MeiraGTx Holdings plc

MeiraGTx Holdings plc

MGTXยทNASDAQ

$9.39

+1.6%
HealthcareBiotechnology

MeiraGTx Holdings plc, a clinical stage gene therapy company, focusing on developing treatments for patients with serious diseases. The company develops various therapies for ocular diseases, including inherited blindness, as well as Xerostomia following radiation treatment for head and neck cancers; degenerative diseases; neurodegenerative diseases, such as amyotrophic lateral sclerosis; and Parkinson's diseases. Its programs in clinical development include Phase 1/2 clinical stage programs in Achromatopsia, X-Linked Retinitis Pigmentosa, RPE65-deficiency, and radiation-induced Xerostomia, as well as Parkinson's program. The company also focuses on initiating a clinical program in xerostomia related to Sjogren's syndrome and have preclinical programs in neurodegenerative diseases. It has a research collaboration agreement with Janssen Pharmaceuticals, Inc. to develop regulatable gene therapy treatment using the company's proprietary riboswitch technology. MeiraGTx Holdings plc was incorporated in 2015 and is based in New York, New York.

At a Glance

Live Snapshot
Market Cap$869.60M
EPS-1.4200
P/E Ratio-6.61
Earnings Date08/06/2026
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MeiraGTx Holdings plc Street Expectations Map

MGTX ยท NASDAQ

Wall Street analysts project that MGTX stock may rise significantly over the coming 12 months. The consensus 1-year price target stands at 25.00, with estimates ranging from a low of 24.00 to a high of 26.00.

Lowest Target
24.00
155.59%
Consensus Target
25.00
166.24%
Highest Target
26.00
176.89%

The consensus 1-year price target stands at 25.00, with estimates ranging from a low of 24.00 to a high of 26.00.

Analyst Consensus Analysis

Upside Potential

+166.2%

Substantial upside potential. Analysts see significant value gap, suggesting the stock may be materially undervalued at current levels.

Analyst Agreement

8.0% spread

High analyst agreement. Narrow target range indicates strong consensus on valuation, suggesting clear investment thesis and predictable outlook.

Analyst Conviction

Very High

Strong buy conviction: High upside with tight consensus suggests compelling investment opportunity backed by analyst confidence.

Market Sentiment Insight

Rare opportunity: Exceptional upside potential with strong analyst consensus creates a compelling setup. The combination of significant price target premium and tight agreement suggests high-conviction undervaluation that may attract institutional capital.

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MeiraGTx Holdings plc Forward Estimates of Revenue

MGTX ยท NASDAQ
Latest Revenue
81.39M
FY 2025
Avg Estimate
49.29M
FY 2026
Estimate Range
367.12K - 184.32M
Analyst Spread

Forward Growth Analysis

Projected Growth-39.4%

Significant contraction projectedโ€”major business challenges or industry disruption likely.

Analyst Coverage6 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread373%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookCautious

Analyst skepticism evidentโ€”carefully evaluate risks before investment decisions.

Key Insight

Declining estimates with wide disagreement: Analysts projecting contraction without consensus signals significant business uncertaintyโ€”exercise caution.

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MeiraGTx Holdings plc Forward Estimates of Net Income

MGTX ยท NASDAQ
Latest Net Income
-114.20M
FY 2025
Avg Estimate
-166.32M
FY 2026
Estimate Range
-185.90M - -43.54M
Analyst Spread

Forward Growth Analysis

Projected Growth-45.6%

Significant contraction projectedโ€”major business challenges or industry disruption likely.

Analyst Coverage6 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread86%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookCautious

Analyst skepticism evidentโ€”carefully evaluate risks before investment decisions.

Key Insight

Declining estimates with wide disagreement: Analysts projecting contraction without consensus signals significant business uncertaintyโ€”exercise caution.

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MeiraGTx Holdings plc Forward Estimates of EPS

MGTX ยท NASDAQ
Latest EPS
-1.42
FY 2025
Avg Estimate
$-1.61
FY 2026
Estimate Range
$-2.31 - $-0.54
Analyst Spread

Forward Growth Analysis

Projected Growth-13.6%

Significant contraction projectedโ€”major business challenges or industry disruption likely.

