image
Healthcare - Biotechnology - NASDAQ - US
$ 0.814
-2.78 %
$ 102 M
Market Cap
-0.78
P/E
1. INTRINSIC VALUE

Karyopharm Therapeutics Inc., a commercial-stage pharmaceutical company, discovers, develops, and commercializes drugs directed against nuclear export for the treatment of cancer and other diseases. The company discovers, develops, and commercializes novel and Selective Inhibitor of Nuclear Export (SINE) compounds function by binding with and inhibiting the nuclear export protein XPO1. Its lead compound, include XPOVIO in combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myeloma, in combination with dexamethasone for the treatment of adult patients with heavily pretreated multiple myeloma, and for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma. The company has license agreement with Menarini Group to develop and commercialize NEXPOVIO for human oncology indications in Europe, including the United Kingdom; Latin America; and other countries.[ Read More ]

The intrinsic value of one KPTI stock under the base case scenario is HIDDEN Compared to the current market price of 0.814 USD, Karyopharm Therapeutics Inc. is HIDDEN

2. FUNDAMENTAL ANALYSIS

Price Chart KPTI

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FINANCIALS
146 M REVENUE
-7.03%
-130 M OPERATING INCOME
8.90%
-143 M NET INCOME
13.43%
-92.7 M OPERATING CASH FLOW
38.00%
7.94 M INVESTING CASH FLOW
107.62%
1.12 M FINANCING CASH FLOW
-99.42%
38.8 M REVENUE
-9.36%
-26.3 M OPERATING INCOME
6.53%
-32.1 M NET INCOME
-134.80%
-19.5 M OPERATING CASH FLOW
49.47%
7.47 M INVESTING CASH FLOW
-85.42%
0 FINANCING CASH FLOW
0.00%
Balance Sheet Decomposition Karyopharm Therapeutics Inc.
image
Current Assets 234 M
Cash & Short-Term Investments 192 M
Receivables 27 M
Other Current Assets 14.9 M
Non-Current Assets 6.52 M
Long-Term Investments 0
PP&E 4.88 M
Other Non-Current Assets 1.64 M
Current Liabilities 69.5 M
Accounts Payable 3.12 M
Short-Term Debt 6.62 M
Other Current Liabilities 59.7 M
Non-Current Liabilities 307 M
Long-Term Debt 174 M
Other Non-Current Liabilities 133 M
EFFICIENCY
Earnings Waterfall Karyopharm Therapeutics Inc.
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Revenue 146 M
Cost Of Revenue 4.94 M
Gross Profit 141 M
Operating Expenses 271 M
Operating Income -130 M
Other Expenses 13.6 M
Net Income -143 M
RATIOS
96.62% GROSS MARGIN
96.62%
-88.71% OPERATING MARGIN
-88.71%
-97.99% NET MARGIN
-97.99%
105.06% ROE
105.06%
-59.52% ROA
-59.52%
-341.48% ROIC
-341.48%
FREE CASH FLOW ANALYSIS
Free Cash Flow Analysis Karyopharm Therapeutics Inc.
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Net Income -143 M
Depreciation & Amortization 530 K
Capital Expenditures 0
Stock-Based Compensation 21.7 M
Change in Working Capital 31.4 M
Others 6.48 M
Free Cash Flow -92.7 M
3. WALL STREET ANALYSTS ESTIMATES
Wall Street Analysts Price Targets Karyopharm Therapeutics Inc.
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Wall Street analysts predict an average 1-year price target for KPTI of $6.6 , with forecasts ranging from a low of $3 to a high of $14 .
KPTI Lowest Price Target Wall Street Target
3 USD 268.55%
KPTI Average Price Target Wall Street Target
6.6 USD 710.81%
KPTI Highest Price Target Wall Street Target
14 USD 1619.90%
4. DIVIDEND ANALYSIS
0.00% DIVIDEND YIELD
0 USD DIVIDEND PER SHARE
5. COMPETITION
6. Ownership
Insider Ownership Karyopharm Therapeutics Inc.
image
Sold
0-3 MONTHS
21 K USD 4
3-6 MONTHS
1.46 M USD 4
6-9 MONTHS
297 K USD 6
9-12 MONTHS
19.3 K USD 2
Bought
0 USD 0
0-3 MONTHS
0 USD 0
3-6 MONTHS
0 USD 0
6-9 MONTHS
0 USD 0
9-12 MONTHS
Date Value Insider Amount Avg Price
1 week ago
Nov 05, 2024
Sell 3.35 K USD
Paulson Richard A.
President and CEO
- 3675
0.9106 USD
1 month ago
Oct 04, 2024
Sell 3.17 K USD
Paulson Richard A.
President and CEO
- 3607
0.8793 USD
2 months ago
Sep 04, 2024
Sell 2.87 K USD
Mano Michael
SVP, General Counsel&Secretary
- 3971
0.7218 USD
2 months ago
Sep 04, 2024
Sell 2.65 K USD
Paulson Richard A.
President and CEO
- 3667
0.7218 USD
2 months ago
Sep 04, 2024
Sell 5.09 K USD
Mason Michael
EVP, CFO & Treasurer
- 7050
0.7218 USD
2 months ago
Sep 04, 2024
Sell 3.87 K USD
Cheng Sohanya Roshan
EVP & Chief Commercial Officer
- 5356
0.7218 USD
3 months ago
Aug 06, 2024
Sell 3.36 K USD
Paulson Richard A.
President and CEO
- 3608
0.9299 USD
3 months ago
Jul 30, 2024
Sell 3.06 K USD
Poulton Stuart
EVP, Chief Development Officer
- 2883
1.06 USD
4 months ago
Jul 05, 2024
Sell 3.08 K USD
Paulson Richard A.
