Pyxis Oncology, Inc.

Pyxis Oncology, Inc.

PYXS·NASDAQ

$1.70

+0.30%
HealthcareBiotechnology

Pyxis Oncology, Inc., a preclinical stage biopharmaceutical company, engages in the development of therapies to treat cancers. Its immune-oncology product candidates include PYX-106, an investigational fully human immunoglobulin G1 isotype siglec-15 targeting antibody for the treatment of thyroid cancer, head and neck squamous cell carcinoma, non-small cell lung cancer (NSCLC), and other solid tumors; and PYX-102, an investigational immune-therapeutic for treatment of solid tumors. The company's antibody drug conjugate (ADC) product candidates comprise of PYX-201, an investigational novel ADC to treat NSCLC, breast cancer, and other solid tumors; PYX-202, an investigational novel ADC for treatment of SCLC, soft tissue sarcoma, and other solid tumors; and PYX-203, an investigational ADC for the treatment of acute myeloid leukemia and myeloid dysplastic syndrome. The company was incorporated in 2018 and is headquartered in Cambridge, Massachusetts.

At a Glance

Live Snapshot
Market Cap$107.70M
EPS-1.2800
P/E Ratio-1.33
Earnings Date08/13/2026
3Y-
5Y-
10Y-
3Y-34.0%
5Y+521.0%
10Y+2888.0%
3Y-29.0%
5Y+530.0%
10Y+2736.0%
Pyxis Oncology, Inc.

Pyxis Oncology, Inc. Profit Bridge

PYXS · NASDAQ
Revenue13.86M
Cost of Goods Sold (2.39M)
Gross Profit11.47M
Operating Expenses (95.89M)
Operating Income-84.42M
Interest Expense (0.00)
Other Income/Expense6.18M
Pretax Income-78.23M
Income Tax (1.39M)
Net Income-79.62M
Net Income
-79.62M

Profitability Analysis

Gross Margin

82.8%

Exceptional pricing power and cost management. The company retains over half of revenue after direct costs.

Operating Margin

-609.2%

Operating losses indicate the core business is unprofitable. Requires restructuring or revenue growth.

Net Profit Margin

-574.5%

Net losses indicate the company is burning cash. Sustainability depends on path to profitability.

Profitability Insight

Margin squeeze alert: Healthy gross margins but weak operating margins suggest excessive operating expenses. Cost optimization could unlock significant value.

Pyxis Oncology, Inc. Income Statement

PYXS • NASDAQ

Pyxis Oncology, Inc. Income StatementDec 2025Dec 2024Dec 2023Dec 2022Dec 2021Dec 2020Dec 2019
REVENUE
13.9M
16.1M
0.0
0.0
0.0
0.0
0.0
GROSS PROFIT
(2.4M)
(475K)
(0.0)
(0.0)
(0.0)
(444K)
(0.0)
11.5M
15.7M
0.0
0.0
0.0
-444K
0.0
OPERATING INCOME
(95.9M)
(105.1M)
(82.2M)
(123.5M)
(69.7M)
(12.5M)
(2.9M)
(22.2M)
(25.4M)
(32.6M)
(37.4M)
(18.7M)
(3.8M)
(1.7M)
(73.7M)
(58.7M)
(49.6M)
(86.1M)
(51.1M)
(8.6M)
(1.2M)
-84.4M
-89.5M
-82.2M
-123.5M
-69.7M
-12.9M
-2.9M
PRE-TAX INCOME
3.6M
7M
6.6M
2.8M
23K
66K
0.0
(0.0)
(21M)
(0.0)
(0.0)
(0.0)
(0.0)
(0.0)
6.2M
10M
8.4M
2.8M
-6.3M
66K
107K
-78.2M
-79.5M
-73.8M
-120.7M
-76M
-12.8M
-2.8M
NET INCOME
(1.4M)
-2.2M
(0.0)
(0.0)
(0.0)
(0.0)
-107K
-79.6M
-77.3M
-73.8M
-120.7M
-76M
-12.8M
-2.7M

SEC Filings

PYXS - Filing history and reports

Filing TypeFiling DatePeriod EndingFiscal YearActions
10-Q

10-Q 2026 Q1

Q1

May 14, 2026
March 31, 2026
2026
8-K

8-K 2026

N/A

May 14, 2026
May 14, 2026
2026
8-K/A

8-K/A 2026 (Amended)

N/A

April 30, 2026
February 06, 2026
2026
DEF 14A

DEF 14A 2026

N/A

April 30, 2026
April 30, 2026
2026
10-K

10-K 2025 FY

FY

March 23, 2026
December 31, 2025
2025
8-K

8-K 2026

N/A

March 23, 2026
March 23, 2026
2026
8-K

8-K 2026

N/A

February 06, 2026
February 06, 2026
2026
8-K

8-K 2025

N/A

December 18, 2025
December 18, 2025
2025
S-3

S-3

N/A

November 26, 2025
November 26, 2025
 
10-Q

10-Q 2025 Q3

Q3

November 03, 2025
September 30, 2025
2025
Showing 1 to 10 of 87 filings