops biologic drugs for the selective modulation of the human immune system to treat a range of cancers, chronic infectious diseases, and autoimmune disorders. Its lead drug candidate is CUE-101, a fusion protein biologic that is in Phase 1b clinical trial designed to target and activate antigen-specific T cells for human papilloma virus-driven cancers. The company offers CUE-102, a fusion protein biologic to target and activate antigen-specific T cells to fight cancers; CUE-103 a CUE-100 series Immuno-STAT targeting the KRAS G12V mutation, including colorectal carcinoma, lung cancer, and pancreatic cancer; CUE-200 that focuses on cell surface receptors, including CD80 and/or 4-1BBL to address T cell exhaustion associated with chronic infections; and CUE-300 and CUE-400 framework to target various autoimmune diseases. Cue Biopharma, Inc. has collaboration agreements with Merck Sharp & Dohme Corp. for the research and development of its proprietary biologics that target various autoimmune disease indications; LG Chem Life Sciences for the development of Immuno-STATs focused on the field of oncology; and Albert Einstein College of Medicine. The company was formerly known as Imagen Biopharma, Inc. and changed its name to Cue Biopharma, Inc. in October 2016. Cue Biopharma, Inc. was incorporated in 2014 and is headquartered in Cambridge, Massachusetts.

At a Glance

Live Snapshot
Market Cap$74.24M
EPS-8.4000
P/E Ratio-3.36
Earnings Date08/18/2026
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Cue Biopharma, Inc. Street Expectations Map

CUE · NASDAQ

Wall Street analysts project that CUE stock may decline over the coming 12 months. The consensus 1-year price target stands at 4.33, with estimates ranging from a low of 2.00 to a high of 7.00.

Lowest Target
2.00
-92.92%
Consensus Target
4.33
-84.67%
Highest Target
7.00
-75.22%

The consensus 1-year price target stands at 4.33, with estimates ranging from a low of 2.00 to a high of 7.00.

Analyst Consensus Analysis

Upside Potential

-84.7%

Significant downside risk. Stock trading well above analyst consensus suggests elevated valuation concerns and potential correction.

Analyst Agreement

115.5% spread

High uncertainty. Very wide target spread indicates significant disagreement among analysts—major valuation uncertainty or transformation underway.

Risk-Reward Profile

0.81x

Unfavorable risk-reward. Downside risk exceeds upside potential. Consider defensive positioning or alternative opportunities.

Analyst Conviction

Low

High uncertainty: Wide dispersion indicates analysts struggle to agree on valuation—proceed with caution and independent analysis.

Market Sentiment Insight

Extreme uncertainty: Massive dispersion in price targets reflects fundamental disagreement on business trajectory. This could signal transformation, disruption, or complex valuation—requires deep sector expertise and contrarian mindset.

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Cue Biopharma, Inc. Forward Estimates of Revenue

CUE · NASDAQ
Latest Revenue
27.47M
FY 2025
Avg Estimate
12.80M
FY 2026
Estimate Range
12.80M - 12.80M
Analyst Spread

Forward Growth Analysis

Projected Growth-53.4%

Significant contraction projected—major business challenges or industry disruption likely.

Analyst Coverage1 Analysts

Limited coverage may indicate reduced institutional interest or information availability.

Estimate Spread0%

Narrow estimate range signals strong analyst consensus and predictable business outlook.

OutlookNeutral

Mixed signals—some positive indicators offset by concerns about growth or uncertainty.

Key Insight

Limited coverage with volatile estimates: Few analysts covering despite significant projected changes may indicate information gaps or emerging risks.

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Cue Biopharma, Inc. Forward Estimates of Net Income

CUE · NASDAQ
Latest Net Income
-26.60M
FY 2025
Avg Estimate
-20.97M
FY 2026
Estimate Range
-20.97M - -20.97M
Analyst Spread

Forward Growth Analysis

Projected Growth+21.2%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage1 Analysts

Limited coverage may indicate reduced institutional interest or information availability.

Estimate Spread0%

Narrow estimate range signals strong analyst consensus and predictable business outlook.

OutlookPositive

Generally favorable outlook with reasonable growth prospects and analyst support.

Key Insight

Limited coverage with volatile estimates: Few analysts covering despite significant projected changes may indicate information gaps or emerging risks.