President and CEO
- 3616
0.851 USD
5 months ago
Jun 05, 2024
Sell 444 K USD
PAKIANATHAN DEEPIKA
Director
- 463518
0.9582 USD
5 months ago
Jun 06, 2024
Sell 115 K USD
PAKIANATHAN DEEPIKA
Director
- 117307
0.9828 USD
5 months ago
Jun 05, 2024
Sell 4.34 K USD
PAKIANATHAN DEEPIKA
Director
- 4526
0.9582 USD
5 months ago
Jun 06, 2024
Sell 1.13 K USD
PAKIANATHAN DEEPIKA
Director
- 1145
0.9828 USD
5 months ago
Jun 07, 2024
Sell 2.13 K USD
PAKIANATHAN DEEPIKA
Director
- 2240
0.9507 USD
5 months ago
Jun 04, 2024
Sell 645 USD
Mason Michael
EVP, CFO & Treasurer
- 652
0.99 USD
5 months ago
Jun 04, 2024
Sell 3.56 K USD
Paulson Richard A.
President and CEO
- 3592
0.99 USD
5 months ago
May 31, 2024
Sell 193 K USD
PAKIANATHAN DEEPIKA
Director
- 202418
0.954 USD
5 months ago
Jun 03, 2024
Sell 358 K USD
PAKIANATHAN DEEPIKA
Director
- 357256
1.0007 USD
5 months ago
Jun 04, 2024
Sell 322 K USD
PAKIANATHAN DEEPIKA
Director
- 337742
0.9521 USD
5 months ago
May 31, 2024
Sell 1.89 K USD
PAKIANATHAN DEEPIKA
Director
- 1976
0.954 USD
5 months ago
Jun 03, 2024
Sell 3.49 K USD
PAKIANATHAN DEEPIKA
Director
- 3488
1.0007 USD
5 months ago
Jun 04, 2024
Sell 3.14 K USD
PAKIANATHAN DEEPIKA
Director
- 3298
0.9521 USD
6 months ago
May 06, 2024
Sell 4.04 K USD
Paulson Richard A.
President and CEO
- 3576
1.13 USD
6 months ago
Apr 22, 2024
Sell 7.94 K USD
Rangwala Reshma
EVP & Chief Medical Officer
- 6789
1.17 USD
7 months ago
Apr 04, 2024
Sell 4.6 K USD
Paulson Richard A.
President and CEO
- 3563
1.29 USD
8 months ago
Mar 05, 2024
Sell 4.64 K USD
Paulson Richard A.
President and CEO
- 3573
1.3 USD
8 months ago
Feb 29, 2024
Sell 18.3 K USD
Rangwala Reshma
EVP & Chief Medical Officer
- 15667
1.17 USD
8 months ago
Mar 01, 2024
Sell 7.16 K USD
Rangwala Reshma
EVP & Chief Medical Officer
- 5969
1.2 USD
8 months ago
Feb 29, 2024
Sell 19.1 K USD
Poulton Stuart
EVP, Chief Development Officer
- 16311
1.17 USD
8 months ago
Mar 01, 2024
Sell 7.39 K USD
Poulton Stuart
EVP, Chief Development Officer
- 6155
1.2 USD
8 months ago
Feb 29, 2024
Sell 32.4 K USD
Mason Michael
EVP, CFO & Treasurer
- 27687
1.17 USD
8 months ago
Mar 01, 2024
Sell 7.39 K USD
Mason Michael
EVP, CFO & Treasurer
- 6162
1.2 USD
8 months ago
Feb 29, 2024
Sell 19.9 K USD
Mano Michael
SVP, General Counsel&Secretary
- 16973
1.17 USD
8 months ago
Mar 01, 2024
Sell 4.29 K USD
Mano Michael
SVP, General Counsel&Secretary
- 3576
1.2 USD
8 months ago
Feb 29, 2024
Sell 25.6 K USD
Cheng Sohanya Roshan
EVP & Chief Commercial Officer
- 21840
1.17 USD
8 months ago
Mar 01, 2024
Sell 6.13 K USD
Cheng Sohanya Roshan
EVP & Chief Commercial Officer
- 5109
1.2 USD
8 months ago
Feb 29, 2024
Sell 94.1 K USD
Paulson Richard A.
President and CEO
- 80470
1.17 USD
8 months ago
Mar 01, 2024
Sell 23.2 K USD
Paulson Richard A.
President and CEO
- 19374
1.2 USD
8 months ago
Feb 27, 2024
Sell 3.37 K USD
Mason Michael
EVP, CFO & Treasurer
- 2545
1.3238 USD
9 months ago
Feb 15, 2024
Sell 7.64 K USD
Poulton Stuart
EVP, Chief Development Officer
- 5748
1.33 USD
9 months ago
Feb 15, 2024
Sell 139 USD
Poulton Stuart
EVP, Chief Development Officer
- 99
1.4 USD
9 months ago
Feb 06, 2024
Sell 6.67 K USD
Mason Michael
EVP, CFO & Treasurer
- 4205
1.5865 USD
9 months ago
Feb 06, 2024
Sell 6.37 K USD
Paulson Richard A.
President and CEO
- 4012
1.5865 USD
10 months ago
Jan 04, 2024
Sell 3.37 K USD
Paulson Richard A.
President and CEO
- 4114
0.82 USD
11 months ago
Dec 04, 2023
Sell 2.86 K USD
Paulson Richard A.
President and CEO
- 3622
0.79 USD
1 year ago
Nov 06, 2023
Sell 3.32 K USD
Paulson Richard A.
President and CEO
- 3606
0.9203 USD
1 year ago
Oct 04, 2023
Sell 4.56 K USD
Paulson Richard A.
President and CEO
- 3589
1.27 USD
1 year ago
Sep 12, 2023
Bought 50 K USD
BOHLIN GAREN G
Director
+ 41140
1.215 USD
1 year ago
Sep 05, 2023
Sell 4.73 K USD
Paulson Richard A.
President and CEO
- 3558
1.33 USD
1 year ago
Sep 05, 2023
Sell 84.5 USD
Paulson Richard A.
