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Healthcare - Biotechnology - NASDAQ - US
$ 1.06
10 %
$ 65.3 M
Market Cap
-0.8
P/E
1. INTRINSIC VALUE

This DCF valuation model was last updated on Apr, 22, 2025.

The intrinsic value of one PYXS stock under the worst case scenario is HIDDEN Compared to the current market price of 1.06 USD, Pyxis Oncology, Inc. is HIDDEN

This DCF valuation model was last updated on Apr, 22, 2025.

The intrinsic value of one PYXS stock under the base case scenario is HIDDEN Compared to the current market price of 1.06 USD, Pyxis Oncology, Inc. is HIDDEN

This DCF valuation model was last updated on Apr, 22, 2025.

The intrinsic value of one PYXS stock under the best case scenario is HIDDEN Compared to the current market price of 1.06 USD, Pyxis Oncology, Inc. is HIDDEN

2. FUNDAMENTAL ANALYSIS

Price Chart PYXS

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$5.0$5.0$4.5$4.5$4.0$4.0$3.5$3.5$3.0$3.0$2.5$2.5$2.0$2.0$1.5$1.5$1.0$1.0$0.5$0.5Nov '24Nov '2415 Nov15 NovDec '24Dec '2415 Dec15 DecJan '25Jan '2515 Jan15 JanFeb '25Feb '2515 Feb15 FebMar '25Mar '2515 Mar15 MarApr '25Apr '2515 Apr15 Apr
FINANCIALS
16.1 M REVENUE
0.00%
-89.5 M OPERATING INCOME
-8.84%
-77.3 M NET INCOME
-4.80%
-57.7 M OPERATING CASH FLOW
18.44%
8.16 M INVESTING CASH FLOW
107.78%
59.3 M FINANCING CASH FLOW
900.61%
0 REVENUE
0.00%
-40.1 M OPERATING INCOME
-68.68%
-35.6 M NET INCOME
-67.76%
-19.3 M OPERATING CASH FLOW
-31.54%
26.7 M INVESTING CASH FLOW
333312.50%
50 K FINANCING CASH FLOW
-96.98%
Balance Sheet Pyxis Oncology, Inc.
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Current Assets 132 M
Cash & Short-Term Investments 127 M
Receivables 0
Other Current Assets 5.51 M
Non-Current Assets 24.7 M
Long-Term Investments 0
PP&E 22.1 M
Other Non-Current Assets 2.6 M
80.75 %3.50 %14.09 %Total Assets$157.2m
Current Liabilities 17.7 M
Accounts Payable 4.86 M
Short-Term Debt 1.45 M
Other Current Liabilities 11.4 M
Non-Current Liabilities 18.8 M
Long-Term Debt 18.8 M
Other Non-Current Liabilities 0
13.34 %3.98 %31.21 %51.47 %Total Liabilities$36.4m
EFFICIENCY
Earnings Waterfall Pyxis Oncology, Inc.
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Revenue 16.1 M
Cost Of Revenue 475 K
Gross Profit 15.7 M
Operating Expenses 105 M
Operating Income -89.5 M
Other Expenses -12.1 M
Net Income -77.3 M
20m20m00(20m)(20m)(40m)(40m)(60m)(60m)(80m)(80m)(100m)(100m)16m(475k)16m(105m)(89m)12m(77m)RevenueRevenueCost Of RevenueCost Of RevenueGross ProfitGross ProfitOperating ExpensesOperating ExpensesOperating IncomeOperating IncomeOther ExpensesOther ExpensesNet IncomeNet Income
RATIOS
97.06% GROSS MARGIN
97.06%
-554.07% OPERATING MARGIN
-554.07%
-478.95% NET MARGIN
-478.95%
-64.04% ROE
-64.04%
-49.20% ROA
-49.20%
-61.74% ROIC
-61.74%
FREE CASH FLOW ANALYSIS
Free Cash Flow Analysis Pyxis Oncology, Inc.
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00(10m)(10m)(20m)(20m)(30m)(30m)(40m)(40m)(50m)(50m)(60m)(60m)(70m)(70m)(80m)(80m)(90m)(90m)(100m)(100m)202020202021202120222022202320232024202420252025
Net Income -77.3 M
Depreciation & Amortization 2.98 M
Capital Expenditures -237 K
Stock-Based Compensation 12.9 M
Change in Working Capital 0
Others -7.13 M
Free Cash Flow -57.9 M
3. WALL STREET ANALYSTS ESTIMATES
Wall Street Analysts Price Targets Pyxis Oncology, Inc.
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Wall Street analysts predict an average 1-year price target for PYXS of $9 , with forecasts ranging from a low of $7 to a high of $10 .
PYXS Lowest Price Target Wall Street Target
7 USD 560.38%
PYXS Average Price Target Wall Street Target
9 USD 749.06%
PYXS Highest Price Target Wall Street Target
10 USD 843.40%
Price
Max Price Target
Min Price Target
Average Price Target
101099887766554433221100Jun '24Jun '24Jul '24Jul '24Aug '24Aug '24Oct '24Oct '24Nov '24Nov '2420252025Feb '25Feb '25Apr '25Apr '25Jun '25Jun '25Jul '25Jul '25Aug '25Aug '25Oct '25Oct '25Nov '25Nov '2520262026Feb '26Feb '26Apr '26Apr '26
4. DIVIDEND ANALYSIS
5. COMPETITION
slide 2 of 12
6. Ownership
Insider Ownership Pyxis Oncology, Inc.
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Sold
0-3 MONTHS
0 USD 0
3-6 MONTHS
0 USD 0
6-9 MONTHS
0 USD 0
9-12 MONTHS
0 USD 0
Bought
0 USD 0
0-3 MONTHS
174 K USD 1
3-6 MONTHS
0 USD 0
6-9 MONTHS
0 USD 0
9-12 MONTHS
7. News
Top Cancer Stocks to Buy to Boost Your Portfolio's Health If the cancer space appeals to you, it's time to consider stocks like Pyxis Oncology, Verastem Oncology and Relay Therapeutics. zacks.com - 2 weeks ago
Pyxis Oncology to Participate in the Stifel 2025 Virtual Targeted Oncology Forum BOSTON, April 02, 2025 (GLOBE NEWSWIRE) -- Pyxis Oncology, Inc. (Nasdaq: PYXS), a clinical-stage company developing next-generation therapeutics for difficult-to-treat cancers, today announced that Lara S. Sullivan, M.D., President, Chief Executive Officer and Chief Medical Officer, will participate in a fireside chat at the Stifel 2025 Virtual Targeted Oncology Forum on Wednesday, April 9, 2025, at 11:30 a.m. ET. The Company will also be holding one-on-one investor meetings at the event. globenewswire.com - 1 month ago
Pyxis Oncology to Present New Preclinical Data Supporting Development of First-In-Concept ADC Targeting EDB+FN in Tumor Microenvironment at AACR 2025 Expression data from patient-derived xenograft (PDX) mouse models exposed to micvotabart pelidotin (MICVO) indicate gene signatures associated with efficacy, deepening understanding of MOA and potential patient response globenewswire.com - 1 month ago
