AnaptysBio, Inc.

AnaptysBio, Inc.

ANABยทNASDAQ

$51.24

-3.6%
HealthcareBiotechnology

AnaptysBio, Inc., a clinical stage biotechnology company, engages in developing therapeutic product candidates for inflammation and immuno-oncology indications. Its products include Imsidolimab, an antibody that inhibits the interleukin-36 receptor (IL-36R) for the treatment of various dermatological inflammatory diseases; Rosnilimab, an anti-PD-1 agonist antibody program designed to augment PD-1 signaling through rosnilimab treatment to suppress T-cell driven human inflammatory diseases; and ANB032, an anti-BTLA modulator antibody applicable to human inflammatory diseases associated with lymphoid and myeloid immune cell dysregulation. The company also focuses on developing various antibody programs that are advanced to preclinical and clinical milestones under its collaborations. It has a collaboration and license agreement with GlaxoSmithKline, Inc. and Bristol-Myers Squibb; and license agreements with United Kingdom Research and Innovation, as well as Millipore Corporation. The company was formerly known as Anaptys Biosciences, Inc. and changed its name to AnaptysBio, Inc. in July 2006. AnaptysBio, Inc. was incorporated in 2005 and is based in San Diego, California.

At a Glance

Live Snapshot
Market Cap$2.21B
EPS-0.4600
P/E Ratio-111.39
Earnings Date08/05/2026
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AnaptysBio, Inc. Street Expectations Map

ANAB ยท NASDAQ

Wall Street analysts project that ANAB stock may rise significantly over the coming 12 months. The consensus 1-year price target stands at 83.14, with estimates ranging from a low of 50.00 to a high of 140.00.

Lowest Target
50.00
-2.42%
Consensus Target
83.14
62.26%
Highest Target
140.00
173.22%

The consensus 1-year price target stands at 83.14, with estimates ranging from a low of 50.00 to a high of 140.00.

Analyst Consensus Analysis

Upside Potential

+62.3%

Substantial upside potential. Analysts see significant value gap, suggesting the stock may be materially undervalued at current levels.

Analyst Agreement

108.3% spread

High uncertainty. Very wide target spread indicates significant disagreement among analystsโ€”major valuation uncertainty or transformation underway.

Risk-Reward Profile

71.58x

Favorable risk-reward. Potential upside significantly exceeds downside risk, offering asymmetric return profile attractive for risk-tolerant investors.

Analyst Conviction

Low

High uncertainty: Wide dispersion indicates analysts struggle to agree on valuationโ€”proceed with caution and independent analysis.

Market Sentiment Insight

High risk, high reward: Substantial upside potential exists, but wide analyst disagreement signals execution risk or unclear catalysts. Thorough due diligence essential before committing capital.

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AnaptysBio, Inc. Forward Estimates of Revenue

ANAB ยท NASDAQ
Latest Revenue
234.60M
FY 2025
Avg Estimate
123.99M
FY 2026
Estimate Range
33.35M - 214.65M
Analyst Spread

Forward Growth Analysis

Projected Growth-47.1%

Significant contraction projectedโ€”major business challenges or industry disruption likely.

Analyst Coverage4 Analysts

Limited coverage may indicate reduced institutional interest or information availability.

Estimate Spread146%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookCautious

Analyst skepticism evidentโ€”carefully evaluate risks before investment decisions.

Key Insight

Declining estimates with wide disagreement: Analysts projecting contraction without consensus signals significant business uncertaintyโ€”exercise caution.

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AnaptysBio, Inc. Forward Estimates of Net Income

ANAB ยท NASDAQ
Latest Net Income
-13.23M
FY 2025
Avg Estimate
6.12M
FY 2026
Estimate Range
-107.07M - 43.83M
Analyst Spread

Forward Growth Analysis

Projected Growth+146.2%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage4 Analysts

Limited coverage may indicate reduced institutional interest or information availability.

Estimate Spread2466%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookNeutral

Mixed signalsโ€”some positive indicators offset by concerns about growth or uncertainty.

Key Insight

Limited coverage with volatile estimates: Few analysts covering despite significant projected changes may indicate information gaps or emerging risks.

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AnaptysBio, Inc. Forward Estimates of EPS

ANAB ยท NASDAQ
Latest EPS
-0.46
FY 2025
Avg Estimate
$-2.04
FY 2026
Estimate Range
$-3.42 - $1.40
Analyst Spread

Forward Growth Analysis

Projected Growth-342.5%

Significant contraction projectedโ€”major business challenges or industry disruption likely.

Analyst Coverage4 Analysts

Limited coverage may indicate reduced institutional interest or information availability.