President and CEO
- 64
1.32 USD
1 year ago
Sep 01, 2023
Sell 9.2 K USD
Mason Michael
EVP, CFO & Treasurer
- 6913
1.3313 USD
1 year ago
Sep 01, 2023
Sell 5.18 K USD
Mano Michael
SVP, General Counsel&Secretary
- 3888
1.3313 USD
1 year ago
Sep 01, 2023
Sell 9.87 K USD
Cheng Sohanya Roshan
EVP & Chief Commercial Officer
- 7415
1.3313 USD
1 year ago
Aug 07, 2023
Sell 6.4 K USD
Paulson Richard A.
President and CEO
- 3722
1.72 USD
1 year ago
Jul 28, 2023
Sell 4.84 K USD
Poulton Stuart
EVP, Chief Development Officer
- 2845
1.7 USD
1 year ago
Jul 05, 2023
Sell 6.09 K USD
Paulson Richard A.
President and CEO
- 3538
1.72 USD
1 year ago
Jun 08, 2023
Sell 4.32 K USD
Cheng Sohanya Roshan
EVP & Chief Commercial Officer
- 1839
2.35 USD
1 year ago
Jun 05, 2023
Sell 7.92 K USD
Paulson Richard A.
President and CEO
- 3536
2.2404 USD
1 year ago
Jun 02, 2023
Sell 1.4 K USD
Mason Michael
EVP, CFO & Treasurer
- 631
2.22 USD
1 year ago
May 04, 2023
Sell 12.8 K USD
Paulson Richard A.
President and CEO
- 3805
3.3516 USD
1 year ago
Apr 20, 2023
Sell 463 USD
Rangwala Reshma
EVP & Chief Medical Officer
- 115
4.0267 USD
1 year ago
Apr 20, 2023
Sell 27 K USD
Rangwala Reshma
EVP & Chief Medical Officer
- 6655
4.05 USD
1 year ago
Apr 04, 2023
Sell 13.9 K USD
Paulson Richard A.
President and CEO
- 3497
3.97 USD
1 year ago
Mar 06, 2023
Sell 11.1 K USD
Paulson Richard A.
President and CEO
- 3506
3.16 USD
1 year ago
Mar 01, 2023
Sell 19.3 K USD
Mitchener Stephen
SVP, Chief Business Officer
- 6357
3.0292 USD
1 year ago
Mar 01, 2023
Sell 20.8 K USD
Mano Michael
SVP, General Counsel&Secretary
- 6878
3.0292 USD
1 year ago
Mar 01, 2023
Sell 34 K USD
Cheng Sohanya Roshan
EVP & Chief Commercial Officer
- 11239
3.0292 USD
1 year ago
Mar 01, 2023
Sell 33.9 K USD
Mason Michael
EVP, CFO & Treasurer
- 11205
3.0292 USD
1 year ago
Mar 01, 2023
Sell 100 K USD
Paulson Richard A.
President and CEO
- 33033
3.0292 USD
1 year ago
Feb 27, 2023
Sell 8.51 K USD
Mason Michael
EVP, CFO & Treasurer
- 2802
3.0368 USD
1 year ago
Feb 15, 2023
Sell 18.1 K USD
Poulton Stuart
EVP, Chief Development Officer
- 5665
3.19 USD
1 year ago
Feb 15, 2023
Sell 25.8 USD
Poulton Stuart
EVP, Chief Development Officer
- 8
3.23 USD
1 year ago
Feb 15, 2023
Sell 619 USD
Poulton Stuart
EVP, Chief Development Officer
- 196
3.16 USD
1 year ago
Feb 06, 2023
Sell 14.1 K USD
Mason Michael
EVP, CFO & Treasurer
- 4141
3.4 USD
1 year ago
Feb 06, 2023
Sell 13.4 K USD
Paulson Richard A.
President and CEO
- 3950
3.4 USD
1 year ago
Jan 04, 2023
Sell 12.8 K USD
Paulson Richard A.
President and CEO
- 3922
3.27 USD
1 year ago
Dec 05, 2022
Sell 18 K USD
Paulson Richard A.
President and CEO
- 3490
5.17 USD
2 years ago
Nov 04, 2022
Sell 15.9 K USD
Paulson Richard A.
President and CEO
- 3493
4.54 USD
2 years ago
Oct 04, 2022
Sell 20.5 K USD
Paulson Richard A.
President and CEO
- 3488
5.87 USD
2 years ago
Sep 08, 2022
Sell 84.1 USD
Paulson Richard A.
President and CEO
- 16
5.2563 USD
2 years ago
Sep 08, 2022
Sell 18.1 K USD
Paulson Richard A.
President and CEO
- 3463
5.23 USD
2 years ago
Aug 04, 2022
Sell 10.4 K USD
Paulson Richard A.
President and CEO
- 2314
4.48 USD
2 years ago
Jul 08, 2022
Sell 10.9 K USD
Paulson Richard A.
President and CEO
- 2115
5.1762 USD
2 years ago
Jun 13, 2022
Sell 353 USD
Cheng Sohanya Roshan
Chief Commercial Officer
- 66
5.345 USD
2 years ago
Jun 08, 2022
Sell 2.1 M USD
PAKIANATHAN DEEPIKA
Director
- 322825
6.5033 USD
2 years ago
Jun 09, 2022
Sell 1.29 M USD
PAKIANATHAN DEEPIKA
Director
- 209455
6.1798 USD
2 years ago
Jun 10, 2022
Sell 7.77 K USD
PAKIANATHAN DEEPIKA
Director
- 1294
6.0019 USD
2 years ago
Jun 08, 2022
Sell 20.5 K USD
PAKIANATHAN DEEPIKA
Director
- 3152
6.5033 USD
2 years ago
Jun 09, 2022
Sell 12.6 K USD
PAKIANATHAN DEEPIKA
Director
- 2045
6.1798 USD
2 years ago
Jun 08, 2022
Sell 78 USD
PAKIANATHAN DEEPIKA
director:
- 13
6.0019 USD
2 years ago
Jun 07, 2022
Sell 14.6 K USD
Paulson Richard A.
