Protalix BioTherapeutics, Inc.

Protalix BioTherapeutics, Inc.

PLX·AMEX

$2.01

+1.8%
HealthcareBiotechnology

Protalix BioTherapeutics, Inc., a biopharmaceutical company, focuses on the development and commercialization of recombinant therapeutic proteins based on its proprietary ProCellEx plant cell-based protein expression system in the United States, Australia, Canada, Israel, Brazil, Russia, Turkey, and internationally. The company offers Elelyso for the treatment of Gaucher disease. Its product pipeline comprises PRX-102, a therapeutic protein candidate, which is in the last stage of clinical trials for the treatment of Fabry diseases; PRX-110, a proprietary plant cell recombinant form of human deoxyribonuclease I that has completed phase IIa clinical trials for the treatment of cystic fibrosis; PRX-115, a plant cell-expressed recombinant PEGylated Uricase for the treatment of gout; and PRX-119, a plant cell-expressed PEGylated recombinant human DNase I product candidate for the treatment of NETs-related diseases. The company has agreements and partnerships with Pfizer; Fundação Oswaldo Cruz (Fiocruz); and Chiesi Farmaceutici S.p.A. The company was founded in 1993 and is based in Hackensack, New Jersey.

At a Glance

Live Snapshot
Market Cap$161.95M
EPS-0.0841
P/E Ratio-23.90
Earnings Date08/13/2026
-9.61%
Return on Invested Capital
-271%
3Y-82.0%
5Y-247.0%
10Y-80.0%
-13.69%
Return on Equity
-302%
3Y-110.0%
5Y-157.0%
10Y-105.0%
-8.02%
Return on Assets
-301%
3Y-70.0%
5Y-16.0%
10Y-78.0%
Protalix BioTherapeutics, Inc.

Protalix BioTherapeutics, Inc. Management Team

PLX · AMEX
MD

Mr. Dror Bashan

President, Chief Executive Officer & Director

Compensation

$490,671

Born 1967(Age 59)
male
MG

Mr. Gilad Mamlok

Senior Vice President & Chief Financial Officer

Born 1968(Age 58)
male
MY

Mr. Yaron Naos B.Sc., MBA

Senior Vice President of Operations

Compensation

$396,471

Born 1964(Age 62)
male
MY

Ms. Yael Fellous

Vice President of Human Resources

female
plx

Protalix BioTherapeutics, Inc. Insider Positioning

PLX · AMEX

During the last 12 months, insiders have purchased $307K and sold $314 worth of PLX shares, resulting in $307K of net buying activity.

3 Months

Bought

0

0.00

Sold

0

0.00

Net Activity

+0

+$0

3-6 Months

Bought

56.0K

101.36K

Sold

0

0.00

Net Activity

+101K

+$101K

6-9 Months

Bought

0

0.00

Sold

168

314.00

Net Activity

-314

-$314

9-12 Months

Bought

129.0K

205.88K

Sold

0

0.00

Net Activity

+206K

+$206K

Top Buyers

1
SA

Schwartz Aharon

Director

129.0K shares1 transactions

$206K

2
BD

Bashan Dror

Director, Officer: President And Ceo

56.0K shares1 transactions

$101K

Top Sellers

1
BA

Bar-Shalev Amos

Director

168 shares1 transactions

$314

Insider Activity Analysis

Net Insider Sentiment

Bullish

Strong bullish signal with $307K net buying. Insiders are aggressively accumulating shares, suggesting significant confidence in future prospects.

Buy/Sell Ratio

978.48:1

Exceptional buy/sell ratio. Buying dramatically outweighs selling—one of the strongest possible insider signals.

Insider Participation

Moderate Buying

2 insider buyers vs. 1 sellers. More insiders buying than selling indicates positive sentiment.

Insider Activity Insight

Compelling insider conviction: The combination of strong buy/sell ratio and multiple buyers suggests insiders see attractive risk/reward. Consider this alongside fundamental analysis for confirmation.

SEC Filings

PLX - Filing history and reports

Filing TypeFiling DatePeriod EndingFiscal YearActions
DEF 14A

DEF 14A 2026

N/A

April 30, 2026
June 25, 2026
2026
DEF 14A

DEF 14A 2025

N/A

April 30, 2025
June 26, 2025
2025
DEF 14A

DEF 14A 2024

N/A

April 29, 2024
June 27, 2024
2024
DEF 14A

DEF 14A 2023

N/A

May 18, 2023
June 28, 2023
2023
DEF 14A

DEF 14A 2022

N/A

April 29, 2022
June 30, 2022
2022
DEF 14A

DEF 14A 2021

N/A

September 30, 2021
November 24, 2021
2021
DEF 14A

DEF 14A 2021

N/A

June 04, 2021
July 07, 2021
2021
DEF 14A

DEF 14A 2020

N/A

April 15, 2020
June 07, 2020
2020
DEF 14A

DEF 14A 2019

N/A

October 15, 2019
December 09, 2019
2019
DEF 14A

DEF 14A 2019

N/A

April 12, 2019
May 30, 2019
2019
Showing 1 to 10 of 26 filings