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Good day, ladies and gentlemen, and welcome to the Second Quarter 2023 Illumina Earnings Conference Call. At this time, all participants are in a listen-only mode. After the speakers' presentation, there will be a question-and-answer session. Please be advised that today's conference is being recorded. I would now like to hand the conference over to Salli Schwartz, Vice President of Investor Relations.

Hello, everyone. And welcome to our earnings call for the second quarter of 2023. During the call today, we will review the financial results released after the close of the market, and offer commentary on our commercial activity, after which we will host a question and answer session. If you have not had a chance to review the earnings release, it can be found in the Investor Relations section of our website at illumina.com. Participating for Illumina today will be Charles Dadswell, Interim Chief Executive Officer and General Counsel, and Joydeep Goswami, Chief Financial Officer and Chief Strategy and Corporate Development Officer. Chuck will provide an update on the state of Illumina's business and Joydeep will review our financial results which include GRAIL. As a reminder, GRAIL must be held and operated separately and independently from Illumina pursuant to the interim measures ordered by the European Commission, which prohibited our acquisition of GRAIL under the EU Merger Regulation. This call is being recorded and the audio portion will be archived in the Investor section of our website. It is our intent that all forward-looking statements regarding our financial results and commercial activity made during today's call will be protected under the Private Securities Litigation Reform Act of 1995. Forward-looking statements are subject to risks and uncertainties. Actual events or results may differ materially from those projected or discussed. All forward-looking statements are based upon current available information, and Illumina assumes no obligation to update these statements. To better understand the risks and uncertainties that could cause actual results to differ, we refer you to the documents that Illumina files with the Securities and Exchange Commission, including Illumina's most recent forms 10-Q and 10-K. With that, I will now turn the call over to Chuck.

