Sionna Therapeutics, Inc.

Sionna Therapeutics, Inc.

SIONยทNASDAQ

$37.38

+1.8%
HealthcareBiotechnology

Sionna Therapeutics, Inc. is a biopharmaceutical company. The Company provides treatment paradigm for cystic fibrosis patients by developing medicines that normalize the function of the cystic fibrosis transmembrane conductance regulator.

At a Glance

Live Snapshot
Market Cap$1.69B
EPS-1.8800
P/E Ratio-19.88
Earnings Date08/10/2026
sion

Sionna Therapeutics, Inc. Street Expectations Map

SION ยท NASDAQ

Wall Street analysts project that SION stock may rise significantly over the coming 12 months. The consensus 1-year price target stands at 54.00, with estimates ranging from a low of 50.00 to a high of 58.00.

Lowest Target
50.00
33.78%
Consensus Target
54.00
44.48%
Highest Target
58.00
55.18%

The consensus 1-year price target stands at 54.00, with estimates ranging from a low of 50.00 to a high of 58.00.

Analyst Consensus Analysis

Upside Potential

+44.5%

Substantial upside potential. Analysts see significant value gap, suggesting the stock may be materially undervalued at current levels.

Analyst Agreement

14.8% spread

High analyst agreement. Narrow target range indicates strong consensus on valuation, suggesting clear investment thesis and predictable outlook.

Analyst Conviction

Very High

Strong buy conviction: High upside with tight consensus suggests compelling investment opportunity backed by analyst confidence.

Market Sentiment Insight

Rare opportunity: Exceptional upside potential with strong analyst consensus creates a compelling setup. The combination of significant price target premium and tight agreement suggests high-conviction undervaluation that may attract institutional capital.

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Sionna Therapeutics, Inc. Forward Estimates of Revenue

SION ยท NASDAQ
Latest Revenue
0.00
FY 2025
Avg Estimate
0.00
FY 2026
Estimate Range
0.00 - 0.00
Analyst Spread

Forward Growth Analysis

OutlookCautious

Analyst skepticism evidentโ€”carefully evaluate risks before investment decisions.

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Sionna Therapeutics, Inc. Forward Estimates of Net Income

SION ยท NASDAQ
Latest Net Income
-75.27M
FY 2025
Avg Estimate
-106.36M
FY 2026
Estimate Range
-128.60M - -71.08M
Analyst Spread

Forward Growth Analysis

Projected Growth-41.3%

Significant contraction projectedโ€”major business challenges or industry disruption likely.

Estimate Spread54%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookCautious

Analyst skepticism evidentโ€”carefully evaluate risks before investment decisions.

Key Insight

Declining estimates with wide disagreement: Analysts projecting contraction without consensus signals significant business uncertaintyโ€”exercise caution.

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Sionna Therapeutics, Inc. Forward Estimates of EPS

SION ยท NASDAQ
Latest EPS
-1.88
FY 2025
Avg Estimate
$-2.25
FY 2026
Estimate Range
$-2.91 - $-1.61
Analyst Spread

Forward Growth Analysis

Projected Growth-19.9%

Significant contraction projectedโ€”major business challenges or industry disruption likely.

Analyst Coverage6 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread58%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookCautious

Analyst skepticism evidentโ€”carefully evaluate risks before investment decisions.

Key Insight

Declining estimates with wide disagreement: Analysts projecting contraction without consensus signals significant business uncertaintyโ€”exercise caution.

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Sionna Therapeutics, Inc. Forward Estimates of EBIT

SION ยท NASDAQ
Latest EBIT
-88.98M
FY 2025
Avg Estimate
0.00
FY 2026
Estimate Range
0.00 - 0.00
Analyst Spread

Forward Growth Analysis

Projected Growth+100.0%

Strong growth expectations signal robust business momentum and market opportunity expansion.

OutlookNeutral

Mixed signalsโ€”some positive indicators offset by concerns about growth or uncertainty.

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Sionna Therapeutics, Inc. Forward Estimates of EBITDA

SION ยท NASDAQ
Latest EBITDA
-88.33M
FY 2025
Avg Estimate
0.00
FY 2026
Estimate Range
0.00 - 0.00
Analyst Spread

Forward Growth Analysis

Projected Growth+100.0%

Strong growth expectations signal robust business momentum and market opportunity expansion.

OutlookNeutral

Mixed signalsโ€”some positive indicators offset by concerns about growth or uncertainty.

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Sionna Therapeutics, Inc. Forward Estimates of SG&A Expense

SION ยท NASDAQ
Latest SG&A Expense
28.72M
FY 2025
Avg Estimate
0.00
FY 2026
Estimate Range
0.00 - 0.00
Analyst Spread

Forward Growth Analysis

Projected Growth-100.0%

Significant contraction projectedโ€”major business challenges or industry disruption likely.

OutlookCautious

Analyst skepticism evidentโ€”carefully evaluate risks before investment decisions.

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Sionna Therapeutics, Inc. Insider Positioning

SION ยท NASDAQ

During the last 12 months, insiders have sold $104.66M worth of SION shares, with no buying activity reported.

3 Months

Bought

0

0.00

Sold

1.7M

77.57M

Net Activity

-77.6M

-$77.57M

3-6 Months

Bought

0

0.00

Sold

392.6K

16.25M

Net Activity

-16.2M

-$16.25M

6-9 Months

Bought

0

0.00

Sold

246.5K

10.84M

Net Activity

-10.8M

-$10.84M

9-12 Months

Bought

0

0.00

Sold

0

0.00

Net Activity

+0

+$0

Top Buyers

No buying activity

Top Sellers

1
TPA

Thompson Peter A.

Director

1.0M sharesโ€ข18 transactions

$46.55M

2
OAL

Orbimed Advisors Llc

Director

1.0M sharesโ€ข18 transactions

$46.55M

3
TGAL

Tpg Gp A, Llc

10 Percent Owner

250.0K sharesโ€ข1 transactions

$10.00M

4
RCML

Ra Capital Management, L.P.

Director, 10 Percent Owner:

20.1K sharesโ€ข4 transactions

$795K

5
FJ

Fitzpatrick Jennifer

Officer: Chief Legal Officer

20.5K sharesโ€ข2 transactions

$762K

Insider Activity Analysis

Net Insider Sentiment

Bearish

Strong bearish signal with $104.66M net selling. Heavy insider selling may indicate concerns about valuation or near-term prospects.

Buy/Sell Ratio

0.00:1

Very poor ratio. Heavy selling with minimal buying suggests insiders may be concerned about valuation or outlook.

Recent Trend (3 Months)

$77.57M

Heavy recent selling activity. Recent insider sales notably exceed purchasesโ€”may warrant investigation into company developments.

Insider Participation

High Selling

5 insider sellers vs. 0 buyers. Widespread selling across multiple insiders may signal concerns.

Insider Activity Insight

Multiple red flags: Heavy selling, numerous sellers, and continued recent selling create a concerning pattern. Investigate fundamental drivers and consider whether company guidance or industry conditions have deteriorated.