Xeris Biopharma Holdings, Inc.

Xeris Biopharma Holdings, Inc.

XERS·NASDAQ

$5.89

-1.8%
HealthcareBiotechnology

Xeris Biopharma Holdings, Inc., a biopharmaceutical company, engages in developing and commercializing therapies for patient populations in endocrinology, neurology, and gastroenterology. The company markets Gvoke, a ready-to-use liquid glucagon for the treatment of severe hypoglycemia; and Keveyis, a therapy for the treatment of hyperkalemic, hypokalemic, and related variants of primary periodic paralysis; and Recorlev, a cortisol synthesis inhibitor proved for the treatment of endogenous hypercortisolemia in adult patients with Cushing's syndrome. It also has a pipeline of development programs to extend the marketed products into new indications and uses and bring new products using its proprietary formulation technology platforms, XeriSol and XeriJect. The company was incorporated in 2005 and is headquartered in Chicago, Illinois.

At a Glance

Live Snapshot
Market Cap$1.02B
EPS0.0035
P/E Ratio1682.86
Earnings Date08/06/2026
8.89%
Return on Invested Capital
-167%
3Y-130.0%
5Y-114.0%
10Y-121.0%
4.05%
Return on Equity
-98%
3Y-102.0%
5Y-101.0%
10Y-90.0%
0.14%
Return on Assets
-101%
3Y-101.0%
5Y-100.0%
10Y-100.0%
Xeris Biopharma Holdings, Inc.

Xeris Biopharma Holdings, Inc. Management Team

XERS · NASDAQ
MJ

Mr. John P. Shannon

Chief Executive Officer & Director

Compensation

$1,065,572

Born 1962(Age 64)
male
MS

Mr. Steven M. Pieper

Chief Financial Officer

Compensation

$747,017

Born 1978(Age 48)
male
MB

Ms. Beth P. Hecht J.D.

Chief Legal Officer & Corporate Secretary

Compensation

$767,825

Born 1964(Age 62)
female
DA

Dr. Anh Nguyen M.B.A., M.D.

Chief Medical Officer

Born 1975(Age 51)
MK

Mr. Kevin McCulloch

President & Chief Operating Officer

Compensation

$777,048

Born 1964(Age 62)
male
MB

Mr. Brian Conner

SVice President of Quality and Chief Compliance & Risk Officer

male
MP

Mr. Paul R. Edick J.D.

Senior Advisor

Compensation

$2,597,639

Born 1956(Age 70)
male
MK

Ms. Kendal Korte

Senior Vice President of Human Resources

female
MA

Ms. Allison Wey

Senior Vice President of Investor Relations & Corporate Communications

female
xers

Xeris Biopharma Holdings, Inc. Insider Positioning

XERS · NASDAQ

During the last 12 months, insiders have purchased $313K and sold $2.63M worth of XERS shares, resulting in $2.32M of net selling activity.

3 Months

Bought

0

0.00

Sold

60.8K

364.68K

Net Activity

-365K

-$365K

3-6 Months

Bought

0

0.00

Sold

240.2K

1.73M

Net Activity

-1.7M

-$1.73M

6-9 Months

Bought

0

0.00

Sold

72.8K

539.18K

Net Activity

-539K

-$539K

9-12 Months

Bought

47.0K

313.29K

Sold

0

0.00

Net Activity

+313K

+$313K

Top Buyers

1
SJW

Sherman Jeffrey W

Director

47.0K shares1 transactions

$313K

Top Sellers

1
JJ

Johnson John

Director

135.4K shares1 transactions

$977K

2
HB

Hecht Beth

Officer: See Remarks

133.2K shares8 transactions

$896K

3
SJPJ

Shannon John Patrick Jr

Director, Officer: See Remarks

48.1K shares2 transactions

$350K

4
MK

Mcculloch Kevin

Officer: See Remarks

15.7K shares2 transactions

$126K

5
PM

Persky Marla

Director

15.5K shares1 transactions

$120K

Insider Activity Analysis

Net Insider Sentiment

Bearish

Strong bearish signal with $2.32M net selling. Heavy insider selling may indicate concerns about valuation or near-term prospects.

Buy/Sell Ratio

0.12:1

Weak buy/sell ratio. Selling significantly exceeds buying—monitor for potential fundamental concerns.

Recent Trend (3 Months)

$365K

Heavy recent selling activity. Recent insider sales notably exceed purchases—may warrant investigation into company developments.

Insider Participation

High Selling

5 insider sellers vs. 1 buyers. Widespread selling across multiple insiders may signal concerns.

Insider Activity Insight

Multiple red flags: Heavy selling, numerous sellers, and continued recent selling create a concerning pattern. Investigate fundamental drivers and consider whether company guidance or industry conditions have deteriorated.

SEC Filings

XERS - Filing history and reports

Filing TypeFiling DatePeriod EndingFiscal YearActions
DEF 14A

DEF 14A 2025

N/A

April 23, 2026
December 31, 2025
2025
DEF 14A

DEF 14A 2024

N/A

April 23, 2025
December 31, 2024
2024
DEF 14A

DEF 14A 2024

N/A

April 23, 2024
June 05, 2024
2024
DEF 14A

DEF 14A 2022

N/A

April 26, 2023
December 31, 2022
2022
DEF 14A

DEF 14A 2021

N/A

April 28, 2022
December 31, 2021
2021
Showing 1 to 5 of 5 filings