President and CEO
- 2542
5.7602 USD
2 years ago
Jun 03, 2022
Sell 3.61 K USD
Mason Michael
EVP, CFO, Treasurer
- 598
6.04 USD
2 years ago
Jun 03, 2022
Sell 18.2 USD
Mason Michael
EVP, CFO, Treasurer
- 3
6.067 USD
2 years ago
May 04, 2022
Sell 3.96 K USD
Paulson Richard A.
President and CEO
- 633
6.2614 USD
2 years ago
May 04, 2022
Sell 174 K USD
Paulson Richard A.
President and CEO
- 27869
6.2272 USD
2 years ago
Feb 28, 2022
Sell 17 K USD
Frenkel Ran
EVP, Chief Dev. Officer
- 1663
10.2376 USD
2 years ago
Feb 28, 2022
Sell 24.5 K USD
Mason Michael
EVP, CFO & Treasurer
- 2398
10.2375 USD
2 years ago
Feb 28, 2022
Sell 63.7 K USD
Shacham Sharon
Chief Scientific Officer
- 6226
10.2375 USD
2 years ago
Feb 28, 2022
Sell 63.7 K USD
Shacham Sharon
Chief Scientific Officer
- 6226
10.2375 USD
2 years ago
Feb 28, 2022
Sell 63.7 K USD
Kauffman Michael
Director
- 6226
10.2375 USD
2 years ago
Feb 28, 2022
Sell 63.7 K USD
Kauffman Michael
Director
- 6226
10.2375 USD
2 years ago
Feb 17, 2022
Sell 15.8 K USD
Shah Jatin
EVP, Chief Medical Officer
- 1306
12.1234 USD
2 years ago
Feb 17, 2022
Sell 35.5 K USD
Frenkel Ran
EVP, Chief Dev. Officer
- 2929
12.1234 USD
2 years ago
Feb 17, 2022
Sell 110 K USD
Shacham Sharon
Chief Scientific Officer
- 9088
12.1234 USD
2 years ago
Feb 17, 2022
Sell 110 K USD
Shacham Sharon
Chief Scientific Officer
- 9079
12.1234 USD
2 years ago
Feb 17, 2022
Sell 110 K USD
Kauffman Michael
Director
- 9088
12.1234 USD
2 years ago
Feb 17, 2022
Sell 110 K USD
Kauffman Michael
Director
- 9079
12.1234 USD
2 years ago
Feb 07, 2022
Sell 16.8 K USD
Shah Jatin
EVP, Chief Medical Officer
- 1704
9.862 USD
2 years ago
Feb 07, 2022
Sell 19.6 K USD
Frenkel Ran
EVP, Chief Dev. Officer
- 1991
9.862 USD
2 years ago
Feb 07, 2022
Sell 38.9 K USD
Mason Michael
EVP, CFO & Treasurer
- 3947
9.862 USD
2 years ago
Feb 07, 2022
Sell 66.1 K USD
Kauffman Michael
Director
- 6707
9.862 USD
2 years ago
Feb 07, 2022
Sell 66.7 K USD
Kauffman Michael
Director
- 6764
9.862 USD
2 years ago
Feb 07, 2022
Sell 66.1 K USD
Shacham Sharon
Chief Scientific Officer
- 6707
9.862 USD
2 years ago
Feb 07, 2022
Sell 66.7 K USD
Shacham Sharon
Chief Scientific Officer
- 6764
9.862 USD
2 years ago
Dec 02, 2021
Sell 3.34 K USD
Mitchener Stephen
SVP, Chief Business Officer
- 499
6.69 USD
3 years ago
Jun 02, 2021
Sell 4.91 K USD
Mitchener Stephen
SVP, Chief Business Officer
- 528
9.29 USD
3 years ago
May 07, 2021
Bought 200 K USD
Shah Jatin
EVP, Chief Medical Officer
+ 23250
8.6018 USD
3 years ago
May 06, 2021
Bought 31.3 K USD
BOHLIN GAREN G
Director
+ 4000
7.82 USD
3 years ago
Mar 18, 2021
Sell 49.6 K USD
Shacham Sharon
President & CSO
- 4000
12.3882 USD
3 years ago
Mar 18, 2021
Sell 49.6 K USD
Kauffman Michael
Chief Executive Officer
- 4000
12.3882 USD
3 years ago
Feb 18, 2021
Sell 17.6 K USD
Shah Jatin
EVP, Chief Medical Officer
- 1186
14.8312 USD
3 years ago
Feb 18, 2021
Sell 42.8 K USD
Frenkel Ran
EVP, Chief Dev. Officer
- 2887
14.8312 USD
3 years ago
Feb 18, 2021
Sell 141 K USD
Shacham Sharon
President & CSO
- 9495
14.8312 USD
3 years ago
Feb 18, 2021
Sell 141 K USD
Shacham Sharon
President & CSO
- 9495
14.8312 USD
3 years ago
Feb 18, 2021
Sell 141 K USD
Kauffman Michael
Chief Executive Officer
- 9495
14.8312 USD
3 years ago
Feb 18, 2021
Sell 141 K USD
Kauffman Michael
Chief Executive Officer
- 9495
14.8312 USD
3 years ago
Feb 11, 2021
Sell 31.8 K USD
Lewis Tanya
EVP, Chief Reg. Affairs
- 2046
15.5191 USD
3 years ago
Feb 11, 2021
Sell 27.1 K USD
Shah Jatin
EVP, Chief Medical Officer
- 1748
15.5191 USD
3 years ago
Feb 11, 2021
Sell 31.8 K USD
Frenkel Ran
EVP, Chief Dev. Officer
- 2046
15.519 USD
3 years ago
Feb 11, 2021
Sell 44.4 K USD
Mason Michael
SVP, CFO & Treasurer
- 2858
15.5191 USD
3 years ago
Feb 11, 2021
Sell 103 K USD
Shacham Sharon
President & CSO
- 6642
15.519 USD
3 years ago
Feb 11, 2021
Sell 102 K USD
Shacham Sharon
President & CSO
- 6601
15.519 USD
3 years ago
Feb 11, 2021
Sell 103 K USD
Kauffman Michael
Chief Executive Officer
- 6642
15.519 USD
3 years ago
Feb 11, 2021
Sell 102 K USD
Kauffman Michael
Chief Executive Officer
- 6601
15.519 USD
3 years ago
Dec 18, 2020
Sell 90 K USD
Mirza Mansoor Raza
Director
- 5000
18 USD
3 years ago
Dec 07, 2020
Sell 80.2 K USD
Mirza Mansoor Raza
Director
- 5000
16.0461 USD
3 years ago
Dec 07, 2020
Sell 80.2 K USD
Mirza Mansoor Raza
Director
- 5000
16.0453 USD
3 years ago
Dec 07, 2020
Sell 80.2 K USD
