Arrowhead Pharmaceuticals, Inc.

Arrowhead Pharmaceuticals, Inc.

Healthcare

NASDAQ:ARWR · NASDAQ Global Select

Market Cap $10.48B Beta 1.27 P/E (TTM) -35.1
$74.52 -0.42%

-$0.31 today

52W Low $14.30High $82.26

Vol 1.17M · Avg 1.89M

EPS (TTM)-$2.11
Biotechnology

Management

Put operating results in leadership context

Review returns on capital, executive background, insider transactions, and growth quality to judge whether management is compounding value well.

Return Metrics

ROE, ROIC & ROA over time

Management

ROE

-0.3%

avg -66.9%

ROIC

4.6%

avg -36.2%

ROA

-0.1%

avg -30.6%

Analysis

ROIC is currently the strongest return metric at 4.6% versus its period average of -36.2%. 0 of 3 return metrics are above their quality threshold, which helps indicate how efficiently the company turns capital and assets into profit.

Management

Key executives, compensation & ownership

Management
NameTitleCompensationTenureAgeShares OwnedOwnership %

Christopher R. Anzalone

Chairman, Chief Executive Officer & President$2.22M57$3.80M2.70%

Patrick O'Brien

COO & Secretary$1.05M62$472,848.000.34%

Daniel J. Apel

Chief Financial Officer$1.04M60$162,905.000.12%

James C. Hamilton

Chief Medical Officer and Head of R&D$987,213.0047$226,958.000.16%

Bruce D. Given

Chief Medical Scientist$486,308.0072$62,514.000.04%

Mark Davis

Founder and Founder & Director of Insert Therapeutics Inc & Calando

Vincent Anzalone

Head of Investor Relations & Vice President$3.80M2.70%

Mark Seefeld

Head of Toxicology & Vice President72

Aaron Tan

Head of Tax

Tao Pei

Chief Scientific Officer

Howard Lovy

Director of Communications

Insider Trading

SEC Form 4 transactions — last 12 months

Management

Buys

0

$0.00

Sells

67

$37.88M

Net Sentiment

$37.88M

Net selling

Most Active

Anzalone Christopher Richard

25 transactions

DateInsiderTypeSharesPriceValue
May 12, 2026

Lu Hongbo

Direct

Sell3.0K$76.88$228,333.60
Apr 23, 2026

Hamilton James C

Direct

Sell10.0K$75.00$750,000.00
Apr 22, 2026

Apel Daniel Joseph

Direct

Sell8.7K$71.92$627,861.60
Apr 22, 2026

Apel Daniel Joseph

Direct

Sell3.2K$70.11$224,912.88
Apr 22, 2026

Apel Daniel Joseph

Direct

Sell1.2K$70.45$81,510.65
Mar 5, 2026

Hamilton James C

Direct

Sell10.0K$64.19$641,900.00
Jan 5, 2026

O'Brien Patrick

Direct

Sell5.9K$62.91$369,470.43
Jan 5, 2026

O'Brien Patrick

Direct

Sell900$66.01$59,409.00
Jan 5, 2026

O'Brien Patrick

Direct

Sell313$68.00$21,284.00
Jan 5, 2026

O'Brien Patrick

Direct

Sell600$61.12$36,672.00

1–10 of 67

Analysis

Insiders reported 0 buys worth $0.00 and 67 sells worth $37.88M over the last 12 months. That adds up to net selling of $37.88M. Anzalone Christopher Richard was the most active insider with 25 transactions.

Growth Analysis

Historical CAGR & forward analyst estimates

Metric 10yr5yr3yr Fwd Est.
EPSN/AN/AN/A
N/A7 analysts
RevenueN/AN/A+37.5%
+74.3% (15yr)5 analysts
Net IncomeN/AN/AN/A
N/A5 analysts
EBITN/AN/AN/A
N/A5 analysts

Analysis

Recent growth has been strongest in Revenue at +37.5% over three years. Forward estimates point to Revenue at +74.3% (15yr), giving you a quick check on whether expectations are accelerating or cooling.

Who manages ARWR?

Arrowhead Pharmaceuticals, Inc. (ARWR) lists 11 active executives. The top listed executive is Mark Davis, Founder and Founder & Director of Insert Therapeutics Inc & Calando.

Are ARWR insiders buying or selling?

Recent insider activity shows net selling of $52.68M.

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