Tyra Biosciences, Inc.

Tyra Biosciences, Inc.

TYRAยทNASDAQ

$28.69

-5.6%
HealthcareBiotechnology

Tyra Biosciences, Inc., a preclinical-stage biopharmaceutical company, focuses on developing therapies to overcome tumor resistance and enhance outcomes for patients with cancer. Its lead product candidate is TYRA-300, a selective inhibitor of fibroblast growth factor receptor (FGFR)3 for the treatment of muscle invasive bladder cancer. The company is also developing programs targeting FGFR2- intrahepatic cholangiocarcinoma,FGFR3-related achondroplasia, REarranged during transfection kinase, and FGFR4-related cancers. In addition, the company offers SNAP platform which enable rapid structural design through iterative molecular SNAPshots. Tyra Biosciences, Inc. was incorporated in 2018 and is based in Carlsbad, California.

At a Glance

Live Snapshot
Market Cap$1.71B
EPS-2.0100
P/E Ratio-14.27
Earnings Date08/06/2026
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Tyra Biosciences, Inc. Street Expectations Map

TYRA ยท NASDAQ

Wall Street analysts project that TYRA stock may rise significantly over the coming 12 months. The consensus 1-year price target stands at 50.50, with estimates ranging from a low of 42.00 to a high of 59.00.

Lowest Target
42.00
46.39%
Consensus Target
50.50
76.02%
Highest Target
59.00
105.65%

The consensus 1-year price target stands at 50.50, with estimates ranging from a low of 42.00 to a high of 59.00.

Analyst Consensus Analysis

Upside Potential

+76.0%

Substantial upside potential. Analysts see significant value gap, suggesting the stock may be materially undervalued at current levels.

Analyst Agreement

33.7% spread

Good consensus alignment. Moderate target spread reflects general agreement on value drivers with some variance in assumptions.

Analyst Conviction

High

Positive outlook with reasonable agreement. Analysts generally optimistic about prospects with manageable uncertainty.

Market Sentiment Insight

Monitor and evaluate: Current analyst consensus suggests limited conviction or near-term catalysts. Stay informed on company developments and reassess positioning as new information emerges.

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Tyra Biosciences, Inc. Forward Estimates of Revenue

TYRA ยท NASDAQ
Latest Revenue
0.00
FY 2025
Avg Estimate
687.43K
FY 2026
Estimate Range
687.43K - 687.43K
Analyst Spread

Forward Growth Analysis

Analyst Coverage4 Analysts

Limited coverage may indicate reduced institutional interest or information availability.

Estimate Spread0%

Narrow estimate range signals strong analyst consensus and predictable business outlook.

OutlookNeutral

Mixed signalsโ€”some positive indicators offset by concerns about growth or uncertainty.

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Tyra Biosciences, Inc. Forward Estimates of Net Income

TYRA ยท NASDAQ
Latest Net Income
-119.95M
FY 2025
Avg Estimate
-145.08M
FY 2026
Estimate Range
-150.17M - -103.28M
Analyst Spread

Forward Growth Analysis

Projected Growth-21.0%

Significant contraction projectedโ€”major business challenges or industry disruption likely.

Analyst Coverage4 Analysts

Limited coverage may indicate reduced institutional interest or information availability.

Estimate Spread32%

Moderate uncertainty in forecastsโ€”typical for companies with evolving business models.

OutlookCautious

Analyst skepticism evidentโ€”carefully evaluate risks before investment decisions.

Key Insight

Declining estimates with wide disagreement: Analysts projecting contraction without consensus signals significant business uncertaintyโ€”exercise caution.

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Tyra Biosciences, Inc. Forward Estimates of EPS

TYRA ยท NASDAQ
Latest EPS
-2.01
FY 2025
Avg Estimate
$-2.21
FY 2026
Estimate Range
$-2.62 - $-1.80
Analyst Spread

Forward Growth Analysis

Projected Growth-9.7%

Declining expectations indicate headwindsโ€”investigate whether temporary or structural issues.

Analyst Coverage7 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread37%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookCautious

Analyst skepticism evidentโ€”carefully evaluate risks before investment decisions.

Key Insight

Declining estimates with wide disagreement: Analysts projecting contraction without consensus signals significant business uncertaintyโ€”exercise caution.

