Good morning, and welcome to Ionis' Third Quarter 2023 Financial Results Conference Call. As a reminder this call is being recorded. At this time, I would like to turn the call over Mr. Wade Walke, Senior Vice President of Investor Relations to lead off the call. Please begin, sir..

Thank you, Chuck. Before we begin I encourage everyone to go to the Investors section of the Ionis website to view the press release and related financial tables we will be discussing today, including a reconciliation of GAAP to non-GAAP financials.

We believe non-GAAP financial results better represent the economics of our business and how we manage our business. We have also posted slides on our website that accompany today's call.

With me this morning are Brett Monia, Chief Executive Officer; Onaiza Cadoret, Chief Global Product Strategy and Operations Officer; Richard Geary, Chief Development Officer; and Beth Hougen, Chief Financial Officer; Eric Swayze, Executive Vice President of Research; and Eugene Schneider Chief Clinical Development Officer will also join us for the Q&A portion of the call.

I would like to draw your attention to Slide 3, which contains our forward-looking statement. During this call, we will be making forward-looking language statements that are based on our current expectations and beliefs. These statements are subject to certain risks and uncertainties and our actual results may differ materially.

I encourage you to consult the risk factors contained in our SEC filings for additional detail. With that, I'll turn the call over to Brett..

launch and to briefly review the status of our go-to-market activities for Olezarsen and Donidalorsen. After Onaiza Richard will discuss our recent pipeline progress and after that Beth will review our third quarter financial results. And then, I'll wrap things up before taking your questions. And with that, over to Onaiza..

Thank you, Brett. As Brett outlined and as you will hear from Richard in more detail in a moment Ionis' pipeline holds tremendous promise. And today we are ready to begin delivering our medicines to patients.

With an estimated 40,000 patients worldwide and fewer than 20% of patients on an approved treatment, hereditary ATTR Polyneuropathy remains significantly under-diagnosed and largely underserved disease.

In large part the low rate of diagnosis is driven by the systemic nature and the heterogeneous presentation of this disease, while Peripheral Neuropathy may be the most important symptom in many patients. Others may present with Cardiomyopathy and still others with symptoms like GI disease leading to muscle wasting.

By leveraging Ionis' deep knowledge of ATTR and AstraZeneca's significant commercial reach, we are uniquely positioned to recognize ATTR in undiagnosed patients and get them on treatment early in their disease progress. And in doing so we are well positioned to grow this largely untapped market.

Our field team is built and deployed and already executing on our strategy to drive Eplontersen growth through disease education and brand awareness.

Additionally, we recently launched our unbranded disease education campaign called "See the Patterns" aimed at accelerating diagnosis by helping HCP spot potential ATTR in patients with seemingly disparate systems. We also recently launched our health care professional website aimed at driving disease and brand awareness among ATTR treaters.

Additionally, we are investing in rich data sources with the potential to identify ATTR-PN patients and support the field team's effectiveness to improve the diagnosis and treatment rates. With this potential approval in about six weeks we and AstraZeneca are ready to deliver Eplontersen to patients with ATTR Polyneuropathy.

And as our launch gets underway a key measure of our success will be in achieving our goal of Eplontersen becoming the preferred choice for newly diagnosed patients with ATTR Polyneuropathy. We expect Olezarsen to be the first medicine we launch independently.

We are developing Olezarsen in two indications the rare FCS indication and the broader sHTG indication with potential first mover advantage in both settings. Additionally, the fast track designation we have for FCS gives us the potential for an expedited review.

And together with the extremely positive results we reported from the Phase 3 BALANCE study in patients with FCS. In hand, we are moving forward with our launch preparations with even greater pace.

With the capabilities established for the Eplontersen launch, we are in a strong position to build upon this foundation and enable stronger launch readiness for FCS.

And as we prepare for the follow-on sHTG indication we plan to further scale these capabilities to realize the full potential of the product pending Phase 3 trial results and FDA approval. We expect our next independent launch to be with Donidalorsen for the prophylactic treatment of HAE.

This is an attractive market for us because it involves fairly concentrated set of prescribers allowing us to deliver Donidalorsen to HAE patients with an efficiently sized field team.

With the compelling Phase 2 and OLE data we have seen to-date, together with a once-monthly self-administration profile we believe Donidalorsen is positioned to be an important new Prophylactic Treatment for HAE patients, once approved.

I'm pleased to say that we are right where we should be in preparing for our first independent launches of Olezarsen and Donidalorsen. Our commercial infrastructure is in place and we are ready to begin delivering our medicines to people in need as they come to the market. This is a very exciting time for Ionis.

I'm proud to be part of it, and I look forward to keeping you up-to-date as our next important step unfold. Now, over to Richard..

Thank you, Onaiza. We could not be more pleased with the performance of our pipeline. Eplontersen has continued to perform exceptionally well demonstrating durable and sustained efficacy and safety through 85 weeks of treatment in patients with ATTR polyneuropathy.

Just this morning, we presented new data at the European ATTR amyloidosis meeting that further reinforces these results, demonstrating improvements in measures of neuropathy impairment and quality of life that were seen in a substantial number of patients at 35 and 66 weeks and were sustained through the 85 week analysis.

And benefit across secondary endpoints at 85 weeks showed improved neuropathy specific and physical health related patient quality of life stabilized or improved ambulatory status, and stabilized nutritional status with eplontersen treatment.