Thank you, Salli. Good afternoon, everyone, and thank you for joining today's call. As you know, I assumed the role of Illumina's interim CEO two months ago. Our search for a CEO is underway, and we look forward to updating you soon. Our Board is pleased with the outstanding candidates they are seeing. Before going into our second quarter results, I wanted to take a moment to acknowledge and thank our former CEO, Francis deSouza, and our former Chairman of the Board, John Thompson, for their thoughtfulness and commitment while at Illumina. I would also like to welcome our new Board members, Stephen MacMillan, our new Chairman of the Board, as well as Andrew Teno and Scott Ullem. I also wanted to acknowledge changes in our executive leadership team, including the departures of our Chief Technology Officer, Alex Aravanis, and our Chief Medical Officer, Phil Febbo. I speak for the whole company in wishing both of them every success in the future. We also are pleased to announce that Steve Barnard, a 25-year Illumina employee and distinguished scientist in our field, will drive Illumina's legacy of innovation forward as our next Chief Technology Officer. We will be conducting a search for our next Chief Medical Officer. Turning to our second quarter results: In Q2, Illumina delivered revenue of approximately $1.18 billion and diluted non-GAAP EPS of $0.32, both ahead of the guidance we provided in Q1. We shipped 109 NovaSeq X instruments in the quarter and have increased our expectations for our full year supply capacity to more than 390 instruments. However, as you saw from our earnings release, we are reducing our guidance, and now expect core Illumina full year 2023 revenue to be approximately flat with 2022, primarily as a result of three factors. First, a larger-than-expected temporary decline in high throughput consumables as we transition more-than-expected customers to the NovaSeq X. Second, many of our customers are remaining more cautious in their purchasing behaviors. And finally, in China, there is both a more protracted economic recovery and an increasingly challenged competitive landscape, in contrast to the Americas and Europe, where we are still expecting year-over-year growth in 2023. Joydeep will provide additional details on our revised guidance during his remarks. One area I'd like to touch on further is the rollout of NovaSeq X. This has been a more challenging process than we anticipated. NovaSeq X is the most sophisticated platform we have ever launched and includes the most comprehensive end-to-end software we have ever released. Also, the rollout of the X has occurred at an unprecedented magnitude and pace. And we have identified issues in the field that are typical in new product releases. To address these issues, we have taken actions including a planned software update that was released in June after our first customer shipment in March. We have deployed Illumina technical teams worldwide to work with our customers to accelerate bringing their systems online. While the rollout of NovaSeq X will take longer than we originally expected, the continued strong interest and commitment of capital to purchase NovaSeq Xs remains encouraging. To date, 20% of customers who have purchased a NovaSeq X have ordered more than one instrument. This early demand for multiple instruments and the capacity they represent underscores our confidence that customers are planning to increase their sequencing activity. Customers have clear intentions to do more sequencing in the future: Our customers have commented that larger scale single cell and spatial analysis experiments become more practical with the NovaSeq X, and they are requesting funding for these applications. Customers engaged in large population genomics initiatives have stated they plan to run additional multiomic programs for population-specific variants, which can be used to develop treatments for various demographics that will be more effective in those populations. And, as some of you have heard, several of our largest customers are using the X to accelerate the move from targeted panels and exomes to whole genome sequencing. We expect these types of projects to scale and ramp in the near future, and we will be closely engaged with our customers to support their needs. We continue to consciously and actively reduce our expense base and have accelerated actions within the $100 million-plus annual run rate expense reduction program we announced at our last earnings call. As you saw in our late June 8K filing, we have reduced our global headcount and are downsizing our global real estate footprint. We also are optimizing our third-party vendor spend and have reduced travel-related and other costs. For 2023, these steps are helping mitigate the impact of lower full-year revenue on our operating margin. Looking forward, these actions will continue to support our margins and create flexibility for further investment in high-growth areas. Let me give you an update on a couple of our platforms: We saw continued global interest in the NovaSeq X series in Q2, and we exited the quarter with more than 260 orders since launch. Our shipments of 109 NovaSeq X instruments in Q2 were above our expectation of 80 for the quarter and brought our total installed base to 176 instruments. We now expect to be able to ship more than 390 NovaSeq X instruments this year, up from the 330 we had previously expected for the year. In mid-throughput, we shipped approximately 160 NextSeq 1k/2k units in the second quarter, an increase of 8% year-over- year, as customers expanded their current fleets or migrated from the MiSeq or NextSeq 550. More than 20% of NextSeq 1k/2k units in Q2 were placed with new-to-Illumina customers. We continue to experience lengthened sales cycles, in some cases as customers take time to raise funding or prioritize their investment dollars, and in other cases as they run longer procurement processes. Our win rate across the midthroughput segment, outside of China, increased from the first quarter. We believe there is a long runway of differentiation for the 1k/2k, notably with X-LEAP SBS chemistry coming available on these instruments next year. Moving to our markets. In Q2, clinical represented approximately 53% of our total sequencing consumables revenue. In oncology, progress continued for next generation sequencing-based testing reimbursement. Anthem, the second largest commercial payer in the US, and Blue Cross Blue Shield of Michigan, both added coverage for comprehensive genomic profiling for patients with advanced cancers, adding more than 30 million additional covered lives. We also saw coverage continue to progress in Europe, with Switzerland now reimbursing large next generation sequencing panels, including comprehensive genomic profiling. Illumina's market leading TruSight Oncology assay, TSO 500, remains on track to exceed more than $100 million in 2023 revenue. Growth continues to be driven by greater utilization and broader adoption of our assay. In Q2, we also completed our TSO Comprehensive submission for IVD registration in the United States. Also in oncology, GRAIL continues to achieve solid progress in the adoption of its Galleri multi-cancer early detection test. In Q2, GRAIL achieved its 100,000th commercial Galleri test milestone, and the test has now been prescribed by more than 7,500 providers in the US and ordered in more than 80 health systems. As an update, on the NHS-Galleri study, in Q2 GRAIL completed second-year follow up visits, in which 130,000 participants returned, giving the trial a retention rate of 91.3%. Invitations for the third and final-year visits have begun, and the first appointments for those visits are expected this fall. Evidence for Galleri continues to grow. At the most recent annual meeting held by the American Society of Clinical Oncology, GRAIL announced results from the University of Oxford-sponsored SYMPLIFY study, reporting high specificity, positive predictive value, and accuracy of the cancer signal detected and cancer signal origin prediction, as well as demonstrating the feasibility of using an MCED test to assist clinicians with decisions regarding referrals from primary care physicians. GRAIL is also making progress on its unique multi-cancer minimal residual disease test. At the American Association for Cancer Research annual meeting, GRAIL and Astra

