CytomX Therapeutics, Inc.

CytomX Therapeutics, Inc.

CTMXยทNASDAQ

$3.22

-6.7%
HealthcareBiotechnology

CytomX Therapeutics, Inc. operates as an oncology-focused biopharmaceutical company in the United States. The company develops antibody therapeutics based on its Probody technology platform for the treatment of cancer. The company's product candidates include CX-2009, an antibody drug conjugates (ADC) against CD166, which is in Phase II clinical trials for the treatment of breast cancer; CX-2029 that is in Phase II clinical trials for the treatment of squamous non-small cell lung cancer, head and neck squamous cell carcinoma, esophageal and gastro-esophageal junction cancers, and diffuse large B-cell lymphoma; BMS-986249, a CTLA-4 Probody therapeutic drug, which is in Phase I/II clinical trials for the treatment of metastatic melanoma; and BMS-986288, an anti-CTLA-4 Probody drug, which is in Phase I clinical trials for the treatment of solid tumors. It also develops CX-2043, a conditionally activated ADC targeting the epithelial cell adhesion molecule, as well as CX-904, a conditionally activated epidermal growth factor receptor for the treatment of solid tumor. The company has strategic collaborations with AbbVie Ireland Unlimited Company, Amgen, Inc., Bristol-Myers Squibb Company, ImmunoGen, Inc., Pfizer Inc., and Astellas Pharma Inc. to develop Probody therapeutics. CytomX Therapeutics, Inc. was founded in 2008 and is headquartered in South San Francisco, California.

At a Glance

Live Snapshot
Market Cap$517.85M
EPS-0.1500
P/E Ratio-21.47
Earnings Date08/06/2026
ctmx

CytomX Therapeutics, Inc. Street Expectations Map

CTMX ยท NASDAQ

Wall Street analysts project that CTMX stock may rise significantly over the coming 12 months. The consensus 1-year price target stands at 10.71, with estimates ranging from a low of 6.00 to a high of 16.00.

Lowest Target
6.00
86.34%
Consensus Target
10.71
232.61%
Highest Target
16.00
396.89%

The consensus 1-year price target stands at 10.71, with estimates ranging from a low of 6.00 to a high of 16.00.

Analyst Consensus Analysis

Upside Potential

+232.6%

Substantial upside potential. Analysts see significant value gap, suggesting the stock may be materially undervalued at current levels.

Analyst Agreement

93.4% spread

High uncertainty. Very wide target spread indicates significant disagreement among analystsโ€”major valuation uncertainty or transformation underway.

Analyst Conviction

Low

High uncertainty: Wide dispersion indicates analysts struggle to agree on valuationโ€”proceed with caution and independent analysis.

Market Sentiment Insight

High risk, high reward: Substantial upside potential exists, but wide analyst disagreement signals execution risk or unclear catalysts. Thorough due diligence essential before committing capital.

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CytomX Therapeutics, Inc. Forward Estimates of Revenue

CTMX ยท NASDAQ
Latest Revenue
76.20M
FY 2025
Avg Estimate
30.73M
FY 2026
Estimate Range
7.05M - 47.57M
Analyst Spread

Forward Growth Analysis

Projected Growth-59.7%

Significant contraction projectedโ€”major business challenges or industry disruption likely.

Analyst Coverage6 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread132%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookCautious

Analyst skepticism evidentโ€”carefully evaluate risks before investment decisions.

Key Insight

Declining estimates with wide disagreement: Analysts projecting contraction without consensus signals significant business uncertaintyโ€”exercise caution.

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CytomX Therapeutics, Inc. Forward Estimates of Net Income

CTMX ยท NASDAQ
Latest Net Income
-17.37M
FY 2025
Avg Estimate
-31.25M
FY 2026
Estimate Range
-40.66M - -21.83M
Analyst Spread

Forward Growth Analysis

Projected Growth-79.9%

Significant contraction projectedโ€”major business challenges or industry disruption likely.

Analyst Coverage6 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread60%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookCautious

Analyst skepticism evidentโ€”carefully evaluate risks before investment decisions.

Key Insight

Declining estimates with wide disagreement: Analysts projecting contraction without consensus signals significant business uncertaintyโ€”exercise caution.

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CytomX Therapeutics, Inc. Forward Estimates of EPS

CTMX ยท NASDAQ
Latest EPS
-0.15
FY 2025
Avg Estimate
$-0.38
FY 2026
Estimate Range
$-0.48 - $-0.26
Analyst Spread

Forward Growth Analysis

Projected Growth-154.7%

Significant contraction projectedโ€”major business challenges or industry disruption likely.