And last month at HFSA, we showed data demonstrating improvement in cardiac function and structure in a predefined cardiac subpopulation of polyneuropathy patients from the neuro transform study.

The positive results from NEURO-TTRansform also support our confidence in the potential for eplontersen to benefit patients in the larger ATTR cardiomyopathy indication. With CARDIO-TTRansform fully enrolled, we remain on track for data as early as the first half of 2025.

As a reminder, with over 1,400 patients CARDIO-TTRansform is the largest study in this patient population to-date, designed to generate the data physicians and payers want and need to understand the value of eplontersen offers for patients and to enable the best possible treatment decisions for patients.

Following eplontersen, olezarsen is the next drug we expect to bring to the market, and is the first we expect to commercialize independently.

In the BALANCE study the 80-milligram dose of olezarsen demonstrated statistically significant reductions in triglycerides, robust target engagement and a favorable safety and tolerability profile consistent with the profile seen with our other like medicines.

In addition, olezarsen demonstrated unprecedented substantial and clinically meaningful reductions in acute pancreatitis attacks. This is remarkable, because it's the first time a lipid-lowering therapy has ever achieved this result in a clinical trial setting.

Based on the positive data we reported from the Phase 3 BALANCE study, we believe that olezarsen is poised to become the standard of care for patients with FCS. Our next step will be to file for marketing approval in the U.S.

and EU in the first half of next year positioning olezarsen for its first potential approval in late 2024 assuming priority review in the U.S. In addition to our clinical development program for FCS, we also have an ongoing program for patients with severe hypertriglyceridemia, or SHTG.

Phase 3 studies in SHTG patients are ongoing, and we expect those studies to read out in late 2024 or early 2025 depending on enrollment. Following closely behind olezarsen is our next wholly-owned medicine donidalorsen to treat patients with hereditary angioedema.

Despite several treatments already on the market, HAE continues to represent a significant unmet need. For example, in a study recently conducted by the Hereditary Angioedema Association of over 500 patients with HAE, only 13% of these patients reported having good control of their disease with more than 85% reporting two or more attacks per year.

Data reported from the ongoing Phase 2 open-label extension study of donidalorsen show sustained and durable reductions in HAE attacks and favorable safety and tolerability over two years and support donidalorsen's potential to address the unmet need.

We look forward to presenting a comprehensive look at the two-year OLE data next week at the ACAAI Conference. With enrollment completed in the Phase 3 OASIS-HAE study, we remain on track for data in the first half of next year. And from our robust late-stage pipeline we look forward to updates from bepirovirsen and IONIS-FB-LRx.

Next week at AASLD GSK plans to present new data from the Phase 2b B together study of bepirovirsen in combination with pegylated interferon. In this weekend at Kidney Week, we plan to present new interim results from our ongoing Phase 2 study of our Roche partnered medicine IONIS-FB-LRx in patients with IgA nephropathy.

We also made significant advances with our industry-leading neurology franchise this year. Today, we have two approved breakthrough medicines for neurological disease on the market SPINRAZA and QALSODY. And we have another 12 in clinical development. and more than 10 new programs in preclinical development or lead optimization.

Among our partner neurology programs we recently completed enrollment in the Phase ½ study of ION582 in patients with Angelman syndrome putting us on track for data around the middle of next year.

And we were encouraged by the positive data our partner Biogen recently reported from the Phase 1b and long-term extension studies of IONIS-MAPTRx in patients with early Alzheimer's disease.

Data presented at the clinical trials on Alzheimer's disease conference showed numerical improvements on multiple cognitive and functional scales and continued favorable safety and tolerability in this small early-stage study.

The data published in JAMA Neurology showed a rapid substantial and sustained reduction in Tau and phosphorylate and Tau in CSF as well as reduced Tau pathology on PET imaging with up to 100 weeks of IONIS and MAPTRx treatment.

And we're particularly excited with the progress we're making in building and advancing our wholly-owned neurology pipeline, which represents one of our highest priorities. As Brett mentioned, we advanced Zilganersen into Phase 3 development in patients with Alexander's disease a rare debilitating pediatric leukodystrophy with no approved treatment.

We're on track to advance ION 717 into Phase 1/2 first in human study in patients with prion disease before the end of the year. And following ION 717, we expect to advance three more wholly-owned neurological disease medicines into the clinic next year.

This has been an eventful year so far and we're looking forward to several additional key events in the coming months including the US Eplontersen approval launch and additional regulatory filings and approvals outside the US. Olezarsen regulatory filings in FCF and Donidalorsen Phase 3 data.

We will keep you updated on our progress on these events and more throughout the coming year. And with that over to Beth..

Thank you, Richard. Our year-to-date financial results keep us on track to achieve our 2023 financial guidance, while we continue to execute on our strategy to unlock next level value.

Revenue continued to be substantial and sustained with revenues of $144 million and $463 million in the three and nine months ended September 30, 2023 reflecting a 10% decrease and a 6% increase, respectively compared to the same periods last year and driven by the timing of certain partner payments.

As anticipated, our operating expenses and operating loss for the third quarter and year-to-date increased over the same period last year as we advanced our commercial readiness activities and our pipeline, especially, our late-stage programs.