Pyxis Oncology Reports Fourth Quarter and Full Year 2024 Financial Results and Provides Business Update - Recently reported positive preliminary data from Phase 1 dose escalation trial of micvotabart pelidotin (“MICVO,” formerly PYX-201), including a confirmed 50% objective response rate by RECIST 1.1 in recurrent and metastatic head and neck squamous cell carcinoma (R/M HNSCC) - Received Fast Track Designation from the U.S. Food and Drug Administration for MICVO for the treatment of adult patients with R/M HNSCC whose disease has progressed following treatment with platinum-based chemotherapy and an anti-PD-(L)1 therapy - Initiated monotherapy expansion cohorts of MICVO for 2L and 3L R/M HNSCC patients who have received prior platinum-based chemotherapy and prior PD-(L)1 inhibitor therapy with preliminary data expected in 2H25 and 2/3L R/M HNSCC patients who have received prior EGFRi and PD-1 inhibitor therapy with preliminary data expected 1H26 - Initiated MICVO in combination with Merck's anti-PD-1 therapy, KEYTRUDA® (pembrolizumab), in 1/2L+ R/M HNSCC patients as part of a recently announced Clinical Trial Collaboration Agreement with Merck (known as MSD outside of the US and Canada) with preliminary data expected in 2H25 - Streamlined organization and implemented operational initiatives to focus resources on the execution of the MICVO clinical program, including workforce reduction of approximately 20% - Expected cash runway into 2H26 BOSTON, March 18, 2025 (GLOBE NEWSWIRE) -- Pyxis Oncology, Inc. (Nasdaq: PYXS), a clinical-stage company developing next-generation therapeutics for difficult-to-treat cancers, today reported financial results for the year and quarter ended December 31, 2024, and provided a business update. “We are committed to the development of a novel therapy for patients with recurrent or metastatic head and neck squamous cell carcinoma who will progress following platinum-based therapies and prior PD-(L)1 therapy, and those that progress after current and emerging EGFRi therapies,” said Lara S. globenewswire.com - 1 month ago
Pyxis Oncology to Participate at the Leerink Partners Global Healthcare Conference BOSTON, March 03, 2025 (GLOBE NEWSWIRE) -- Pyxis Oncology, Inc. (Nasdaq: PYXS), a clinical-stage company developing next-generation therapeutics for difficult-to-treat cancers, today announced that Lara S. Sullivan, M.D. globenewswire.com - 1 month ago
Pyxis Oncology Granted FDA Fast Track Designation for PYX-201 Monotherapy in Patients with Recurrent or Metastatic Head and Neck Cancer Designation applies to the treatment of adult patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) whose disease has progressed following treatment with platinum-based chemotherapy and an anti-PD-(L)1 antibody Designation applies to the treatment of adult patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) whose disease has progressed following treatment with platinum-based chemotherapy and an anti-PD-(L)1 antibody globenewswire.com - 2 months ago
Pyxis Oncology Initiates New PYX-201 Combination Trial and Initiates Cohort Expansions of Ongoing Monotherapy Trial - Initiation of Phase 1/2 combination trial with PYX-201, an extracellular ADC targeting Extradomain-B Fibronectin (EDB+FN) and Merck's KEYTRUDA® (pembrolizumab) in multiple solid tumors globenewswire.com - 2 months ago
Pyxis Oncology Announces Portfolio Prioritization, Focusing Resources on its Lead Clinical Program, PYX-201 - The Company will focus resources on advancing its lead asset, PYX-201 - PYX-201 is a novel first-in-concept antibody-drug conjugate (ADC) where significant RECIST responses were seen in head and neck squamous cell carcinoma (HNSCC) with additional potential in other solid tumors - Current cash runway expected to fund development into 2H 2026 BOSTON, Dec. 19, 2024 (GLOBE NEWSWIRE) -- Pyxis Oncology, Inc. (Nasdaq: PYXS), a clinical-stage company developing next-generation therapeutics for difficult-to-treat cancers, today announced a portfolio prioritization, focusing resources on advancing its lead clinical program, PYX-201, a first-in-concept antibody-drug conjugate (ADC) with a microtubule inhibitor (optimized auristatin) payload that uniquely targets Extradomain-B Fibronectin (EDB+FN), a non-cellular structural component within the tumor extracellular matrix. In November 2024, Pyxis Oncology reported positive preliminary data from the ongoing Phase 1 dose-escalation study of PYX-201, evaluating its safety and efficacy in multiple solid tumor types. globenewswire.com - 4 months ago
Pyxis Oncology: Speculative Buy Opportunity With Multiple Catalysts Ahead Pyxis Oncology's lead candidate, PYX-201, showed promising response rates in Phase 1 trials but raised safety concerns due to a patient's death. The company's valuation appears deeply discounted, with a P/B ratio of 0.7 compared to a sector median of 2.4, reflecting market pessimism. PYX-201's ongoing trials and upcoming catalysts in 2025-2026 are crucial for addressing safety concerns and demonstrating efficacy across multiple cancer types. seekingalpha.com - 4 months ago
Pyxis Oncology's Cancer Drug Progress Stirs Analyst Concerns On Wednesday, Pyxis Oncology, Inc.  PYXS released preliminary data from the ongoing Phase 1 clinical dose escalation study evaluating PYX-201 in multiple solid tumors. benzinga.com - 5 months ago
Pyxis Oncology Announces Favorable Preliminary PYX-201 Clinical Phase 1 Part 1 Data — PYX-201 achieved a confirmed 50% ORR by RECIST 1.1 including one Complete Response and 100% Disease Control Rate in six heavily pretreated HNSCC patients, supporting differentiated mono and front-line combo therapy expansion trials to begin dosing 1Q25 globenewswire.com - 5 months ago
Pyxis Oncology's Cancer Drug Platform Shows Potential, Analyst Sees Over 190% Upside Stephens has initiated coverage on Pyxis Oncology Inc PYXS, highlighting the company's technology platform aimed at developing next-gen antibody-drug conjugates (ADCs) with enhanced potency, stability, and tolerability. benzinga.com - 5 months ago
8. Profile Summary

