Maze Therapeutics, Inc.

Maze Therapeutics, Inc.

MAZEยทNASDAQ

$25.06

+3.2%
HealthcareBiotechnology

Maze Therapeutics, Inc., a clinical stage biopharmaceutical company, develops small molecule precision medicines for the treatment of renal, cardiovascular, related metabolic diseases, and obesity in the United States. Its lead programs includes MZE829, an oral small molecule inhibitor of apolipoprotein L1, which is in phase II clinical trial for the treatment of patients with APOL1 kidney disease; and MZE782, an oral small molecule inhibitor of the solute transporter SLC6A19, which is in phase I clinical trial for the treatment of chronic kidney disease. Maze Therapeutics, Inc. was formerly known as Modulus Therapeutics, Inc. and changed its name to Maze Therapeutics, Inc. in September 2018. The company was incorporated in 2017 and is based in South San Francisco, California.

At a Glance

Live Snapshot
Market Cap$1.39B
EPS-3.0500
P/E Ratio-8.22
Earnings Date08/11/2026
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Maze Therapeutics, Inc. Street Expectations Map

MAZE ยท NASDAQ

Wall Street analysts project that MAZE stock may rise significantly over the coming 12 months. The consensus 1-year price target stands at 61.60, with estimates ranging from a low of 46.00 to a high of 97.00.

Lowest Target
46.00
83.56%
Consensus Target
61.60
145.81%
Highest Target
97.00
287.07%

The consensus 1-year price target stands at 61.60, with estimates ranging from a low of 46.00 to a high of 97.00.

Analyst Consensus Analysis

Upside Potential

+145.8%

Substantial upside potential. Analysts see significant value gap, suggesting the stock may be materially undervalued at current levels.

Analyst Agreement

82.8% spread

High uncertainty. Very wide target spread indicates significant disagreement among analystsโ€”major valuation uncertainty or transformation underway.

Analyst Conviction

Low

High uncertainty: Wide dispersion indicates analysts struggle to agree on valuationโ€”proceed with caution and independent analysis.

Market Sentiment Insight

High risk, high reward: Substantial upside potential exists, but wide analyst disagreement signals execution risk or unclear catalysts. Thorough due diligence essential before committing capital.

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Maze Therapeutics, Inc. Forward Estimates of Revenue

MAZE ยท NASDAQ
Latest Revenue
0.00
FY 2025
Avg Estimate
2.00M
FY 2026
Estimate Range
2.00M - 2.00M
Analyst Spread

Forward Growth Analysis

Analyst Coverage6 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread0%

Narrow estimate range signals strong analyst consensus and predictable business outlook.

OutlookNeutral

Mixed signalsโ€”some positive indicators offset by concerns about growth or uncertainty.

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Maze Therapeutics, Inc. Forward Estimates of Net Income

MAZE ยท NASDAQ
Latest Net Income
-131.12M
FY 2025
Avg Estimate
-151.96M
FY 2026
Estimate Range
-169.12M - -117.93M
Analyst Spread

Forward Growth Analysis

Projected Growth-15.9%

Significant contraction projectedโ€”major business challenges or industry disruption likely.

Analyst Coverage6 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread34%

Moderate uncertainty in forecastsโ€”typical for companies with evolving business models.

OutlookCautious

Analyst skepticism evidentโ€”carefully evaluate risks before investment decisions.

Key Insight

Declining estimates with wide disagreement: Analysts projecting contraction without consensus signals significant business uncertaintyโ€”exercise caution.

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Maze Therapeutics, Inc. Forward Estimates of EPS

MAZE ยท NASDAQ
Latest EPS
-3.05
FY 2025
Avg Estimate
$-3.12
FY 2026
Estimate Range
$-3.86 - $-2.69
Analyst Spread

Forward Growth Analysis

Projected Growth-2.3%

Declining expectations indicate headwindsโ€”investigate whether temporary or structural issues.

Analyst Coverage5 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread37%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookCautious

Analyst skepticism evidentโ€”carefully evaluate risks before investment decisions.