Mirza Mansoor Raza
Director
- 5000
16.0445 USD
3 years ago
Dec 07, 2020
Sell 80.7 K USD
Mirza Mansoor Raza
Director
- 5000
16.1407 USD
3 years ago
Dec 01, 2020
Sell 1.38 M USD
Primiano Christopher Brett
EVP, CBO, GC & Secretary
- 78124
17.66 USD
3 years ago
Dec 01, 2020
Sell 1.02 M USD
Primiano Christopher Brett
EVP, CBO, GC & Secretary
- 58937
17.35 USD
4 years ago
Oct 30, 2020
Sell 3.52 K USD
Lewis Tanya
EVP,Chief Reg.&Quality Officer
- 226
15.58 USD
4 years ago
Jul 15, 2020
Sell 11.5 K USD
Shah Jatin
EVP, Chief Medical Officer
- 589
19.46 USD
4 years ago
Nov 02, 2020
Sell 11.5 K USD
Primiano Christopher Brett
EVP, CBO, GC & Secretary
- 772
14.92 USD
4 years ago
Oct 13, 2020
Sell 12.4 K USD
Primiano Christopher Brett
EVP, CBO, GC & Secretary
- 721
17.2 USD
4 years ago
Oct 13, 2020
Sell 650 K USD
Primiano Christopher Brett
EVP, CBO, GC & Secretary
- 38550
16.85 USD
4 years ago
Oct 12, 2020
Sell 112 K USD
Kauffman Michael
Chief Executive Officer
- 7500
14.891 USD
4 years ago
Oct 12, 2020
Sell 112 K USD
Shacham Sharon
President & CSO
- 7500
14.891 USD
4 years ago
Sep 08, 2020
Sell 151 K USD
Primiano Christopher Brett
EVP, CBO, GC & Secretary
- 10054
14.98 USD
4 years ago
Aug 26, 2020
Bought 109 K USD
DEMAREE JOHN
Chief Commercial Officer
+ 7500
14.535 USD
4 years ago
Aug 17, 2020
Sell 22.2 K USD
Kauffman Michael
Chief Executive Officer
- 1477
15 USD
4 years ago
Aug 17, 2020
Sell 22.2 K USD
Shacham Sharon
President & CSO
- 1477
15 USD
4 years ago
Jul 15, 2020
Sell 146 K USD
Kauffman Michael
Chief Executive Officer
- 7500
19.4297 USD
4 years ago
Jul 15, 2020
Sell 146 K USD
Shacham Sharon
President & CSO
- 7500
19.4297 USD
4 years ago
Jul 09, 2020
Sell 146 K USD
Kauffman Michael
Chief Executive Officer
- 7500
19.5316 USD
4 years ago
Jul 10, 2020
Sell 137 K USD
Kauffman Michael
Chief Executive Officer
- 7200
18.976 USD
4 years ago
Jul 10, 2020
Sell 5.91 K USD
Kauffman Michael
Chief Executive Officer
- 300
19.7067 USD
4 years ago
Jul 09, 2020
Sell 146 K USD
Shacham Sharon
President & CSO
- 7500
19.5316 USD
4 years ago
Jul 10, 2020
Sell 137 K USD
Shacham Sharon
President & CSO
- 7200
18.976 USD
4 years ago
Jul 10, 2020
Sell 5.91 K USD
Shacham Sharon
President & CSO
- 300
19.7067 USD
4 years ago
Jun 22, 2020
Sell 150 K USD
Kauffman Michael
Chief Executive Officer
- 7500
20 USD
4 years ago
Jun 22, 2020
Sell 150 K USD
Shacham Sharon
President & CSO
- 7500
20 USD
4 years ago
Jun 15, 2020
Sell 117 K USD
Kauffman Michael
Chief Executive Officer
- 7143
16.3791 USD
4 years ago
Jun 15, 2020
Sell 5.78 K USD
Kauffman Michael
Chief Executive Officer
- 357
16.2 USD
4 years ago
Jun 15, 2020
Sell 117 K USD
Shacham Sharon
President & CSO
- 7143
16.3791 USD
4 years ago
Jun 15, 2020
Sell 5.78 K USD
Shacham Sharon
President & CSO
- 357
16.2 USD
4 years ago
Jun 09, 2020
Sell 139 K USD
Kauffman Michael
Chief Executive Officer
- 7500
18.4994 USD
4 years ago
Jun 10, 2020
Sell 136 K USD
Kauffman Michael
Chief Executive Officer
- 7500
18.1259 USD
4 years ago
Jun 09, 2020
Sell 139 K USD
Shacham Sharon
President & CSO
- 7500
18.4994 USD
4 years ago
Jun 10, 2020
Sell 136 K USD
Shacham Sharon
President & CSO
- 7500
18.1259 USD
4 years ago
May 15, 2020
Sell 140 K USD
Kauffman Michael
Chief Executive Officer
- 7500
18.6454 USD
4 years ago
May 18, 2020
Sell 150 K USD
Kauffman Michael
Chief Executive Officer
- 7500
20 USD
4 years ago
May 15, 2020
Sell 140 K USD
Shacham Sharon
President & CSO
- 7500
18.6454 USD
4 years ago
May 18, 2020
Sell 150 K USD
Shacham Sharon
President & CSO
- 7500
20 USD
4 years ago
May 07, 2020
Sell 39.5 K USD
Frenkel Ran
Chief Dev Operations Officer
- 1974
20 USD
4 years ago
May 07, 2020
Sell 132 K USD
Primiano Christopher Brett
EVP, CBO, GC & Secretary
- 6714
19.6168 USD
4 years ago
May 07, 2020
Sell 58.9 K USD
Primiano Christopher Brett
EVP, CBO, GC & Secretary
- 2946
20 USD
4 years ago
May 07, 2020
Sell 147 K USD
Shacham Sharon
President & CSO
- 7500
19.6273 USD
4 years ago
May 07, 2020
Sell 147 K USD
Shacham Sharon
President & CSO
- 7500
19.6279 USD
4 years ago
May 07, 2020
Sell 147 K USD
Kauffman Michael
Chief Executive Officer
- 7500
19.6273 USD
4 years ago
May 07, 2020
Sell 147 K USD
Kauffman Michael
Chief Executive Officer
- 7500
19.6279 USD
4 years ago
Apr 08, 2020
Sell 186 K USD
Kauffman Michael
Chief Executive Officer
- 10000
18.6115 USD
4 years ago
Apr 09, 2020
Sell 206 K USD
Kauffman Michael
