Xeris Biopharma Holdings, Inc.

Xeris Biopharma Holdings, Inc.

XERSยทNASDAQ

$5.89

-1.8%
HealthcareBiotechnology

Xeris Biopharma Holdings, Inc., a biopharmaceutical company, engages in developing and commercializing therapies for patient populations in endocrinology, neurology, and gastroenterology. The company markets Gvoke, a ready-to-use liquid glucagon for the treatment of severe hypoglycemia; and Keveyis, a therapy for the treatment of hyperkalemic, hypokalemic, and related variants of primary periodic paralysis; and Recorlev, a cortisol synthesis inhibitor proved for the treatment of endogenous hypercortisolemia in adult patients with Cushing's syndrome. It also has a pipeline of development programs to extend the marketed products into new indications and uses and bring new products using its proprietary formulation technology platforms, XeriSol and XeriJect. The company was incorporated in 2005 and is headquartered in Chicago, Illinois.

At a Glance

Live Snapshot
Market Cap$1.02B
EPS0.0035
P/E Ratio1682.86
Earnings Date08/06/2026
xers

Xeris Biopharma Holdings, Inc. Street Expectations Map

XERS ยท NASDAQ

Wall Street analysts project that XERS stock may rise significantly over the coming 12 months. The consensus 1-year price target stands at 9.00, with estimates ranging from a low of 9.00 to a high of 9.00.

Lowest Target
9.00
52.80%
Consensus Target
9.00
52.80%
Highest Target
9.00
52.80%

The consensus 1-year price target stands at 9.00, with estimates ranging from a low of 9.00 to a high of 9.00.

Analyst Consensus Analysis

Upside Potential

+52.8%

Substantial upside potential. Analysts see significant value gap, suggesting the stock may be materially undervalued at current levels.

Analyst Agreement

0.0% spread

High analyst agreement. Narrow target range indicates strong consensus on valuation, suggesting clear investment thesis and predictable outlook.

Analyst Conviction

Very High

Strong buy conviction: High upside with tight consensus suggests compelling investment opportunity backed by analyst confidence.

Market Sentiment Insight

Rare opportunity: Exceptional upside potential with strong analyst consensus creates a compelling setup. The combination of significant price target premium and tight agreement suggests high-conviction undervaluation that may attract institutional capital.

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Xeris Biopharma Holdings, Inc. Forward Estimates of Revenue

XERS ยท NASDAQ
Latest Revenue
291.85M
FY 2025
Avg Estimate
367.52M
FY 2026
Estimate Range
332.18M - 424.98M
Analyst Spread

Forward Growth Analysis

Projected Growth+25.9%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage5 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread25%

Moderate uncertainty in forecastsโ€”typical for companies with evolving business models.

OutlookPositive

Generally favorable outlook with reasonable growth prospects and analyst support.

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Xeris Biopharma Holdings, Inc. Forward Estimates of Net Income

XERS ยท NASDAQ
Latest Net Income
554.00K
FY 2025
Avg Estimate
28.60M
FY 2026
Estimate Range
7.72M - 45.22M
Analyst Spread

Forward Growth Analysis

Projected Growth+5061.9%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage5 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread131%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookNeutral

Mixed signalsโ€”some positive indicators offset by concerns about growth or uncertainty.

Key Insight

High forecast uncertainty: Wide estimate range indicates analysts struggling to predict outcomesโ€”suggests elevated risk and potential volatility.

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Xeris Biopharma Holdings, Inc. Forward Estimates of EPS

XERS ยท NASDAQ
Latest EPS
0.00
FY 2025
Avg Estimate
$0.18
FY 2026
Estimate Range
$0.05 - $0.31
Analyst Spread

Forward Growth Analysis

Projected Growth+5053.1%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage4 Analysts

Limited coverage may indicate reduced institutional interest or information availability.

Estimate Spread142%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookNeutral

Mixed signalsโ€”some positive indicators offset by concerns about growth or uncertainty.

Key Insight

Limited coverage with volatile estimates: Few analysts covering despite significant projected changes may indicate information gaps or emerging risks.

