Rhythm Pharmaceuticals, Inc.

Rhythm Pharmaceuticals, Inc.

RYTMยทNASDAQ

$84.71

+0.097%
HealthcareBiotechnology

Rhythm Pharmaceuticals, Inc., a commercial-stage biopharmaceutical company, focuses on the development and commercialization of therapeutics for the treatment of rare genetic diseases of obesity. The company's lead product candidate is IMCIVREE, a potent melanocortin-4 receptor for the treatment of pro-opiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1, leptin receptor (LEPR) deficiency obesity, and Bardet-Biedl and Alstrรถm syndrome. It is also developing setmelanotide, which is in Phase II clinical trials for treating POMC or LEPR heterozygous deficiency obesities, steroid receptor coactivator 1 deficiency obesity, SH2B1 deficiency obesity, MC4 receptor deficiency obesity, Smith-Magenis syndrome obesity, POMC epigenetic disorders, and other MC4R disorders. Rhythm Pharmaceuticals, Inc. has a collaborative research agreement with the Clinical Registry Investigating Bardet-Biedl Syndrome. The company was formerly known as Rhythm Metabolic, Inc. and changed its name to Rhythm Pharmaceuticals, Inc. in October 2015. Rhythm Pharmaceuticals, Inc. was founded in 2008 and is headquartered in Boston, Massachusetts.

At a Glance

Live Snapshot
Market Cap$5.81B
EPS-3.1100
P/E Ratio-27.24
Earnings Date08/04/2026
rytm

Rhythm Pharmaceuticals, Inc. Street Expectations Map

RYTM ยท NASDAQ

Wall Street analysts project that RYTM stock may rise significantly over the coming 12 months. The consensus 1-year price target stands at 140.20, with estimates ranging from a low of 125.00 to a high of 157.00.

Lowest Target
125.00
47.56%
Consensus Target
140.20
65.51%
Highest Target
157.00
85.34%

The consensus 1-year price target stands at 140.20, with estimates ranging from a low of 125.00 to a high of 157.00.

Analyst Consensus Analysis

Upside Potential

+65.5%

Substantial upside potential. Analysts see significant value gap, suggesting the stock may be materially undervalued at current levels.

Analyst Agreement

22.8% spread

Good consensus alignment. Moderate target spread reflects general agreement on value drivers with some variance in assumptions.

Analyst Conviction

Very High

Strong buy conviction: High upside with tight consensus suggests compelling investment opportunity backed by analyst confidence.

Market Sentiment Insight

Rare opportunity: Exceptional upside potential with strong analyst consensus creates a compelling setup. The combination of significant price target premium and tight agreement suggests high-conviction undervaluation that may attract institutional capital.

rytm

Rhythm Pharmaceuticals, Inc. Forward Estimates of Revenue

RYTM ยท NASDAQ
Latest Revenue
189.76M
FY 2025
Avg Estimate
292.52M
FY 2026
Estimate Range
246.04M - 362.26M
Analyst Spread

Forward Growth Analysis

Projected Growth+54.2%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage14 Analysts

Good analyst coverage ensures reliable estimates with diverse professional perspectives.

Estimate Spread40%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookPositive

Generally favorable outlook with reasonable growth prospects and analyst support.

rytm

Rhythm Pharmaceuticals, Inc. Forward Estimates of Net Income

RYTM ยท NASDAQ
Latest Net Income
-196.54M
FY 2025
Avg Estimate
-166.43M
FY 2026
Estimate Range
-233.62M - -44.80M
Analyst Spread

Forward Growth Analysis

Projected Growth+15.3%

Solid growth trajectory indicates healthy business performance and competitive positioning.

Analyst Coverage14 Analysts

Good analyst coverage ensures reliable estimates with diverse professional perspectives.

Estimate Spread113%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookPositive

Generally favorable outlook with reasonable growth prospects and analyst support.

Key Insight

High forecast uncertainty: Wide estimate range indicates analysts struggling to predict outcomesโ€”suggests elevated risk and potential volatility.

rytm

Rhythm Pharmaceuticals, Inc. Forward Estimates of EPS

RYTM ยท NASDAQ
Latest EPS
-3.11
FY 2025
Avg Estimate
$-2.69
FY 2026
Estimate Range
$-3.83 - $-0.73
Analyst Spread

Forward Growth Analysis

Projected Growth+13.6%

Solid growth trajectory indicates healthy business performance and competitive positioning.

Analyst Coverage11 Analysts

Good analyst coverage ensures reliable estimates with diverse professional perspectives.

Estimate Spread115%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookPositive

Generally favorable outlook with reasonable growth prospects and analyst support.

