OT

OnKure Therapeutics, Inc.

OKUR·NASDAQ

$4.20

+1.9%
HealthcareBiotechnology

OnKure, Inc. engages in the discovery and development of oncology-precision medicines for the treatment of cancer. The company focuses on developing selective inhibitors of histone deacetylases. Its portfolio includes OKI-179, an inhibitor for the treatment of both hematological and solid tumors. The company was incorporated in 2011 and is based in Boulder, Colorado.

At a Glance

Live Snapshot
Market Cap$57.43M
EPS-4.4000
P/E Ratio-0.95
Earnings Date08/11/2026
-110.93%
Return on Invested Capital
114%
3Y-60.0%
5Y+187.0%
10Y+187.0%
-105.93%
Return on Equity
109%
3Y-295.0%
5Y-329.0%
10Y-329.0%
-95.81%
Return on Assets
109%
3Y-48.0%
5Y+172.0%
10Y+172.0%
OT

OnKure Therapeutics, Inc. Management Team

OKUR · NASDAQ
JA

Jason A. Leverone

Chief Financial Officer

Compensation

$565,258

Born 1974(Age 52)
male
SA

Samuel Agresta

Chief Medical Officer

Compensation

$650,371

Born 1973(Age 53)
DH

Dylan Hartley

Chief Scientific Officer

Born 1969(Age 57)
RN

Rogan Nunn

General Counsel & Secretary

male
NA

Nicholas A. Saccomano

President, Chief Executive Officer & Director

Compensation

$741,743

Born 1959(Age 67)
RA

Roberta Alton

Senior VP of Clinical Operations

female
JB

James Blake

Senior Vice President of Computational Drug Discovery

KS

Kevin S. Litwiler

Senior Vice President of DMPK & Clinical Pharmacology

ML

Mark L. Boys

Senior Vice President of Discovery Chemistry

o

OnKure Therapeutics, Inc. Insider Positioning

OKUR · NASDAQ

During the last 12 months, insiders have sold $5K worth of OKUR shares, with no buying activity reported.

3 Months

Bought

0

0.00

Sold

387

1.61K

Net Activity

-2K

-$2K

3-6 Months

Bought

0

0.00

Sold

389

1.15K

Net Activity

-1K

-$1K

6-9 Months

Bought

0

0.00

Sold

391

1.02K

Net Activity

-1K

-$1K

9-12 Months

Bought

0

0.00

Sold

391

931.00

Net Activity

-931

-$931

Top Buyers

No buying activity

Top Sellers

1
LJA

Leverone Jason A.

Officer: Chief Financial Officer

1.2K shares4 transactions

$4K

2
SNA

Saccomano Nicholas A

Director, Officer: President And Ceo

349 shares4 transactions

$1K

Insider Activity Analysis

Net Insider Sentiment

Bearish

Strong bearish signal with $5K net selling. Heavy insider selling may indicate concerns about valuation or near-term prospects.

Buy/Sell Ratio

0.00:1

Very poor ratio. Heavy selling with minimal buying suggests insiders may be concerned about valuation or outlook.

Recent Trend (3 Months)

$2K

Heavy recent selling activity. Recent insider sales notably exceed purchases—may warrant investigation into company developments.

Insider Participation

High Selling

2 insider sellers vs. 0 buyers. Widespread selling across multiple insiders may signal concerns.

Insider Activity Insight

Persistent selling pressure: Consistent insider selling with weak buy/sell ratio suggests insiders may be capitalizing on current valuation. Exercise caution and review recent earnings quality and management commentary.

SEC Filings

OKUR - Filing history and reports

Filing TypeFiling DatePeriod EndingFiscal YearActions
DEF 14A

DEF 14A 2026

N/A

April 21, 2026
June 03, 2026
2026
DEF 14A

DEF 14A 2025

N/A

April 16, 2025
May 27, 2025
2025
DEF 14A

DEF 14A 2023

N/A

April 26, 2023
June 06, 2023
2023
DEF 14A

DEF 14A 2022

N/A

April 22, 2022
June 01, 2022
2022
Showing 1 to 4 of 4 filings