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Tyra Biosciences, Inc. Forward Estimates of EBIT

TYRA ยท NASDAQ
Latest EBIT
-119.95M
FY 2025
Avg Estimate
0.00
FY 2026
Estimate Range
0.00 - 0.00
Analyst Spread

Forward Growth Analysis

Projected Growth+100.0%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage4 Analysts

Limited coverage may indicate reduced institutional interest or information availability.

OutlookNeutral

Mixed signalsโ€”some positive indicators offset by concerns about growth or uncertainty.

Key Insight

Limited coverage with volatile estimates: Few analysts covering despite significant projected changes may indicate information gaps or emerging risks.

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Tyra Biosciences, Inc. Forward Estimates of EBITDA

TYRA ยท NASDAQ
Latest EBITDA
-119.40M
FY 2025
Avg Estimate
0.00
FY 2026
Estimate Range
0.00 - 0.00
Analyst Spread

Forward Growth Analysis

Projected Growth+100.0%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage4 Analysts

Limited coverage may indicate reduced institutional interest or information availability.

OutlookNeutral

Mixed signalsโ€”some positive indicators offset by concerns about growth or uncertainty.

Key Insight

Limited coverage with volatile estimates: Few analysts covering despite significant projected changes may indicate information gaps or emerging risks.

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Tyra Biosciences, Inc. Forward Estimates of SG&A Expense

TYRA ยท NASDAQ
Latest SG&A Expense
29.83M
FY 2025
Avg Estimate
0.00
FY 2026
Estimate Range
0.00 - 0.00
Analyst Spread

Forward Growth Analysis

Projected Growth-100.0%

Significant contraction projectedโ€”major business challenges or industry disruption likely.

Analyst Coverage4 Analysts

Limited coverage may indicate reduced institutional interest or information availability.

OutlookCautious

Analyst skepticism evidentโ€”carefully evaluate risks before investment decisions.

Key Insight

Limited coverage with volatile estimates: Few analysts covering despite significant projected changes may indicate information gaps or emerging risks.

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Tyra Biosciences, Inc. Insider Positioning

TYRA ยท NASDAQ

During the last 12 months, insiders have purchased $27.26M and sold $10.97M worth of TYRA shares, resulting in $16.29M of net buying activity.

3 Months

Bought

0

0.00

Sold

14.3K

528.51K

Net Activity

-529K

-$529K

3-6 Months

Bought

0

0.00

Sold

27.1K

696.80K

Net Activity

-697K

-$697K

6-9 Months

Bought

701

6.40K

Sold

502.4K

9.11M

Net Activity

-9.1M

-$9.11M

9-12 Months

Bought

2.7M

27.25M

Sold

61.4K

628.26K

Net Activity

+26.6M

+$26.62M

Top Buyers

1
RCML

Ra Capital Management, L.P.

Director, 10 Percent Owner:

1.6M sharesโ€ข6 transactions

$15.32M

2
HT

Harris Todd

Director, Officer: President And Ceo

570.0K sharesโ€ข1 transactions

$6.13M

3
WDJ

Warner Douglas J

Officer: Chief Medical Officer

200.0K sharesโ€ข1 transactions

$2.15M

4
FA

Fuhrman Alan

Officer: Chief Financial Officer

170.7K sharesโ€ข2 transactions

$1.83M

5
BD

Bensen Daniel

Officer: Chief Operating Officer

170.0K sharesโ€ข1 transactions

$1.83M

Top Sellers

1
MRJ

More Robert J

Director

256.9K sharesโ€ข2 transactions

$5.25M

2
BD

Bensen Daniel

Officer: Chief Discovery Officer

272.6K sharesโ€ข8 transactions

$4.56M

3
KG

Kaplan Gilla

Director

75.7K sharesโ€ข6 transactions

$1.16M

Insider Activity Analysis

Net Insider Sentiment

Bullish

Positive insider sentiment with $16.29M net buying. Buying activity substantially exceeds selling, indicating insider confidence.

Buy/Sell Ratio

2.49:1

Strong buy/sell ratio. Buying is at least double the selling activity, suggesting robust insider confidence.

Recent Trend (3 Months)

$529K

Heavy recent selling activity. Recent insider sales notably exceed purchasesโ€”may warrant investigation into company developments.

Insider Participation

Moderate Buying

5 insider buyers vs. 3 sellers. More insiders buying than selling indicates positive sentiment.

Insider Activity Insight

Compelling insider conviction: The combination of strong buy/sell ratio and multiple buyers suggests insiders see attractive risk/reward. Consider this alongside fundamental analysis for confirmation.