OPKO Health, Inc.

OPKO Health, Inc.

OPK·NASDAQ

$1.42

+1.6%
HealthcareBiotechnology

OPKO Health, Inc., a healthcare company, engages in the diagnostics and pharmaceuticals businesses in the United States, Ireland, Chile, Spain, Israel, Mexico, and internationally. The company's Diagnostics segment operates BioReference Laboratories that offers laboratory testing services for the detection, diagnosis, evaluation, monitoring, and treatment of diseases, including esoteric testing, molecular diagnostics, anatomical pathology, genetics, women's health, and correctional healthcare to physician offices, clinics, hospitals, employers and governmental units; and a novel diagnostic instrument system to provide blood test results in the point-of-care setting, as well as 4Kscore prostate cancer testing services. Its Pharmaceutical segment offers Rayaldee to treat secondary hyperparathyroidism in adults with stage 3 or 4 chronic kidney disease, and vitamin D insufficiency; OPK88004, an orally administered selective androgen receptor modulator; OPK88003, a once-weekly administered peptide for the treatment of type 2 diabetes and associated obesity that is in Phase IIb trials; and hGH-CTP, a once-weekly human growth hormone injection that completed Phase III clinical trial in partnership with Pfizer, Inc. This segment develops and commercializes longer-acting proprietary versions of already approved therapeutic proteins. The company also offers specialty APIs; develops, manufactures, markets, and sells pharmaceutical, nutraceutical, veterinary, and ophthalmic products; commercializes food supplements and over the counter products; manufactures and sells products primarily in the generics market; and imports, markets, distributes, and sells pharmaceutical products in a range of indications, including cardiovascular products, vaccines, antibiotics, gastro-intestinal products, hormones, and others. In addition, it operates pharmaceutical platforms in Ireland, Chile, Spain, and Mexico. The company was founded in 1991 and is headquartered in Miami, Florida.

At a Glance

Live Snapshot
Market Cap$1.07B
EPS-0.3000
P/E Ratio-4.74
Earnings Date07/30/2026
-11.32%
Return on Invested Capital
52%
3Y+20.0%
5Y-760.0%
10Y+1544.0%
-17.80%
Return on Equity
357%
3Y-15.0%
5Y-1073.0%
10Y+670.0%
-11.68%
Return on Assets
383%
3Y-23.0%
5Y-1044.0%
10Y+568.0%
OPKO Health, Inc.

OPKO Health, Inc. Management Team

OPK · NASDAQ
DP

Dr. Phillip Frost Ph.D.

Chairman & Chief Executive Officer

Compensation

$1,453,800

Born 1936(Age 90)
DC

Dr. Charles W. Bishop Ph.D.

Chief Executive Officer of OPKO Renal

Born 1952(Age 74)
DG

Dr. Gary J. Nabel M.D., Ph.D.

Chief Innovation Officer & Director

Born 1955(Age 71)
MG

Mr. Giovanni Abbadessa M.D., Ph.D.

Chief Medical Officer

male
MS

Mr. Steven D. Rubin Esq., J.D.

Executive Vice President of Administration & Director

Compensation

$1,223,800

Born 1960(Age 66)
male
DE

Dr. Elias Adam Zerhouni M.D.

President & Vice Chairman

Compensation

$1,363,800

Born 1951(Age 75)
DA

Dr. Arie Gutman Ph.D.

President of API

Born 1954(Age 72)
MA

Mr. Adam E. Logal

Senior Vice President & Chief Financial Officer

Compensation

$1,188,800

Born 1978(Age 48)
male
DA

Dr. Akhtar Ashfaq FACP, FASN, M.D.

Senior Vice President of Clinical Research & Development and Medical Affairs - Opko Renal

DJ

Dr. Jane H. Hsiao M.B.A., Ph.D.

Vice Chairman & Chief Technical Officer

Compensation

$1,363,800

Born 1947(Age 79)
opk

OPKO Health, Inc. Insider Positioning

OPK · NASDAQ

During the last 12 months, insiders have purchased $1.58M worth of OPK shares, with no selling activity reported.

3 Months

Bought

10.0K

11.35K

Sold

0

0.00

Net Activity

+11K

+$11K

3-6 Months

Bought

0

0.00

Sold

0

0.00

Net Activity

+0

+$0

6-9 Months

Bought

498.4K

676.17K

Sold

0

0.00

Net Activity

+676K

+$676K

9-12 Months

Bought

675.0K

891.00K

Sold

0

0.00

Net Activity

+891K

+$891K

Top Buyers

1
FPMEA

Frost Phillip Md Et Al

Director, 10 Percent Owner, Officer: Ceo & Chairman

1.2M shares4 transactions

$1.57M

2
PJA

Paganelli John A

Director

10.0K shares1 transactions

$11K

Top Sellers

No selling activity

Insider Activity Analysis

Net Insider Sentiment

Bullish

Strong bullish signal with $1.58M net buying. Insiders are aggressively accumulating shares, suggesting significant confidence in future prospects.

Buy/Sell Ratio

∞:1

Perfect buy/sell ratio. Only buying activity with zero selling—the most bullish possible insider signal.

Recent Trend (3 Months)

$11K

Very strong recent buying momentum. Recent insider purchases significantly outpace sales, suggesting near-term optimism.

Insider Participation

High Buying

2 insider buyers vs. 0 sellers. Broad-based buying across management team suggests widespread confidence.

Insider Activity Insight

Compelling insider conviction: The combination of strong buy/sell ratio and multiple buyers suggests insiders see attractive risk/reward. Consider this alongside fundamental analysis for confirmation.

SEC Filings

OPK - Filing history and reports

Filing TypeFiling DatePeriod EndingFiscal YearActions
DEF 14A

DEF 14A 2026

N/A

April 30, 2026
April 30, 2026
2026
DEF 14A

DEF 14A 2025

N/A

March 14, 2025
April 23, 2025
2025
DEF 14A

DEF 14A 2024

N/A

February 29, 2024
March 28, 2024
2024
DEF 14A

DEF 14A

N/A

May 01, 2023
May 01, 2023
 
DEF 14A

DEF 14A 2022

N/A

June 03, 2022
June 03, 2022
2022
DEF 14A

DEF 14A 2021

N/A

April 30, 2021
June 24, 2021
2021
DEF 14A

DEF 14A 2020

N/A

April 29, 2020
June 25, 2020
2020
DEF 14A

DEF 14A 2019

N/A

April 26, 2019
June 20, 2019
2019
DEF 14A

DEF 14A 2018

N/A

April 30, 2018
June 21, 2018
2018
DEF 14A

DEF 14A 2017

N/A

April 28, 2017
June 15, 2017
2017
Showing 1 to 10 of 30 filings