Thank you, Chuck. I'll start by reviewing our consolidated financial results, followed by segment results for core Illumina and GRAIL, and then conclude with my remarks on our current outlook for 2023. I will be discussing non-GAAP results which include stock-based compensation. I encourage you to review the GAAP reconciliation of these non-GAAP measures which can be found in today's release and in the supplementary data available on our website. As Chuck noted, in the second quarter, consolidated revenue was $1.18 billion, up 8% from the first quarter of 2023 and exceeding the high end of our guidance range on stronger than expected shipments of NovaSeq X. Consolidated revenue was up 1% year-over-year, and up 3% on a constant currency basis. Non-GAAP net income was $50 million, or $0.32 per diluted share, which includes dilution from GRAIL's non-GAAP operating loss of $164 million for the quarter. Non-GAAP EPS exceeded our expectations primarily due to continued execution of expense reduction initiatives, gross margin favorability, and our higher revenue for the quarter. Our non-GAAP tax rate was 39.3% for the quarter, which increased from 25.8% in Q2 2022, with both quarters reflecting the impact of R&D capitalization requirements. Although the non-GAAP tax expense impact of R&D capitalization requirements in dollars was the same in both periods, the impact to our effective tax rate in Q2 2023 was more significant due to our lower earnings. Our non-GAAP weighted average diluted share count for the quarter was approximately 158 million. Moving to segment results. Core Illumina revenue of $1.16 billion was approximately flat year-over-year, or up 2% on a constant currency basis, which included an anticipated reduction from COVID surveillance of approximately 180 basis points. COVID surveillance contributed approximately $6 million in total revenue in Q2 2023 compared to $27 million in Q2 2022. Core Illumina sequencing consumables revenue of $739 million was down 1% year-over-year. Mid-teens growth in clinical led by continued momentum in oncology and genetic disease testing was offset by anticipated headwinds impacting research, including an approximately 260 basis point reduction from COVID surveillance, as well as sanctions in Russia, the impact on NovaSeq 6K consumables as customers start to transition to, but before they have fully ramped up on NovaSeq X, and constrained funding impacting many of our customers globally. Total sequencing activity on our connected high- and mid-throughput instruments grew 3% from Q1 2023 and 9% year-over-year. Research and applied was flat from Q1 and declined 1% year-over-year. Clinical sequencing activity growth remained strong, up 6% from Q1 and 23% year-over-year. As a reminder, we believe this data is a useful reference that shows the general activity trends across our installed base and is directionally correlated with revenue over time. We have been providing this information on the basis of number of sequencing runs, but in the future we will disclose these metrics in terms of gigabases sequenced to better reflect activity trends given the significant increase in output per run enabled by NovaSeq X and NextSeq 1K/2K. Sequencing instruments revenue for Core Illumina of $193 million grew 2% year-over-year. Stronger-than-expected shipments of NovaSeq X more than offset the anticipated decline in NovaSeq 6000 shipments globally and NextSeq 550 placements in China, as well as a decrease in MiSeq shipments as customers transition to NextSeq 1K/2K. We continued to see strong demand for NextSeq 1K/2K from new-to-Illumina customers, with shipments growing 8% year-over-year. Core Illumina sequencing service and other revenue of $134 million was up 7% year-over-year, driven primarily by higher instrument service contract revenue on a growing installed base, partially offset by lower contributions from codevelopment partnerships. Moving to regional results for Core Illumina. All regions continued to be impacted by tighter funding and budget pressures that are affecting customers' project planning and purchasing behaviors. Additionally, all regions faced the impact of high throughput customers transitioning to NovaSeq X, where we saw customers reduce NovaSeq 6K consumables purchases before they have fully ramped up activity on NovaSeq X. As Chuck mentioned, that though anticipated, this effect was magnified by the larger than expected number of NovaSeq X deliveries and a slower than expected ramp of these instruments coming online in Q2. Continued global demand for NovaSeq X instruments and our stronger-than-anticipated supply in Q2 helped offset these factors. Strong momentum in clinical also continued across the Americas, Europe and AMEA, with consumables shipments to clinical customers in these regions growing just under 20% year-over-year. Europe also benefited from the NIPT reimbursement decision in Germany last year and the national NIPT program in the Netherlands. Americas revenue of $623 million was down 2% year-over-year, and Europe revenue of $303 million grew 11% year-over-year, or 14% on a constant currency basis. AMEA revenue of $118 million declined 10% year-over-year, or 6% on a constant currency basis, which included a 14 percentage point impact from sanctions affecting our ability to conduct business in Russia. As a reminder, these regions also continued to be impacted by the slowdown in COVID surveillance year-over-year. Greater China revenue of $115 million represented a 3% decrease year-over-year, or a 1% increase on a constant currency basis. In addition to persistent macroeconomic and geopolitical challenges that are impacting this region, revenue was negatively impacted by the local competitive landscape, particularly in mid-throughput. Moving to the rest of the Core Illumina P&L. Core Illumina non-GAAP gross