Praxis Precision Medicines, Inc.

Praxis Precision Medicines, Inc.

Healthcare

NASDAQ:PRAX · NASDAQ Global Select

Market Cap $5.64B Beta 2.75 P/E (TTM) -23.6
$266.58 +7.50%

+$18.60 today

52W Low $37.19High $366.52

Vol 0.42M · Avg 0.44M

EPS (TTM)-$11.31
Biotechnology

Management

Put operating results in leadership context

Review returns on capital, executive background, insider transactions, and growth quality to judge whether management is compounding value well.

Return Metrics

ROE, ROIC & ROA over time

Management

ROE

-34.5%

avg -111.4%

ROIC

-37.1%

avg -105.6%

ROA

-32.3%

avg -85.2%

Analysis

ROA is currently the strongest return metric at -32.3% versus its period average of -85.2%. 0 of 3 return metrics are above their quality threshold, which helps indicate how efficiently the company turns capital and assets into profit.

Management

Key executives, compensation & ownership

Management
NameTitleCompensationTenureAgeShares OwnedOwnership %

Marcio Souza

President, Chief Executive Officer & Director$2.65M47$77,016.000.36%

Timothy Edwin Kelly

Chief Financial Officer & Treasurer$1.18M53$31,167.000.15%

Alex Nemiroff

General Counsel & Secretary$1.03M47$26,010.670.12%

Karl Hansen

Chief Technical Operations Officer

Brian Spar

Chief of Staff

Alyssa J. S. Wyant

Chief Regulatory & Quality Officer51

Megan T. Sniecinski

Chief Operating Officer45$28,664.000.14%

Orrin Devinsky

Head of Clinical Strategy68

Steven Petrou

Co-Founder and President of Research & Development

Kelly McCue

Chief People Officer$31,167.000.15%

Insider Trading

SEC Form 4 transactions — last 12 months

Management

Buys

10

$33.20M

Sells

6

$7.46M

Net Sentiment

+$25.73M

Net buying

Most Active

Adage Capital Management, L.P.

10 transactions

DateInsiderTypeSharesPriceValue
Nov 20, 2025

Nemiroff Alex

Direct

Sell1.7K$190.86$327,139.18
Nov 20, 2025

Nemiroff Alex

Direct

Sell13.3K$192.53$2,568,197.69
Nov 20, 2025

Nemiroff Alex

Direct

Sell977$193.23$188,788.64
Nov 20, 2025

Nemiroff Alex

Direct

Sell9.1K$194.30$1,768,130.00
Nov 20, 2025

Mastrocola Lauren

Direct

Sell11.5K$191.96$2,198,878.89
Nov 20, 2025

Mastrocola Lauren

Direct

Sell2.1K$192.71$413,365.10
Oct 16, 2025

Adage Capital Management, L.P.

Indirect

Buy12.6K$90.00$1,134,031.50
Oct 16, 2025

Adage Capital Management, L.P.

Indirect

Buy447$91.04$40,694.97
Oct 16, 2025

Adage Capital Management, L.P.

Indirect

Buy1.4K$92.03$125,440.98
Oct 16, 2025

Adage Capital Management, L.P.

Indirect

Buy559$100.11$55,961.10

1–10 of 16

Analysis

Insiders reported 10 buys worth $33.20M and 6 sells worth $7.46M over the last 12 months. That adds up to net buying of $25.73M. Adage Capital Management, L.P. was the most active insider with 10 transactions.

Growth Analysis

Historical CAGR & forward analyst estimates

Metric 10yr5yr3yr Fwd Est.
EPSN/AN/AN/A
N/A6 analysts
RevenueN/AN/AN/A
N/A7 analysts
Net IncomeN/AN/AN/A
N/A7 analysts
EBITN/AN/AN/A
N/A7 analysts

Analysis

Analysis will appear once historical growth or forward estimates are available for this company.

Who manages PRAX?

Praxis Precision Medicines, Inc. (PRAX) lists 10 active executives. The top listed executive is Karl Hansen, Chief Technical Operations Officer.

Are PRAX insiders buying or selling?

Recent insider activity shows net buying of $74.42M.

Explore More

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