Crinetics Pharmaceuticals, Inc.

Crinetics Pharmaceuticals, Inc.

CRNX·NASDAQ

$33.09

+0.98%
HealthcareBiotechnology

Crinetics Pharmaceuticals, Inc., a clinical stage pharmaceutical company, focuses on the discovery, development, and commercialization of therapeutics for rare endocrine diseases and endocrine-related tumors. Its lead product candidate is Paltusotine, an oral selective nonpeptide somatostatin receptor type 2 agonist that has completed phase III clinical trial for the treatment of acromegaly, as well as completed phase II clinical trial to treat carcinoid syndrome and nonfunctional neuroendocrine tumors (NETs). The company is also developing CRN04777, an oral selective nonpeptide somatostatin type 5 receptor agonist, which is in phase I clinical trial for the treatment of congenital hyperinsulinism; and CRN04894, an oral adrenocorticotrophic hormone antagonist that is in phase I clinical trial for the treatment of Cushing's and congenital adrenal hyperplasia diseases. Crinetics Pharmaceuticals, Inc. was incorporated in 2008 and is headquartered in San Diego, California.

At a Glance

Live Snapshot
Market Cap$3.49B
EPS-4.9500
P/E Ratio-6.68
Earnings Date08/06/2026
-48.89%
Return on Invested Capital
99%
3Y-5.0%
5Y+13.0%
10Y-5.0%
-46.90%
Return on Equity
108%
3Y-9.0%
5Y+7.0%
10Y-148.0%
-40.98%
Return on Assets
97%
3Y-12.0%
5Y+2.0%
10Y-14.0%
Crinetics Pharmaceuticals, Inc.

Crinetics Pharmaceuticals, Inc. Management Team

CRNX · NASDAQ
DA

Dr. Alan S. Krasner M.D.

Chief Endocrinologist

Compensation

$653,924

Born 1963(Age 63)
MT

Mr. Tobin C. Schilke

Chief Financial Officer

Born 1975(Age 51)
male
MA

Ms. Adriana Cabre M.B.A.

Chief Human Resources Officer

female
MG

Ms. Garlan Adams

Chief Legal Officer & Corporate Secretary

female
MG

Ms. Garlan Adams J.D.

Chief Legal Officer & Corporate Secretary

female
DD

Dr. Dana Pizzuti M.D.

Chief Medical & Development Officer

Compensation

$801,708

Born 1956(Age 70)
MJ

Mr. Jeff E. Knight

Chief Operating Officer

Compensation

$714,970

Born 1971(Age 55)
male
MJ

Mr. Jeff E. Knight M.P.H.

Chief Operating Officer

Compensation

$714,970

Born 1971(Age 55)
male
DS

Dr. Stephen F. Betz Ph.D.

Co-Founder & Chief Scientific Officer

Compensation

$715,917

Born 1966(Age 60)
DR

Dr. R. Scott Struthers Ph.D.

Founder, President, Chief Executive Officer & Director

Compensation

$1,064,629

Born 1962(Age 64)
MK

Mr. Kevin Capps

Head of Intellectual Property

male
MG

Ms. Gayathri Diwakar

Head of Investor Relations

female
crnx

Crinetics Pharmaceuticals, Inc. Insider Positioning

CRNX · NASDAQ

During the last 12 months, insiders have sold $10.06M worth of CRNX shares, with no buying activity reported.

3 Months

Bought

0

0.00

Sold

95.6K

3.80M

Net Activity

-3.8M

-$3.80M

3-6 Months

Bought

0

0.00

Sold

12.2K

522.81K

Net Activity

-523K

-$523K

6-9 Months

Bought

0

0.00

Sold

30.1K

1.33M

Net Activity

-1.3M

-$1.33M

9-12 Months

Bought

0

0.00

Sold

139.0K

4.40M

Net Activity

-4.4M

-$4.40M

Top Buyers

No buying activity

Top Sellers

1
KJE

Knight Jeff E.

Officer: Chief Dev. & Operating Officer

91.1K shares2 transactions

$3.64M

2
BSF

Betz Stephen F.

Officer: Chief Scientific Officer

97.5K shares1 transactions

$3.14M

3
PD

Pizzuti Dana

Officer: Chief Med And Dev Officer

51.6K shares6 transactions

$1.70M

4
FMK

Fust Matthew K

Director

16.0K shares1 transactions

$716K

5
ST

Schilke Tobin

Officer: Chief Financial Officer

6.7K shares1 transactions

$266K

Insider Activity Analysis

Net Insider Sentiment

Bearish

Strong bearish signal with $10.06M net selling. Heavy insider selling may indicate concerns about valuation or near-term prospects.

Buy/Sell Ratio

0.00:1

Very poor ratio. Heavy selling with minimal buying suggests insiders may be concerned about valuation or outlook.

Recent Trend (3 Months)

$3.80M

Heavy recent selling activity. Recent insider sales notably exceed purchases—may warrant investigation into company developments.

Insider Participation

High Selling

5 insider sellers vs. 0 buyers. Widespread selling across multiple insiders may signal concerns.

Insider Activity Insight

Multiple red flags: Heavy selling, numerous sellers, and continued recent selling create a concerning pattern. Investigate fundamental drivers and consider whether company guidance or industry conditions have deteriorated.

SEC Filings

CRNX - Filing history and reports

Filing TypeFiling DatePeriod EndingFiscal YearActions
DEF 14A

DEF 14A 2026

N/A

April 29, 2026
June 18, 2026
2026
DEF 14A

DEF 14A 2025

N/A

April 23, 2025
June 11, 2025
2025
DEF 14A

DEF 14A 2024

N/A

April 25, 2024
April 25, 2024
2024
DEF 14A

DEF 14A

N/A

April 27, 2023
April 27, 2023
 
DEF 14A

DEF 14A 2022

N/A

April 28, 2022
June 17, 2022
2022
DEF 14A

DEF 14A 2021

N/A

April 30, 2021
June 22, 2021
2021
DEF 14A

DEF 14A 2020

N/A

April 28, 2020
June 19, 2020
2020
DEF 14A

DEF 14A 2019

N/A

April 29, 2019
June 21, 2019
2019
Showing 1 to 8 of 8 filings