margin of 67.0% decreased 280 basis points year-over-year. primarily driven by lower instrument margins due to the NovaSeq X launch, which is typical in a launch year, as well as less fixed cost leverage on lower manufacturing volumes, and higher field services and installation costs. Core Illumina non-GAAP operating expenses of $531 million were up $12 million year-over-year primarily due to the full year impact of our headcount growth in 2022. Non-GAAP operating expenses were lower than expected due to the acceleration of our expense reduction initiatives and lower performance-based compensation. As a result of the above, Core Illumina non-GAAP operating margin was 21.2% in Q2 2023 compared to 24.9% in Q2 2022. Transitioning to the financial results for GRAIL. GRAIL revenue of $22 million for the quarter grew 83% year-over-year, driven primarily by accelerating adoption of Galleri. GRAIL non-GAAP operating expenses totaled $174 million and increased $18 million year-over-year, driven primarily by continued investments to scale GRAIL's commercial organization. Moving to consolidated cash flow and balance sheet items. Cash flow provided by operations was $105 million. Second quarter 2023 capital expenditures were $47 million and free cash flow was $58 million. We did not repurchase any common stock in the quarter. We ended the quarter with approximately $1.6 billion in cash, cash equivalents and short-term investments. As you are aware, we have $750 million in convertible debt that matures this month. Additionally, on July 12, 2023, the European Commission imposed a €432 million fine on Illumina due to the completion of the GRAIL acquisition during the pendency of the European Commission's review. We plan to issue a guarantee and defer the payment of the fine pending the outcome of the appeal of the EU General Court's ruling that the European Commission has jurisdiction to review the GRAIL acquisition. Moving now to 2023 guidance. We now expect full year 2023 consolidated revenue to grow approximately 1%, including Core Illumina revenue that's approximately flat with 2022. As a reminder, these ranges include anticipated reductions from COVID surveillance of approximately 200 basis points, the impact on our business from sanctions on Russia of approximately 100 basis points, as well as a year-over-year negative impact from foreign exchange rates. GRAIL revenue is still expected to be in the range of $90 million to $110 million for 2023. For fiscal 2023, we now expect Core Illumina sequencing instrument revenue growth of approximately 3% year-over-year reflecting our higher NovaSeq X shipment expectation, partially offset by capital and cash flow constraints that have continued to impact our customers' purchasing behaviors, including in China which also had an increased impact from local competition, primarily affecting mid-throughput. We also expect Core Illumina sequencing consumables revenue to decline approximately 3% year-over-year, driven predominately by, one, a more persistent impact of funding issues and cautious purchasing behaviors causing project delays; a more meaningful decrease in NovaSeq 6000 sequencing ahead of planned transitions to NovaSeq X, in part due to our higher shipment expectations for NovaSeq X; three, a delay in the expected ramp of consumables on NovaSeq X; and four, a slower than anticipated second-half recovery in China. We now expect annual pull-through for NovaSeq 6000 of approximately $800,000 to $900,000 per instrument in 2023, NextSeq 550 pull-through in the range of $80,000 to $130,000, and pull-through for MiSeq in the range of $30,000 to $40,000. We still expect pull through for NextSeq 1K/2K to be within the historical guidance range of $120,000 to $170,000 and MiniSeq pull through is still expected to be within the historical range of $20,000 to $25,000 per instrument. With regard to Core Illumina sequencing revenue, we expect it to be approximately flat year-over-year. This includes intercompany sales to GRAIL of approximately $30 million, which are eliminated in consolidation. We now expect consolidated non-GAAP operating margin of approximately 5% and Core Illumina non-GAAP operating margin of approximately 20%. Our revised operating margins reflect our lower revenue expectations for the year and lower gross margins given lower manufacturing volumes and fixed cost leverage. These impacts are partially offset by acceleration of our $100 million-plus annual run rate expense reduction initiatives spanning headcount, real estate, and other costs that Chuck mentioned earlier. We now expect our non-GAAP tax rate to be approximately 41% for 2023, which continues to include an approximately $75 million tax expense impact from R&D capitalization requirements. Although the non-GAAP tax expense impact of R&D capitalization requirements in dollars hasn't changed, the impact to our effective tax rate in 2023 has increased as a result of our lower earnings. Lastly, we now expect non-GAAP earnings per diluted share in the range of $0.75 to $0.90 for 2023, which continues to include dilution from GRAIL's non-GAAP operating loss of approximately $670 million. Before we go to Q&A, I'd like to cover guidance for the third quarter of 2023. We expect Q3 2023 consolidated revenue to grow approximately 2% year-over-year to approximately $1.14 billion. This reflects a sequential decrease of approximately 320 basis points from Q2 2023, primarily driven by a sequential decrease in NovaSeq 6000 consumables as customers continue to transition to NovaSeq X. For the third quarter, we expect non-GAAP diluted EPS of approximately $0.10 to $0.15, reflecting consolidated non-GAAP operating margin of approximately 4% and Core Illumina non-GAAP operating margin of approximately 19%. I will now invite the operator to open the line for Q&A. Thank you.