Analyst Coverage6 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread58%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookCautious

Analyst skepticism evidentโ€”carefully evaluate risks before investment decisions.

Key Insight

Declining estimates with wide disagreement: Analysts projecting contraction without consensus signals significant business uncertaintyโ€”exercise caution.

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CytomX Therapeutics, Inc. Forward Estimates of EBIT

CTMX ยท NASDAQ
Latest EBIT
-19.56M
FY 2025
Avg Estimate
-17.72M
FY 2026
Estimate Range
-27.43M - -4.07M
Analyst Spread

Forward Growth Analysis

Projected Growth+9.4%

Moderate growth expected, typical for mature businesses with stable market positions.

Analyst Coverage6 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread132%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookNeutral

Mixed signalsโ€”some positive indicators offset by concerns about growth or uncertainty.

Key Insight

High forecast uncertainty: Wide estimate range indicates analysts struggling to predict outcomesโ€”suggests elevated risk and potential volatility.

ctmx

CytomX Therapeutics, Inc. Forward Estimates of EBITDA

CTMX ยท NASDAQ
Latest EBITDA
-18.19M
FY 2025
Avg Estimate
-17.51M
FY 2026
Estimate Range
-27.10M - -4.02M
Analyst Spread

Forward Growth Analysis

Projected Growth+3.7%

Flat growth suggests market maturity or near-term challenges offsetting expansion efforts.

Analyst Coverage6 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread132%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookCautious

Analyst skepticism evidentโ€”carefully evaluate risks before investment decisions.

Key Insight

High forecast uncertainty: Wide estimate range indicates analysts struggling to predict outcomesโ€”suggests elevated risk and potential volatility.

ctmx

CytomX Therapeutics, Inc. Forward Estimates of SG&A Expense

CTMX ยท NASDAQ
Latest SG&A Expense
29.97M
FY 2025
Avg Estimate
17.79M
FY 2026
Estimate Range
4.08M - 27.53M
Analyst Spread

Forward Growth Analysis

Projected Growth-40.6%

Significant contraction projectedโ€”major business challenges or industry disruption likely.

Analyst Coverage6 Analysts

Moderate coverageโ€”sufficient for guidance but may lack depth of large-cap analysis.

Estimate Spread132%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookCautious

Analyst skepticism evidentโ€”carefully evaluate risks before investment decisions.

Key Insight

Declining estimates with wide disagreement: Analysts projecting contraction without consensus signals significant business uncertaintyโ€”exercise caution.

ctmx

CytomX Therapeutics, Inc. Insider Positioning

CTMX ยท NASDAQ

During the last 12 months, insiders have purchased $2.43M and sold $1.69M worth of CTMX shares, resulting in $742K of net buying activity.

3 Months

Bought

0

0.00

Sold

191.1K

1.23M

Net Activity

-1.2M

-$1.23M

3-6 Months

Bought

0

0.00

Sold

0

0.00

Net Activity

+0

+$0

6-9 Months

Bought

650.0K

2.43M

Sold

101.8K

461.91K

Net Activity

+2.0M

+$1.97M

9-12 Months

Bought

0

0.00

Sold

0

0.00

Net Activity

+0

+$0

Top Buyers

1
LR

Lester Rachael

Officer: Chief Business Officer

650.0K sharesโ€ข1 transactions

$2.43M

Top Sellers

1
MSA

Mccarthy Sean A.

Director, Officer: Ceo

220.8K sharesโ€ข2 transactions

$1.23M

2
BM

Belvin Marcia

Officer: Svp, Chief Scientific Officer

31.5K sharesโ€ข1 transactions

$202K

3
CY

Chu Yu-Waye

Officer: Chief Medical Officer

21.3K sharesโ€ข1 transactions

$137K

4
OC

Ogden Christopher

Officer: Chief Financial Officer

19.3K sharesโ€ข1 transactions

$124K

Insider Activity Analysis

Net Insider Sentiment

Bullish

Moderately bullish with $742K net buying. Insiders show cautious optimism through measured share purchases.

Buy/Sell Ratio

1.44:1

Positive buy/sell ratio. Buying exceeds or matches selling, indicating net positive insider sentiment.

Recent Trend (3 Months)

$1.23M

Heavy recent selling activity. Recent insider sales notably exceed purchasesโ€”may warrant investigation into company developments.

Insider Participation

High Selling

4 insider sellers vs. 1 buyers. Widespread selling across multiple insiders may signal concerns.