Spero Therapeutics, Inc.

Spero Therapeutics, Inc.

Healthcare

NASDAQ:SPRO · NASDAQ Global Select

Market Cap $165.02M Beta 1.46 P/E (TTM) 10.7
$2.85 +5.56%

+$0.15 today

52W Low $1.80High $3.22

Vol 0.62M · Avg 0.56M

EPS (TTM)$0.27
Biotechnology

Management

Put operating results in leadership context

Review returns on capital, executive background, insider transactions, and growth quality to judge whether management is compounding value well.

Return Metrics

ROE, ROIC & ROA over time

Management

ROE

14.5%

avg -539.8%

ROIC

-0.0%

avg -242.8%

ROA

12.4%

avg -58.5%

Analysis

ROE is currently the strongest return metric at 14.5% versus its period average of -539.8%. 1 of 3 return metrics are above their quality threshold, which helps indicate how efficiently the company turns capital and assets into profit.

Management

Key executives, compensation & ownership

Management
NameTitleCompensationTenureAgeShares OwnedOwnership %

Esther Rajavelu

CEO, President, CFO, Chief Business Officer, Treasurer & Director$1.65M47$986,851.001.70%

Timothy Keutzer

Chief Operating Officer$1.23M58$742,506.001.28%

John Raymond

Senior Vice President of Finance & Business Operations$75,000.000.13%

Sheila Finan

Senior VP & Controller

Insider Trading

SEC Form 4 transactions — last 12 months

Management

Buys

0

$0.00

Sells

11

$568,328.13

Net Sentiment

$568,328.13

Net selling

Most Active

Rajavelu Esther

5 transactions

DateInsiderTypeSharesPriceValue
May 4, 2026

Rajavelu Esther

Direct

Sell25.2K$2.51$63,352.40
Feb 6, 2026

Rajavelu Esther

Direct

Sell37.1K$2.36$87,558.36
Feb 6, 2026

Rajavelu Esther

Direct

Sell50.8K$2.36$119,925.76
Feb 6, 2026

Keutzer Timothy

Direct

Sell18.7K$2.36$44,018.72
Feb 4, 2026

Keutzer Timothy

Direct

Sell3.5K$2.24$7,775.04
Feb 3, 2026

Keutzer Timothy

Direct

Sell24.2K$2.14$51,839.36
Feb 2, 2026

Rajavelu Esther

Direct

Sell18.4K$2.20$40,572.40
Feb 2, 2026

Keutzer Timothy

Direct

Sell18.9K$2.20$41,560.20
Nov 7, 2025

Rajavelu Esther

Direct

Sell40.3K$2.37$95,439.90
Aug 28, 2025

Mahadevia Ankit

Direct

Sell6.6K$1.97$12,946.84

1–10 of 11

Analysis

Insiders reported 0 buys worth $0.00 and 11 sells worth $568,328.13 over the last 12 months. That adds up to net selling of $568,328.13. Rajavelu Esther was the most active insider with 5 transactions.

Growth Analysis

Historical CAGR & forward analyst estimates

Metric 10yr5yr3yr Fwd Est.
EPSN/AN/AN/A
N/A1 analysts
RevenueN/AN/A+278.4%
+18.5% (10yr)1 analysts
Net IncomeN/AN/AN/A
N/A1 analysts
EBITN/AN/AN/A
N/A1 analysts

Analysis

Recent growth has been strongest in Revenue at +278.4% over three years. Forward estimates point to Revenue at +18.5% (10yr), giving you a quick check on whether expectations are accelerating or cooling.

Who manages SPRO?

Spero Therapeutics, Inc. (SPRO) lists 4 active executives. The top listed executive is Esther Rajavelu, CEO, President, CFO, Chief Business Officer, Treasurer & Director.

Are SPRO insiders buying or selling?

Recent insider activity shows net buying of $23.13M.

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