Chief Executive Officer
- 10000
20.6404 USD
4 years ago
Apr 08, 2020
Sell 186 K USD
Shacham Sharon
President & CSO
- 10000
18.6115 USD
4 years ago
Apr 09, 2020
Sell 206 K USD
Shacham Sharon
President & CSO
- 10000
20.6404 USD
4 years ago
Mar 09, 2020
Sell 158 K USD
Shacham Sharon
President & CSO
- 7000
22.5791 USD
4 years ago
Mar 09, 2020
Sell 67.1 K USD
Shacham Sharon
President & CSO
- 3000
22.3803 USD
4 years ago
Mar 10, 2020
Sell 175 K USD
Shacham Sharon
President & CSO
- 7932
22.1086 USD
4 years ago
Mar 10, 2020
Sell 46.8 K USD
Shacham Sharon
President & CSO
- 2068
22.6405 USD
4 years ago
Mar 09, 2020
Sell 158 K USD
Kauffman Michael
Chief Executive Officer
- 7000
22.5791 USD
4 years ago
Mar 09, 2020
Sell 67.1 K USD
Kauffman Michael
Chief Executive Officer
- 3000
22.3803 USD
4 years ago
Mar 10, 2020
Sell 175 K USD
Kauffman Michael
Chief Executive Officer
- 7932
22.1086 USD
4 years ago
Mar 10, 2020
Sell 46.8 K USD
Kauffman Michael
Chief Executive Officer
- 2068
22.6405 USD
4 years ago
Mar 02, 2020
Sell 176 K USD
Primiano Christopher Brett
EVP, CBO, GC & Secretary
- 7500
23.5 USD
4 years ago
Mar 02, 2020
Sell 280 K USD
Primiano Christopher Brett
EVP, CBO, GC & Secretary
- 10000
28 USD
4 years ago
Mar 02, 2020
Sell 216 K USD
Primiano Christopher Brett
EVP, CBO, GC & Secretary
- 9000
24.0032 USD
4 years ago
Mar 02, 2020
Sell 118 K USD
Mirza Mansoor Raza
Director
- 5000
23.5 USD
4 years ago
Feb 19, 2020
Sell 22.7 K USD
Shah Jatin
EVP, Chief Medical Officer
- 1375
16.4819 USD
4 years ago
Feb 19, 2020
Sell 49 K USD
Frenkel Ran
Chief Dev Operations Officer
- 2975
16.4819 USD
4 years ago
Feb 19, 2020
Sell 48.8 K USD
Primiano Christopher Brett
EVP, CBO, GC & Secretary
- 2961
16.4819 USD
4 years ago
Feb 19, 2020
Sell 145 K USD
Shacham Sharon
President & CSO
- 8817
16.4819 USD
4 years ago
Feb 19, 2020
Sell 145 K USD
Shacham Sharon
President & CSO
- 8817
16.4819 USD
4 years ago
Feb 19, 2020
Sell 145 K USD
Kauffman Michael
Chief Executive Officer
- 8817
16.4819 USD
4 years ago
Feb 19, 2020
Sell 145 K USD
Kauffman Michael
Chief Executive Officer
- 8817
16.4819 USD
4 years ago
Feb 10, 2020
Sell 169 K USD
Shacham Sharon
President & CSO
- 10000
16.9327 USD
4 years ago
Feb 11, 2020
Sell 174 K USD
Shacham Sharon
President & CSO
- 10000
17.4294 USD
4 years ago
Feb 10, 2020
Sell 169 K USD
Kauffman Michael
Chief Executive Officer
- 10000
16.9327 USD
4 years ago
Feb 11, 2020
Sell 174 K USD
Kauffman Michael
Chief Executive Officer
- 10000
17.4294 USD
4 years ago
Jan 09, 2020
Sell 41.1 K USD
Mirza Mansoor Raza
Director
- 2056
20 USD
4 years ago
Jan 08, 2020
Sell 186 K USD
Kauffman Michael
Chief Executive Officer
- 10000
18.5705 USD
4 years ago
Jan 09, 2020
Sell 192 K USD
Kauffman Michael
Chief Executive Officer
- 10000
19.188 USD
4 years ago
Jan 08, 2020
Sell 186 K USD
Shacham Sharon
President & CSO
- 10000
18.5705 USD
4 years ago
Jan 09, 2020
Sell 192 K USD
Shacham Sharon
President & CSO
- 10000
19.188 USD
4 years ago
Dec 27, 2019
Sell 58.9 K USD
Mirza Mansoor Raza
Director
- 2944
20 USD
4 years ago
Dec 27, 2019
Sell 100 K USD
Primiano Christopher Brett
EVP, CBO, GC & Secretary
- 5000
20 USD
4 years ago
Dec 18, 2019
Sell 85.9 K USD
Mirza Mansoor Raza
Director
- 5000
17.1781 USD
4 years ago
Dec 18, 2019
Sell 122 K USD
Mirza Mansoor Raza
Director
- 7121
17.1809 USD
4 years ago
Dec 09, 2019
Sell 85.1 K USD
Mirza Mansoor Raza
Director
- 5000
17.0216 USD
4 years ago
Dec 09, 2019
Sell 90.9 K USD
Mirza Mansoor Raza
Director
- 5342
17.021 USD
4 years ago
Dec 09, 2019
Sell 170 K USD
Kauffman Michael
Chief Executive Officer
- 10000
17.021 USD
4 years ago
Dec 10, 2019
Sell 160 K USD
Kauffman Michael
Chief Executive Officer
- 10000
15.9896 USD
4 years ago
Dec 09, 2019
Sell 170 K USD
Shacham Sharon
President & CSO
- 10000
17.021 USD
4 years ago
Dec 10, 2019
Sell 160 K USD
Shacham Sharon
President & CSO
- 10000
15.9896 USD
4 years ago
Dec 06, 2019
Sell 87.3 K USD
Primiano Christopher Brett
EVP, CBO, GC & Secretary
- 5000
17.4568 USD
4 years ago
Dec 06, 2019
Sell 87.3 K USD
Primiano Christopher Brett
EVP, CBO, GC & Secretary
- 5000
17.4512 USD
4 years ago
Dec 06, 2019
Sell 52.4 K USD
Primiano Christopher Brett
EVP, CBO, GC & Secretary
- 3000
17.456 USD
5 years ago
Nov 08, 2019
Sell 146 K USD
Kauffman Michael
Chief Executive Officer
- 10000
14.6254 USD
5 years ago
Nov 11, 2019
Sell 148 K USD
Kauffman Michael
Chief Executive Officer
- 10000
14.761 USD
