Taysha Gene Therapies, Inc.

Taysha Gene Therapies, Inc.

Healthcare

NASDAQ:TSHA · NASDAQ Global Select

Market Cap $1.35B Beta 1.18 P/E (TTM) -16.1
$5.71 +2.33%

+$0.13 today

52W Low $2.25High $7.30

Vol 2.02M · Avg 2.73M

EPS (TTM)-$0.35
Biotechnology

Management

Put operating results in leadership context

Review returns on capital, executive background, insider transactions, and growth quality to judge whether management is compounding value well.

Return Metrics

ROE, ROIC & ROA over time

Management

ROE

-44.1%

avg -2455.1%

ROIC

-34.9%

avg 65.2%

ROA

-31.7%

avg -1116.4%

Analysis

ROA is currently the strongest return metric at -31.7% versus its period average of -1116.4%. 0 of 3 return metrics are above their quality threshold, which helps indicate how efficiently the company turns capital and assets into profit.

Management

Key executives, compensation & ownership

Management
NameTitleCompensationTenureAgeShares OwnedOwnership %

Sean Nolan

Chief Executive Officer & Chairman$1.19M58$2.91M1.01%

Sukumar Nagendran

President, Head of Research & Development and Director$1.04M59$1.14M0.40%

Kamran Alam

Chief Financial Officer & Corporate Secretary$741,904.0048$1.44M0.50%

Berge Minassian

Chief Medical Advisor of UT Southwestern Gene Therapy Program

Hayleigh Collins

Director of Corporate Communications & Investor Relations

David McNinch

Chief Commercial Officer57

Frederick Porter

Chief of Staff & Technical Operations Officer

Sean McAuliffe

Chief Business Officer$2.91M1.01%

Emily McGinnis

Chief Patient & External Affairs Officer

Rumana Haque-Ahmed

Chief Regulatory Officer

Steven Gray

Chief Scientific Advisor of UT Southwestern Gene Therapy Program

Insider Trading

SEC Form 4 transactions — last 12 months

Management

Buys

0

$0.00

Sells

14

$6.37M

Net Sentiment

$6.37M

Net selling

Most Active

Nagendran Sukumar

8 transactions

DateInsiderTypeSharesPriceValue
Apr 10, 2026

Nagendran Sukumar

Direct

Sell200.0K$4.46$892,000.00
Feb 4, 2026

Alam Kamran

Direct

Sell1.7K$4.52$7,480.60
Jan 26, 2026

Nolan Sean P.

Direct

Sell41.3K$4.61$190,448.32
Jan 26, 2026

Nagendran Sukumar

Direct

Sell26.9K$4.61$124,091.98
Jan 26, 2026

Alam Kamran

Direct

Sell23.8K$4.61$109,943.89
Jan 23, 2026

Nolan Sean P.

Direct

Sell136.8K$4.75$649,747.75
Jan 23, 2026

Nagendran Sukumar

Direct

Sell89.1K$4.75$423,377.00
Jan 23, 2026

Alam Kamran

Direct

Sell79.0K$4.75$375,098.00
Jan 12, 2026

Nagendran Sukumar

Direct

Sell200.0K$4.71$942,000.00
Dec 1, 2025

Nagendran Sukumar

Direct

Sell260.0K$4.51$1,172,811.97

1–10 of 14

Analysis

Insiders reported 0 buys worth $0.00 and 14 sells worth $6.37M over the last 12 months. That adds up to net selling of $6.37M. Nagendran Sukumar was the most active insider with 8 transactions.

Growth Analysis

Historical CAGR & forward analyst estimates

Metric 10yr5yr3yr Fwd Est.
EPSN/AN/AN/A
N/A2 analysts
RevenueN/AN/AN/A
+80.3% (7yr)3 analysts
Net IncomeN/AN/AN/A
N/A3 analysts
EBITN/AN/AN/A
N/A3 analysts

Analysis

Forward estimates point to Revenue at +80.3% (7yr), giving you a quick read on expected growth from here.

Who manages TSHA?

Taysha Gene Therapies, Inc. (TSHA) lists 11 active executives. The top listed executive is Berge Minassian, Chief Medical Advisor of UT Southwestern Gene Therapy Program.

Are TSHA insiders buying or selling?

Recent insider activity shows net buying of $54.40M.

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