We remain well capitalized with $2.2 billion in cash and investments at the end of September enabling us to continue investing in our strategic goals. Our commercial revenue from SPINRAZA royalties was $67 million and $179 million in the third quarter and year-to-date respectively.

Reflecting SPINRAZA's resilience against emerging competition in the US and abroad, SPINRAZA's global sales in the third quarter demonstrated a low single-digit increase compared to last quarter and compared to the same quarter last year.

As a result, our revenue from SPINRAZA royalties increased by 9% compared to last quarter and 8% compared to the same quarter last year. We earned R&D revenue of $60 million in the third quarter and $233 million year-to-date.

The significant R&D revenue we continue to generate reflects the value that IONIS' technology is creating as numerous partnered programs advance. In line with our goal to invest for revenue growth, our non-GAAP operating expenses increased in the third quarter and year-to-date compared to last year.

With most of our ongoing Phase 3 studies fully enrolled our study costs increased as expected which resulted in higher R&D expenses. And as we prepare to launch eplontersen, olezarsen, and donidalorsen, our SG&A expenses also increased modestly year-over-year. Our year-to-date results keep us on track to meet our 2023 financial guidance.

We continue to project revenues of more than $575 million. We expect our fourth quarter R&D revenue to be driven by the potential $50 million milestone payment from AstraZeneca for the US approval of eplontersen.

R&D revenue from continued development about eplontersen and additional revenue from Biogen and from our recently expanded collaborations with Novartis and Roche. We project our 2023 non-GAAP operating expenses to come in at the higher end of our guidance, which is between $970 million and $995 million.

And looking ahead we expect to generate a substantial and sustained base of R&D revenue from multiple sources in 2024 as our partnered programs advance. And we expect that eplontersen will continue to be an important source of revenue in 2024. We have the potential to earn a milestone payment for an additional eplontersen approval outside the US.

We also expect to begin generating modest royalty revenue next year with growth expected as the launch ramps up. We project our expenses to grow modestly next year with our R&D expenses approaching steady state as our late-stage programs are fully enrolled.

And our SG&A expenses to ramp up in line with the planned launches of eplontersen, olezarsen, and donidalorsen.

We have a strong financial foundation substantial recurring R&D revenue, a substantial and sustainable royalty revenue that can continue to grow and we expect to add new product revenue from our advancing and expanding wholly owned pipeline.

Together with our prolific technology, we believe we are on a path to successfully bring our medicines to patients and to unlock next level value. And with that I'll turn the call back over to Brett..

Thanks Beth. We are very proud of the remarkable progress we've made this year. We believe that the successes we've achieved so far this year position us to drive substantial value for patients, our shareholders, and all Ionis stakeholders.

Strategically, we have arrived where we are today by being focused on a clear vision and by being focused on all our support and strategic objectives necessary to achieve our vision. We've now established all of the functional capabilities we need to deliver a steady cadence of new and potentially transformational medicines to the market.

We are advancing and growing our wholly owned pipeline and have established Ionis as a leader in cardiovascular and neurology drug development.

We continue to extend our leadership position in Oligonucleotide type therapeutics by expanding and diversifying our technology further optimizing our capabilities for existing therapeutic areas and opening up new areas for drug discovery and we continue to strengthen our financial foundation, providing the means to support all our strategic objectives.

And today, with one of the most robust late-stage pipelines in the industry, with nine medicines in development for 11 indications, we're turning that promise into new medicines for patients in need and not just one or two, but a steady and growing cadence of new transformational medicines over the mid and long-term.

And in achieving this goal, we are positioned to drive great value for all Ionis stakeholders. With that, I'll now open the call up for questions.

Operator?.

Thank you. We will now begin the question-and-answer session. [Operator Instructions] And the first question will come from Gary Nachman with Raymond James. Please go ahead..

Hi. Thanks for taking the question. So, on eplontersen for ATTRPN, any additional updates regarding your interactions with the FDA? And how everything is progressing in front of the PDUFA? Have they requested any additional data and are label discussions progressing in the way you would like them to? And then, just on the commercial plans.

Given the competitive dynamics in the space with [Indiscernible], how will payers be viewing Eplontersen? What's your work telling you there? Will all these drugs be covered on most formularies? And where is AstraZeneca on the hiring of the sales force? Just give us a sense of how big you think that will be? Thanks..

Thank you, Gary. I'll take the first one and briefly give you an update on regulatory. And then I'll ask Onaiza to cover the second part of your question on competitive dynamics. So, it's -- we don't comment on ongoing regulatory discussions for drugs under review for potential approval.

But what I can say with high confidence is that, we're very pleased with the progress we're making with the FDA and bringing up on teen to an on-time potential approval either PDUFA date on December 22. So there's been really -- everything is moving on track with that.

And I also want to remind you everybody that we are now under review with our filings accepted in Canada and in Europe with potential approvals for those markets as well for next year for Eplontersen and TTR polyneuropathy.

Onaiza?.

Hi Gary. Your launch plans are really underway. I would say they're actually in place. We have hired all the necessary people for a very, very effective launch. The salespeople as you know is being led by AstraZeneca are hired and deployed in market. They are in the field.

They are working on disease and brand awareness, really given that this is a very growth market, identifying with different physician sets, the types of symptoms that ATTRPM patients present with is very much underway. You've seen some of the campaigns on see the patterns. So they're out there really since the last month in field.

