Upstream Bio, Inc.

Healthcare

NASDAQ:UPB · NASDAQ Global Select

Market Cap $340.12M Beta 1.11 P/E (TTM) -2.2
$6.25 +1.63%

+$0.10 today

52W Low $5.85High $33.68

Vol 0.79M · Avg 0.66M

EPS (TTM) -$2.89Biotechnology

Management

Put operating results in leadership context

Review returns on capital, executive background, insider transactions, and growth quality to judge whether management is compounding value well.

Return Metrics

ROE, ROIC & ROA over time

Management

ROE

-42.2%

avg -4.1%

ROIC

-47.0%

avg -68.5%

ROA

-40.5%

avg -50.1%

Analysis

ROA is currently the strongest return metric at -40.5% versus its period average of -50.1%. 0 of 3 return metrics are above their quality threshold, which helps indicate how efficiently the company turns capital and assets into profit.

Management

Key executives, compensation & ownership

Management
NameTitleCompensationTenureAgeShares OwnedOwnership %

E. Rand Sutherland

Chief Executive Officer & Director$1.00M56$70,812.000.13%

Aaron Deykin

Chief Medical Officer and Head of Research & Development$741,800.0059$33,197.000.06%

Michael Paul Gray

Chief Financial Officer & Chief Operating Officer$706,300.0055$28,795.000.05%

Allison Ambrose

Senior Vice President, General Counsel & Secretary$59,792.0041$16,048.000.03%

Adam Houghton

Chief Business Officer55$23,601.000.04%

Meggan Buckwell

Director of Corporate Communications & Investor Relations

Mersedeh Miraliakbari

Senior Vice President of Regulatory Affairs & Quality

Stacy Price

Chief Technology Officer57

Lisa Fiering

Senior Vice President of People & Culture

Fang Xie

Vice President & Head of Biometrics

Insider Trading

SEC Form 4 transactions — last 12 months

Management

Buys

0

$0.00

Sells

10

$77,192.77

Net Sentiment

$77,192.77

Net selling

Most Active

GRAY MICHAEL

2 transactions

DateInsiderTypeSharesPriceValue
Jun 16, 2026

GRAY MICHAEL

Direct

Sell853$6.10$5,203.30
Jun 16, 2026

Sutherland Everett Rand

Direct

Sell2.1K$6.10$12,779.50
Jun 16, 2026

Houghton Adam

Direct

Sell700$6.10$4,270.00
Jun 16, 2026

Deykin Aaron

Direct

Sell895$6.10$5,459.50
Jun 16, 2026

Ambrose Allison

Direct

Sell477$6.10$2,909.70
Mar 16, 2026

GRAY MICHAEL

Direct

Sell852$9.29$7,915.08
Mar 16, 2026

Deykin Aaron

Direct

Sell894$9.29$8,305.26
Mar 16, 2026

Sutherland Everett Rand

Direct

Sell2.1K$9.29$19,443.97
Mar 16, 2026

Ambrose Allison

Direct

Sell475$9.29$4,412.75
Mar 16, 2026

Houghton Adam

Direct

Sell699$9.29$6,493.71

Analysis

Insiders reported 0 buys worth $0.00 and 10 sells worth $77,192.77 over the last 12 months. That adds up to net selling of $77,192.77. GRAY MICHAEL was the most active insider with 2 transactions.

Growth Analysis

Historical CAGR & forward analyst estimates

Metric 10yr 5yr3yr Fwd Est.
EPSN/AN/AN/A
N/A5 analysts
RevenueN/AN/A+33.0%
+91.7% (5yr)6 analysts
Net IncomeN/AN/AN/A
N/A6 analysts
EBITN/AN/AN/A
N/A6 analysts

Analysis

Recent growth has been strongest in Revenue at +33.0% over three years. Forward estimates point to Revenue at +91.7% (5yr), giving you a quick check on whether expectations are accelerating or cooling.

Who manages UPB?

Upstream Bio, Inc. (UPB) lists 10 active executives. The top listed executive is Adam Houghton, Chief Business Officer.

Are UPB insiders buying or selling?

Recent insider activity shows net buying of $16.38M.

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