image
Healthcare - Biotechnology - NASDAQ - US
$ 4.04
4.66 %
$ 34 M
Market Cap
-0.29
P/E
1. INTRINSIC VALUE

This DCF valuation model was last updated on Apr, 8, 2025.

The intrinsic value of one KPTI stock under the worst case scenario is HIDDEN Compared to the current market price of 4.04 USD, Karyopharm Therapeutics Inc. is HIDDEN

This DCF valuation model was last updated on Apr, 8, 2025.

The intrinsic value of one KPTI stock under the base case scenario is HIDDEN Compared to the current market price of 4.04 USD, Karyopharm Therapeutics Inc. is HIDDEN

This DCF valuation model was last updated on Apr, 8, 2025.

The intrinsic value of one KPTI stock under the best case scenario is HIDDEN Compared to the current market price of 4.04 USD, Karyopharm Therapeutics Inc. is HIDDEN

2. FUNDAMENTAL ANALYSIS

Price Chart KPTI

image
$16.0$16.0$14.0$14.0$12.0$12.0$10.0$10.0$8.0$8.0$6.0$6.0$4.0$4.0$2.0$2.015 Oct15 OctNov '24Nov '2415 Nov15 NovDec '24Dec '2415 Dec15 DecJan '25Jan '2515 Jan15 JanFeb '25Feb '2515 Feb15 FebMar '25Mar '2515 Mar15 MarApr '25Apr '25
FINANCIALS
145 M REVENUE
-0.55%
-119 M OPERATING INCOME
7.79%
-76.4 M NET INCOME
46.60%
-127 M OPERATING CASH FLOW
-37.49%
95.5 M INVESTING CASH FLOW
1102.43%
41.6 M FINANCING CASH FLOW
3605.16%
30.5 M REVENUE
-21.25%
-31.3 M OPERATING INCOME
-19.02%
-30.8 M NET INCOME
4.03%
-25.8 M OPERATING CASH FLOW
-32.68%
14.8 M INVESTING CASH FLOW
97.98%
680 K FINANCING CASH FLOW
0.00%
Balance Sheet Karyopharm Therapeutics Inc.
image
Current Assets 156 M
Cash & Short-Term Investments 109 M
Receivables 30.8 M
Other Current Assets 17 M
Non-Current Assets 7.93 M
Long-Term Investments 0
PP&E 6.28 M
Other Non-Current Assets 1.64 M
66.12 %18.71 %10.35 %3.82 %Total Assets$164.4m
Current Liabilities 92.3 M
Accounts Payable 5.11 M
Short-Term Debt 876 K
Other Current Liabilities 86.3 M
Non-Current Liabilities 258 M
Long-Term Debt 99.5 M
Other Non-Current Liabilities 159 M
24.62 %28.39 %45.28 %Total Liabilities$350.4m
EFFICIENCY
Earnings Waterfall Karyopharm Therapeutics Inc.
image
Revenue 145 M
Cost Of Revenue 6.01 M
Gross Profit 139 M
Operating Expenses 259 M
Operating Income -119 M
Other Expenses -43 M
Net Income -76.4 M
150m150m100m100m50m50m00(50m)(50m)(100m)(100m)(150m)(150m)145m(6m)139m(259m)(119m)43m(76m)RevenueRevenueCost Of RevenueCost Of RevenueGross ProfitGross ProfitOperating ExpensesOperating ExpensesOperating IncomeOperating IncomeOther ExpensesOther ExpensesNet IncomeNet Income
RATIOS
95.86% GROSS MARGIN
95.86%
-82.24% OPERATING MARGIN
-82.24%
-52.62% NET MARGIN
-52.62%
41.08% ROE
41.08%
-46.48% ROA
-46.48%
-163.68% ROIC
-163.68%
FREE CASH FLOW ANALYSIS
Free Cash Flow Analysis Karyopharm Therapeutics Inc.
image
00(20m)(20m)(40m)(40m)(60m)(60m)(80m)(80m)(100m)(100m)(120m)(120m)(140m)(140m)(160m)(160m)(180m)(180m)(200m)(200m)20162016201720172018201820192019202020202021202120222022202320232024202420252025
Net Income -76.4 M
Depreciation & Amortization -2.16 M
Capital Expenditures -142 K
Stock-Based Compensation 18.4 M
Change in Working Capital 0
Others -67.3 M
Free Cash Flow -128 M
3. WALL STREET ANALYSTS ESTIMATES
Wall Street Analysts Price Targets Karyopharm Therapeutics Inc.
image
Wall Street analysts predict an average 1-year price target for KPTI of $6.6 , with forecasts ranging from a low of $3 to a high of $14 .
KPTI Lowest Price Target Wall Street Target
3 USD -25.74%
KPTI Average Price Target Wall Street Target
6.6 USD 63.37%
KPTI Highest Price Target Wall Street Target
14 USD 246.53%
Price
Max Price Target
Min Price Target
Average Price Target
1818161614141212101088664422May '24May '24Jul '24Jul '24Aug '24Aug '24Oct '24Oct '24Nov '24Nov '2420252025Feb '25Feb '25Apr '25Apr '25Jun '25Jun '25Jul '25Jul '25Aug '25Aug '25Oct '25Oct '25Nov '25Nov '2520262026Feb '26Feb '26Apr '26Apr '26
4. DIVIDEND ANALYSIS
5. COMPETITION
slide 2 of 20
6. Ownership
Insider Ownership Karyopharm Therapeutics Inc.
image
Sold
0-3 MONTHS
24 K USD 3
3-6 MONTHS
9.45 K USD 1
6-9 MONTHS
24.1 K USD 5
9-12 MONTHS
1.47 M USD 4
Bought
0 USD 0
0-3 MONTHS
0 USD 0
3-6 MONTHS
0 USD 0
6-9 MONTHS
0 USD 0
9-12 MONTHS
7. News
Karyopharm Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) NEWTON, Mass. , April 1, 2025 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced that the Company granted an aggregate of 1,850 restricted stock units (RSUs) to two newly-hired employees. prnewswire.com - 2 weeks ago
XPOVIO® (selinexor) Approved for Commercialization in Indonesia, Further Expanding Antengene's Commercial Presence in APAC - XPOVIO ® is the first and only approved XPO1 inhibitor in Indonesia. - From the second half of 2024 to now, XPOVIO ®  was successively approved in Thailand, Malaysia and Indonesia, significantly expanding Antengene's commercial presence in APAC. prnewswire.com - 1 month ago