And we are just awaiting approval, PDUFA is December 22 and all things are in motion. Our nurse case managers on the Ionis side are hired and have been trained. And since they're mostly post approval, we would deploy them right after. And as you know the field medical team has been in place for the last 18 months to two years.

So, all signals are ready to go. From a payer perspective, I think we have a very strong payer strategy. We've done a lot of research with the majority of the payers in the US. We don't expect anything different than other kind of agents that have been priced on the analogs of rare disease pricing. Again, we believe this is a really active rare disease.

We do not expect tons of beyond the normal prior authorization for a rare disease to get through. We haven't seen much shift in the landscape here so far..

All right. Great. Thank you..

The next question will come from Luca Issi with RBC Capital. Please go ahead..

Great. Thanks so much for taking the questions. Maybe two quick ones. One on Hepatitis B.

What was your reaction to GSK in licensing the ex- RNAi from Arrowhead and J&J, given that they already have a sound thing agent with you, why do you think they need a second one? And then maybe circling back on the prior question so TTR polyneuropathy in PDUFA, any color on manufacturing? Has the tech transfer to AstraZeneca been successfully completed? Has the FDA expected the facility that will provide the commercial supply? Just trying to understand, if there is anything that keeps you up at night ahead of PDUFA? Thanks so much..

Thanks, Luca. So we have a very good relationship with GSK. So we're aware of what was coming, what was announced this week. The way to think about it is that, the acquisition of the RNAi molecule from Vanson really represents a double down, a triple down if you will on Bepirovirsen.

Bepirovirsen is the only treatment that has produced a meaningful percentage of patients achieving a functional cure patients with HPV, chronic HPV. And in the Phase IIb in the CLEAR study, what we demonstrated with GSK was about a 10% functional cure rate.

However, in patients with a lower HPV burden like 1,000 IUs per million, I think per milliliter that functional cure rate was well into the 20%-plus range, which is really impressive.

And so the strategy that GSK has stated for bringing in the RNAi molecule, which has not shown functional cures but what it has shown is reduction in HPV antigen levels, two levels that -- which has a substantial percentage of patients can get below that 1,000 IU level is to do a sequential treatment to reach even more patients to achieve even greater percentage of functional cures by bringing patients down to a level maybe below 1,000, more patients below 1,000 IUs per milliliter and then coming in with Bepirovirsen.

So this is an added dimension to a very comprehensive clinical program for Bepirovirsen to reach as many patients as possible and to achieve the highest percentage possible for functional cures for Bepirovirsen.

And it's also consistent with everything that GSK has been saying in which they will be exploring different combinations for Bepirovirsen to maximize success on this market, which as you know is hundreds of millions of people suffering from chronic HPV. So we're very pleased about this new outcome with GSK for Bepirovirsen.

And Beth maybe you could talk a little bit about where we are with the our launch preparations for commercial supply?.

Sure. Absolutely. We are all ready to go just as we are on the commercial side and the medical affairs side. All of the products needed for launch has been manufactured. It was manufactured through the regulatory process has been reviewed is ready to go.

We just are waiting for a final label to do label and packaging and get product into channel shortly after approval, and all of the tech transfer necessary from Ionis to AstraZeneca with the commercial manufacturer the contract manufacturer is done. And all of that has gone extremely well. So we are -- all systems is ready to go..

Great. Thanks so much..

The next question will come from Yale Jen with Laidlaw & Company. Please go ahead..

Good morning and thanks for taking the questions. I've got two quick ones here. The first one is for the SPINRAZA sales, I believe that will be ordinarily announced by Biogen.

But, nevertheless, you indicated that the growth -- small growth quarter-over-quarter, should we at believe that this is again consistent with the stabilization of the franchise in the larger SMA space? Then I have a quick follow-up..

So, what I would say is we're very pleased with the low single-digit growth in -- against last quarter and against the previous quarter -- same quarter last year.

We believe that demonstrates SPINRAZA's continued resiliency even in the face of emerging competition Beyond that I really need to respect Biogen's earnings call next week and I really can't go any further..

Okay, great. That’s helpful.

And in terms of a JAMA publication regarding the eplontersen to sustain the benefit, how should we think about that to incorporate into the marketing strategy, particularly for newly treated or untreated patients?.

The publication specifically? I mean, that's going to be a really effective tool to, right, Onaiza?.

Yeah, I think with the promotional and regulatory guidance, looking at the JAMA publication and where our promotional messages are headed. It's going to be highly supportive.

The JAMA publication is also very consistent with the label that we expect so that will allow for use by both the medical teams as well as the sales teams as well and that's what we expect..

Yeah. So in other words, although our package that's under review at the FDA is based on the week 35 interim data that we reported last year having this publication for week 66 and week 85 is very, very helpful from a marketing standpoint and we expect to utilize that publication very effectively. I think that was the basis of your question..

Thanks On and Brett. .

The next question will come from Paul Matteis with Stifel. Please go ahead. .

Hi, this is James [ph] on for Paul. Just one on Olezarsen, quickly. I guess as we get ready for the FCS launch I guess how are you thinking about pricing just given that the higher trade opportunity may be coming behind it and assuming there will be different price points there.

And I guess, just as you've kind of put some of this commercial infrastructure in place for the FCS launch, how much I guess leverage either from like a sales force or spend perspective do you anticipate getting from this FCS infrastructure as you think about launching the higher trigs opportunity? Thanks so much.