[Operator Instructions]. And our first question will come from Puneet Souda with Leerink Partners.

The NovaSeq field challenges that you're having in the market, can you talk a little bit about that? How soon can you fix these challenges? What is getting this recovery? And what does that mean for the installs in the third and fourth quarter and maybe even 2024? My question there is, the market sort of freezes to see if these challenges are resolved before taking on more instruments? And then, on the elasticity of demand, clearly, there is significantly more higher dip this year, there's a decline in sequencing consumables versus when we look at the last product launch of NovaSeq 6000. You mentioned a number of factors, but just trying to understand how much of that is due to the challenges that you're facing in the field. And, look, the NovaSeq is definitely selling despite the challenges, so maybe could you just update us on the CEO search as well?

I've been listening to you guys now for a long time and it's nice to be able to be part of the conversation. So as far as the NovaSeq X, some of the positives of the launch of an instrument of this magnitude are that we've placed more instruments than we thought. It also has some of the biggest software placements that we've ever seen. And it's revolutionary from the ground up. What we did is we underestimated the amount of time it would ultimately take to bring these instruments online. But our technical teams are working with our customers to bring them up to speed as quickly as we can.

Puneet, maybe I'll jump in. A couple of things. First, as you know, with any of these launches of this magnitude, as you go out into the field, and as you start installing it, you find some bugs that you have to go resolve. So what we have seen in Q2 was nothing out of the ordinary. We have actually – already have fixes for the issues that we have seen and are in the process of deploying these fixes to our customers. So it has meant a little bit of delay in our original expectations of when these instruments would be fully up to speed. But it hasn't changed any of our or our customer expectations on NovaSeq X. And I will also really urge you to consider that it's not all customers that see this. So some customers are fully [Technical Difficulty], while others, as they have experienced these issues, we are really all hands on deck to go fix these issues in the field. The other thing is that you talked about elasticity in terms of volume increase and sequencing volume increase. Look, we're not seeing any fundamental change to elasticity. The issues that you've seen are more related to transition to the X. So what we have seen is because of the larger number of Xs installed in the in the area because we moved up some of the supply of Xs, we have seen that the decline in the 6k consumables has been faster and larger than we had expected. Again, this is the flip side of people really being excited about the X and our ability to deliver more Xs. So that's what has happened. It's a temporary decline. And we expect that as we ramp up fully on the on the Xs that that volume will come back on in terms of X consumables. But what you're seeing now is this timing gap that we have between those two events. And you said something about – I think there was – whether these challenges on the X are continuing or they'll cause a stall in the market. actually, they haven't caused a stall in the market. We have seen demand for the X and our late stage pipeline continue to ramp up. As Chuck mentioned in his prepared remarks that we have seen the X actually enable experiments and solutions that were not hitherto possible. So we do see continued interest in the X and the continued interest in doing things that were not possible before. And, Chuck, I'll turn it back over to you to for the CEO search.

In regards to the CEO search, the board's actively searching for our new CEO. The search includes both internal and external candidates. They've been really encouraged about the outstanding quality of candidates they're seeing. But, of course, you know that the details of the board's processes on this are confidential. We'll be able to update you as soon as we can.

And our next question will come from Dan Brennan with TD Cowen.

Maybe a couple here packed into one, I guess. The $25 billion flow cell, is that still on track? When will that ship, given some of the issues that you've cited? Second part, China. China actually grew in the quarter, but I know you called out some pressure there. So kind of what's baked in now for China in the back half of the year. Third part would be, reference customer challenges throughout which obviously the broader tool spaces that are really challenging second quarter, but that said, the academic and government end market has actually been pretty robust outside of China. So I'm wondering if you can discuss a little bit where are you seeing these challenges? And then the final point would just be on the NovaSeq consumable pull-through card, and you're mentioning customers are switching faster over to the X. I guess, how do we get comfortable that you're not seeing some either competitive impact or some dampening of utilization, I guess. Kind of what was different this time around, do you think, in terms of your forecasting versus [indiscernible] management forecasted during the last cycle?

I think, first, we continue to prioritize our investments. They're proprietary and we still continue to focus on the differentiation of products. We probably have the biggest and the best proprietary pipeline in the industry. And we continue to lean on it. The 25b flow cell remains on track for launch in second half of 2023. We continue to push forward on the Illumina CLR enrichment assay. That's particularly compelling when you're using it with the 25B flow cell. We continue to move forward on the X-LEAP SBS chemistry for NovaSeq 1k/2k. And we're going to have future offerings for emerging markets for things like proteomics, multiomics, and spatial

