Fulcrum Therapeutics, Inc.

Fulcrum Therapeutics, Inc.

Healthcare

NASDAQ:FULC · NASDAQ Global Market

Market Cap $192.10M Beta 2.92 P/E (TTM) -3.5
$3.45 -2.82%

-$0.10 today

52W Low $2.83High $15.74

Vol 1.34M · Avg 1.73M

EPS (TTM)-$1.00
Biotechnology

Management

Put operating results in leadership context

Review returns on capital, executive background, insider transactions, and growth quality to judge whether management is compounding value well.

Return Metrics

ROE, ROIC & ROA over time

Management

ROE

-21.5%

avg -234.4%

ROIC

-23.8%

avg -201.9%

ROA

-20.4%

avg -93.5%

Analysis

ROA is currently the strongest return metric at -20.4% versus its period average of -93.5%. 0 of 3 return metrics are above their quality threshold, which helps indicate how efficiently the company turns capital and assets into profit.

Management

Key executives, compensation & ownership

Management
NameTitleCompensationTenureAgeShares OwnedOwnership %

Alexander C. Sapir

Chief Executive Officer, President & Director$1.20M59$650,000.001.20%

Alan A. Musso

Chief Financial Officer$802,215.0064$170,000.000.31%

Curtis G. Oltmans

Chief Legal Officer, Head of External Affairs & Corporate Secretary$689,500.0063$170,000.000.31%

Gregory Tourangeau

Controller & Principal Accounting Officer$57,000.000.11%

Rudolf Jaenisch

Founder

Jeffrey W. Jacobs

Chief Scientific Officer63

Danny Reinberg

Founder

Michael R. Green

Founder

Kim Hazen

Chief People Officer

Tsun-Huei Lee

Founder62

Bradley E. Bernstein

Founder

Insider Trading

SEC Form 4 transactions — last 12 months

Management

Buys

0

$0.00

Sells

8

$59.09M

Net Sentiment

$59.09M

Net selling

Most Active

Gould Robert J

4 transactions

DateInsiderTypeSharesPriceValue
Feb 2, 2026

Gould Robert J

Direct

Sell15.0K$10.72$160,857.00
Jan 2, 2026

Gould Robert J

Direct

Sell15.0K$10.87$163,089.00
Jan 2, 2026

Gould Robert J

Direct

Sell15.0K$11.87$178,089.00
Dec 15, 2025

Oltmans Curtis Gale

Direct

Sell3.5K$12.92$44,599.84
Dec 8, 2025

RA CAPITAL MANAGEMENT, L.P.

Indirect

Sell2.71M$14.28$38,647,349.16
Dec 8, 2025

RA CAPITAL MANAGEMENT, L.P.

Indirect

Sell1.38M$13.33$18,355,676.60
Dec 8, 2025

RA CAPITAL MANAGEMENT, L.P.

Indirect

Sell91.7K$14.98$1,373,995.56
Nov 19, 2025

Gould Robert J

Direct

Sell15.0K$11.03$165,495.00

Analysis

Insiders reported 0 buys worth $0.00 and 8 sells worth $59.09M over the last 12 months. That adds up to net selling of $59.09M. Gould Robert J was the most active insider with 4 transactions.

Growth Analysis

Historical CAGR & forward analyst estimates

Metric 10yr5yr3yr Fwd Est.
EPSN/AN/AN/A
N/A1 analysts
RevenueN/AN/AN/A
+30.0% (9yr)2 analysts
Net IncomeN/AN/AN/A
N/A2 analysts
EBITN/AN/AN/A
N/A2 analysts

Analysis

Forward estimates point to Revenue at +30.0% (9yr), giving you a quick read on expected growth from here.

Who manages FULC?

Fulcrum Therapeutics, Inc. (FULC) lists 11 active executives. The top listed executive is Alexander C. Sapir, Chief Executive Officer, President & Director.

Are FULC insiders buying or selling?

Recent insider activity shows net buying of $29.57M.

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