Sure.

So we've done some extensive work with payers to understand kind of this dual indication that we're going after in prevalent and rare disease does that actually really make a shift in your pricing strategy? Do -- we know that once we have the more prevalent indication, the pricing will obviously be in line with good kind of cardiovascular premium priced products.

We see really no indication in terms of, thinking about this differently as a result of the two indications, if they were to single indications in different molecules. We priced the rare disease along rare disease, pricing corridors and the broader indication along the quarters of a good cardiovascular premium price benchmark as well.

So, you should think about it that way. I would say, that the SCS account sales team, we'll be calling on obviously, a much smaller portion than the total universe of physicians you would call on for SHTG.

It will be more focused on the lipidologists, but extend out a bit beyond that as well for where we believe the FCS patient population is we're doing a lot of work from our integrated data analysis, and qualifying where those physicians are that actually have FCS patients.

And then, as we get into the broader indication, those sales teams will obviously stay on board and we will extend the size of the sales team for the broader SHTG market, to incorporate some of the other physician specialties that we believe will be very important for the uptake of that product..

Excellent. Thank you..

The next question will come from Allison Bratzel with Piper Sandler. Please go ahead. .

Hi. Thanks for taking the question. So first, I guess I just wanted to ask on the anti-tau update last week for BIIB080. I know Biogen is responsible for development of the asset. But I'd still be curious just to get your thoughts on how that approach could fit into the Alzheimer's treatment paradigm, be it in combo or monotherapy or what have you.

I'm then hoping, you could also just describe how that data maybe influences your confidence in the wholly owned neurology assets. And then on a second front, just on the complement Factor B program looking at that interim Phase 2 data being presented at ASN in a couple of days.

Is there any update just on your view of the IgA nephropathy market and potential opportunity in IgAN just given the context of an evolving competitive landscape there? Thank you..

Thank you, Allison. The Phase 2 study evaluating tau in patients with Alzheimer's disease is underway and enrolling. And it's a very -- it's really quite an extensive study with more than 700 patients to be treated for well over a year, with the primary endpoint really being efficacy improvement in cognition.

And the purpose of that Phase 2 study, is to really make a decision to set up and support a path forward to go to Phase 3 development for a pivotal study.

And in this study, we are exploring different dose levels as well as different dose regimens including, twice a year dosing and that's based on the data that you're referring to which is the Phase 1/2 study that is now published in JAMA Neurology and was presented at CTAD last week and is incredibly supportive of that Phase 2 study and the Tau program overall.

We and our partner Biogen could not be more thrilled with the data that was generated from the long-term extension of the Phase 1/2 study in patients with Alzheimer's disease.

tau is considered by exploring essentially all the efforts in the field as being the most important target for Alzheimer's disease based on the neurofibrillary tangles that appeared just before cognition impairment occurs. It's downstream of beta amyloid, which can be present long before cognition deficits occur.

But it's a difficult-to-drug target because what matters most is intracellular tau that closes the neurofibrillary tangles from neurodegenerative. What we have shown for the first time is not only can we substantially lower our all forms of tau in CSF, we can actually reverse tau pathology in the long-term extension data in patients by PET imaging.

But now we also have from the long-term extension data actually signs, trends that patients are actually improving in cognition. So we couldn't be more thrilled about the data. And this has built on our confidence from the CLIA Phase 2 study that's underway that I referred to earlier.

As far as combination monotherapy that kind of thing that's – this is the start of a development program for a drug that's leading the way to target tau. The Phase 2 study is intended to assess the benefits of tau on cognition as a monotherapy.

That does not preclude future studies looking at different combinations as this field evolves, whether it be with the beta amyloid treatment in combination with the tau-driven and so on. That will require further development and – but it can make sense.

We can see how those two mechanisms can actually complement each other and maybe even synergize with each other. So all that is on the table. But right now Biogen and Ionis are focused on the Phase 2 study to bring that forward as quickly as possible.

And as far as confidence in neuro, this is just another piece of data, evidence, validation of our leading neurology platform.

I would start with SPINRAZA and QALSODY, two approved breakthrough treatments for neurodegenerative diseases using the same platform as tau, using the same platform as our Angelman's program, using the same platform as all of our 12 drugs that are currently in clinical development for all kinds of different neurodegenerative neurodevelopmental disorders.

And as Richard highlighted in his earlier remarks, we expect to start a prion program wholly owned program by the end of this year and three more next year that are wholly-owned, neurology programs for diseases that have a high unmet medical need for both rare and large indications. So it just adds to our confidence in our leading neurology platform.

As far as IgAN FB-LRx to be presented at Kidney Week coming up. This will be an additional data cut that was presented at Kidney Week last year in patients with IgAN nephropathy just showing more data, more patients, longer treatment, showing reductions in proteinuria in that study. As far as the competitive landscape, it's crowded.

There's no question and we're glad Roche has taken a lead on this because they have a tremendous global might, global strength, global presence get the drug to successful – to bring it to as many patients as possible. But I really think that that's to be determined once we see the Phase 3 data and to see how this positions itself.

But really, we couldn't be more pleased to have. When you're a competitive market like this with a high unmet need, it's great to have the global strength of a partner like Roche..

The next question will come from Yanan Zhu with Wells Fargo. Please go ahead..

