Castle Biosciences, Inc.

Castle Biosciences, Inc.

CSTLยทNASDAQ

$20.39

+3.4%
HealthcareMedical - Diagnostics & Research

Castle Biosciences, Inc., a commercial-stage diagnostics company, focuses to provide diagnostic and prognostic testing services for dermatological cancers. Its lead product is DecisionDx-Melanoma, a multi-gene expression profile (GEP) test to identify the risk of metastasis for patients diagnosed with invasive cutaneous melanoma. The company also offers DecisionDx-UM test, a proprietary GEP test that predicts the risk of metastasis for patients with uveal melanoma, a rare eye cancer; DecisionDx-SCC, a proprietary 40-gene expression profile test that uses an individual patient's tumor biology to predict individual risk of squamous cell carcinoma metastasis for patients with one or more risk factors; and DecisionDx DiffDx-Melanoma and myPath Melanoma, a proprietary GEP test to diagnose suspicious pigmented lesions. It offers test services through physicians and their patients. The company was founded in 2007 and is headquartered in Friendswood, Texas.

At a Glance

Live Snapshot
Market Cap$618.43M
EPS-0.8300
P/E Ratio-24.57
Earnings Date08/03/2026
cstl

Castle Biosciences, Inc. Street Expectations Map

CSTL ยท NASDAQ

Wall Street analysts project that CSTL stock may rise significantly over the coming 12 months. The consensus 1-year price target stands at 44.80, with estimates ranging from a low of 35.00 to a high of 52.00.

Lowest Target
35.00
71.65%
Consensus Target
44.80
119.72%
Highest Target
52.00
155.03%

The consensus 1-year price target stands at 44.80, with estimates ranging from a low of 35.00 to a high of 52.00.

Analyst Consensus Analysis

Upside Potential

+119.7%

Substantial upside potential. Analysts see significant value gap, suggesting the stock may be materially undervalued at current levels.

Analyst Agreement

37.9% spread

Good consensus alignment. Moderate target spread reflects general agreement on value drivers with some variance in assumptions.

Analyst Conviction

High

Positive outlook with reasonable agreement. Analysts generally optimistic about prospects with manageable uncertainty.

Market Sentiment Insight

Monitor and evaluate: Current analyst consensus suggests limited conviction or near-term catalysts. Stay informed on company developments and reassess positioning as new information emerges.

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Castle Biosciences, Inc. Forward Estimates of Revenue

CSTL ยท NASDAQ
Latest Revenue
344.23M
FY 2025
Avg Estimate
329.42M
FY 2026
Estimate Range
327.59M - 331.26M
Analyst Spread

Forward Growth Analysis

Projected Growth-4.3%

Declining expectations indicate headwindsโ€”investigate whether temporary or structural issues.

Analyst Coverage6 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread1%

Narrow estimate range signals strong analyst consensus and predictable business outlook.

OutlookNeutral

Mixed signalsโ€”some positive indicators offset by concerns about growth or uncertainty.

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Castle Biosciences, Inc. Forward Estimates of Net Income

CSTL ยท NASDAQ
Latest Net Income
-24.16M
FY 2025
Avg Estimate
-43.23M
FY 2026
Estimate Range
-55.74M - -27.08M
Analyst Spread

Forward Growth Analysis

Projected Growth-79.0%

Significant contraction projectedโ€”major business challenges or industry disruption likely.

Analyst Coverage6 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread66%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookCautious

Analyst skepticism evidentโ€”carefully evaluate risks before investment decisions.

Key Insight

Declining estimates with wide disagreement: Analysts projecting contraction without consensus signals significant business uncertaintyโ€”exercise caution.

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Castle Biosciences, Inc. Forward Estimates of EPS

CSTL ยท NASDAQ
Latest EPS
-0.83
FY 2025
Avg Estimate
$-1.42
FY 2026
Estimate Range
$-1.91 - $-0.93
Analyst Spread

Forward Growth Analysis

Projected Growth-71.4%

Significant contraction projectedโ€”major business challenges or industry disruption likely.

Analyst Coverage5 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread69%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookCautious

Analyst skepticism evidentโ€”carefully evaluate risks before investment decisions.