Maybe I'll jump in on China, right. So, yes, we did see, like other companies, a slower than expected recovery in the second half of the year. Remember, we had expected China in the first half of the year to be somewhat soft and recovering from the COVID challenges. And then we had expected an acceleration in that recovery in the second half of the year. We do not currently see that happening, both because of some of the challenges that you've seen in the broader economy in China, but also for us from an increased competitive intensity that we are seeing in China in the mid throughput and low throughput segments. Your second part of the question was on the everything ex-China, right? So, there it's a – I don't think the situation is dire as it was in last year. What we are seeing is a little bit of conservatism, given the economic uncertainty in the speed at which people are coming back online or purchasing. So we have seen a little bit of lengthening of cycles in terms of purchasing behavior, both on our instrument side for mid throughput and low throughput and also on some of the consumables pieces. Activity, as I indicated, remains strong, but it's just that any newer projects and newer instruments that are coming in are slower than we had expected. Our win rate in – and we track this pretty closely – in terms of both mid throughput and, of course, on the high throughput side remains high. In fact, it picked up slightly compared to Q1 in Q2. So, again, I think it's more of a lengthening out of cycles and purchasing cycles, rather than anything related to competitive intensity on those fronts. On the X, the issue is not competition at all. As I indicated, we are seeing continued strong interest and strong interest from, of course, our existing customers, but also new newer customers or people that are moving up from mid throughput. We continue to see that our ability to actually deliver on the instruments continues to maintain that interest. As Chuck mentioned, in terms of what these instruments are enabling, there's a whole new set of experiments that are on a larger scale going forward. Again, this is a lead indicator for us. Obviously, people have not ramped up on the X fully. But it is a lot about transitioning to the X and being able to take advantage of the many capabilities that it's providing beyond just the price aspect of it. So the DRAGEN onboard, the faster capabilities, the simplicity of the workflow, obviously, the ambient ship reagents. So there's a lot that goes into that, beyond just the focus on, oh, it's going to help us with the lower price per Gb.

And our next question will come from Dan Arias with Stifel.

Joydeep, obviously, quite a few moving parts here on the top line and the OpEx line. And it looks like what you're doing in terms of cost reduction and expense management is part of a multiyear effort. I guess, given where this year is headed, how are you thinking about op margins next year for the core business relative to the 25% target that you talked about last quarter?

A couple of things. So, one, you're right, we started off as we committed to in our Q1 earnings call. We started off a broad look at cost structure. And actually at the end of Q1, we proceeded with beginning a cost reset that we have executed on and actually have taken out on a run rate basis more than $100 million annually of cost. During the second half of the year, just given some of the uncertainties in the broader economic space, we continue to keep a very close eye on managing expenses and being very careful about allocating expenses to the highest return areas, including the innovation areas that that Chuck talked about. Given the challenges we are having this year, obviously, we acknowledge that getting to margins next year is going to seem like a stretch, but we remain very committed to planning for and delivering on those margins. And that's the way we're moving forward.

And we have a question from Vijay Kumar with Evercore ISI.

I had a two part question. Mostly on the guidance here. I think, third quarter, you said 3%. Your comps for fourth quarter look pretty easy. And historically, when I've looked at your sequential revenue ramp from second quarter, it's always been up. Now look at your second quarter trends sequentially, instruments are up, consumables are up, your pull-through per box is up, China was up. So, anything incremental headwinds that we should be thinking about for the back half? Why your back half shouldn't follow historical patterns? And I think a related question here. You mentioned 800,000 to 900,000 pull through on the Nova 6k. I think there's been some concern. The pull through on the NovaSeq X perhaps might be lower because of the lower sample price point. Maybe can you just walk us through your assumptions around pull through for the Nova X? Could we perhaps see a rebound because I'm assuming inventory levels here for customers are pretty low and they need to restock?