Key Insight

High forecast uncertainty: Wide estimate range indicates analysts struggling to predict outcomesโ€”suggests elevated risk and potential volatility.

rytm

Rhythm Pharmaceuticals, Inc. Forward Estimates of EBIT

RYTM ยท NASDAQ
Latest EBIT
-175.46M
FY 2025
Avg Estimate
-175.51M
FY 2026
Estimate Range
-217.36M - -147.62M
Analyst Spread

Forward Growth Analysis

Projected Growth-0.0%

Declining expectations indicate headwindsโ€”investigate whether temporary or structural issues.

Analyst Coverage14 Analysts

Good analyst coverage ensures reliable estimates with diverse professional perspectives.

Estimate Spread40%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookNeutral

Mixed signalsโ€”some positive indicators offset by concerns about growth or uncertainty.

Key Insight

Declining estimates with wide disagreement: Analysts projecting contraction without consensus signals significant business uncertaintyโ€”exercise caution.

rytm

Rhythm Pharmaceuticals, Inc. Forward Estimates of EBITDA

RYTM ยท NASDAQ
Latest EBITDA
-174.12M
FY 2025
Avg Estimate
-175.51M
FY 2026
Estimate Range
-217.36M - -147.62M
Analyst Spread

Forward Growth Analysis

Projected Growth-0.8%

Declining expectations indicate headwindsโ€”investigate whether temporary or structural issues.

Analyst Coverage14 Analysts

Good analyst coverage ensures reliable estimates with diverse professional perspectives.

Estimate Spread40%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookNeutral

Mixed signalsโ€”some positive indicators offset by concerns about growth or uncertainty.

Key Insight

Declining estimates with wide disagreement: Analysts projecting contraction without consensus signals significant business uncertaintyโ€”exercise caution.

rytm

Rhythm Pharmaceuticals, Inc. Forward Estimates of SG&A Expense

RYTM ยท NASDAQ
Latest SG&A Expense
194.94M
FY 2025
Avg Estimate
1.71B
FY 2026
Estimate Range
1.44B - 2.12B
Analyst Spread

Forward Growth Analysis

Projected Growth+777.3%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage14 Analysts

Good analyst coverage ensures reliable estimates with diverse professional perspectives.

Estimate Spread40%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookPositive

Generally favorable outlook with reasonable growth prospects and analyst support.

rytm

Rhythm Pharmaceuticals, Inc. Insider Positioning

RYTM ยท NASDAQ

During the last 12 months, insiders have sold $15.10M worth of RYTM shares, with no buying activity reported.

3 Months

Bought

0

0.00

Sold

4.6K

428.13K

Net Activity

-428K

-$428K

3-6 Months

Bought

0

0.00

Sold

13.6K

1.35M

Net Activity

-1.3M

-$1.35M

6-9 Months

Bought

0

0.00

Sold

42.2K

4.45M

Net Activity

-4.4M

-$4.45M

9-12 Months

Bought

0

0.00

Sold

97.9K

8.88M

Net Activity

-8.9M

-$8.88M

Top Buyers

No buying activity

Top Sellers

1
SHC

Smith Hunter C

Officer: Chief Financial Officer

56.1K sharesโ€ข6 transactions

$5.15M

2
SJ

Shulman Joseph

Officer: Chief Technical Officer

44.9K sharesโ€ข7 transactions

$4.70M

3
CPJ

Cramer Pamela J.

Officer: Chief Human Resources Officer

41.6K sharesโ€ข7 transactions

$3.88M

4
GCP

German Christopher Paul

Officer: Corporate Controller & Cao

15.7K sharesโ€ข5 transactions

$1.37M

5
GA

Garfield Alastair

Officer: Chief Scientific Officer

6 sharesโ€ข1 transactions

$387

Insider Activity Analysis

Net Insider Sentiment

Bearish

Strong bearish signal with $15.10M net selling. Heavy insider selling may indicate concerns about valuation or near-term prospects.

Buy/Sell Ratio

0.00:1

Very poor ratio. Heavy selling with minimal buying suggests insiders may be concerned about valuation or outlook.

Recent Trend (3 Months)

$428K

Heavy recent selling activity. Recent insider sales notably exceed purchasesโ€”may warrant investigation into company developments.

Insider Participation

High Selling

5 insider sellers vs. 0 buyers. Widespread selling across multiple insiders may signal concerns.

Insider Activity Insight

Multiple red flags: Heavy selling, numerous sellers, and continued recent selling create a concerning pattern. Investigate fundamental drivers and consider whether company guidance or industry conditions have deteriorated.