Vertex Pharmaceuticals Incorporated

Vertex Pharmaceuticals Incorporated

Healthcare

NASDAQ:VRTX · NASDAQ Global Select

Market Cap $112.65B Beta 0.31 P/E (TTM) 26.0
$443.84 -0.27%

-$1.21 today

52W Low $362.50High $507.92

Vol 0.43M · Avg 1.26M

EPS (TTM)$17.07
Biotechnology

Intrinsic Value

VRTX Intrinsic Value

Start with the valuation result. Compare the current market price with the system DCF estimate, then use the supporting sections below to decide whether the assumptions are reasonable.

Intrinsic Value

System DCF · consensus of 4 models

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Price Alerts

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Baseline
$443.84
Current Price

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Valuation History

Is VRTX cheaper or more expensive than usual?

Review how the market has valued Vertex Pharmaceuticals Incorporated over time before deciding whether today’s discount or premium is unusual.

Price History

Dividend-adjusted closing price

Events

Change

-3.53%

Period High

$499.17

Period Low

$366.54

Latest

$443.82

Analyst Targets

See where analysts expect VRTX to trade next

Compare the latest consensus target range with the current share price to understand how much upside or downside Wall Street is pricing in.

Wall Street Price Targets

1-year price history with analyst consensus target

Growth

Current

$443.82

Low Target

$436.00

Avg Target

$553.93

High Target

$616.00

Upside (Avg)

+24.81%

Alternatives to VRTX

Compare Vertex Pharmaceuticals Incorporated with similar companies

A stock can look attractive in isolation and still be less compelling than a peer. Check competitors before committing to the thesis.

Fundamental Analysis

Capture the investment case and test company quality

Write down the key idea, risks, and what would change your mind. Then review growth, profitability, returns, owner payouts, and insider activity.

My Notes

Journal entries for VRTX

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Quality Snapshot

Start with the numbers that compound value

Check whether earnings, revenue, equity, cash, and returns on capital are moving in the same direction as your written thesis.

Big Five Numbers

CAGR by period · ROIC shows average

Metric 10yr 5yr3yr1yr
EPS
N/AN/AN/AN/A
Revenue
N/AN/A-12.2%+77.9%
Equity
+24.1%+48.2%+31.0%+17.2%
Cash
N/AN/A+13.5%+14.3%
ROIC
-4.3%9.3%20.1%21.0%

Analysis

Latest growth is strongest in Revenue at +77.9% and weakest in Cash at +14.3%. Three-year average ROIC is 20.1%, which helps show whether that growth is being earned efficiently.

Growth Profile

Compare historical growth with forward expectations

Strong past growth matters more when analysts still expect the business to expand without relying on one temporary driver.

Growth Analysis

Historical CAGR & forward analyst estimates

Metric 10yr5yr3yr Fwd Est.
EPSN/AN/AN/A
N/A12 analysts
RevenueN/AN/A-12.2%
+21.6% (15yr)12 analysts
Net IncomeN/AN/AN/A
N/A12 analysts
EBITN/AN/AN/A
N/A12 analysts

Analysis

Recent growth has been strongest in Revenue at -12.2% over three years. Forward estimates point to Revenue at +21.6% (15yr), giving you a quick check on whether expectations are accelerating or cooling.

Earnings Quality

Follow revenue through to net income

Use the waterfall to see which costs, margins, and operating lines explain how much of each sales dollar becomes profit.

Earnings Waterfall

Revenue to Net Income

Key Ratios

EPS$16.86
Gross Margin86.3%
Net Margin35.4%
P/E Ratio25.6
P/S Ratio36.2

Analysis

$12.3B of revenue converted into $4.3B of net income for the selected period. Gross margin is 86.3% and net margin is 35.4%, showing how much revenue survives after costs and taxes. EPS is $16.86, tying the income statement back to per-share earnings.

Capital Efficiency

Measure how well Vertex Pharmaceuticals Incorporated turns capital into returns

Returns on equity, invested capital, and assets help separate durable operators from businesses that only grow by adding more capital.

Return Metrics

ROE, ROIC & ROA over time

Management

ROE

21.2%

avg 11.6%

ROIC

18.1%

avg 7.6%

ROA

15.1%

avg 10.6%

Analysis

ROE is currently the strongest return metric at 21.2% versus its period average of 11.6%. 3 of 3 return metrics are above their quality threshold, which helps indicate how efficiently the company turns capital and assets into profit.

Owner Returns

Review how cash comes back to shareholders

Dividends, buybacks, and debt paydown show whether excess cash is being reinvested, returned, or used to strengthen the balance sheet.

Shareholder Returns

Dividend, buyback & debt paydown yields

Management

Dividend Yield (TTM)

0.00%

Buyback Yield (TTM)

1.71%

Debt Paydown (TTM)

0.00%

Total Yield (TTM)

1.72%

Analysis

Total TTM shareholder yield is 1.72% including 0.00% from debt paydown. The largest current contributor is buybacks at 1.71%, which helps show whether capital returns are coming from direct cash payouts, share count reduction, or balance sheet cleanup.