Karyopharm Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) NEWTON, Mass. , March 3, 2025 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced that the Company granted an aggregate of 3,316 restricted stock units (RSUs) to five newly-hired employees. prnewswire.com - 1 month ago
Karyopharm Announces 1-for-15 Reverse Stock Split NEWTON, Mass. , Feb. 24, 2025 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced that it will implement a 1-for-15 reverse stock split of the issued shares of the Company's common stock ("Reverse Stock Split"), effective at 5:00 p.m. prnewswire.com - 1 month ago
Karyopharm Therapeutics Inc. (KPTI) Q4 2024 Earnings Call Transcript Karyopharm Therapeutics Inc. (NASDAQ:KPTI ) Q4 2024 Earnings Call February 19, 2025 8:00 AM ET Company Participants Brendan Strong - SVP, IR Richard Paulson - President and CEO Reshma Rangwala - CMO & Head of Research Sohanya Cheng - CCO & Head of Business Development Lori Macomber - EVP, CFO, & Treasurer Conference Call Participants Colleen Kusy - Baird Maury Raycroft - Jefferies Unidentified Analyst - Barclays Jonathan Chang - Leerink Partners Unidentified Analyst - RBC Capital Markets Ed White - H.C. Wainwright Operator Good morning. seekingalpha.com - 2 months ago
Karyopharm Therapeutics (KPTI) Reports Q4 Loss, Tops Revenue Estimates Karyopharm Therapeutics (KPTI) came out with a quarterly loss of $0.24 per share versus the Zacks Consensus Estimate of a loss of $0.26. This compares to loss of $0.36 per share a year ago. zacks.com - 2 months ago
Karyopharm Reports Fourth Quarter and Full Year 2024 Financial Results, Announces Update to Phase 3 XPORT-EC-042 Trial and Highlights Recent Company Progress – Total Revenue of $145 Million and U.S. XPOVIO® (selinexor) Net Product Revenue of $113 Million for Full Year 2024 – – Top-Line Data Readout from Phase 3 SENTRY Trial Evaluating Selinexor in Combination with Ruxolitinib in Patients with JAKi-Naïve Myelofibrosis Anticipated in 2H 2025; Company on Track to Complete Enrollment in 1H 2025 – – Company Announces Update to Phase 3 XPORT-EC-042 Trial of Selinexor as Maintenance Therapy in Advanced or Recurrent TP53 Wild-Type Endometrial Cancer. Following Dialogue with the FDA Regarding the Evolving Treatment Landscape, Trial to Focus Enrollment on Patients with Either pMMR Tumors or Patients with dMMR Tumors that are Medically Ineligible for Checkpoint Inhibitors. prnewswire.com - 2 months ago
Antengene Announces XPOVIO® Approved for Public Health Insurance Coverage in Taiwan Market, Benefiting More Patients with R/R MM in the Region XPOVIO® is the first XPO1 inhibitor approved in Taiwan for the treatment of adult patients with relapsed/refractory multiple myeloma (R/R MM). After the mainland of China, South Korea, Australia and Singapore, Taiwan market is the fifth APAC market in which XPOVIO® has been approved for public health insurance coverage. prnewswire.com - 2 months ago
Karyopharm to Report Fourth Quarter and Full Year 2024 Financial Results on February 19, 2025 -- Conference Call Scheduled for Wednesday, February 19, 2025, at 8:00 a.m. ET -- NEWTON, Mass. prnewswire.com - 2 months ago
Karyopharm Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) NEWTON, Mass. , Feb. 3, 2025 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced that the Company granted an aggregate of 28,000 restricted stock units (RSUs) to three newly-hired employees. prnewswire.com - 2 months ago
Karyopharm Announces Preliminary Unaudited 2024 Revenue and 2025 Objectives – Opportunity to Define a New Myelofibrosis Treatment Paradigm with Top-Line Data Readout from Phase 3 SENTRY Trial Evaluating Selinexor in Combination with Ruxolitinib in Patients with JAKi-Naïve Myelofibrosis Anticipated in 2H 2025; Company On Track to Complete Enrollment in 1H 2025 –  – Recently Announced Key Leadership Changes, including the Appointment of Lori Macomber as Chief Financial Officer and Brendan Strong as SVP of Investor Relations and Corporate Communications –  – Preliminary Unaudited Full Year 2024 Total Revenue and U.S. XPOVIO® (selinexor) Net Product Revenue Expected to be Approximately $145 Million and $113 Million, Respectively – NEWTON, Mass. , Jan. 13, 2025 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced preliminary unaudited fourth quarter and full year 2024 total revenue and U.S. XPOVIO net product revenue estimates and outlined its 2024 achievements and 2025 objectives. prnewswire.com - 3 months ago
Karyopharm Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) NEWTON, Mass. , Jan. 2, 2025 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced that the Company granted a stock option to purchase an aggregate of 101,250 shares of Karyopharm's common stock and an aggregate of 108,540 restricted stock units (RSUs) to four newly-hired employees. prnewswire.com - 3 months ago
8. Profile Summary