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Cue Biopharma, Inc. Forward Estimates of EPS

CUE · NASDAQ
Latest EPS
-8.40
FY 2025
Avg Estimate
$-6.64
FY 2026
Estimate Range
$-6.64 - $-6.64
Analyst Spread

Forward Growth Analysis

Projected Growth+21.0%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage1 Analysts

Limited coverage may indicate reduced institutional interest or information availability.

Estimate Spread0%

Narrow estimate range signals strong analyst consensus and predictable business outlook.

OutlookPositive

Generally favorable outlook with reasonable growth prospects and analyst support.

Key Insight

Limited coverage with volatile estimates: Few analysts covering despite significant projected changes may indicate information gaps or emerging risks.

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Cue Biopharma, Inc. Forward Estimates of EBIT

CUE · NASDAQ
Latest EBIT
-26.52M
FY 2025
Avg Estimate
-12.64M
FY 2026
Estimate Range
-12.64M - -12.64M
Analyst Spread

Forward Growth Analysis

Projected Growth+52.3%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage1 Analysts

Limited coverage may indicate reduced institutional interest or information availability.

Estimate Spread0%

Narrow estimate range signals strong analyst consensus and predictable business outlook.

OutlookPositive

Generally favorable outlook with reasonable growth prospects and analyst support.

Key Insight

Limited coverage with volatile estimates: Few analysts covering despite significant projected changes may indicate information gaps or emerging risks.

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Cue Biopharma, Inc. Forward Estimates of EBITDA

CUE · NASDAQ
Latest EBITDA
-23.04M
FY 2025
Avg Estimate
-12.32M
FY 2026
Estimate Range
-12.32M - -12.32M
Analyst Spread

Forward Growth Analysis

Projected Growth+46.6%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage1 Analysts

Limited coverage may indicate reduced institutional interest or information availability.

Estimate Spread0%

Narrow estimate range signals strong analyst consensus and predictable business outlook.

OutlookPositive

Generally favorable outlook with reasonable growth prospects and analyst support.

Key Insight

Limited coverage with volatile estimates: Few analysts covering despite significant projected changes may indicate information gaps or emerging risks.

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Cue Biopharma, Inc. Forward Estimates of SG&A Expense

CUE · NASDAQ
Latest SG&A Expense
16.24M
FY 2025
Avg Estimate
49.52M
FY 2026
Estimate Range
49.52M - 49.52M
Analyst Spread

Forward Growth Analysis

Projected Growth+204.9%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage1 Analysts

Limited coverage may indicate reduced institutional interest or information availability.

Estimate Spread0%

Narrow estimate range signals strong analyst consensus and predictable business outlook.

OutlookPositive

Generally favorable outlook with reasonable growth prospects and analyst support.

Key Insight

Limited coverage with volatile estimates: Few analysts covering despite significant projected changes may indicate information gaps or emerging risks.

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Cue Biopharma, Inc. Insider Positioning

CUE · NASDAQ

During the last 12 months, insiders have purchased $23K worth of CUE shares, with no selling activity reported.

3 Months

Bought

0

0.00

Sold

0

0.00

Net Activity

+0

+$0

3-6 Months

Bought

77.4K

23.35K

Sold

0

0.00

Net Activity

+23K

+$23K

6-9 Months

Bought

0

0.00

Sold

0

0.00

Net Activity

+0

+$0

9-12 Months

Bought

0

0.00

Sold

0

0.00

Net Activity

+0

+$0

Top Buyers

1
SP

Sarraf Pasha

Director

77.4K shares1 transactions

$23K

Top Sellers

No selling activity

Insider Activity Analysis

Net Insider Sentiment

Bullish

Strong bullish signal with $23K net buying. Insiders are aggressively accumulating shares, suggesting significant confidence in future prospects.

Buy/Sell Ratio

∞:1

Perfect buy/sell ratio. Only buying activity with zero selling—the most bullish possible insider signal.

Insider Participation

High Buying

1 insider buyers vs. 0 sellers. Broad-based buying across management team suggests widespread confidence.

Insider Activity Insight

Unanimous insider buying: Zero selling combined with active buying is rare and typically very bullish. Insiders appear to see significant upside with limited downside risk.