Analyst Coverage6 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread110%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookCautious

Analyst skepticism evidentโ€”carefully evaluate risks before investment decisions.

Key Insight

Declining estimates with wide disagreement: Analysts projecting contraction without consensus signals significant business uncertaintyโ€”exercise caution.

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MeiraGTx Holdings plc Forward Estimates of EBIT

MGTX ยท NASDAQ
Latest EBIT
-105.97M
FY 2025
Avg Estimate
-49.29M
FY 2026
Estimate Range
-184.32M - -367.12K
Analyst Spread

Forward Growth Analysis

Projected Growth+53.5%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage6 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread373%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookNeutral

Mixed signalsโ€”some positive indicators offset by concerns about growth or uncertainty.

Key Insight

High forecast uncertainty: Wide estimate range indicates analysts struggling to predict outcomesโ€”suggests elevated risk and potential volatility.

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MeiraGTx Holdings plc Forward Estimates of EBITDA

MGTX ยท NASDAQ
Latest EBITDA
-105.97M
FY 2025
Avg Estimate
-49.29M
FY 2026
Estimate Range
-184.32M - -367.12K
Analyst Spread

Forward Growth Analysis

Projected Growth+53.5%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage6 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread373%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookNeutral

Mixed signalsโ€”some positive indicators offset by concerns about growth or uncertainty.

Key Insight

High forecast uncertainty: Wide estimate range indicates analysts struggling to predict outcomesโ€”suggests elevated risk and potential volatility.

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MeiraGTx Holdings plc Forward Estimates of SG&A Expense

MGTX ยท NASDAQ
Latest SG&A Expense
52.90M
FY 2025
Avg Estimate
96.01M
FY 2026
Estimate Range
714.99K - 358.97M
Analyst Spread

Forward Growth Analysis

Projected Growth+81.5%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage6 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread373%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookNeutral

Mixed signalsโ€”some positive indicators offset by concerns about growth or uncertainty.

Key Insight

High forecast uncertainty: Wide estimate range indicates analysts struggling to predict outcomesโ€”suggests elevated risk and potential volatility.

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MeiraGTx Holdings plc Insider Positioning

MGTX ยท NASDAQ

During the last 12 months, insiders have sold $3.05M worth of MGTX shares, with no buying activity reported.

3 Months

Bought

0

0.00

Sold

207.7K

1.86M

Net Activity

-1.9M

-$1.86M

3-6 Months

Bought

0

0.00

Sold

0

0.00

Net Activity

+0

+$0

6-9 Months

Bought

0

0.00

Sold

71.5K

611.40K

Net Activity

-611K

-$611K

9-12 Months

Bought

0

0.00

Sold

71.5K

583.05K

Net Activity

-583K

-$583K

Top Buyers

No buying activity

Top Sellers

1
FA

Forbes Alexandria

Director, Officer: President & Ceo

219.0K sharesโ€ข4 transactions

$1.81M

2
GR

Giroux Richard

Officer: Cfo & Coo

104.0K sharesโ€ข3 transactions

$990K

3
NS

Naylor Stuart

Officer: Chief Dev. Officer

27.7K sharesโ€ข1 transactions

$259K

Insider Activity Analysis

Net Insider Sentiment

Bearish

Strong bearish signal with $3.05M net selling. Heavy insider selling may indicate concerns about valuation or near-term prospects.

Buy/Sell Ratio

0.00:1

Very poor ratio. Heavy selling with minimal buying suggests insiders may be concerned about valuation or outlook.

Recent Trend (3 Months)

$1.86M

Heavy recent selling activity. Recent insider sales notably exceed purchasesโ€”may warrant investigation into company developments.

Insider Participation

High Selling

3 insider sellers vs. 0 buyers. Widespread selling across multiple insiders may signal concerns.

Insider Activity Insight

Multiple red flags: Heavy selling, numerous sellers, and continued recent selling create a concerning pattern. Investigate fundamental drivers and consider whether company guidance or industry conditions have deteriorated.