Spyre Therapeutics, Inc.

Spyre Therapeutics, Inc.

SYREยทNASDAQ

$73.52

+8.3%
HealthcareBiotechnology

Spyre Therapeutics, Inc., a preclinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD). It develops SPY001, a human monoclonal immunoglobulin G1 antibody designed to bind selectively to the a4รŸ7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease). The company is also developing SPY002, a human monoclonal antibody (mAb)candidates designed to bind to tumor necrosis factor-like ligand 1A; and SPY120, a combination of SPY001 (anti-a4รŸ7) and SPY002 (anti-TL1A) antibodies, which are in preclinical studies. In addition, its other early-stage programs include SPY003, an anti-IL-23 mAb; SPY004, a novel mechanism of action (MOA) mAb; SPY130, a combination of anti-a4รŸ7 and anti-IL-23 mAbs; and SPY230, a combination of anti-TL1A and anti-IL-23 mAbs. The company was formerly known as Aeglea BioTherapeutics, Inc. and changed its name to Spyre Therapeutics, Inc. in November 2023. Spyre Therapeutics, Inc. was incorporated in 2013 and is based in Waltham, Massachusetts.

At a Glance

Live Snapshot
Market Cap$4.44B
EPS-1.9800
P/E Ratio-73.04
Earnings Date08/04/2026

No Dividend Yield Data

SYRE has not reported any dividend yield values in the available annual periods.

No Dividend Payout Ratio Data

SYRE has not reported any dividend payout ratio values in the available annual periods.

No Net Dividends Paid Data

SYRE has not reported any net dividends paid values in the available annual periods.

Spyre Therapeutics, Inc.

Spyre Therapeutics, Inc. Dividend History

SYRE ยท NASDAQ
10Y CAGR +0%
Latest $0
Annual $0
Stable dividend payments
Last Period: +0%

SYRE Dividend Payment History

SYRE ยท NASDAQ
DeclarationEx-DatePayment DateDividendAdjustedFrequencyGrowth
No dividend payment history available
syre

Spyre Therapeutics, Inc. Payout Ratio Analysis

SYRE ยท NASDAQ
Dividends Paid
0.00
2025
Net Income
-155.20M
2025
Payout Ratio
0.00%
2025

Dividend Sustainability Analysis

Payout Ratio
0.00%

Conservative payout with excellent safety margin. Company retains significant earnings for growth, acquisitions, or building cash reserves. Dividend is highly sustainable.

FCF Payout Ratio
0.0%

Negative free cash flow while paying dividends is a major red flag. Company burning cash and cannot sustain dividend without external financing.

Sustainability
At Risk

Dividend appears unsustainable based on current metrics. High probability of reduction or elimination. Proceed with caution.