AT

Actuate Therapeutics Inc

ACTU·NASDAQ

$2.11

-4.5%
HealthcareBiotechnology

Actuate Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on developing therapies for the treatment of cancers. The company's lead product candidate is Elraglusib Injection, a novel glycogen synthase kinase-3 inhibitor to treat metastatic pancreatic ductal adenocarcinoma. It also develops Elraglusib for the treatment of Ewing sarcoma, metastatic melanoma, and colorectal cancer. The company was formerly known as Apotheca Therapeutics, Inc. and changed its name to Actuate Therapeutics, Inc. in October 2015. The company was incorporated in 2015 and is based in Fort Worth, Texas.

At a Glance

Live Snapshot
Market Cap$50.48M
EPS-1.0600
P/E Ratio-5.79
Earnings Date06/03/2026
-270.08%
Return on Invested Capital
-94%
3Y+116.0%
5Y+116.0%
10Y+116.0%
-280.51%
Return on Equity
-99%
3Y+106.0%
5Y+106.0%
10Y+106.0%
-158.36%
Return on Assets
-46%
3Y+61.0%
5Y+61.0%
10Y+61.0%
AT

Actuate Therapeutics Inc Management Team

ACTU · NASDAQ
MD

Mr. Daniel M. Schmitt

Chief Executive Officer, President & Director

Compensation

$600,000

Born 1962(Age 64)
male
MP

Mr. Paul J. Lytle CPA

Chief Financial Officer

Compensation

$411,627

Born 1968(Age 58)
male
DA

Dr. Andrew P. Mazar Ph.D.

Co-Founder & Chief Operating Officer

Compensation

$675,000

Born 1962(Age 64)
DA

Dr. Alan Kozikowski Ph.D.

Scientific Founder and Advisor

Born 1951(Age 75)
a

Actuate Therapeutics Inc Insider Positioning

ACTU · NASDAQ

During the last 12 months, insiders have purchased $1.50M and sold $1.62M worth of ACTU shares, resulting in $124K of net selling activity.

3 Months

Bought

0

0.00

Sold

0

0.00

Net Activity

+0

+$0

3-6 Months

Bought

0

0.00

Sold

280.0K

1.62M

Net Activity

-1.6M

-$1.62M

6-9 Months

Bought

0

0.00

Sold

0

0.00

Net Activity

+0

+$0

9-12 Months

Bought

214.3K

1.50M

Sold

0

0.00

Net Activity

+1.5M

+$1.50M

Top Buyers

1
KLW

Kreis Leslie W.

Director, 10 Percent Owner:

71.4K shares1 transactions

$500K

2
BECL

Bios Equity Cof, Lp

Director, 10 Percent Owner:

71.4K shares1 transactions

$500K

3
FAG

Fletcher Aaron G.L.

Director, 10 Percent Owner:

71.4K shares1 transactions

$500K

Top Sellers

1
TTS

Thomson Todd S

Director, 10 Percent Owner:

280.0K shares1 transactions

$1.62M

Insider Activity Analysis

Net Insider Sentiment

Bearish

Slightly bearish with $124K net selling. Selling modestly exceeds buying, which could be routine diversification rather than concern.

Buy/Sell Ratio

0.92:1

Moderately negative ratio. Selling is roughly double the buying, which may be routine or signal caution.

Insider Participation

High Buying

3 insider buyers vs. 1 sellers. Broad-based buying across management team suggests widespread confidence.

Insider Activity Insight

Balanced insider activity: Roughly equal buying and selling suggests normal portfolio management rather than strong directional signals. Look to other metrics for clearer investment insights.

SEC Filings

ACTU - Filing history and reports

Filing TypeFiling DatePeriod EndingFiscal YearActions
DEF 14A

DEF 14A 2026

N/A

April 06, 2026
May 21, 2026
2026
DEF 14A

DEF 14A 2025

N/A

April 08, 2025
May 22, 2025
2025
Showing 1 to 2 of 2 filings