Clene Inc.

Clene Inc.

CLNNยทNASDAQ

$5.76

-0.93%
HealthcareBiotechnology

Clene Inc., a clinical-stage pharmaceutical company, focuses on the discovery, development, and commercialization of novel clean-surfaced nanotechnology (CSN) therapeutics. Its lead drug is CNM-Au8, which is being studied in various clinical trials, including a Phase 2/3 registrational clinical trial for patients with amyotrophic lateral sclerosis (ALS); completed Phase 2 proof of concept clinical trial in patients with early symptomatic ALS; completed two open-label investigator blinded Phase 2 clinical trials on the brain's energy metabolites; ongoing Phase 2 clinical trial for the treatment of visual pathway deficits in chronic optic neuropathy for remyelination in stable relapsing Multiple Sclerosis; and a planned Phase 2 clinical trial for the treatment of patients with Parkinson's Diseases. The company's products also include CNM-AgZn17, a gel polymer suspension of silver and zinc ions that is being developed for the treatment of infectious diseases and to accelerate wound healing; CNM-ZnAg, a broad-spectrum antiviral and antibacterial agent to treat infection disease, such as COVID-19 and to provide immune support for symptom resolution; and CNM-PtAu7, a gold-platinum CSN therapeutic for oncology applications. It also markets and distributes dietary supplements comprising rMetx, an aqueous zinc-silver ion dietary supplement; and KHC46, an aqueous gold dietary supplement of very low-concentration Au nanoparticles. The company is headquartered in Salt Lake City, Utah.

At a Glance

Live Snapshot
Market Cap$59.37M
EPS-2.6500
P/E Ratio-2.17
Earnings Date08/13/2026
clnn

Clene Inc. Street Expectations Map

CLNN ยท NASDAQ

Wall Street analysts project that CLNN stock may rise significantly over the coming 12 months. The consensus 1-year price target stands at 50.00, with estimates ranging from a low of 50.00 to a high of 50.00.

Lowest Target
50.00
768.06%
Consensus Target
50.00
768.06%
Highest Target
50.00
768.06%

The consensus 1-year price target stands at 50.00, with estimates ranging from a low of 50.00 to a high of 50.00.

Analyst Consensus Analysis

Upside Potential

+768.1%

Substantial upside potential. Analysts see significant value gap, suggesting the stock may be materially undervalued at current levels.

Analyst Agreement

0.0% spread

High analyst agreement. Narrow target range indicates strong consensus on valuation, suggesting clear investment thesis and predictable outlook.

Analyst Conviction

Very High

Strong buy conviction: High upside with tight consensus suggests compelling investment opportunity backed by analyst confidence.

Market Sentiment Insight

Rare opportunity: Exceptional upside potential with strong analyst consensus creates a compelling setup. The combination of significant price target premium and tight agreement suggests high-conviction undervaluation that may attract institutional capital.

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Clene Inc. Forward Estimates of Revenue

CLNN ยท NASDAQ
Latest Revenue
200.00K
FY 2025
Avg Estimate
243.33K
FY 2026
Estimate Range
139.05K - 347.62K
Analyst Spread

Forward Growth Analysis

Projected Growth+21.7%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage5 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread86%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookNeutral

Mixed signalsโ€”some positive indicators offset by concerns about growth or uncertainty.

Key Insight

High forecast uncertainty: Wide estimate range indicates analysts struggling to predict outcomesโ€”suggests elevated risk and potential volatility.

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Clene Inc. Forward Estimates of Net Income

CLNN ยท NASDAQ
Latest Net Income
-26.17M
FY 2025
Avg Estimate
-14.32M
FY 2026
Estimate Range
-16.54M - -12.10M
Analyst Spread

Forward Growth Analysis

Projected Growth+45.3%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage5 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread31%

Moderate uncertainty in forecastsโ€”typical for companies with evolving business models.

OutlookPositive

Generally favorable outlook with reasonable growth prospects and analyst support.

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Clene Inc. Forward Estimates of EPS

CLNN ยท NASDAQ
Latest EPS
-2.65
FY 2025
Avg Estimate
$-2.06
FY 2026
Estimate Range
$-2.38 - $-1.74
Analyst Spread

Forward Growth Analysis

Projected Growth+22.3%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage4 Analysts

Limited coverage may indicate reduced institutional interest or information availability.

Estimate Spread31%

Moderate uncertainty in forecastsโ€”typical for companies with evolving business models.

