Protagonist Therapeutics, Inc.

Protagonist Therapeutics, Inc.

Healthcare

NASDAQ:PTGX · NASDAQ Global Market

Market Cap $7.06B Beta 1.83 P/E (TTM) -62.3
$109.78 -0.01%

-$0.01 today

52W Low $49.38High $111.78

Vol 0.44M · Avg 0.73M

EPS (TTM)-$1.76
Biotechnology

Management

Put operating results in leadership context

Review returns on capital, executive background, insider transactions, and growth quality to judge whether management is compounding value well.

Return Metrics

ROE, ROIC & ROA over time

Management

ROE

-21.2%

avg -23.5%

ROIC

-25.2%

avg -39.9%

ROA

-19.4%

avg -32.0%

Analysis

ROA is currently the strongest return metric at -19.4% versus its period average of -32.0%. 0 of 3 return metrics are above their quality threshold, which helps indicate how efficiently the company turns capital and assets into profit.

Management

Key executives, compensation & ownership

Management
NameTitleCompensationTenureAgeShares OwnedOwnership %

Dinesh V. Patel

Chief Executive Officer, President, Secretary & Director$1.41M69$523,478.000.81%

Arturo Molina FACP

Chief Medical Officer$949,992.0067$99,115.000.15%

Asif Ali

Executive Vice President & Chief Financial Officer$826,242.0052$59,003.000.09%

Carena Spivey

Executive VP & Chief Human Resources Officer

Ashok Bhandari

EVP & Chief Discovery Officer62

Newman Yeilding

Executive Vice President, Chief Scientific Officer

Samuel R. Saks

Clinical Development Advisor71$90,000.000.14%

Carter J. King

Executive Vice President of Business Development55

Matthew Gosling

Executive Vice President and Chief Legal & Business Officer55

Venkat Thalladi

EVP & Chief Technical Officer

Abha Bommireddi

Executive Vice President & Chief of Staff

Insider Trading

SEC Form 4 transactions — last 12 months

Management

Buys

0

$0.00

Sells

35

$50.13M

Net Sentiment

$50.13M

Net selling

Most Active

PATEL DINESH V PH D

11 transactions

DateInsiderTypeSharesPriceValue
Jun 10, 2026

Waddill William D.

Direct

Sell9.0K$107.68$969,120.00
May 29, 2026

Waddill William D.

Direct

Sell9.0K$99.64$896,760.00
May 12, 2026

PATEL DINESH V PH D

Direct

Sell75.0K$100.12$7,509,000.00
May 8, 2026

Giraudo Bryan

Direct

Sell5.1K$100.00$513,000.00
May 8, 2026

Giraudo Bryan

Indirect

Sell6.0K$100.00$600,000.00
May 7, 2026

Giraudo Bryan

Direct

Sell36.0K$100.14$3,605,040.00
May 7, 2026

Giraudo Bryan

Indirect

Sell12.0K$100.07$1,200,840.00
Apr 20, 2026

Ali Asif

Direct

Sell1.8K$105.47$184,572.50
Mar 26, 2026

MOLINA ARTURO MD

Direct

Sell15.0K$104.79$1,571,850.00
Mar 26, 2026

SELICK HAROLD E

Direct

Sell24.0K$105.00$2,520,000.00

1–10 of 35

Analysis

Insiders reported 0 buys worth $0.00 and 35 sells worth $50.13M over the last 12 months. That adds up to net selling of $50.13M. PATEL DINESH V PH D was the most active insider with 11 transactions.

Growth Analysis

Historical CAGR & forward analyst estimates

Metric 10yr5yr3yr Fwd Est.
EPSN/AN/AN/A
N/A1 analysts
RevenueN/AN/AN/A
+29.6% (12yr)6 analysts
Net IncomeN/AN/AN/A
N/A6 analysts
EBITN/AN/AN/A
N/A6 analysts

Analysis

Forward estimates point to Revenue at +29.6% (12yr), giving you a quick read on expected growth from here.

Who manages PTGX?

Protagonist Therapeutics, Inc. (PTGX) lists 11 active executives. The top listed executive is Carena Spivey, Executive VP & Chief Human Resources Officer.

Are PTGX insiders buying or selling?

Recent insider activity shows net selling of $41.47M.

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