UPB - NASDAQ

Upstream Bio, Inc.

UPB·NASDAQ

$20.97

-5.9%

HealthcareBiotechnology

Upstream Bio, Inc., a clinical-stage biotechnology company, develops treatments for inflammatory diseases that focuses on severe respiratory disorders. It develops verekitug, a monoclonal antibody that targets and inhibits the thymic stromal lymphopoietin receptor. The company also develops therapies to treat severe asthma, chronic rhinosinusitis with nasal polyps, and chronic obstructive pulmonary disease. Upstream Bio, Inc. was incorporated in 2021 and is based in Waltham, Massachusetts.

Statements Value Model

At a Glance

Live Snapshot

Market Cap$1.13B

EPS-0.7400

P/E Ratio-3.69

Earnings Date11/06/2025

upb

Shares Outstanding

Last Annual Value

51.34M

3-Year CAGR

12%

5-Year CAGR

10-Year CAGR

Adjust for Inflation

Upstream Bio, Inc. Competitors Analysis of shares-outstanding

UPB · NASDAQ

Company	shares-outstanding	CAGR 3Y	CAGR 5Y	CAGR 10Y
Upstream Bio, Inc. NASDAQ:UPB	51.34M	12.2%	N/A	N/A
Dianthus Therapeutics, Inc. NASDAQ:DNTH	37.79M	94.3%	61.6%	32.8%
Praxis Precision Medicines, Inc. NASDAQ:PRAX	22.50M	50.6%	51.4%	N/A
Prime Medicine, Inc. NASDAQ:PRME	148.76M	17.8%	9.2%	N/A
Relay Therapeutics, Inc. NASDAQ:RLAY	171.59M	11.9%	12.5%	N/A
Septerna, Inc. NASDAQ:SEPN	44.26M	31.4%	N/A	N/A
Zenas BioPharma, Inc. NASDAQ:ZBIO	44.73M	5.3%	N/A	N/A
Bicara Therapeutics Inc. Common Stock NASDAQ:BCAX	54.68M	1.8%	N/A	N/A
Nektar Therapeutics NASDAQ:NKTR	16.87M	10.0%	6.7%	6.1%
Phathom Pharmaceuticals, Inc. NASDAQ:PHAT	72.92M	12.4%	14.5%	N/A

Upstream Bio, Inc. Fair Value Envelope

UPB · NASDAQ

Our analysis suggests that UPB has a fair value of HIDDEN per share in the Base Case projection. With shares currently trading at $20.97, this represents a potential HIDDEN relative to our calculated worth for Upstream Bio, Inc..

HIDDEN

Intrinsic Value

Current Price: $20.97

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