Estimate Spread237%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookCautious

Analyst skepticism evidentโ€”carefully evaluate risks before investment decisions.

Key Insight

Declining estimates with wide disagreement: Analysts projecting contraction without consensus signals significant business uncertaintyโ€”exercise caution.

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AnaptysBio, Inc. Forward Estimates of EBIT

ANAB ยท NASDAQ
Latest EBIT
47.90M
FY 2025
Avg Estimate
-92.02M
FY 2026
Estimate Range
-159.30M - -24.75M
Analyst Spread

Forward Growth Analysis

Projected Growth-292.1%

Significant contraction projectedโ€”major business challenges or industry disruption likely.

Analyst Coverage4 Analysts

Limited coverage may indicate reduced institutional interest or information availability.

Estimate Spread146%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookCautious

Analyst skepticism evidentโ€”carefully evaluate risks before investment decisions.

Key Insight

Declining estimates with wide disagreement: Analysts projecting contraction without consensus signals significant business uncertaintyโ€”exercise caution.

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AnaptysBio, Inc. Forward Estimates of EBITDA

ANAB ยท NASDAQ
Latest EBITDA
50.32M
FY 2025
Avg Estimate
-90.94M
FY 2026
Estimate Range
-157.44M - -24.46M
Analyst Spread

Forward Growth Analysis

Projected Growth-280.7%

Significant contraction projectedโ€”major business challenges or industry disruption likely.

Analyst Coverage4 Analysts

Limited coverage may indicate reduced institutional interest or information availability.

Estimate Spread146%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookCautious

Analyst skepticism evidentโ€”carefully evaluate risks before investment decisions.

Key Insight

Declining estimates with wide disagreement: Analysts projecting contraction without consensus signals significant business uncertaintyโ€”exercise caution.

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AnaptysBio, Inc. Forward Estimates of SG&A Expense

ANAB ยท NASDAQ
Latest SG&A Expense
50.74M
FY 2025
Avg Estimate
174.28M
FY 2026
Estimate Range
46.87M - 301.71M
Analyst Spread

Forward Growth Analysis

Projected Growth+243.5%

Strong growth expectations signal robust business momentum and market opportunity expansion.

Analyst Coverage4 Analysts

Limited coverage may indicate reduced institutional interest or information availability.

Estimate Spread146%

Wide estimate range reveals significant forecast uncertainty and potential volatility.

OutlookNeutral

Mixed signalsโ€”some positive indicators offset by concerns about growth or uncertainty.

Key Insight

Limited coverage with volatile estimates: Few analysts covering despite significant projected changes may indicate information gaps or emerging risks.

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AnaptysBio, Inc. Insider Positioning

ANAB ยท NASDAQ

During the last 12 months, insiders have sold $4.54M worth of ANAB shares, with no buying activity reported.

3 Months

Bought

0

0.00

Sold

13.1K

730.58K

Net Activity

-731K

-$731K

3-6 Months

Bought

0

0.00

Sold

77.7K

3.74M

Net Activity

-3.7M

-$3.74M

6-9 Months

Bought

0

0.00

Sold

5.0K

70.10K

Net Activity

-70K

-$70K

9-12 Months

Bought

0

0.00

Sold

0

0.00

Net Activity

+0

+$0

Top Buyers

No buying activity

Top Sellers

1
LEJ

Loumeau Eric J

Officer: Chief Legal Officer

37.5K sharesโ€ข6 transactions

$1.68M

2
SJP

Schmid John P.

Director

12.6K sharesโ€ข1 transactions

$702K

3
FD

Faga Daniel

Director, Officer: President, Ceo

14.8K sharesโ€ข2 transactions

$667K

4
MD

Mulroy Dennis

Officer: Chief Financial Officer

12.5K sharesโ€ข2 transactions

$612K

5
MM

Marquet Magda

Director

9.3K sharesโ€ข1 transactions

$447K

Insider Activity Analysis

Net Insider Sentiment

Bearish

Strong bearish signal with $4.54M net selling. Heavy insider selling may indicate concerns about valuation or near-term prospects.

Buy/Sell Ratio

0.00:1

Very poor ratio. Heavy selling with minimal buying suggests insiders may be concerned about valuation or outlook.

Recent Trend (3 Months)

$731K

Heavy recent selling activity. Recent insider sales notably exceed purchasesโ€”may warrant investigation into company developments.

Insider Participation

High Selling

5 insider sellers vs. 0 buyers. Widespread selling across multiple insiders may signal concerns.

Insider Activity Insight

Multiple red flags: Heavy selling, numerous sellers, and continued recent selling create a concerning pattern. Investigate fundamental drivers and consider whether company guidance or industry conditions have deteriorated.