Pyxis Oncology, Inc.

Pyxis Oncology, Inc.

PYXSยทNASDAQ

$1.70

+0.30%
HealthcareBiotechnology

Pyxis Oncology, Inc., a preclinical stage biopharmaceutical company, engages in the development of therapies to treat cancers. Its immune-oncology product candidates include PYX-106, an investigational fully human immunoglobulin G1 isotype siglec-15 targeting antibody for the treatment of thyroid cancer, head and neck squamous cell carcinoma, non-small cell lung cancer (NSCLC), and other solid tumors; and PYX-102, an investigational immune-therapeutic for treatment of solid tumors. The company's antibody drug conjugate (ADC) product candidates comprise of PYX-201, an investigational novel ADC to treat NSCLC, breast cancer, and other solid tumors; PYX-202, an investigational novel ADC for treatment of SCLC, soft tissue sarcoma, and other solid tumors; and PYX-203, an investigational ADC for the treatment of acute myeloid leukemia and myeloid dysplastic syndrome. The company was incorporated in 2018 and is headquartered in Cambridge, Massachusetts.

At a Glance

Live Snapshot
Market Cap$107.70M
EPS-1.2800
P/E Ratio-1.33
Earnings Date08/13/2026
pyxs

Pyxis Oncology, Inc. Street Expectations Map

PYXS ยท NASDAQ

Wall Street analysts project that PYXS stock may rise significantly over the coming 12 months. The consensus 1-year price target stands at 5.50, with estimates ranging from a low of 5.00 to a high of 6.00.

Lowest Target
5.00
194.12%
Consensus Target
5.50
223.53%
Highest Target
6.00
252.94%

The consensus 1-year price target stands at 5.50, with estimates ranging from a low of 5.00 to a high of 6.00.

Analyst Consensus Analysis

Upside Potential

+223.5%

Substantial upside potential. Analysts see significant value gap, suggesting the stock may be materially undervalued at current levels.

Analyst Agreement

18.2% spread

High analyst agreement. Narrow target range indicates strong consensus on valuation, suggesting clear investment thesis and predictable outlook.

Analyst Conviction

Very High

Strong buy conviction: High upside with tight consensus suggests compelling investment opportunity backed by analyst confidence.

Market Sentiment Insight

Rare opportunity: Exceptional upside potential with strong analyst consensus creates a compelling setup. The combination of significant price target premium and tight agreement suggests high-conviction undervaluation that may attract institutional capital.

pyxs

Pyxis Oncology, Inc. Forward Estimates of Revenue

PYXS ยท NASDAQ
Latest Revenue
13.86M
FY 2025
Avg Estimate
6.25M
FY 2026
Estimate Range
6.25M - 6.25M
Analyst Spread

Forward Growth Analysis

Projected Growth-54.9%

Significant contraction projectedโ€”major business challenges or industry disruption likely.

Analyst Coverage8 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread0%

Narrow estimate range signals strong analyst consensus and predictable business outlook.

OutlookPositive

Generally favorable outlook with reasonable growth prospects and analyst support.

pyxs

Pyxis Oncology, Inc. Forward Estimates of Net Income

PYXS ยท NASDAQ
Latest Net Income
-79.62M
FY 2025
Avg Estimate
-74.57M
FY 2026
Estimate Range
-85.38M - -63.75M
Analyst Spread

Forward Growth Analysis

Projected Growth+6.3%

Moderate growth expected, typical for mature businesses with stable market positions.

Analyst Coverage8 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread29%

Moderate uncertainty in forecastsโ€”typical for companies with evolving business models.

OutlookPositive

Generally favorable outlook with reasonable growth prospects and analyst support.

pyxs

Pyxis Oncology, Inc. Forward Estimates of EPS

PYXS ยท NASDAQ
Latest EPS
-1.28
FY 2025
Avg Estimate
$-1.22
FY 2026
Estimate Range
$-1.46 - $-1.09
Analyst Spread

Forward Growth Analysis

Projected Growth+4.4%

Flat growth suggests market maturity or near-term challenges offsetting expansion efforts.

Analyst Coverage6 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread30%

Moderate uncertainty in forecastsโ€”typical for companies with evolving business models.

OutlookNeutral

Mixed signalsโ€”some positive indicators offset by concerns about growth or uncertainty.

pyxs

Pyxis Oncology, Inc. Forward Estimates of EBIT

PYXS ยท NASDAQ
Latest EBIT
-84.42M
FY 2025
Avg Estimate
3.75M
FY 2026
Estimate Range
3.75M - 3.75M
Analyst Spread

Forward Growth Analysis

Projected Growth+104.4%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage8 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread0%

Narrow estimate range signals strong analyst consensus and predictable business outlook.

OutlookStrong

Positive analyst consensus with strong growth expectations and forecast confidence.

pyxs

Pyxis Oncology, Inc. Forward Estimates of EBITDA

PYXS ยท NASDAQ
Latest EBITDA
-79.91M
FY 2025
Avg Estimate
3.75M
FY 2026
Estimate Range
3.75M - 3.75M
Analyst Spread

Forward Growth Analysis

Projected Growth+104.7%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage8 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread0%

Narrow estimate range signals strong analyst consensus and predictable business outlook.

OutlookStrong

Positive analyst consensus with strong growth expectations and forecast confidence.

pyxs

Pyxis Oncology, Inc. Forward Estimates of SG&A Expense

PYXS ยท NASDAQ
Latest SG&A Expense
22.19M
FY 2025
Avg Estimate
6.97M
FY 2026
Estimate Range
6.97M - 6.97M
Analyst Spread

Forward Growth Analysis

Projected Growth-68.6%

Significant contraction projectedโ€”major business challenges or industry disruption likely.

Analyst Coverage8 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread0%

Narrow estimate range signals strong analyst consensus and predictable business outlook.

OutlookPositive

Generally favorable outlook with reasonable growth prospects and analyst support.

pyxs

Pyxis Oncology, Inc. Insider Positioning

PYXS ยท NASDAQ

During the last 12 months, there has been no insider trading activity reported for PYXS.

3 Months

Bought

0

0.00

Sold

0

0.00

Net Activity

+0

+$0

3-6 Months

Bought

0

0.00

Sold

0

0.00

Net Activity

+0

+$0

6-9 Months

Bought

0

0.00

Sold

0

0.00

Net Activity

+0

+$0

9-12 Months

Bought

0

0.00

Sold

0

0.00

Net Activity

+0

+$0

Top Buyers

No buying activity

Top Sellers

No selling activity

Insider Activity Analysis

Net Insider Sentiment

Neutral

No insider trading activity reported. This could indicate blackout periods, lack of conviction, or regulatory restrictions.

Insider Participation

No Activity

No insider trading activity reported from any insiders in the past year.