Syndax Pharmaceuticals, Inc.

Syndax Pharmaceuticals, Inc.

Healthcare

NASDAQ:SNDX · NASDAQ Global Select

Market Cap $1.59B Beta 0.39 P/E (TTM) -6.5
$18.25 +1.90%

+$0.34 today

52W Low $8.59High $25.59

Vol 1.05M · Avg 1.67M

EPS (TTM)-$2.81
Biotechnology

Management

Put operating results in leadership context

Review returns on capital, executive background, insider transactions, and growth quality to judge whether management is compounding value well.

Return Metrics

ROE, ROIC & ROA over time

Management

ROE

-441.6%

avg -100.8%

ROIC

-66.6%

avg -51.8%

ROA

-53.9%

avg -42.6%

Analysis

ROA is currently the strongest return metric at -53.9% versus its period average of -42.6%. 0 of 3 return metrics are above their quality threshold, which helps indicate how efficiently the company turns capital and assets into profit.

Management

Key executives, compensation & ownership

Management
NameTitleCompensationTenureAgeShares OwnedOwnership %

Michael A. Metzger

Chief Executive Officer & Director$1.61M55$139,252.000.16%

Nicholas Botwood MBBS

Head of Research & Development and Chief Medical Officer$876,846.0058$60,885.000.07%

Keith Alan Goldan

CFO, Treasurer & Principal Accounting Officer$852,548.0055$139,252.000.16%

Luke J. Albrecht

Senior Vice President, General Counsel & Secretary$842,308.0047$14,000.000.02%

Steven Closter

Chief Commercial Officer$822,878.0057

Michael Downes

Co-Founder$484,843.000.55%

Peter Ordentlich

Co-Founder & Chief Scientific Officer57$0.00<0.01%

Ronald Evans

Co-Founder, Advisor and Chair of Scientific Advisory Board76

Kevin McManus

Chief People Officer57

Sharon Klahre

Vice President of Investor Relations & Communications

Richard A. Heyman

Co-Founder69$139,252.000.16%

Insider Trading

SEC Form 4 transactions — last 12 months

Management

Buys

0

$0.00

Sells

14

$5.50M

Net Sentiment

$5.50M

Net selling

Most Active

Metzger Michael A

5 transactions

DateInsiderTypeSharesPriceValue
Jun 12, 2026

Botwood Nicholas A.J.

Direct

Sell31.2K$18.14$566,602.90
Jun 11, 2026

Botwood Nicholas A.J.

Direct

Sell34.3K$18.00$617,040.00
Jun 1, 2026

Metzger Michael A

Direct

Sell6.8K$18.99$130,024.53
Jun 1, 2026

Goldan Keith A.

Direct

Sell1.2K$18.99$22,351.23
Feb 9, 2026

Metzger Michael A

Direct

Sell17.2K$21.03$360,819.45
Feb 9, 2026

Goldan Keith A.

Direct

Sell3.4K$21.03$71,705.48
Feb 6, 2026

Goldan Keith A.

Direct

Sell2.1K$20.62$42,930.84
Feb 6, 2026

Metzger Michael A

Direct

Sell7.4K$20.62$152,835.44
Sep 8, 2025

Metzger Michael A

Direct

Sell157.3K$16.41$2,582,021.37
Aug 18, 2025

Podlesak Dennis

Direct

Sell19.2K$15.84$304,170.24

1–10 of 14

Analysis

Insiders reported 0 buys worth $0.00 and 14 sells worth $5.50M over the last 12 months. That adds up to net selling of $5.50M. Metzger Michael A was the most active insider with 5 transactions.

Growth Analysis

Historical CAGR & forward analyst estimates

Metric 10yr5yr3yr Fwd Est.
EPSN/AN/AN/A
N/A6 analysts
RevenueN/AN/AN/A
+64.5% (15yr)5 analysts
Net IncomeN/AN/AN/A
N/A5 analysts
EBITN/AN/AN/A
N/A5 analysts

Analysis

Forward estimates point to Revenue at +64.5% (15yr), giving you a quick read on expected growth from here.

Who manages SNDX?

Syndax Pharmaceuticals, Inc. (SNDX) lists 11 active executives. The top listed executive is Michael Downes, Co-Founder.

Are SNDX insiders buying or selling?

Recent insider activity shows net buying of $46.14M.

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