Maze Therapeutics, Inc.

Maze Therapeutics, Inc.

MAZE·NASDAQ

$25.06

+3.2%
HealthcareBiotechnology

Maze Therapeutics, Inc., a clinical stage biopharmaceutical company, develops small molecule precision medicines for the treatment of renal, cardiovascular, related metabolic diseases, and obesity in the United States. Its lead programs includes MZE829, an oral small molecule inhibitor of apolipoprotein L1, which is in phase II clinical trial for the treatment of patients with APOL1 kidney disease; and MZE782, an oral small molecule inhibitor of the solute transporter SLC6A19, which is in phase I clinical trial for the treatment of chronic kidney disease. Maze Therapeutics, Inc. was formerly known as Modulus Therapeutics, Inc. and changed its name to Maze Therapeutics, Inc. in September 2018. The company was incorporated in 2017 and is based in South San Francisco, California.

At a Glance

Live Snapshot
Market Cap$1.39B
EPS-3.0500
P/E Ratio-8.22
Earnings Date08/11/2026
-37.67%
Return on Invested Capital
-250%
3Y-55.0%
5Y-55.0%
10Y-55.0%
-36.94%
Return on Equity
-239%
3Y-67.0%
5Y-67.0%
10Y-67.0%
-33.02%
Return on Assets
-252%
3Y-57.0%
5Y-57.0%
10Y-57.0%
Maze Therapeutics, Inc.

Maze Therapeutics, Inc. Management Team

MAZE · NASDAQ
DJ

Dr. Jason V. Coloma M.B.A., M.P.H., Ph.D.

Chief Executive Officer & Director

Compensation

$812,262

Born 1976(Age 50)
MA

Mr. Atul Dandekar

Chief Strategy & Business Officer

Born 1972(Age 54)
male
MC

Ms. Courtney J. Phillips J.D.

General Counsel & Corporate Secretary

Compensation

$354,780

Born 1976(Age 50)
female
DH

Dr. Harold S. Bernstein M.D., Ph.D.

President of Research & Development and Chief Medical Officer

Compensation

$764,167

Born 1960(Age 66)
MW

Mr. Winston Tse

Senior Vice President of Drug Discovery

male
MA

Ms. Amy Bachrodt

Senior Vice President of Finance & Chief Financial Officer

female
MM

Mr. Matt Krause

Senior Vice President of Human Resources

male
MM

Mr. Maarten Hoek

Senior Vice President of Research

male
MN

Ms. Nazila Habibizad

Senior Vice President of Technical Operations & Supply Chain

Born 1964(Age 62)
female
MV

Mr. Vipin Vijayakumar

Vice President of R&D Infrastructure and Operations

male
maze

Maze Therapeutics, Inc. Insider Positioning

MAZE · NASDAQ

During the last 12 months, insiders have purchased $991K and sold $9.45M worth of MAZE shares, resulting in $8.46M of net selling activity.

3 Months

Bought

0

0.00

Sold

100.8K

3.54M

Net Activity

-3.5M

-$3.54M

3-6 Months

Bought

0

0.00

Sold

135.0K

5.44M

Net Activity

-5.4M

-$5.44M

6-9 Months

Bought

36.0K

990.72K

Sold

20.7K

464.03K

Net Activity

+527K

+$527K

9-12 Months

Bought

0

0.00

Sold

0

0.00

Net Activity

+0

+$0

Top Buyers

1
HH

Hoppenot Herve

Director

36.0K shares1 transactions

$991K

Top Sellers

1
BH

Bernstein Harold

Officer: President, R&D & Cmo

77.8K shares7 transactions

$3.36M

2
DA

Dandekar Atul

Officer: Csbo

89.3K shares5 transactions

$3.32M

3
SCA

Sohn Catherine A.

Director

29.4K shares2 transactions

$1.15M

4
CJV

Coloma Jason V

Director, Officer: Chief Executive Officer

31.9K shares3 transactions

$830K

5
SRH

Scheller Richard H

Director

20.7K shares1 transactions

$464K

Insider Activity Analysis

Net Insider Sentiment

Bearish

Strong bearish signal with $8.46M net selling. Heavy insider selling may indicate concerns about valuation or near-term prospects.

Buy/Sell Ratio

0.10:1

Weak buy/sell ratio. Selling significantly exceeds buying—monitor for potential fundamental concerns.

Recent Trend (3 Months)

$3.54M

Heavy recent selling activity. Recent insider sales notably exceed purchases—may warrant investigation into company developments.

Insider Participation

High Selling

5 insider sellers vs. 1 buyers. Widespread selling across multiple insiders may signal concerns.

Insider Activity Insight

Multiple red flags: Heavy selling, numerous sellers, and continued recent selling create a concerning pattern. Investigate fundamental drivers and consider whether company guidance or industry conditions have deteriorated.

SEC Filings

MAZE - Filing history and reports

Filing TypeFiling DatePeriod EndingFiscal YearActions
DEF 14A

DEF 14A 2026

N/A

April 28, 2026
June 08, 2026
2026
Showing 1 to 1 of 1 filings