That was a long, multipart question. So let me let me try to get to unpack some of that. So first of all, for the full year guidance, given that it has come down, the components roughly fall into three categories. About 25% of the reduction kin guidance really comes from China. And as I mentioned earlier, for China, that's a two part thing. We are seeing a slower than expected recovery in the larger economy, including some liquidity challenges for mainly our clinical customers. And we are seeing a higher competitive intensity that affect the mid throughput and low throughput segments. That's 25%. The other 75% is roughly equally split into two buckets. So one part is around the transition to the X and the gap we are seeing in terms of the high throughput consumables, right? And this is an issue of the 6k consumables going down pretty rapidly as people are planning to transition to the X and again exacerbate it somewhat by the larger number of Xs we are delivering. And the other part is a slightly slower than expected ramp up on the full utilization of the X. The other 50% of that 75% is coming from some of the customer conservatism that we're seeing in terms of longer sales cycles and slower than expected recovery across the board beyond China. So now second quarter versus the first quarter and then third quarter versus second quarter, so we did see a ramp up from first quarter and the second quarter across many dimensions. Obviously, we shipped more Xs. So we saw a jump on the instrument side. We did see a healthy ramp up on our 6k consumables, primarily driven by the clinical segment. And you're right, we did actually see a jump from Q1 to Q2 in China. But that was expected given China was really depressed for us and other companies in Q1. Moving on to Q3, what you're seeing in some of the sequential ramp down, there are two big reasons for it, right? One, the aforementioned 6k consumable reduction is going to hit sort of a local maxima there because of the larger transition expected to the X. So we're shipping more Xs. That impact on the 6k consumables is going to ramp up. And we don't yet have a full ramp up on our X consumables yet, right? We expect that in Q4, and I'll come back to that. And the other piece is we do expect China to actually be down slightly from Q2, again, because of the expectation that the recovery is proceeding unfortunately more slowly than we had expected. And then, the last piece around that, and just we do expect Q4 to be up significantly, and Q4 is the first quarter you actually start seeing the X consumables come in. You see your traditional end of the year ramp up in some of the spend from company. So you are still seeing that, and that's built into our guidance. The last thing you mentioned was about pull through. By the way, we have not given you pull through on X. As with all new instruments, we'll only come out with that once the instrument ramp up has stayed stabilized. So we do expect, given the interest in X and the kinds of cohort studies and experiments that our customers are telling us they want to do on X, we do expect that our initial assumptions and pull through are still justified. On the NovaSeq 6000, which is probably what you were referring to, we have called down our pull through numbers for this year. But that is really driven by the transition to the X and the larger than expected impact of that transition that I've talked about.

And we'll take a question from Tejas Savant with Morgan Stanley.

One, Chuck, for you on the leadership changes here. Perhaps, Joydeep, feel free to chime in as well. Dan asked about sort of margins and your commitment to 25% and you call that sort of stretchy, but something that you're certainly committed to. Would that sort of framing apply to your mid-teens girls that you talked about at the analyst day as well for Core Illumina. Chuck, for you on the leadership changes, beyond sort of the CEO seat, obviously, the CTO and CMO search is underway as well. Any color you can share there on the thought process behind that? On the base business itself, on the NovaSeq, placements here for the X clearly came in, I think it was 28 to 30 units above the piece where we were, but sequencing instrument revenue beat us by only about 5% to 6%. Right? So the question really is, are you seeing more aggressive discounting? Is that something Illumina is pushing through in response to the macroenvironment? You called out sort of BGI starting to be sort of competitive in China, but just any color on just the pricing dynamics on the instrument side would be helpful as well.

On the executive team and on the process here, so I think the first thing we want to do is just both thank Alex and Phil for all the things that they've done for Illumina. With Alex, what we know is that he's moving on to a new role. He'll be taking the CEO in another company. And I think that we should be really proud to see the kind of leaderships that we grow out of Illumina. So Alex started with Illumina, went over to GRAIL, he came back to Illumina and now he's going to land as a CEO. And we're all looking forward to kind of where that's going to be. We have a really deep bench in our R&D program. And it's really heartening to see employee number four, Steve Barnard, who is the first scientist the company ever hired, bringing him into that role. He knows the technology, he knows the team, and he'll be able to seamlessly pick up where Alex left off. On the Chief Medical Officer, we're going to take some time and look at that organization. We're going to evaluate where we are on the clinical side and on the medical side. Our commitment to our clinical customers, our clinical markets, and our clinical programs continues, and we'll open up that search after we have some time to examine exactly where that organization fits and what we need.

Picking up on your other questions, first of all, in terms of margins and the implied long term growth in mid-teens, look, the long term growth in mid-teens – by the way, our expectations on that have not changed and that, as you know, underpinned on two things. One, a large and growing market that NGS is still under penetrated in and the ability then by – through our innovations addressing the core needs of that market for NGS and Illumina to take an ever growing share. And that then manifests itself in the sequencing volume growth along the three dimensions I had mentioned earlier, first around ever increasing number of samples, again, more cohorts and things like spatial and single cell really driving more of that. The increasing number of analyses per sample. So again, that's really being driven by NGS being able to handle more of the multiomics side of the questions that our customers are asking. And lastly, just the higher sequencing intensity, right? So as you move towards larger panels, as you do more things in liquid biopsy, or things like MRD. So all those remain intact. I think where we are really looking for in the next year or so, as X kind of comes online and enables a lot of these moves into things that we talked about, how quickly does that ramp take place? But in the long term, nothing of what we had guided to really has changed in our mind, and we are looking forward to seeing how the X kind of evolves us down that path. You had asked two other questions. So one was around – the X and the revenue growth on the instrument side not being that high. As I mentioned, right, so we are very pleased that we were able to deliver on the X and ramp up our supply much faster than expected. I think it's a good thing in the long run. What offset that higher number of Xs was two things that I mentioned earlier. So, one, we did see on the China side that we did have a lower than expected number of mid-throughput and low throughput instruments. And in general, overall, given some of the lengthening of the purchasing cycles, we did see a lower than expected mid-throughput and low throughput instrument sales across the world. Now, unlike as in China where competitive intensity was a factor, in the rest of the world, we actually did not see our win rate go down. We actually saw it climb a little bit in Q2. Also, with respect to pricing, we track this very closely, right? So in China, yes, we are being very surgical about when to use price and given the type of customer. But we did see a price decline overall in China. In the rest of the world, our price actually remains on track to where we expected it to be. And we're proceeding along what we wanted to do with – using price as a means to encourage faster adoption of our technologies.