Great. Thanks for taking the questions. Three questions if I may.

On Eplontersen, what launch metrics would you provide so that we can have an understanding of how the drug is performing in the market in the early launch quarters? On the tau program, can you talk about how you see the visibility of the Inotersen [ph] route of the administration in this very large indication.

On the –lastly on the Angelman syndrome program, following the recent updated data from Ultragenyx, any insights you could share regarding how your program could be differentiated from that program as we look forward to data in mid-2024? Thank you..

Thanks Yanan.

And maybe we'll start with launch metrics?.

Sure. So Yanan, I think the way to think about this market, as I said, it's a growth market and we have a lot of patients to get diagnosed and get treated on eplontersen. And I think the phenomenon that you might be seeing now with switches is very temporary. And I think we will have -- they will have worked through that.

We're squarely focused on growth and growth mindset on newly diagnosed patients. As such our launch success will be measured on getting eplontersen as a preferred choice for newly diagnosed patients new to silencers..

Got it. Thanks..

So next year, we'll be providing some metrics and we'll see how that -- so stay tuned for that Yanan.

Regarding the Tau program, so Alzheimer's disease, despite the really remarkable progress, that's been made recently on delivering medicines to the market to patients for AD, this is still a very severe neurodegenerative disease with a very high unmet medical need.

And like I touched on earlier, we think Tau is the best target for treating this disease broadly. And with that comes the need for treatments and we don't -- we believe that intrathecal delivery will be well accepted if the drug is as efficacious as we expect it to be.

With that said, the Tau program is an example of the great progress we're making in further optimizing and advancing our neurological disease drug discovery capabilities with homedicinal chemistry and just experience.

In the Tau program, we actually have a treatment arm that we expect will be efficacious with twice a year dosing, so we've moved from monthly to every three months for many programs and now we've been moving some programs to twice per year dosing intrathecal. That is part of the Tau program that's in Phase 2 development today.

In addition as we highlighted at Innovation Day, a few weeks ago, we're making great progress from our research organization in overcoming the blood-brain barrier as an obstacle for delivery of our treatments, our drugs for using subcutaneous or intravenous administration. And obviously, programs like Tau are on our radar as our other programs.

So we also think that that could be in the future for a large population chronic disease indication like Alzheimer's disease. So, no promises there yet but we're very pleased with the progress we're making there. Regarding Angelman syndrome, I prefer not to comment on other people's programs other companies' programs.

What I will say is that we are fully enrolled in our Angelman's program. We actually overenrolled the study a bit. We expect data midyear next year. We expect data on efficacy as well as, of course, safety and biomarker data from that trial. And that trial is designed to set up a potential Phase 3 decision based on all that.

And then what I'll also say is that -- and it's kind of related to the earlier question that I got that I tried to address, which is we have a vast amount of experience with our platform in neurological diseases thousands and thousands and thousands of patients have been treated for very extended periods of time with our chemical platform, with our know-how with everything.

And we think that that bodes very well for the Angelman's patient community, because they're going to be able to take -- they're going to benefit from the vast experience that we have at Ionis with delivering neuro drugs for the treatment of severe neurological diseases like Angelman syndrome. So stay tuned for all that.

We're very much looking forward to the data next year..

Great. Very helpful. Thank you..

The next question will come from Debjit Chattopadhyay with Guggenheim. Please go ahead..

Hey. Good morning, team. This is Robert on for Debjit. Thanks for taking our questions. Two from us this morning. First, could you share any pricing thoughts on eplontersen. Specifically would you anticipate launch price in line with current PN treatments on the high end or CM treatments in the low end.

And for the Alexander program, what pace of enrollment would you hope to see in the Phase 3? And subsequently when would you potentially anticipate a Phase 3 readout based on those time lines? Thank you..

Onaiza, would you want to take the launch price PN and CM?.

Yes. So Robert I think that we would expect that again the two indications are both rare disease indications, but they are priced differently if you looked at analogs in the marketplace. Based on all the work that we've done, we don't believe there is any reason to kind of shift from that in terms of our pricing strategy.

So I would expect that as the price is set by AZ that we would expect polyneuropathy to be priced according to the analogs and benchmarks of other polyneuropathy products..

And regarding our newest Phase 3 program our Alexander disease program most of the time we're enrolling rare disease indications can be challenging, because they are rare in finding patients into your study obviously can present challenges.

But what's unique about our Phase 3 program for Alexander disease is that we designed a seamless Phase 1 through 3 design such that it's all the same sites. It's all the same -- the protocol has already been baked and everything like that. And after our Phase 2 results, which was when we reviewed it we had two decisions to make not really.

One was to dose escalate or to move into Phase 3 development. And during that review process when you go through all the data you're collecting the data you're cleaning the data and before we actually review the data enrollment is put on pause right? Because we don't know what the next step will be for the program.

And what happened in this situation is that patients were on the sideline waiting to get into either the dose escalation phase of the next step or the Phase 3 part of the program.

So with that said, we think actually enrollment will go well for the Alexander program because we have patients on the sideline waiting to qualify to enter our Phase 3 program now that we've activated it. So enrollment is ongoing and we expect data in 2025..

The next question will come from Yaron Werber with Cowen. Please go ahead..

Hi, guys. This is Brendan on for Yaron. Thanks so much for taking the question. Just a couple of quick ones from us.

