OT

OnKure Therapeutics, Inc.

OKUR·NASDAQ

$4.20

+1.9%
HealthcareBiotechnology

OnKure, Inc. engages in the discovery and development of oncology-precision medicines for the treatment of cancer. The company focuses on developing selective inhibitors of histone deacetylases. Its portfolio includes OKI-179, an inhibitor for the treatment of both hematological and solid tumors. The company was incorporated in 2011 and is based in Boulder, Colorado.

At a Glance

Live Snapshot
Market Cap$57.43M
EPS-4.4000
P/E Ratio-0.95
Earnings Date08/11/2026
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OnKure Therapeutics, Inc. Street Expectations Map

OKUR · NASDAQ

Wall Street analysts project that OKUR stock may rise significantly over the coming 12 months. The consensus 1-year price target stands at 35.00, with estimates ranging from a low of 35.00 to a high of 35.00.

Lowest Target
35.00
733.33%
Consensus Target
35.00
733.33%
Highest Target
35.00
733.33%

The consensus 1-year price target stands at 35.00, with estimates ranging from a low of 35.00 to a high of 35.00.

Analyst Consensus Analysis

Upside Potential

+733.3%

Substantial upside potential. Analysts see significant value gap, suggesting the stock may be materially undervalued at current levels.

Analyst Agreement

0.0% spread

High analyst agreement. Narrow target range indicates strong consensus on valuation, suggesting clear investment thesis and predictable outlook.

Analyst Conviction

Very High

Strong buy conviction: High upside with tight consensus suggests compelling investment opportunity backed by analyst confidence.

Market Sentiment Insight

Rare opportunity: Exceptional upside potential with strong analyst consensus creates a compelling setup. The combination of significant price target premium and tight agreement suggests high-conviction undervaluation that may attract institutional capital.

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OnKure Therapeutics, Inc. Forward Estimates of Revenue

OKUR · NASDAQ
Latest Revenue
0.00
FY 2025
Avg Estimate
500.00K
FY 2026
Estimate Range
500.00K - 500.00K
Analyst Spread

Forward Growth Analysis

Analyst Coverage3 Analysts

Limited coverage may indicate reduced institutional interest or information availability.

Estimate Spread0%

Narrow estimate range signals strong analyst consensus and predictable business outlook.

OutlookNeutral

Mixed signals—some positive indicators offset by concerns about growth or uncertainty.

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OnKure Therapeutics, Inc. Forward Estimates of Net Income

OKUR · NASDAQ
Latest Net Income
-59.52M
FY 2025
Avg Estimate
-35.48M
FY 2026
Estimate Range
-48.64M - -22.33M
Analyst Spread

Forward Growth Analysis

Projected Growth+40.4%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage3 Analysts

Limited coverage may indicate reduced institutional interest or information availability.

Estimate Spread74%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookNeutral

Mixed signals—some positive indicators offset by concerns about growth or uncertainty.

Key Insight

Limited coverage with volatile estimates: Few analysts covering despite significant projected changes may indicate information gaps or emerging risks.

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OnKure Therapeutics, Inc. Forward Estimates of EPS

OKUR · NASDAQ
Latest EPS
-4.40
FY 2025
Avg Estimate
$-2.79
FY 2026
Estimate Range
$-3.60 - $-1.65
Analyst Spread

Forward Growth Analysis

Projected Growth+36.5%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage3 Analysts

Limited coverage may indicate reduced institutional interest or information availability.

Estimate Spread70%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookNeutral

Mixed signals—some positive indicators offset by concerns about growth or uncertainty.

Key Insight

Limited coverage with volatile estimates: Few analysts covering despite significant projected changes may indicate information gaps or emerging risks.

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OnKure Therapeutics, Inc. Forward Estimates of EBIT

OKUR · NASDAQ
Latest EBIT
-62.95M
FY 2025
Avg Estimate
0.00
FY 2026
Estimate Range
0.00 - 0.00
Analyst Spread

Forward Growth Analysis

Projected Growth+100.0%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage3 Analysts

Limited coverage may indicate reduced institutional interest or information availability.

OutlookNeutral

Mixed signals—some positive indicators offset by concerns about growth or uncertainty.

Key Insight

Limited coverage with volatile estimates: Few analysts covering despite significant projected changes may indicate information gaps or emerging risks.

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OnKure Therapeutics, Inc. Forward Estimates of EBITDA

OKUR · NASDAQ
Latest EBITDA
-62.12M
FY 2025
Avg Estimate
0.00
FY 2026
Estimate Range
0.00 - 0.00
Analyst Spread

Forward Growth Analysis

Projected Growth+100.0%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage3 Analysts

Limited coverage may indicate reduced institutional interest or information availability.

OutlookNeutral

Mixed signals—some positive indicators offset by concerns about growth or uncertainty.

Key Insight

Limited coverage with volatile estimates: Few analysts covering despite significant projected changes may indicate information gaps or emerging risks.

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OnKure Therapeutics, Inc. Forward Estimates of SG&A Expense

OKUR · NASDAQ
Latest SG&A Expense
14.69M
FY 2025
Avg Estimate
0.00
FY 2026
Estimate Range
0.00 - 0.00
Analyst Spread

Forward Growth Analysis

Projected Growth-100.0%

Significant contraction projected—major business challenges or industry disruption likely.

Analyst Coverage3 Analysts

Limited coverage may indicate reduced institutional interest or information availability.

OutlookCautious

Analyst skepticism evident—carefully evaluate risks before investment decisions.

Key Insight

Limited coverage with volatile estimates: Few analysts covering despite significant projected changes may indicate information gaps or emerging risks.

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OnKure Therapeutics, Inc. Insider Positioning

OKUR · NASDAQ

During the last 12 months, insiders have sold $5K worth of OKUR shares, with no buying activity reported.

3 Months

Bought

0

0.00

Sold

387

1.61K

Net Activity

-2K

-$2K

3-6 Months

Bought

0

0.00

Sold

389

1.15K

Net Activity

-1K

-$1K

6-9 Months

Bought

0

0.00

Sold

391

1.02K

Net Activity

-1K

-$1K

9-12 Months

Bought

0

0.00

Sold

391

931.00

Net Activity

-931

-$931

Top Buyers

No buying activity

Top Sellers

1
LJA

Leverone Jason A.

Officer: Chief Financial Officer

1.2K shares4 transactions

$4K

2
SNA

Saccomano Nicholas A

Director, Officer: President And Ceo

349 shares4 transactions

$1K

Insider Activity Analysis

Net Insider Sentiment

Bearish

Strong bearish signal with $5K net selling. Heavy insider selling may indicate concerns about valuation or near-term prospects.

Buy/Sell Ratio

0.00:1

Very poor ratio. Heavy selling with minimal buying suggests insiders may be concerned about valuation or outlook.

Recent Trend (3 Months)

$2K

Heavy recent selling activity. Recent insider sales notably exceed purchases—may warrant investigation into company developments.

Insider Participation

High Selling

2 insider sellers vs. 0 buyers. Widespread selling across multiple insiders may signal concerns.

Insider Activity Insight

Persistent selling pressure: Consistent insider selling with weak buy/sell ratio suggests insiders may be capitalizing on current valuation. Exercise caution and review recent earnings quality and management commentary.