5 years ago
Nov 08, 2019
Sell 146 K USD
Shacham Sharon
President & CSO
- 10000
14.6254 USD
5 years ago
Nov 11, 2019
Sell 148 K USD
Shacham Sharon
President & CSO
- 10000
14.761 USD
5 years ago
Nov 01, 2019
Sell 120 K USD
Shacham Sharon
President & CSO
- 10000
12 USD
5 years ago
Nov 01, 2019
Sell 120 K USD
Shacham Sharon
President & CSO
- 10000
12 USD
5 years ago
Nov 01, 2019
Sell 120 K USD
Kauffman Michael
Chief Executive Officer
- 10000
12 USD
5 years ago
Nov 01, 2019
Sell 120 K USD
Kauffman Michael
Chief Executive Officer
- 10000
12 USD
5 years ago
Sep 16, 2019
Sell 120 K USD
Kauffman Michael
Chief Executive Officer
- 10000
12 USD
5 years ago
Sep 16, 2019
Sell 120 K USD
Kauffman Michael
Chief Executive Officer
- 10000
12 USD
5 years ago
Sep 16, 2019
Sell 120 K USD
Shacham Sharon
President & CSO
- 10000
12 USD
5 years ago
Sep 16, 2019
Sell 120 K USD
Shacham Sharon
President & CSO
- 10000
12 USD
7. News
Karyopharm Therapeutics Inc. (KPTI) Q3 2024 Earnings Call Transcript Karyopharm Therapeutics Inc. (NASDAQ:KPTI ) Q3 2024 Earnings Conference Call November 5, 2024 8:00 AM ET Company Participants Elhan Webb - Senior Vice President, Investor Relations Richard Paulson - President and Chief Executive Officer Reshma Rangwala - Chief Medical Officer Sohanya Cheng - Chief Commercial Officer Michael Mason - Chief Financial Officer Conference Call Participants Brian Abrahams - RBC Capital Markets Ed White - H.C. Wainwright Peter Lawson - Barclays Maury Raycroft - Jefferies Operator Good morning. seekingalpha.com - 1 week ago
Antengene to Present Results from Two Late-Stage Studies of Selinexor Signaling Potential Clinical Breakthrough at ASH 2024 SHANGHAI and HONG KONG , Nov. 5, 2024 /PRNewswire/ -- Antengene Corporation Limited ("Antengene", SEHK: 6996.HK), a leading innovative, commercial-stage global biopharmaceutical company dedicated to discovering, developing and commercializing first-in-class and/or best-in-class medicines for cancer, today announced that it will present the latest data from two clinical studies of selinexor in two Posters at the 2024 American Society of Hematology Annual Meeting (ASH 2024), taking place on December 7-10, 2024, in San Diego, CA, the United States. Details on the Posters: Title: Weekly Selinexor, Bortizomib and Dexamethasone (SVd) Versus Twice Weekly Bortizomib and Dexamethasone (Vd) in Chinese Patients with Relapsed and Refractory Multiple Myeloma (RRMM): Primary Analysis of Phase III Bench Study Publication Number: 4748 Session: 654. prnewswire.com - 1 week ago
Karyopharm Therapeutics (KPTI) Reports Q3 Loss, Tops Revenue Estimates Karyopharm Therapeutics (KPTI) came out with a quarterly loss of $0.26 per share versus the Zacks Consensus Estimate of a loss of $0.27. This compares to loss of $0.30 per share a year ago. zacks.com - 1 week ago
Karyopharm Reports Third Quarter 2024 Financial Results and Highlights Recent Company Progress – Achieves Third Quarter 2024 Total Revenue of $38.8 Million and U.S. XPOVIO® (selinexor) Net Product Revenue of $29.5 Million; Continued Regulatory and Reimbursement Approvals Globally – – Following FDA Alignment, Absolute Change in Total Symptom Score (Abs-TSS) Will Replace TSS50 as a Co-Primary Endpoint in Phase 3 SENTRY Trial in JAKi Naïve Myelofibrosis (MF); Expected Top-line Data Read-out Remains on Track for 2H 2025 – – Narrows Full-Year 2024 Total Revenue Guidance Range to $145.0 Million to $155.0 Million; U.S. XPOVIO Net Product Revenue Guidance Range to $110.0 Million to $115.0 Million; R&D and SG&A Expense Guidance Range to $255.0 Million to $265.0 Million – NEWTON, Mass. , Nov. 5, 2024 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today reported financial results for the quarter ended September 30, 2024, and highlighted select corporate milestones and progress on its key clinical development programs. prnewswire.com - 1 week ago
Karyopharm Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) NEWTON, Mass. , Nov. 1, 2024 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced that the Company granted an aggregate of 10,500 restricted stock units (RSUs) to three newly-hired employees. prnewswire.com - 2 weeks ago
Karyopharm Therapeutics (KPTI) May Report Negative Earnings: Know the Trend Ahead of Q3 Release Karyopharm Therapeutics (KPTI) doesn't possess the right combination of the two key ingredients for a likely earnings beat in its upcoming report. Get prepared with the key expectations. zacks.com - 2 weeks ago