Dividend Record

Check payout durability before counting on yield

A dividend is more useful when growth, payout ratio, and free cash flow support the current yield.

Dividends

Dividend history, growth & yield

Dividends

Yield

0.00%

Annual Div/Share

$0.00

Payout Ratio

0.0%

Frequency

Shareholder Yield

1.79%

Next Ex-Date

Not announced

Next Payment

Analysis

The current indicated dividend yield is 0.00%. The payout ratio is 0.0%, so compare payout growth against earnings coverage.

Company Overview

Understand how Vertex Pharmaceuticals Incorporated makes money

Finish by grounding the numbers in the company profile, leadership, balance sheet, and free cash flow.

Key Information

Filings
No data available

Leadership

Put the business in management context

Company facts explain what Vertex Pharmaceuticals Incorporated does; leadership context helps you judge who is responsible for capital allocation and execution.

Management

Key executives, compensation & ownership

Management
NameTitleCompensationTenureAgeShares OwnedOwnership %

Reshma Kewalramani FASN

Chief Executive Officer, President & Director$6.14M53$100,003.000.04%

Charles F. Wagner Jr.

Executive Vice President, Chief Operating Officer & Chief Financial Officer$2.99M58$47,042.000.02%

Mark Bunnage D.Phil

Executive Vice President & Chief Scientific Officer$2.39M57$7,284.00<0.01%

Carmen Bozic

Executive VP of Global Medicines Development & Medical Affairs and Chief Medical Officer$2.27M63$21,015.00<0.01%

Ourania Tatsis

Executive Vice President and Chief Regulatory & Quality Officer$2.07M56$46,763.000.02%

Amit K. Sachdev

Executive Vice President & Chief Patient and External Affairs Officer$1.88M58$55,570.000.02%

Jeffrey Marc Leiden

Executive Chairman70$34,797.000.01%

Kristen C. Ambrose

Senior Vice President & Chief Accounting Officer49$6,624.00<0.01%

Joy Liu

EVP, Chief Legal Officer & Corporate Secretary48$20,729.00<0.01%

Susie Lisa

Senior Vice President of Investor Relations

Insider Trading

SEC Form 4 transactions — last 12 months

Management

Buys

0

$0.00

Sells

83

$144.46M

Net Sentiment

$144.46M

Net selling

Most Active

LEIDEN JEFFREY M

14 transactions

DateInsiderTypeSharesPriceValue
Jun 5, 2026

Bozic Carmen

Direct

Sell1.7K$450.00$785,250.00
May 29, 2026

Bozic Carmen

Direct

Sell2.0K$450.00$888,300.00
May 15, 2026

Bunnage Mark E.

Direct

Sell33$453.45$14,963.85
May 15, 2026

Bozic Carmen

Direct

Sell1.4K$453.45$613,971.30
May 12, 2026

Bozic Carmen

Direct

Sell7.0K$450.00$3,144,600.00
May 4, 2026

Bhatia Sangeeta N.

Direct

Sell318$423.73$134,746.14
May 1, 2026

Liu Joy

Direct

Sell1.1K$425.02$469,222.08
Apr 1, 2026

Liu Joy

Direct

Sell978$449.17$439,288.26
Mar 27, 2026

Bozic Carmen

Direct

Sell2.3K$450.95$1,050,262.55
Mar 13, 2026

Bozic Carmen

Direct

Sell2.3K$481.79$1,122,088.91

1–10 of 83

Analysis

Insiders reported 0 buys worth $0.00 and 83 sells worth $144.46M over the last 12 months. That adds up to net selling of $144.46M. LEIDEN JEFFREY M was the most active insider with 14 transactions.

Financial Position

Check what supports the company underneath the income statement

The balance sheet shows liquidity, debt, asset mix, and book value quality before you rely on earnings or growth assumptions.

Balance Sheet

Assets, liabilities & equity

Cash & Equivalents$5.5B
Short-term Investments$1.8B
Receivables$2.0B
Inventory$1.8B
Other Current$720.8M
Total Current Assets$11.7B
PP&E (Net)$1.6B
Goodwill$1.1B
Intangible Assets$418.5M
Long-term Investments$5.7B
Tax Assets$2.9B
Other Non-current$2.9B
Total Non-current Assets$14.8B
Total Assets$26.5B

Analysis

Selected assets total $26.5B for Latest. The largest visible component is Long-term Investments at $5.7B, about 21.7% of the tab total. Use the mix to judge balance sheet concentration, liquidity, leverage, and how much of book value is supported by tangible operating assets.

Cash Generation

Finish by testing whether profit turns into cash

Free cash flow connects accounting earnings to owner earnings, showing how much cash remains after reinvestment needs.

Free Cash Flow

Net Income to FCF bridge

Cash Flow Statement

Analysis

Analysis will appear once cash flow data is available for this period.

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