Pyxis Oncology, Inc. PYXS

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COUNTRY US
INDUSTRY Biotechnology
MARKET CAP $ 65.3 M
Dividend Yield 0.00%
Description Pyxis Oncology, Inc., a preclinical stage biopharmaceutical company, engages in the development of therapies to treat cancers. Its immune-oncology product candidates include PYX-106, an investigational fully human immunoglobulin G1 isotype siglec-15 targeting antibody for the treatment of thyroid cancer, head and neck squamous cell carcinoma, non-small cell lung cancer (NSCLC), and other solid tumors; and PYX-102, an investigational immune-therapeutic for treatment of solid tumors. The company's antibody drug conjugate (ADC) product candidates comprise of PYX-201, an investigational novel ADC to treat NSCLC, breast cancer, and other solid tumors; PYX-202, an investigational novel ADC for treatment of SCLC, soft tissue sarcoma, and other solid tumors; and PYX-203, an investigational ADC for the treatment of acute myeloid leukemia and myeloid dysplastic syndrome. The company was incorporated in 2018 and is headquartered in Cambridge, Massachusetts.
Contact 35 Cambridgepark Drive, Cambridge, MA, 02140 https://www.pyxisoncology.com
IPO Date Oct. 8, 2021
Employees 44
Officers Dr. Lara S. Sullivan M.D., MBA Chief Executive Officer, President, Chief Medical Officer & Director Dr. Michael Bui Head of Global Regulatory Affairs Dr. Jan Pinkas Ph.D. Chief Scientific Officer Ms. Pamela Yanchik Connealy M.B.A. Chief Financial Officer & Chief Operating Officer Dr. Balu N. Balasubramanian Ph.D. Interim Chief Technology Officer Ms. Sondra Smyrnios Head of Global Clinical Operations Mr. Stephen T. Worsley MBA Senior Vice President & Chief Business Officer Dr. Thuy Craveiro Pharm.D. Vice President & Head of Clinical Pharmacology Dr. Supriya Roth Ph.D. Head of Commercial Development Dr. Charles T. Gombar Ph.D. Senior Vice President of Portfolio & Program Management