Karyopharm to Report Third Quarter 2024 Financial Results on November 5, 2024 -- Conference Call Scheduled for Tuesday, November 5, 2024, at 8:00 a.m. ET -- NEWTON, Mass. prnewswire.com - 2 weeks ago
Karyopharm Announces Favorable Change in Co-Primary Endpoint for Pivotal Phase 3 SENTRY Trial in Myelofibrosis Co-primary Endpoint Changed to Absolute Total Symptom Score (Abs-TSS) from Total Symptom Score Improvement of ≥ 50% (TSS50) Following Alignment with the FDA Spleen Volume Response Rate ≥ 35% (SVR35) Remains a Co-primary Endpoint Promising Improvement in Abs-TSS and SVR35 from Phase 1 Trial of Selinexor in Combination with Ruxolitinib Adds Confidence in Phase 3 SENTRY Trial Proactively Increasing Total Sample Size of the SENTRY Trial to Approximately 350 Patients to Further Increase the Statistical Powering; Expected Top-line Data Read-out Remains in 2H 2025 Company to Host a Conference Call Today at 8:00 a.m. ET Featuring Drs. prnewswire.com - 2 weeks ago
Antengene Announces XPOVIO® (selinexor) Approved for Its Third Indication in South Korea, Bringing Fresh Hope to Patients with MM in the Country This approval for XPOVIO® for the treatment of patients with multiple myeloma (MM) marks the third approved indication of the drug in South Korea. To date, XPOVIO® has already been included in national health insurance or reimbursement schemes in South Korea, the mainland of China, Australia and Singapore, and is expected to achieve national reimbursement coverage in more APAC markets. prnewswire.com - 4 weeks ago
Karyopharm Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) NEWTON, Mass. , Oct. 1, 2024 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced that the Company granted an aggregate of 17,000 restricted stock units (RSUs) to three newly-hired employees. prnewswire.com - 1 month ago
Antengene Announces XPOVIO® (selinexor) Approved for Commercialization in Thailand XPOVIO® is the first and only approved XPO1 inhibitor in Thailand. XPOVIO® has been approved for multiple indications in nine markets across the APAC region. prnewswire.com - 1 month ago
8. Profile Summary

Karyopharm Therapeutics Inc. KPTI

image
COUNTRY US
INDUSTRY Biotechnology
MARKET CAP $ 102 M
Dividend Yield 0.00%
Description Karyopharm Therapeutics Inc., a commercial-stage pharmaceutical company, discovers, develops, and commercializes drugs directed against nuclear export for the treatment of cancer and other diseases. The company discovers, develops, and commercializes novel and Selective Inhibitor of Nuclear Export (SINE) compounds function by binding with and inhibiting the nuclear export protein XPO1. Its lead compound, include XPOVIO in combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myeloma, in combination with dexamethasone for the treatment of adult patients with heavily pretreated multiple myeloma, and for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma. The company has license agreement with Menarini Group to develop and commercialize NEXPOVIO for human oncology indications in Europe, including the United Kingdom; Latin America; and other countries. Its oral SINE compounds also designed to force nuclear accumulation in the levels of multiple tumor suppressor and growth regulatory proteins. The company was incorporated in 2008 and is headquartered in Newton, Massachusetts.
Contact 85 Wells Avenue, Newton, MA, 02459 https://www.karyopharm.com
IPO Date Nov. 6, 2013
Employees 325
Officers Ms. Sohanya Cheng M.B.A. Executive Vice President, Chief Commercial Officer & Head of Business Development Dr. Mansoor Raza Mirza M.D. Clinical Consultant, Member of Scientific Advisory Board & Independent Director Mr. Stuart Poulton Executive Vice President & Chief Development Officer Dr. Reshma Rangwala M.D., Ph.D. Executive Vice President, Chief Medical Officer & Head of Research Dr. Sharon Shacham M.B.A., Ph.D. Co-Founder & Chairman of Scientific Advisory Board Mr. Cameron Peters Vice President of Finance, Assistant Treasurer & Principal Accounting Officer Ms. Elhan Webb C.F.A. Senior Vice President of Investor Relations Mr. Michael J. Mano J.D. Senior Vice President, General Counsel & Secretary Mr. James Accumanno J.D. Chief Compliance Officer Mr. Richard A. Paulson M.B.A. President, Chief Executive Officer & Director