Key Insight

Declining estimates with wide disagreement: Analysts projecting contraction without consensus signals significant business uncertaintyโ€”exercise caution.

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Castle Biosciences, Inc. Forward Estimates of EBIT

CSTL ยท NASDAQ
Latest EBIT
-29.43M
FY 2025
Avg Estimate
-81.89M
FY 2026
Estimate Range
-82.35M - -81.44M
Analyst Spread

Forward Growth Analysis

Projected Growth-178.3%

Significant contraction projectedโ€”major business challenges or industry disruption likely.

Analyst Coverage6 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread1%

Narrow estimate range signals strong analyst consensus and predictable business outlook.

OutlookNeutral

Mixed signalsโ€”some positive indicators offset by concerns about growth or uncertainty.

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Castle Biosciences, Inc. Forward Estimates of EBITDA

CSTL ยท NASDAQ
Latest EBITDA
11.34M
FY 2025
Avg Estimate
-67.07M
FY 2026
Estimate Range
-67.45M - -66.70M
Analyst Spread

Forward Growth Analysis

Projected Growth-691.3%

Significant contraction projectedโ€”major business challenges or industry disruption likely.

Analyst Coverage6 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread1%

Narrow estimate range signals strong analyst consensus and predictable business outlook.

OutlookNeutral

Mixed signalsโ€”some positive indicators offset by concerns about growth or uncertainty.

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Castle Biosciences, Inc. Forward Estimates of SG&A Expense

CSTL ยท NASDAQ
Latest SG&A Expense
229.32M
FY 2025
Avg Estimate
273.80M
FY 2026
Estimate Range
272.28M - 275.33M
Analyst Spread

Forward Growth Analysis

Projected Growth+19.4%

Solid growth trajectory indicates healthy business performance and competitive positioning.

Analyst Coverage6 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread1%

Narrow estimate range signals strong analyst consensus and predictable business outlook.

OutlookStrong

Positive analyst consensus with strong growth expectations and forecast confidence.

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Castle Biosciences, Inc. Insider Positioning

CSTL ยท NASDAQ

During the last 12 months, insiders have sold $7.84M worth of CSTL shares, with no buying activity reported.

3 Months

Bought

0

0.00

Sold

117.9K

3.01M

Net Activity

-3.0M

-$3.01M

3-6 Months

Bought

0

0.00

Sold

80.4K

2.94M

Net Activity

-2.9M

-$2.94M

6-9 Months

Bought

0

0.00

Sold

52.9K

1.89M

Net Activity

-1.9M

-$1.89M

9-12 Months

Bought

0

0.00

Sold

0

0.00

Net Activity

+0

+$0

Top Buyers

No buying activity

Top Sellers

1
MDJ

Maetzold Derek J

Director, Officer: Pres. & Chief Exec. Officer

151.3K sharesโ€ข26 transactions

$4.54M

2
OKM

Oelschlager Kristen M

Officer: Chief Operating Officer

33.8K sharesโ€ข2 transactions

$1.25M

3
JTW

Juvenal Tobin W

Officer: Chief Commercial Officer

40.2K sharesโ€ข7 transactions

$1.24M

4
SF

Stokes Frank

Officer: Chief Financial Officer

21.2K sharesโ€ข4 transactions

$670K

5
CGB

Cole G Bradley

Director

4.7K sharesโ€ข1 transactions

$135K

Insider Activity Analysis

Net Insider Sentiment

Bearish

Strong bearish signal with $7.84M net selling. Heavy insider selling may indicate concerns about valuation or near-term prospects.

Buy/Sell Ratio

0.00:1

Very poor ratio. Heavy selling with minimal buying suggests insiders may be concerned about valuation or outlook.

Recent Trend (3 Months)

$3.01M

Heavy recent selling activity. Recent insider sales notably exceed purchasesโ€”may warrant investigation into company developments.

Insider Participation

High Selling

5 insider sellers vs. 0 buyers. Widespread selling across multiple insiders may signal concerns.

Insider Activity Insight

Multiple red flags: Heavy selling, numerous sellers, and continued recent selling create a concerning pattern. Investigate fundamental drivers and consider whether company guidance or industry conditions have deteriorated.