Seres Therapeutics, Inc.

Seres Therapeutics, Inc.

MCRB·NASDAQ

$7.17

-5.3%
HealthcareBiotechnology

Seres Therapeutics, Inc., a microbiome therapeutics platform company, engages in developing bacterial consortia that are designed to functionally interact with host cells and tissues to treat disease. The company's lead product candidate is the SER-109, an oral microbiome therapeutic candidate that has completed Phase III clinical trial for the treatment of clostridium difficile infection (CDI). It is also developing SER-155, a cultivated bacteria microbiome drug, which is Phase Ib clinical trial to reduce incidences of gastrointestinal infections, bloodstream infections, and graft versus host diseases in immunocompromised patients receiving allogeneic hematopoietic stem cell transplantation and solid organ transplants. In addition, the company engages in the development of SER-287 and SER-301 that are in Phase Ib to treat ulcerative colitis; SER-401 for patients with metastatic melanoma; and SER-262 to treat Clostridioides difficile infection. It has license and collaboration agreements with Nestec Ltd. and Memorial Sloan Kettering Cancer Center. The company was formerly known as Seres Health, Inc. and changed its name to Seres Therapeutics, Inc. in May 2015. Seres Therapeutics, Inc. was incorporated in 2010 and is headquartered in Cambridge, Massachusetts.

At a Glance

Live Snapshot
Market Cap$69.43M
EPS0.6400
P/E Ratio11.20
Earnings Date08/05/2026
-72.70%
Return on Invested Capital
-36%
3Y+8.0%
5Y+149.0%
10Y+90.0%
12.88%
Return on Equity
1206%
3Y-101.0%
5Y-125.0%
10Y-119.0%
4.12%
Return on Assets
4136%
3Y-106.0%
5Y-116.0%
10Y-112.0%
Seres Therapeutics, Inc.

Seres Therapeutics, Inc. Management Team

MCRB · NASDAQ
MC

Ms. Caroline Hensley

Assistant General Counsel

female
MT

Mr. Thomas J. DesRosier Esq., J.D.

Chief Legal Officer, Executive Vice President & Secretary

Compensation

$707,142

Born 1955(Age 71)
male
MM

Ms. Marella Thorell CPA

Executive Vice President & Chief Financial Officer

Born 1967(Age 59)
female
DM

Dr. Matthew R. Henn Ph.D.

Executive Vice President & Chief Scientific Officer

Compensation

$643,828

Born 1975(Age 51)
DT

Dr. Teresa L. Young Ph.D., R.Ph.

Executive Vice President and Chief Commercial & Strategy Officer

Compensation

$606,327

Born 1967(Age 59)
ME

Mr. Eric D. Shaff M.B.A.

President, Chief Executive Officer & Director

Compensation

$1,105,297

Born 1976(Age 50)
male
MK

Ms. Kelly Brady

Senior Vice President of Clinical Development

female
DD

Dr. Dennis M. Walling M.D.

Senior Vice President of Clinical Development & Head of Clinical Research

MC

Mr. Chris McChalicher

Senior Vice President of Manufacturing, Quality, and Process Development

male
MA

Ms. Ann Kurowski

Senior Vice President of Regulatory Affairs

female
mcrb

Seres Therapeutics, Inc. Insider Positioning

MCRB · NASDAQ

During the last 12 months, insiders have purchased $261K and sold $60K worth of MCRB shares, resulting in $201K of net buying activity.

3 Months

Bought

0

0.00

Sold

474

3.57K

Net Activity

-4K

-$4K

3-6 Months

Bought

0

0.00

Sold

501

4.24K

Net Activity

-4K

-$4K

6-9 Months

Bought

0

0.00

Sold

2.6K

44.84K

Net Activity

-45K

-$45K

9-12 Months

Bought

24.4K

261.04K

Sold

425

7.08K

Net Activity

+254K

+$254K

Top Buyers

1
BS

Berenson Stephen

Director

11.5K shares1 transactions

$123K

2
FC

Fraser Claire

Director

6.5K shares1 transactions

$69K

3
ADA

Ausiello Dennis A

Director

6.5K shares1 transactions

$69K

Top Sellers

1
HMR

Henn Matthew R

Officer: See Remarks

1.5K shares4 transactions

$24K

2
YTL

Young Teresa L.

Officer: See Remarks

1.2K shares3 transactions

$20K

3
SED

Shaff Eric D.

Director

952 shares4 transactions

$12K

4
DT

Desrosier Thomas

Officer: See Remarks

309 shares4 transactions

$4K

5
BK

Brady Kelly

Officer: See Remarks

59 shares1 transactions

$444

Insider Activity Analysis

Net Insider Sentiment

Bullish

Strong bullish signal with $201K net buying. Insiders are aggressively accumulating shares, suggesting significant confidence in future prospects.

Buy/Sell Ratio

4.37:1

Exceptional buy/sell ratio. Buying dramatically outweighs selling—one of the strongest possible insider signals.

Recent Trend (3 Months)

$4K

Heavy recent selling activity. Recent insider sales notably exceed purchases—may warrant investigation into company developments.

Insider Participation

Moderate Selling

5 insider sellers vs. 3 buyers. More insiders selling than buying suggests cautious or negative sentiment.

Insider Activity Insight

Compelling insider conviction: The combination of strong buy/sell ratio and multiple buyers suggests insiders see attractive risk/reward. Consider this alongside fundamental analysis for confirmation.

SEC Filings

MCRB - Filing history and reports

Filing TypeFiling DatePeriod EndingFiscal YearActions
DEF 14A

DEF 14A 2026

N/A

April 27, 2026
June 09, 2026
2026
DEF 14A

DEF 14A 2025

N/A

March 13, 2025
March 13, 2025
2025
DEF 14A

DEF 14A 2024

N/A

March 05, 2024
March 05, 2024
2024
DEF 14A

DEF 14A

N/A

April 25, 2023
April 25, 2023
 
DEF 14A

DEF 14A 2022

N/A

April 29, 2022
June 22, 2022
2022
DEF 14A

DEF 14A 2021

N/A

April 30, 2021
June 16, 2021
2021
DEF 14A

DEF 14A 2020

N/A

April 30, 2020
June 18, 2020
2020
DEF 14A

DEF 14A 2019

N/A

April 30, 2019
June 13, 2019
2019
DEF 14A

DEF 14A 2018

N/A

April 30, 2018
June 26, 2018
2018
DEF 14A

DEF 14A 2017

N/A

May 01, 2017
June 20, 2017
2017
Showing 1 to 10 of 11 filings