Vertex Pharmaceuticals Incorporated

Vertex Pharmaceuticals Incorporated

Healthcare

NASDAQ:VRTX · NASDAQ Global Select

Market Cap $112.65B Beta 0.31 P/E (TTM) 26.0
$443.84 -0.27%

-$1.21 today

52W Low $362.50High $507.92

Vol 0.43M · Avg 1.26M

EPS (TTM)$17.07
Biotechnology

Management

Put operating results in leadership context

Review returns on capital, executive background, insider transactions, and growth quality to judge whether management is compounding value well.

Return Metrics

ROE, ROIC & ROA over time

Management

ROE

21.2%

avg 11.6%

ROIC

18.1%

avg 7.6%

ROA

15.1%

avg 10.6%

Analysis

ROE is currently the strongest return metric at 21.2% versus its period average of 11.6%. 3 of 3 return metrics are above their quality threshold, which helps indicate how efficiently the company turns capital and assets into profit.

Management

Key executives, compensation & ownership

Management
NameTitleCompensationTenureAgeShares OwnedOwnership %

Reshma Kewalramani FASN

Chief Executive Officer, President & Director$6.14M53$100,003.000.04%

Charles F. Wagner Jr.

Executive Vice President, Chief Operating Officer & Chief Financial Officer$2.99M58$47,042.000.02%

Mark Bunnage D.Phil

Executive Vice President & Chief Scientific Officer$2.39M57$7,284.00<0.01%

Carmen Bozic

Executive VP of Global Medicines Development & Medical Affairs and Chief Medical Officer$2.27M63$21,015.00<0.01%

Ourania Tatsis

Executive Vice President and Chief Regulatory & Quality Officer$2.07M56$46,763.000.02%

Amit K. Sachdev

Executive Vice President & Chief Patient and External Affairs Officer$1.88M58$55,570.000.02%

Jeffrey Marc Leiden

Executive Chairman70$34,797.000.01%

Kristen C. Ambrose

Senior Vice President & Chief Accounting Officer49$6,624.00<0.01%

Joy Liu

EVP, Chief Legal Officer & Corporate Secretary48$20,729.00<0.01%

Susie Lisa

Senior Vice President of Investor Relations

Insider Trading

SEC Form 4 transactions — last 12 months

Management

Buys

0

$0.00

Sells

83

$144.46M

Net Sentiment

$144.46M

Net selling

Most Active

LEIDEN JEFFREY M

14 transactions

DateInsiderTypeSharesPriceValue
Jun 5, 2026

Bozic Carmen

Direct

Sell1.7K$450.00$785,250.00
May 29, 2026

Bozic Carmen

Direct

Sell2.0K$450.00$888,300.00
May 15, 2026

Bunnage Mark E.

Direct

Sell33$453.45$14,963.85
May 15, 2026

Bozic Carmen

Direct

Sell1.4K$453.45$613,971.30
May 12, 2026

Bozic Carmen

Direct

Sell7.0K$450.00$3,144,600.00
May 4, 2026

Bhatia Sangeeta N.

Direct

Sell318$423.73$134,746.14
May 1, 2026

Liu Joy

Direct

Sell1.1K$425.02$469,222.08
Apr 1, 2026

Liu Joy

Direct

Sell978$449.17$439,288.26
Mar 27, 2026

Bozic Carmen

Direct

Sell2.3K$450.95$1,050,262.55
Mar 13, 2026

Bozic Carmen

Direct

Sell2.3K$481.79$1,122,088.91

1–10 of 83

Analysis

Insiders reported 0 buys worth $0.00 and 83 sells worth $144.46M over the last 12 months. That adds up to net selling of $144.46M. LEIDEN JEFFREY M was the most active insider with 14 transactions.

Growth Analysis

Historical CAGR & forward analyst estimates

Metric 10yr5yr3yr Fwd Est.
EPSN/AN/AN/A
N/A12 analysts
RevenueN/AN/A-12.2%
+21.6% (15yr)12 analysts
Net IncomeN/AN/AN/A
N/A12 analysts
EBITN/AN/AN/A
N/A12 analysts

Analysis

Recent growth has been strongest in Revenue at -12.2% over three years. Forward estimates point to Revenue at +21.6% (15yr), giving you a quick check on whether expectations are accelerating or cooling.

Who manages VRTX?

Vertex Pharmaceuticals Incorporated (VRTX) lists 10 active executives. The top listed executive is Amit K. Sachdev, Executive Vice President & Chief Patient and External Affairs Officer.

Are VRTX insiders buying or selling?

Recent insider activity shows net selling of $187.78M.

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