And our next question is from Sung Ji Nam with Scotiabank.

Just a clarification question in terms of the cautious purchasing behavior, is that more for your academic customers? Or is it also across clinical as well? And then sorry if I missed it, but what percentage, I guess, of the consumable delay in purchases is attributable to the launch of the higher density, the 25B, and kind of waiting for the better economics in terms of sequencing?

The cautious purchasing behavior, again, broadly, ex of China is across both academic and clinical segments, right? The reasons are slightly different. I think a lot of our clinical customers are not profit making companies. So they are managing their cash as you would expect them to. And while they continue to have sequencing at their core, we have seen that their purchasing intensity has come off less quickly than we had expected it to. In terms of your second question on how much of a delay is there for 25B, I don't think there's a delay in 25B. So what I was trying to articulate is, the reset in guidance for the whole year, about 25% of that came from the impact from China, the other 75%, about 50% of that 75% really came down to this impact on high throughput consumables due to the transition on X. So that includes, as I said, more transition on the 6k faster and then a little bit of a delay, given some of the issues I had mentioned in Q2 that we're already deploying solutions in the field. There's a little bit of delay that is that is flowing through in 2023.

And we have a question from Rachel Vatnsdal with J.P. Morgan.

First up on guidance, you cut revenue growth by 750 basis points at the midpoint for the year. You've walked through a few of the moving pieces between more cautious CapEx environment in China and then some of these lower consumables as customers are transitioning to the new platform. So can you just give us a more granular breakdown from that 750 basis point cut? How is it really broken out across those three areas? As a follow up, I just want to follow up on some of the earlier comments on China, just mainly relating to some of these stimulus packages. We've heard that there could potentially be another tranche of stimulus in 4Q. So what are you hearing regarding stimulus packages? I know you guys weren't seeing much of the benefit in 1Q, but did you see anything in 2Q? And then how is stimulus contemplated in guidance for the back half of the year?

I mentioned the breakdowns earlier. So very quickly, Rachel, I think about 25% of that guidance reset is really coming from the impact from China. Of the remaining 75%, approximately 50% of that 75% really was coming from the impact on high throughput consumables related to the transition to the X. And then the other 50% is some of the cash conservatism that we're seeing with customers outside of China. Right? So that's roughly how we see the math working out. In China, first of all, there is no stimulus built into our expectations for the second half of the year. There never was in our guidance as well. As far as we could see, the stimulus in the first half of the year benefited more of the industrial segments, which we don't play in. And there is no – we didn't see any stimulus in the second half – sorry, the second quarter either, right? So it's consistent. We've not built it in and we hadn't initially as well.

And our next question will come from John Sourbeer with UBS.

Maybe just a couple of clarifications. So appreciate confirming the long term guidance in the mid-teens. It does sound, though, that some of the China headwinds there could be structural with some of the competition increases there. I guess, just has the long term outlook for that market change at all? Just follow up here, just on the complete long reads, any color there? What you're seeing the demand for that launch?

Let me take those in order. So, I think for China in terms of the long term outlook, I think China remains an important market for us. And we are committed to serving our customers in China. Our brand in China actually is very positive. And again, we remain committed to serving that market. Now, again, given some of the changes we're seeing, we will continue to kind of refine our strategy in terms of how we go to market there, the kinds of partners we choose in order to reach the relevant segments, the highest growing segments of the market better and more efficiently. So none of that has changed. But we continue to observe how China is going to evolve from its current condition as most other people in our space are. In terms of the Illumina complete long reads, so the interest on that has been very high, right? We have a large number of customers that have taken the current WGS product, and are working on it. I think really we have always anticipated that the real jump into this technology would come from the enrichment product, which we are on track to delivering, but that also is coupled because of the economics involved in it, really coupled with the launch of the 25B flow cell, right? So that is still coming through towards the end of this year and really pick up as we go into 2024.

And that concludes our Q&A session. I will now hand the call back over to Salli Schwartz.

Thank you again for joining us today. As a reminder, a replay of this call will be available in the Investors section of our website. This concludes our call and we look forward to seeing you at upcoming conferences and other events.