Prelude Therapeutics Incorporated

Prelude Therapeutics Incorporated

Healthcare

NASDAQ:PRLD · NASDAQ Global Select

Market Cap $250.50M Beta 1.01 P/E (TTM) -4.8
$4.49 +9.25%

+$0.38 today

52W Low $0.75High $5.54

Vol 0.31M · Avg 0.37M

EPS (TTM)-$0.94
Biotechnology

Management

Put operating results in leadership context

Review returns on capital, executive background, insider transactions, and growth quality to judge whether management is compounding value well.

Return Metrics

ROE, ROIC & ROA over time

Management

ROE

-145.0%

avg -37.2%

ROIC

-114.8%

avg -82.1%

ROA

-70.4%

avg -64.6%

Analysis

ROA is currently the strongest return metric at -70.4% versus its period average of -64.6%. 0 of 3 return metrics are above their quality threshold, which helps indicate how efficiently the company turns capital and assets into profit.

Management

Key executives, compensation & ownership

Management
NameTitleCompensationTenureAgeShares OwnedOwnership %

Krishna Vaddi

Founder, Chief Executive Officer & Director$935,256.0060$837,000.001.07%

Bryant David Lim

Chief Financial Officer, Chief Legal Officer & Corporate Secretary$681,050.0055$38,000.000.05%

Peggy A. Scherle

Chief Scientific Officer$674,206.0064$230,000.000.29%

Andrew Combs

Executive Vice President & Chief Chemistry Officer$562,461.0059$230,000.000.29%

Charles Q. Morris MRCP

Chief Medical Officer61$450,000.000.57%

Madhu Pudipeddi

Senior Vice President of Technical Operations

Wan-Jen Hong

Senior Vice President of Clinical Development47

Naveen Babbar

Senior Vice President of Translation Medicine

Robert A. Doody Jr.

Senior Vice President of Investor Relations

Sean Brusky

Chief Business Officer48$0.00<0.01%

Sri Sahasranaman

Senior Vice President of Clinical Pharmacology

Aimee Crombie

Senior Vice President and Head of Strategic Planning & Operations

Michele Porreca

Chief People Officer

Insider Trading

SEC Form 4 transactions — last 12 months

Management

Buys

6

$25.00M

Sells

0

$0.00

Net Sentiment

+$25.00M

Net buying

Most Active

Bonita David P

2 transactions

DateInsiderTypeSharesPriceValue
Apr 21, 2026

Bonita David P

Indirect

Buy1.69M$4.44$7,499,999.16
Apr 21, 2026

Bonita David P

Indirect

Buy1.13M$4.44$4,999,999.44
Apr 21, 2026

ORBIMED ADVISORS LLC

Indirect

Buy1.69M$4.44$7,499,999.16
Apr 21, 2026

ORBIMED ADVISORS LLC

Indirect

Buy1.13M$4.44$4,999,999.44
Apr 21, 2026

BAKER BROS. ADVISORS LP

Indirect

Buy2.14M$0.00$213.77
Apr 21, 2026

BAKER BROS. ADVISORS LP

Indirect

Buy114.6K$0.00$11.46

Analysis

Insiders reported 6 buys worth $25.00M and 0 sells worth $0.00 over the last 12 months. That adds up to net buying of $25.00M. Bonita David P was the most active insider with 2 transactions.

Growth Analysis

Historical CAGR & forward analyst estimates

Metric 10yr5yr3yr Fwd Est.
EPSN/AN/AN/A
N/A1 analysts
RevenueN/AN/AN/A
N/A1 analysts
Net IncomeN/AN/AN/A
N/A1 analysts
EBITN/AN/AN/A
N/A1 analysts

Analysis

Analysis will appear once historical growth or forward estimates are available for this company.

Who manages PRLD?

Prelude Therapeutics Incorporated (PRLD) lists 13 active executives. The top listed executive is Andrew Combs, Executive Vice President & Chief Chemistry Officer.

Are PRLD insiders buying or selling?

Recent insider activity shows net buying of $66.86M.

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