KalVista Pharmaceuticals, Inc.

KalVista Pharmaceuticals, Inc.

KALVยทNASDAQ

$26.95

+0.037%
HealthcareBiotechnology

KalVista Pharmaceuticals, Inc., a clinical stage pharmaceutical company, discovers, develops, and commercializes small molecule protease inhibitors for diseases with unmet needs. The company's product portfolio comprises small molecule plasma kallikrein inhibitors targeting hereditary angioedema (HAE) and diabetic macular edema (DME); and oral plasma kallikrein inhibitors. Its products include KVD001, a plasma kallikrein inhibitor that completed a Phase II clinical trial for the treatment of DME; sebetralstat, which is initiation of the Phase 3 KONFIDENT trial as a potential oral, on-demand therapy for HAE attacks; KVD824, an oral product candidate for the treatment of HAE; and Factor XIIa, an oral inhibitor program which is in preclinical stage targets an enzyme in HAE. The company is headquartered in Cambridge, Massachusetts.

At a Glance

Live Snapshot
Market Cap$1.43B
EPS-3.2300
P/E Ratio-8.34
Earnings Date08/13/2026
-58.89%
Return on Invested Capital
-35%
3Y-10.0%
5Y+168.0%
10Y-17.0%
6059.98%
Return on Equity
-3251%
3Y-10603.0%
5Y-33803.0%
10Y-10305.0%
-48.99%
Return on Assets
-33%
3Y-3.0%
5Y+188.0%
10Y-10.0%
KalVista Pharmaceuticals, Inc.

KalVista Pharmaceuticals, Inc. Management Team

KALV ยท NASDAQ
DC

Dr. Christopher M. Yea Ph.D.

Chief Development Officer

Compensation

$708,532

Born 1964(Age 62)
MB

Mr. Benjamin L. Palleiko

Chief Executive Officer & Director

Compensation

$983,070

Born 1966(Age 60)
male
MB

Mr. Brian Piekos

Chief Financial Officer

Born 1975(Age 51)
male
DP

Dr. Paul K. Audhya M.B.A., M.D.

Chief Medical Officer

Compensation

$736,815

Born 1973(Age 53)
MJ

Mr. Jeb Ledell

Chief Operating Officer

male
MB

Mr. Brian Krex J.D.

General Counsel

Born 1968(Age 58)
male
MR

Mr. Ryan Baker

Head of Investor Relations

male
DM

Dr. Michael D. Smith Pharm.D.

Senior Vice President of Development

Born 1980(Age 46)
MR

Ms. Rachel M. Morten

Senior Vice President of Regulatory Affairs & QA

female
JA

Jarrod Aldom

Vice President of Corporate Communications

kalv

KalVista Pharmaceuticals, Inc. Insider Positioning

KALV ยท NASDAQ

During the last 12 months, insiders have purchased $3.50M and sold $7.99M worth of KALV shares, resulting in $4.49M of net selling activity.

3 Months

Bought

0

0.00

Sold

262.5K

5.14M

Net Activity

-5.1M

-$5.14M

3-6 Months

Bought

0

0.00

Sold

39.4K

619.32K

Net Activity

-619K

-$619K

6-9 Months

Bought

295.0K

3.50M

Sold

49.7K

690.08K

Net Activity

+2.8M

+$2.81M

9-12 Months

Bought

0

0.00

Sold

104.3K

1.54M

Net Activity

-1.5M

-$1.54M

Top Buyers

1
AB

Arif Bilal

Officer: Chief Operations Officer

100.0K sharesโ€ข1 transactions

$1.15M

2
SB

Sensenig Bethany

Director

45.0K sharesโ€ข1 transactions

$542K

3
FW

Fairey William

Director

30.0K sharesโ€ข1 transactions

$362K

4
UEW

Unkart Edward W

Director

30.0K sharesโ€ข1 transactions

$362K

5
TP

Treanor Patrick

Director

30.0K sharesโ€ข1 transactions

$362K

Top Sellers

1
VHCPIL

Venrock Healthcare Capital Partners Iii, L.P.

10 Percent Owner

174.5K sharesโ€ข1 transactions

$2.96M

2
PBL

Palleiko Benjamin L

Director, Officer: Chief Executive Officer

134.9K sharesโ€ข17 transactions

$2.25M

3
YC

Yea Christopher

Officer: Chief Development Officer

88.9K sharesโ€ข12 transactions

$1.80M

4
APK

Audhya Paul K.

Officer: Chief Medical Officer

31.7K sharesโ€ข11 transactions

$539K

5
SN

Sweeny Nicole

Officer: Chief Commercial Officer

16.3K sharesโ€ข7 transactions

$285K

Insider Activity Analysis

Net Insider Sentiment

Bearish

Negative insider sentiment with $4.49M net selling. Selling notably exceeds buying, warranting closer scrutiny of company fundamentals.

Buy/Sell Ratio

0.44:1

Weak buy/sell ratio. Selling significantly exceeds buyingโ€”monitor for potential fundamental concerns.

Recent Trend (3 Months)

$5.14M

Heavy recent selling activity. Recent insider sales notably exceed purchasesโ€”may warrant investigation into company developments.

Insider Participation

Balanced

5 insider buyers and 5 sellers. Equal participation suggests mixed or neutral insider views.

Insider Activity Insight

Multiple red flags: Heavy selling, numerous sellers, and continued recent selling create a concerning pattern. Investigate fundamental drivers and consider whether company guidance or industry conditions have deteriorated.

SEC Filings

KALV - Filing history and reports

Filing TypeFiling DatePeriod EndingFiscal YearActions
DEF 14A

DEF 14A 2025

N/A

August 21, 2025
October 01, 2025
2025
DEF 14A

DEF 14A 2024

N/A

August 22, 2024
October 03, 2024
2024
DEF 14A

DEF 14A 2023

N/A

August 14, 2023
September 26, 2023
2023
DEF 14A

DEF 14A 2022

N/A

August 22, 2022
October 13, 2022
2022
DEF 14A

DEF 14A 2021

N/A

August 17, 2021
September 30, 2021
2021
DEF 14A

DEF 14A 2020

N/A

August 25, 2020
October 01, 2020
2020
DEF 14A

DEF 14A 2019

N/A

August 23, 2019
October 02, 2019
2019
DEF 14A

DEF 14A 2018

N/A

August 15, 2018
October 03, 2018
2018
DEF 14A

DEF 14A 2017

N/A

August 25, 2017
September 27, 2017
2017
DEF 14A

DEF 14A 2017

N/A

March 02, 2017
March 23, 2017
2017
Showing 1 to 10 of 11 filings