Definium Therapeutics, Inc.

Healthcare

NASDAQ:DFTX · NASDAQ Global Select

Market Cap $2.66B Beta 2.38 P/E (TTM) -11.0
$24.48 -1.67%

-$0.41 today

52W Low $12.88High $26.15

Vol 1.68M · Avg 2.67M

EPS (TTM) -$2.18Biotechnology

Management

Put operating results in leadership context

Review returns on capital, executive background, insider transactions, and growth quality to judge whether management is compounding value well.

Return Metrics

ROE, ROIC & ROA over time

Management
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ROE

-55.3%

avg -57.9%

ROIC

-44.5%

avg -47.7%

ROA

-41.8%

avg -45.4%

Analysis

ROA is currently the strongest return metric at -41.8% versus its period average of -45.4%. 0 of 3 return metrics are above their quality threshold, which helps indicate how efficiently the company turns capital and assets into profit.

Management

Key executives, compensation & ownership

Management
NameTitleCompensationTenureAgeShares OwnedOwnership %

Robert Barrow

Chief Executive Officer & Director$1.05M37$752,454.000.69%

Daniel Rollings Karlin

Chief Medical Officer$738,733.0046$413,317.000.38%

Mark R. Sullivan

Chief Legal Officer & Corporate Secretary$638,607.0055$271,079.000.25%

Brandi L. Roberts

Chief Financial Officer$619,239.0052$150,000.000.14%

Scott Freeman

Co-Founder & Clinical Advisor$307,918.0069

Peter Mack

Senior Vice President of Pharmaceutical Development & Operations

Beth Calitri

Vice President of Corporate Communications

Gitanjali Jain

VP & Head of Investor Relations

Stephanie Fagan

Chief Corporate Affairs Officer

Matthew Wiley

Chief Commercial Officer53$115,000.000.11%

Leonard Latchman

Co-Founder

Gregg Pratt

Chief Regulatory & Quality Assurance Officer

Insider Trading

SEC Form 4 transactions — last 12 months

Management

Buys

0

$0.00

Sells

12

$2.11M

Net Sentiment

$2.11M

Net selling

Most Active

Karlin Daniel

4 transactions

DateInsiderTypeSharesPriceValue
Mar 25, 2026

Karlin Daniel

Direct

Sell8.0K$18.47$148,092.46
Mar 25, 2026

Sullivan Mark

Direct

Sell10.7K$18.47$197,665.94
Mar 25, 2026

Barrow Robert

Direct

Sell24.4K$18.47$451,240.57
Dec 26, 2025

Karlin Daniel

Direct

Sell5.6K$13.15$73,622.64
Dec 26, 2025

Barrow Robert

Direct

Sell25.8K$13.15$339,071.70
Dec 26, 2025

Sullivan Mark

Direct

Sell11.3K$13.15$148,244.44
Sep 25, 2025

Sullivan Mark

Direct

Sell11.3K$9.77$110,186.06
Sep 25, 2025

Barrow Robert

Direct

Sell25.8K$9.77$252,036.69
Sep 25, 2025

Karlin Daniel

Direct

Sell7.7K$9.77$75,268.08
Jun 25, 2025

Sullivan Mark

Direct

Sell11.5K$6.80$78,138.80

1–10 of 12

Analysis

Insiders reported 0 buys worth $0.00 and 12 sells worth $2.11M over the last 12 months. That adds up to net selling of $2.11M. Karlin Daniel was the most active insider with 4 transactions.

Growth Analysis

Historical CAGR & forward analyst estimates

Metric 10yr 5yr3yr Fwd Est.
EPSN/AN/AN/A
N/A4 analysts
RevenueN/AN/AN/A
N/A6 analysts
Net IncomeN/AN/AN/A
N/A6 analysts
EBITN/AN/AN/A
N/A6 analysts

Analysis

Analysis will appear once historical growth or forward estimates are available for this company.

Who manages DFTX?

Definium Therapeutics, Inc. (DFTX) lists 12 active executives. The top listed executive is Peter Mack, Senior Vice President of Pharmaceutical Development & Operations.

Are DFTX insiders buying or selling?

Recent insider activity shows net buying of $12.30M.

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