Karyopharm Therapeutics Inc. KPTI

image
COUNTRY US
INDUSTRY Biotechnology
MARKET CAP $ 34 M
Dividend Yield 0.00%
Description Karyopharm Therapeutics Inc., a commercial-stage pharmaceutical company, discovers, develops, and commercializes drugs directed against nuclear export for the treatment of cancer and other diseases. The company discovers, develops, and commercializes novel and Selective Inhibitor of Nuclear Export (SINE) compounds function by binding with and inhibiting the nuclear export protein XPO1. Its lead compound, include XPOVIO in combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myeloma, in combination with dexamethasone for the treatment of adult patients with heavily pretreated multiple myeloma, and for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma. The company has license agreement with Menarini Group to develop and commercialize NEXPOVIO for human oncology indications in Europe, including the United Kingdom; Latin America; and other countries. Its oral SINE compounds also designed to force nuclear accumulation in the levels of multiple tumor suppressor and growth regulatory proteins. The company was incorporated in 2008 and is headquartered in Newton, Massachusetts.
Contact 85 Wells Avenue, Newton, MA, 02459 https://www.karyopharm.com
IPO Date Nov. 6, 2013
Employees 279
Officers Mr. Stuart Poulton Executive Vice President & Chief Development Officer Dr. Sharon Shacham M.B.A., Ph.D. Co-Founder & Chairman of Scientific Advisory Board Ms. Sohanya Cheng M.B.A. Executive Vice President, Chief Commercial Officer & Head of Business Development Mr. Michael J. Mano J.D. Senior Vice President, General Counsel & Secretary Mr. Brendan Twohig Strong SVice President of Investor Relations & Corporate Communications Ms. Kristin Abate Vice President, Chief Accounting Officer & Assistant Treasurer Mr. Richard A. Paulson M.B.A. President, Chief Executive Officer & Director Dr. Reshma Rangwala M.D., Ph.D. Executive Vice President, Chief Medical Officer & Head of Research Dr. Mansoor Raza Mirza M.D. Clinical Consultant, Member of Scientific Advisory Board & Independent Director Ms. Lori A. Macomber CPA EVice President, Chief Financial Officer & Treasurer