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Xeris Biopharma Holdings, Inc. Forward Estimates of EBIT

XERS ยท NASDAQ
Latest EBIT
554.00K
FY 2025
Avg Estimate
-227.84M
FY 2026
Estimate Range
-263.47M - -205.93M
Analyst Spread

Forward Growth Analysis

Projected Growth-41227.2%

Significant contraction projectedโ€”major business challenges or industry disruption likely.

Analyst Coverage5 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread25%

Moderate uncertainty in forecastsโ€”typical for companies with evolving business models.

OutlookNeutral

Mixed signalsโ€”some positive indicators offset by concerns about growth or uncertainty.

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Xeris Biopharma Holdings, Inc. Forward Estimates of EBITDA

XERS ยท NASDAQ
Latest EBITDA
12.71M
FY 2025
Avg Estimate
-208.93M
FY 2026
Estimate Range
-241.59M - -188.84M
Analyst Spread

Forward Growth Analysis

Projected Growth-1743.8%

Significant contraction projectedโ€”major business challenges or industry disruption likely.

Analyst Coverage5 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread25%

Moderate uncertainty in forecastsโ€”typical for companies with evolving business models.

OutlookNeutral

Mixed signalsโ€”some positive indicators offset by concerns about growth or uncertainty.

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Xeris Biopharma Holdings, Inc. Forward Estimates of SG&A Expense

XERS ยท NASDAQ
Latest SG&A Expense
182.37M
FY 2025
Avg Estimate
668.07M
FY 2026
Estimate Range
603.83M - 772.52M
Analyst Spread

Forward Growth Analysis

Projected Growth+266.3%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage5 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread25%

Moderate uncertainty in forecastsโ€”typical for companies with evolving business models.

OutlookPositive

Generally favorable outlook with reasonable growth prospects and analyst support.

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Xeris Biopharma Holdings, Inc. Insider Positioning

XERS ยท NASDAQ

During the last 12 months, insiders have purchased $313K and sold $2.63M worth of XERS shares, resulting in $2.32M of net selling activity.

3 Months

Bought

0

0.00

Sold

60.8K

364.68K

Net Activity

-365K

-$365K

3-6 Months

Bought

0

0.00

Sold

240.2K

1.73M

Net Activity

-1.7M

-$1.73M

6-9 Months

Bought

0

0.00

Sold

72.8K

539.18K

Net Activity

-539K

-$539K

9-12 Months

Bought

47.0K

313.29K

Sold

0

0.00

Net Activity

+313K

+$313K

Top Buyers

1
SJW

Sherman Jeffrey W

Director

47.0K sharesโ€ข1 transactions

$313K

Top Sellers

1
JJ

Johnson John

Director

135.4K sharesโ€ข1 transactions

$977K

2
HB

Hecht Beth

Officer: See Remarks

133.2K sharesโ€ข8 transactions

$896K

3
SJPJ

Shannon John Patrick Jr

Director, Officer: See Remarks

48.1K sharesโ€ข2 transactions

$350K

4
MK

Mcculloch Kevin

Officer: See Remarks

15.7K sharesโ€ข2 transactions

$126K

5
PM

Persky Marla

Director

15.5K sharesโ€ข1 transactions

$120K

Insider Activity Analysis

Net Insider Sentiment

Bearish

Strong bearish signal with $2.32M net selling. Heavy insider selling may indicate concerns about valuation or near-term prospects.

Buy/Sell Ratio

0.12:1

Weak buy/sell ratio. Selling significantly exceeds buyingโ€”monitor for potential fundamental concerns.

Recent Trend (3 Months)

$365K

Heavy recent selling activity. Recent insider sales notably exceed purchasesโ€”may warrant investigation into company developments.

Insider Participation

High Selling

5 insider sellers vs. 1 buyers. Widespread selling across multiple insiders may signal concerns.

Insider Activity Insight

Multiple red flags: Heavy selling, numerous sellers, and continued recent selling create a concerning pattern. Investigate fundamental drivers and consider whether company guidance or industry conditions have deteriorated.