Lyell Immunopharma, Inc.

Lyell Immunopharma, Inc.

LYEL·NASDAQ

$12.57

-16%
HealthcareBiotechnology

Lyell Immunopharma, Inc., a T cell reprogramming company, engages in developing T cell therapies for patients with solid tumors. The company develops therapies using technology platforms, such as Gen-R, an ex vivo genetic reprogramming technology to overcome T cell exhaustion; and Epi-R, an ex vivo epigenetic reprogramming technology to generate population of T cells with durable stemness. Its pipeline includes LYL797, a T cell product candidate for the treatment of non-small cell lung cancer and triple negative breast cancers; LYL845, that targets multiple solid tumors; and NY-ESO-1 for synovial sarcoma and other solid tumor indications. The company entered into research and development collaboration and license agreement with GlaxoSmithKline for NY-ESO-1 program. Lyell Immunopharma, Inc. was incorporated in 2018 and is headquartered in South San Francisco, California.

At a Glance

Live Snapshot
Market Cap$293.31M
EPS-16.0600
P/E Ratio-0.78
Earnings Date08/11/2026
3Y-100.0%
5Y-100.0%
10Y-95.0%
3Y+50.0%
5Y+34.0%
10Y+126.0%
3Y-12.0%
5Y-7.0%
10Y-480.0%
Lyell Immunopharma, Inc.

Lyell Immunopharma, Inc. Profit Bridge

LYEL · NASDAQ
Revenue36.00K
Cost of Goods Sold (11.54M)
Gross Profit-11.50M
Operating Expenses (192.27M)
Operating Income-203.77M
Interest Expense (0.00)
Other Income/Expense-70.67M
Pretax Income-274.45M
Income Tax (0.00)
Net Income-274.45M
Net Income
-274.45M

Profitability Analysis

Gross Margin

-31952.8%

Negative gross margin indicates the company is losing money on each sale—unsustainable long-term.

Operating Margin

-566038.9%

Operating losses indicate the core business is unprofitable. Requires restructuring or revenue growth.

Net Profit Margin

-762355.6%

Net losses indicate the company is burning cash. Sustainability depends on path to profitability.

Profitability Insight

High margin compression: Large gap between gross and net margins suggests operational inefficiencies or heavy debt burden. Focus on expense management and deleveraging.

Lyell Immunopharma, Inc. Income Statement

LYEL • NASDAQ

Lyell Immunopharma, Inc. Income StatementDec 2025Dec 2024Dec 2023Dec 2022Dec 2021Dec 2020Dec 2019
REVENUE
36K
61K
130K
84.7M
10.7M
7.8M
657K
GROSS PROFIT
(11.5M)
(0.0)
(0.0)
(0.0)
(0.0)
(0.0)
(0.0)
-11.5M
61K
130K
84.7M
10.7M
7.8M
657K
OPERATING INCOME
(192.3M)
(358.8M)
(247.1M)
(271.7M)
(225.4M)
(219.7M)
(102.7M)
(45.1M)
(52M)
(67M)
(117.3M)
(89.1M)
(46.9M)
(39.2M)
(158.7M)
(171.6M)
(182.9M)
(159.2M)
(138.7M)
(182.2M)
(63.6M)
-203.8M
-358.8M
-247M
-187.1M
-214.8M
-211.9M
-102.1M
PRE-TAX INCOME
13.1M
24.1M
23.5M
7.1M
1.2M
5.9M
8.1M
-11.5M
(135.2M)
-2.8M
-4.8M
-2.3M
-9.4M
(0.0)
-70.7M
15.8M
12.4M
3.9M
-35.4M
7.5M
-27.3M
-274.4M
-343M
-234.6M
-183.1M
-250.2M
-204.5M
-129.4M
NET INCOME
(0.0)
(0.0)
(0.0)
(0.0)
(0.0)
(0.0)
-8.1M
-274.4M
-343M
-234.6M
-183.1M
-250.2M
-204.5M
-121.3M

SEC Filings

LYEL - Filing history and reports

Filing TypeFiling DatePeriod EndingFiscal YearActions
10-Q

10-Q 2026 Q1

Q1

May 06, 2026
March 31, 2026
2026
8-K

8-K 2026

N/A

May 06, 2026
May 06, 2026
2026
DEF 14A

DEF 14A 2026

N/A

April 24, 2026
June 10, 2026
2026
S-3

S-3

N/A

April 03, 2026
April 03, 2026
 
10-K

10-K 2025 FY

FY

March 12, 2026
December 31, 2025
2025
8-K

8-K 2026

N/A

March 12, 2026
March 12, 2026
2026
8-K

8-K 2026

N/A

March 09, 2026
March 06, 2026
2026
8-K

8-K 2025

N/A

December 08, 2025
December 07, 2025
2025
8-K

8-K 2025

N/A

December 05, 2025
December 03, 2025
2025
S-3

S-3

N/A

December 05, 2025
December 05, 2025
 
Showing 1 to 10 of 88 filings