Castle Biosciences, Inc.

Castle Biosciences, Inc.

CSTLยทNASDAQ

$20.39

+3.4%
HealthcareMedical - Diagnostics & Research

Castle Biosciences, Inc., a commercial-stage diagnostics company, focuses to provide diagnostic and prognostic testing services for dermatological cancers. Its lead product is DecisionDx-Melanoma, a multi-gene expression profile (GEP) test to identify the risk of metastasis for patients diagnosed with invasive cutaneous melanoma. The company also offers DecisionDx-UM test, a proprietary GEP test that predicts the risk of metastasis for patients with uveal melanoma, a rare eye cancer; DecisionDx-SCC, a proprietary 40-gene expression profile test that uses an individual patient's tumor biology to predict individual risk of squamous cell carcinoma metastasis for patients with one or more risk factors; and DecisionDx DiffDx-Melanoma and myPath Melanoma, a proprietary GEP test to diagnose suspicious pigmented lesions. It offers test services through physicians and their patients. The company was founded in 2007 and is headquartered in Friendswood, Texas.

At a Glance

Live Snapshot
Market Cap$618.43M
EPS-0.8300
P/E Ratio-24.57
Earnings Date08/03/2026
3Y+151.0%
5Y+449.0%
10Y+2403.0%
3Y-64.0%
5Y+135.0%
10Y+95.0%
3Y-254.0%
5Y+552.0%
10Y-626.0%
Castle Biosciences, Inc.

Castle Biosciences, Inc. Profit Bridge

CSTL ยท NASDAQ
Revenue344.23M
Cost of Goods Sold (107.88M)
Gross Profit236.35M
Operating Expenses (279.16M)
Operating Income-42.81M
Interest Expense (86.00K)
Other Income/Expense13.30M
Pretax Income-29.51M
Income Tax (-5.36M)
Net Income-24.16M
Net Income
-24.16M

Profitability Analysis

Gross Margin

68.7%

Exceptional pricing power and cost management. The company retains over half of revenue after direct costs.

Operating Margin

-12.4%

Operating losses indicate the core business is unprofitable. Requires restructuring or revenue growth.

Net Profit Margin

-7.0%

Net losses indicate the company is burning cash. Sustainability depends on path to profitability.

Profitability Insight

Margin squeeze alert: Healthy gross margins but weak operating margins suggest excessive operating expenses. Cost optimization could unlock significant value.

Castle Biosciences, Inc. Income Statement

CSTL โ€ข NASDAQ

Castle Biosciences, Inc. Income StatementDec 2025Dec 2024Dec 2023Dec 2022Dec 2021Dec 2020Dec 2019Dec 2018Dec 2017
REVENUE
344.2M
332.1M
219.8M
137M
94.1M
62.6M
51.9M
22.8M
13.8M
GROSS PROFIT
(107.9M)
(60.2M)
(45M)
(32M)
(15.8M)
(9.7M)
(7.3M)
(5.3M)
(4.9M)
236.3M
271.9M
174.8M
105M
78.3M
53M
44.6M
17.5M
8.8M
OPERATING INCOME
(279.2M)
(263.2M)
(242.8M)
(177.9M)
(118.3M)
(59.5M)
(37.2M)
(21.3M)
(19.7M)
(229.3M)
(200M)
(180.2M)
(143M)
(86.7M)
(48.1M)
(29.8M)
(16.5M)
(15.3M)
(51.9M)
(52M)
(53.6M)
(44.9M)
(29.6M)
(13.3M)
(7.4M)
(4.9M)
(4.5M)
-42.8M
8.7M
-68M
-72.9M
-40.1M
-6.5M
7.3M
-3.8M
-10.9M
PRE-TAX INCOME
(86K)
(577K)
(11K)
(17K)
(1K)
(2.6M)
(4.6M)
(2.3M)
(1.6M)
11.7M
12.3M
10.6M
4M
67K
-2.3M
-4.3M
-2.3M
-1.6M
-2M
(11.1M)
(9M)
-10M
(2M)
-1.9M
(0.0)
(0.0)
(163.3K)
13.3M
12.9M
10.6M
4M
67K
-3.7M
-2M
-2.5M
-1.5M
-29.5M
21.6M
-57.4M
-68.9M
-40M
-10.2M
5.3M
-6.4M
-12.4M
NET INCOME
-5.4M
(3.3M)
(101K)
-1.8M
-8.7M
(84K)
(72K)
(8.6K)
(9.7K)
-24.2M
18.2M
-57.5M
-67.1M
-31.3M
-10.3M
5.3M
-6.4M
-12.4M

SEC Filings

CSTL - Filing history and reports

Filing TypeFiling DatePeriod EndingFiscal YearActions
8-K

8-K 2026

N/A

May 29, 2026
May 28, 2026
2026
10-Q

10-Q 2026 Q1

Q1

May 06, 2026
March 31, 2026
2026
8-K

8-K 2026

N/A

May 06, 2026
May 06, 2026
2026
DEF 14A

DEF 14A 2026

N/A

April 08, 2026
May 28, 2026
2026
10-K

10-K 2025 FY

FY

February 26, 2026
December 31, 2025
2025
8-K

8-K 2026

N/A

February 26, 2026
February 26, 2026
2026
8-K

8-K 2026

N/A

January 13, 2026
January 11, 2026
2026
10-Q

10-Q 2025 Q3

Q3

November 03, 2025
September 30, 2025
2025
8-K

8-K 2025

N/A

November 03, 2025
November 03, 2025
2025
8-K

8-K 2025

N/A

August 08, 2025
August 05, 2025
2025
Showing 1 to 10 of 115 filings