Just another one on Matt Tau -- excuse me, sorry if I missed this but -- just wondering if there's any plan for any interim look at the Phase 2 study or any possibility of any additional data updates there before the full Phase 2 readout assuming maybe 2026 for the full Phase 2.

So just wondering if we can expect anything new there in the meantime? And then quickly on donidalorsen. Obviously you have a few different studies ongoing there. But I think you're planning to incorporate into one filing maybe including the switching study, et cetera.

So can you just maybe give us a sense of timing for data beyond the top line readout in the first half of next year? Maybe how long thereafter do you think you'd need to collect and analyze data, and if you're thinking to maybe file in the second half of next year if that's fair to assume. Thanks very much..

Sure. So there's no plan for an interim look in the Phase 2 study for the tau program at this time. So that's a short answer quick answer. It's very important to get this study right, and you get the richest dataset as you possibly can.

And as I mentioned earlier, it's -- this is -- what we're looking for here is actually evidence to support a Phase 3 decision that we're improving cognition impairment. So that's going to take time that studies over a year long, as I mentioned earlier, more than 700 patients. So no interim look at this time.

For donidalorsen, I don't think we've said that we're expecting to include switch data in the filing for the NDA. Really the Phase 3 data along with all the other data that we've generated from Phase 1 and Phase 2 will be sufficient to support a filing assuming positive outcome.

With that said, we expect Switch data from our Switch study which as a reminder to our knowledge we're the only sponsor that has actually conducted a true Switch study in which patients that are on an existing treatment therapy Prophylactic Treatment are switched over to power of investigational medicine Donidalorsen to and Onaiza mentioned which in our case is Donidalorsen.

And then we assess everything, including protection against HAE attacks on identifying demonstrating that there's, no gaps between one treatment switching to, another treatment.

Tolerability sustained efficacy and actually be able to generate the information that prescribers are going to want to have to understand how do I do this? Okay I want to switch to your drug. I want my patient to go on your drug, but how should I do this? And that's really the goals of the Switch study.

We expect that data to be out next year or at least a cut into that data next year that's going to really allow us to actually demonstrate the value of Donidalorsen in this market which is a Switch market. But we have no plans to include that at this time to my knowledge in the NDA filing..

If we believe that the publication will be more than sufficient to be consistent with label to be used actively by our sales teams in promotion. And to the extent if it's all ready alongside of it, we could actually add it in, but it's really not a requirement nor that we think it's really necessary for commercial uptake.

We like it in the publication. That's what we're really looking for is our strategy going forward..

Okay. Great. Thanks very much..

The next question will come from Jessica Fye with JPMorgan. Please go ahead..

Hey guys. Good afternoon. Thanks for taking my questions.

Can you remind me of your expectations around whether in addition to a clear impact on triglycerides, whether you believe you could show an impact on pancreatitis for Olezarsen in sHTG? And then second forgive me if you stated this, but for CARDIO-TTRansform, I believe the ball is up to 140 weeks.

I just wanted to clarify is there a minimum planned follow-up for those who do not reach 140 weeks. I noticed some of the endpoints are assessed a week I think 121. Is that the minimum assuming the study has not stopped early? Thanks..

Eugene, do you want to take those?.

Sure. Happy to, maybe I'll start with the last one. So as you said of course the fair excruciating level of detail on the statistical analysis plan, but just to summarize it the exposure on the study is up to 140 weeks which means that in some patients if the study reads out early the exposure will be less than that.

We've defined the minimal exposure and the time point specific time points for those early look in our SAP. And I don't think that we've come out and included specific time lines on those other than sort of the general statement about early opportunity for closing the study earlier based on some specific conditions being met. And then,….

In the event you don't stop the study early what the minimum would be?.

Well, if we don't stop the study early we go -- all patients will be treated for 140 weeks. That's the double-blind period..

Yeah. Okay..

Okay.

And then, likelihood of achieving AP in sHTG?.

Yeah. So sHTG again it's of course a very different population from FCS in terms of risk for AP events. Having said that again the program that we designed the two very large studies certainly we believe we'll have an opportunity to show an effect. And what we are also going to be looking at is a combination of those two studies.

So looking at sort of integrated analysis of efficacy combining those two large studies which together amount to about almost 1,000 patients. So we're fairly confident of course today we don't know what the data will show. What we can say is that we were extremely pleased with the effect on AP events in our FCS population.

So we do believe that the thesis is very strong, but we need to wait until the data read out..

The next question will come from Kostas Biliouris with BMO Capital Markets. Please go ahead..

Hi, everyone. Thanks for taking our question. One quick question from us on ATTR.

This morning [Indiscernible] presented data from the literature demonstrating that in addition to the percentage of TTR reduction, the absolute serum TTR levels after treatment are also very important as they can contribute to the ongoing fibril formation and they actually have an impact on survival.

That said I'm wondering whether you have any thoughts around that given that most of the discussions in this space focus on the percentage of TTR reduction rather than the absolute levels of TTR post treatment? Thank you..

Thanks, Kostas. Not a lot of thoughts on gene editing efforts in the TTR space. I mean, the progress that they're making is steady. Percent reductions in TTR are absolutely important for efficacy.

I don't think there's a -- I think we've known for a long time that there's not a threshold effect if that's your question that there's a specific threshold by which if you lower TTR is that you'll achieve benefit on neuropathy or cardiomyopathy or whatever.