OutlookPositive

Generally favorable outlook with reasonable growth prospects and analyst support.

Key Insight

Limited coverage with volatile estimates: Few analysts covering despite significant projected changes may indicate information gaps or emerging risks.

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Clene Inc. Forward Estimates of EBIT

CLNN ยท NASDAQ
Latest EBIT
-23.08M
FY 2025
Avg Estimate
-243.33K
FY 2026
Estimate Range
-347.62K - -139.05K
Analyst Spread

Forward Growth Analysis

Projected Growth+98.9%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage5 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread86%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookNeutral

Mixed signalsโ€”some positive indicators offset by concerns about growth or uncertainty.

Key Insight

High forecast uncertainty: Wide estimate range indicates analysts struggling to predict outcomesโ€”suggests elevated risk and potential volatility.

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Clene Inc. Forward Estimates of EBITDA

CLNN ยท NASDAQ
Latest EBITDA
-21.59M
FY 2025
Avg Estimate
-243.33K
FY 2026
Estimate Range
-347.62K - -139.05K
Analyst Spread

Forward Growth Analysis

Projected Growth+98.9%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage5 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread86%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookNeutral

Mixed signalsโ€”some positive indicators offset by concerns about growth or uncertainty.

Key Insight

High forecast uncertainty: Wide estimate range indicates analysts struggling to predict outcomesโ€”suggests elevated risk and potential volatility.

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Clene Inc. Forward Estimates of SG&A Expense

CLNN ยท NASDAQ
Latest SG&A Expense
9.23M
FY 2025
Avg Estimate
6.67M
FY 2026
Estimate Range
3.81M - 9.52M
Analyst Spread

Forward Growth Analysis

Projected Growth-27.8%

Significant contraction projectedโ€”major business challenges or industry disruption likely.

Analyst Coverage5 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread86%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookCautious

Analyst skepticism evidentโ€”carefully evaluate risks before investment decisions.

Key Insight

Declining estimates with wide disagreement: Analysts projecting contraction without consensus signals significant business uncertaintyโ€”exercise caution.

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Clene Inc. Insider Positioning

CLNN ยท NASDAQ

During the last 12 months, insiders have purchased $1.56M and sold $5.80M worth of CLNN shares, resulting in $4.24M of net selling activity.

3 Months

Bought

0

0.00

Sold

446.6K

2.64M

Net Activity

-2.6M

-$2.64M

3-6 Months

Bought

33.3K

216.66K

Sold

358.7K

1.99M

Net Activity

-1.8M

-$1.77M

6-9 Months

Bought

200.0K

1.20M

Sold

166.6K

1.16M

Net Activity

+49K

+$49K

9-12 Months

Bought

39.1K

140.62K

Sold

4.0K

20.59K

Net Activity

+120K

+$120K

Top Buyers

1
MM

Mortenson Mark

Officer: Chief Science Officer

90.0K sharesโ€ข3 transactions

$540K

2
ERD

Etherington Robert Dee

Director, Officer: President & Ceo

90.0K sharesโ€ข3 transactions

$540K

3
MDJ

Matlin David J

Director

40.6K sharesโ€ข2 transactions

$243K

4
BMR

Brown Morgan R

Officer: Chief Financial Officer

20.0K sharesโ€ข2 transactions

$124K

5
MA

Mosca Alison

Director

5.7K sharesโ€ข1 transactions

$20K

Top Sellers

1
UC

Ugwumba Chidozie

10 Percent Owner

971.8K sharesโ€ข62 transactions

$5.78M

2
GRL

General Resonance Llc

10 Percent Owner

4.0K sharesโ€ข2 transactions

$21K

Insider Activity Analysis

Net Insider Sentiment

Bearish

Strong bearish signal with $4.24M net selling. Heavy insider selling may indicate concerns about valuation or near-term prospects.

Buy/Sell Ratio

0.27:1

Weak buy/sell ratio. Selling significantly exceeds buyingโ€”monitor for potential fundamental concerns.

Recent Trend (3 Months)

$2.64M

Heavy recent selling activity. Recent insider sales notably exceed purchasesโ€”may warrant investigation into company developments.

Insider Participation

High Buying

5 insider buyers vs. 2 sellers. Broad-based buying across management team suggests widespread confidence.

Insider Activity Insight

Persistent selling pressure: Consistent insider selling with weak buy/sell ratio suggests insiders may be capitalizing on current valuation. Exercise caution and review recent earnings quality and management commentary.