Key Insight

Declining estimates with wide disagreement: Analysts projecting contraction without consensus signals significant business uncertaintyโ€”exercise caution.

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Maze Therapeutics, Inc. Forward Estimates of EBIT

MAZE ยท NASDAQ
Latest EBIT
-142.90M
FY 2025
Avg Estimate
1.56M
FY 2026
Estimate Range
1.56M - 1.56M
Analyst Spread

Forward Growth Analysis

Projected Growth+101.1%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage6 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread0%

Narrow estimate range signals strong analyst consensus and predictable business outlook.

OutlookStrong

Positive analyst consensus with strong growth expectations and forecast confidence.

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Maze Therapeutics, Inc. Forward Estimates of EBITDA

MAZE ยท NASDAQ
Latest EBITDA
-140.50M
FY 2025
Avg Estimate
1.58M
FY 2026
Estimate Range
1.58M - 1.58M
Analyst Spread

Forward Growth Analysis

Projected Growth+101.1%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage6 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread0%

Narrow estimate range signals strong analyst consensus and predictable business outlook.

OutlookStrong

Positive analyst consensus with strong growth expectations and forecast confidence.

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Maze Therapeutics, Inc. Forward Estimates of SG&A Expense

MAZE ยท NASDAQ
Latest SG&A Expense
34.45M
FY 2025
Avg Estimate
1.44M
FY 2026
Estimate Range
1.44M - 1.44M
Analyst Spread

Forward Growth Analysis

Projected Growth-95.8%

Significant contraction projectedโ€”major business challenges or industry disruption likely.

Analyst Coverage6 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread0%

Narrow estimate range signals strong analyst consensus and predictable business outlook.

OutlookNeutral

Mixed signalsโ€”some positive indicators offset by concerns about growth or uncertainty.

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Maze Therapeutics, Inc. Insider Positioning

MAZE ยท NASDAQ

During the last 12 months, insiders have purchased $991K and sold $9.45M worth of MAZE shares, resulting in $8.46M of net selling activity.

3 Months

Bought

0

0.00

Sold

100.8K

3.54M

Net Activity

-3.5M

-$3.54M

3-6 Months

Bought

0

0.00

Sold

135.0K

5.44M

Net Activity

-5.4M

-$5.44M

6-9 Months

Bought

36.0K

990.72K

Sold

20.7K

464.03K

Net Activity

+527K

+$527K

9-12 Months

Bought

0

0.00

Sold

0

0.00

Net Activity

+0

+$0

Top Buyers

1
HH

Hoppenot Herve

Director

36.0K sharesโ€ข1 transactions

$991K

Top Sellers

1
BH

Bernstein Harold

Officer: President, R&D & Cmo

77.8K sharesโ€ข7 transactions

$3.36M

2
DA

Dandekar Atul

Officer: Csbo

89.3K sharesโ€ข5 transactions

$3.32M

3
SCA

Sohn Catherine A.

Director

29.4K sharesโ€ข2 transactions

$1.15M

4
CJV

Coloma Jason V

Director, Officer: Chief Executive Officer

31.9K sharesโ€ข3 transactions

$830K

5
SRH

Scheller Richard H

Director

20.7K sharesโ€ข1 transactions

$464K

Insider Activity Analysis

Net Insider Sentiment

Bearish

Strong bearish signal with $8.46M net selling. Heavy insider selling may indicate concerns about valuation or near-term prospects.

Buy/Sell Ratio

0.10:1

Weak buy/sell ratio. Selling significantly exceeds buyingโ€”monitor for potential fundamental concerns.

Recent Trend (3 Months)

$3.54M

Heavy recent selling activity. Recent insider sales notably exceed purchasesโ€”may warrant investigation into company developments.

Insider Participation

High Selling

5 insider sellers vs. 1 buyers. Widespread selling across multiple insiders may signal concerns.

Insider Activity Insight

Multiple red flags: Heavy selling, numerous sellers, and continued recent selling create a concerning pattern. Investigate fundamental drivers and consider whether company guidance or industry conditions have deteriorated.