But then it's actually individualized per patient and percent reductions is very important and we're very pleased with the mid-80% mean reductions that we've achieved in the neuro transform study for eplontersen in polyneuropathy patients, mid-85% range. And as you know we've -- actually a substantial number of patients actually improve.

And about the eplontersen [ph] and quality of life. So I don't know what to say about those other programs except that they have a long way to go. Cardiomyopathy indications are going to require an outcome trial in our view to not just be approvable but to actually compete. And it's going to take a long time to get there.

And it's a new platform that you never know what will come up. So I don't know much else to say about it other than that Kostas, but we love our program and we're very much ahead..

Thank you very much..

The next question will come from Joseph Stringer with Needle & Company. Please go ahead..

Hi. Thanks for taking the question. Just a quick one on Phase 2 GOLDEN trial and geographic atrophy. When can we expect top line data? And given some of the competitor data that's out there, can you handicap expectations on what successful Phase 2 outcome looks like.

And if the results are sufficiently positive what would be the next steps in the program collaboration with Roche?.

You want to take that Richard?.

Yeah. I'll take a stab at it. I think, of course, we want a positive trial on geographic atrophy and comparable if not better results than have been presented by other competitors. So that's the goal. We have no insight into what that is today, but the data will be out next year second half..

Yes. So second half as Richard said in the second half of next year, what I can add to that Joe is that we also had an interim look in this Phase 2 study that allowed us to select the doses to complete the study. We started with a number of those and then whittle goes down to two doses to complete the GOLDEN Phase 2 study bring it to the finish line.

We're seeing excellent tolerability, we're seeing profound reductions in Factor B and in downstream effects like split products exactly where we expect to be. So we're getting great target engagement, we're not seeing any risk associated with that target engagement by blocking the alternative complement pathway, it's going great.

And what we expect to see is -- what we hope to see is slowing down of lesion, formation and improvement in visual acuity. I mean these are the outcomes that we're expecting to support a decision whether to go to Phase 3 or not.

As far as competitive landscape this is a subcu once-per-month drug using -- which could use an autoinjector once it got to the market if it gets there. Simple at home auto-injector like apontersen whereas the drugs that are under review or recently been approved or intravitreal and they have side effects as you well know.

So I think this -- although there's been progress made in GA, I think patients are desperately waiting for a joint that's not so invasive and simple and convenient like a subcu at-home administration..

Great. Thank you for taking our questions..

The next question will come from Myles Minter with William Blair. Please go ahead..

I just had a question on ION904. I think you've got an upcoming presentation at American Heart Association.

Just wondering whether we should be thinking about similar AGT knockdown to the previous like a molecule and just more infrequent dosing or is that potential to get more than that sort of 75% that we're seeing with that molecule? Thanks very much..

You got it, Myles. So our presentation on our AGT program at AHA will really focus on the dose-dependent reductions in AGT that we sought to achieve in our -- in the Phase II study. This is a molecule that is being dosed monthly.

Our earlier generation molecule that you mentioned was weekly and we expect to see greater reductions in our earlier generation molecule because it's a more advanced chemistry. So that's what we're expecting..

Great. Thanks for the question..

The last question will come from David Lebowitz with Citi. Please go ahead..

Thank you very much for taking my question. With respect to Olezarsen given the recent pivotal data, as you look forward to severe hypertriglyceridemia, how -- I know that you achieved benefits with respect to pancreatitis, you received the reductions. But given the dynamics and differences in that population.

How easy do you think it's going to be to show a pancreatitis benefit?.

That's a great question, David. And it's a question that our answer today is a lot different than it would have been earlier this year. The SCS data, we in our wildest dreams we hope to see the AP reductions that we saw in FCS. And those are while the streams turned into reality.

So -- and as we mentioned in our remarks earlier, we have been more pleased and this is the first time anyone has demonstrated that lowering of lipid like triglycerides can actually result in other outcome in AP. My point is that our confidence has grown because the efficacy was so remarkable on reduction in AP events.

And that lends confidence to the SHTG population, which although it's not a genetic form of severely elevated triglycerides, at least no known genetic causes. It's not a monogenic disease like SCS. These patients still suffer from a highly elevated triglycerides much like FCS patients.

Sure, some of those patients could be in the above 500 range to 1,000 range, but many, many of these patients are in the multiple thousands or at least above 1,000 which are which puts them at very high risk for AP. So I think we're going to get AP events and in the Phase III SHTG study.

And based on the effect size or the effect that we saw with Olezarsen and FCS, our confidence is growing, but we have to see that. And despite the fact that the number of AP events per patient may be less in SHTG versus FCS, it's such a bigger study. It's a much bigger study. So we're going to have much more data that we're going to collect.

And as Yuji said, we have the ability to combine two Phase III studies CORE and CORE2 to really look at overall the impact of Olezarsen on AP events in SHTG..

Thanks so much for taking my question..

Thank you, David. And thanks everybody for joining us today and everyone who's participated in our call. We really are proud of all the progress we've made this year and we believe that the future has never been brighter here at Ionis.

And we plan to continue our momentum by delivering on additional key commercial updates pipeline updates technology updates objectives as we go forward. And we very much look forward to it. But until then thank you again and everybody have a great day..